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Transactions of the London and Middlesex Archaeological Society, 1.3, 547-559

There are certain types of biological activity (carcinogenic, œstrogenic, androgenic, progestational and cortical) in which, although little or nothing is known of the mechanism of action, the chemical structures of the primary agents are rather precisely known. While potent carcinogenic and œstrogenic activity is characterized by very low specificity to molecular type, and high androgenic, progestational, and cortical activity is associated in each case with a single specific molecular type, all five types of activity are sensitive to stereochemical structural modification. Thus deoxycorticosterone acetate (I) possesses high cortical activity, whereas 17-isodeoxycorticOsterone acetate (II), which differs only in configuration at C17, is completely inactive1; similarly the activity of progesterone (III) disappears entirely in the epimeric 17-isoprogesterone (IV)2.

Developmental dysplasia of the hip (DDH), formerly known as congenital dislocation of the hip (CDH), is a term used to describe a variety of abnormalities of the hip in development. The treatment options are diverse depending on etiology, degree of dislocation, and age of the child when diagnosis is made. This article provides the reader with a knowledge base to assist with early diagnosis, treatment, and nursing care of the client with dislocations and subluxations of the hip. Presented are the definitions, diagnostic techniques, treatments, and nursing diagnoses and interventions for the client with DDH and for the child's family.