1. [The characteristics of the chromosomal apparatus and functional state of the thyroid in amenorrhea in women].
- Author
-
Shloma DV, Sozans'kyĭ OO, Huleiuk NL, Akopian HR, and Nevzhoda NV
- Subjects
- Adolescent, Adult, Amenorrhea epidemiology, Amenorrhea etiology, Amenorrhea physiopathology, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 9, Female, Genetic Variation genetics, Humans, Incidence, Karyotyping, Phenotype, Amenorrhea genetics, Chromosome Aberrations genetics, Thyroid Gland physiopathology
- Abstract
Girls-teenagers and women with menstrual disturbances were examined cytogenetically and clinically with special respect to the thyroid function. The rate of chromosomal pathology in the studied group was 29.5%. The rate of aberrant cells proved to be elevated in cases of primary and secondary amenorrhea as compared with the control. Chromatid aberrations were typical of the Turner syndrome (8.1% as against 2.1% in controls). In cases of menstrual disturbances the C-segment macrovariants were detected in chromosomes 9 and 16, so as inverted C-segments. The thyroid hyperplasia of the 1st, 2nd stages was detected at the rate of 81.2% among the teenaged girls with menstrual disturbances and TSH-hypophysis-hyperfunction was typical of women with primary or secondary amenorrhea, providing evidence for the secondary origin of thyroid hormonal disturbances. more...
- Published
- 1993