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Atypical cellular neurothekeoma is a rare benign soft-tissue tumour that usually arises in the head and neck region, shoulder girdles, and proximal extremities, predominantly in young women. This dermal neoplasm is under-reported in the literature and is not uncommonly misdiagnosed as a malignant tumour due to its worrisome histologic characteristics. Currently, the diagnosis of cellular neurothekeoma relies on a panel of non-specific immunohistochemical markers and its etiopathogenesis is unknown. Herein, we present the case of an atypical cellular neurothekeoma in the arm of a 49-year-old woman, describing its microscopic features and immunohistochemical profile. Additionally, we present a novel heterozygous predicted inactivating NF1 mutation, not previously reported, which was identified using high-throughput molecular techniques. Such finding might provide insights into the pathogenesis of neurothekeoma, potentially contributing to future refinements in diagnosis, which would enable more precise identification of this neoplasm. [ABSTRACT FROM AUTHOR]

Background: Several tests have been suggested for screening and diagnosis of cervical spine and shoulder girdle conditions underlying shoulder pain with variable degrees of clinical accuracy. The present study aimed to test the reliability, clinical benefit and screening value of the Swimmer Arm-to-Shoulder (SAS) test; a new clinical test developed to differentiate shoulder impingement from cervical radiculopathy in patients with shoulder pain of ≤ 12 weeks. Methods: The study included 718 patients aged 40–65 years, with unilateral and localized shoulder girdle pain lasting for ≤ 12 weeks. Diagnosis based on clinical, electromyography and radiological findings was considered as the reference gold standard for test assessment. Results: Clinical diagnosis identified shoulder pathology in 288 patients (40.1%) and cervical spine pathology in 430 patients (59.9%). SAS test was positive in 274 patients (38.2%). The SAS test proved to be effective in distinguishing shoulder from cervical spine pathology with a sensitivity of 89.2% (95% CI: 85.0-92.6%), specificity of 96.1% (95% CI: 93.8–97.7%), PPV of 93.8% (95% CI: 90.5–96.0%), NPV of 93.0% (95% CI: 90.5–94.9%), LR + of 22.6% (95% CI: 14.1–36.0%), LR- of 0.11 (95% CI: 0.08–0.16) and accuracy of 93.3% (95% CI: 91.2–95.0%). Conclusions: SAS test is an easy to perform, patient dependent and reliable as a screening test and diagnosis confirmatory test. [ABSTRACT FROM AUTHOR]

Golf is an international sport that has become increasingly more popular in recent times. Previous literature has shown that golf approach shots are crucial to the success of elite golfers. However, there is no known publication investigating distances less than 100 yards, known as the short game. The primary purpose of this study was to collect comprehensive data on 3D biomechanical variables of the short game at four target distances in college-aged, male golfers. Participants were instructed to hit five successful shots at each target distance: 30 yards, 50 yards, 70 yards and full swing (maximal distance) yardage. A motion capture system recorded kinematic and temporal parameters of golfer movement, additional to a golf simulator that collected ball carry distance of each shot. Distance did have a significant (p ≤ 0.05) effect on swing phase timing, angular velocities and motion sequencing. Movement sequencing within the short game displayed irregular patterns across all distances and phases, with a partial proximal-to-distal pattern (pelvis → shoulder girdle → arms → club) at best. The findings of this study show that the short game swing did present its own unique motion patterns that will require practice as its own skill. [ABSTRACT FROM AUTHOR]

The Hypancistrus genus is recognized in the Río Orinoco basin and Rio Xingu in the Guiana and Brazilian Shields, respectively. Some of its species are important in ornamental fishing. Despite this significance, many other undescribed species are still awaiting to be named. Here we describe a new species of Hypancistrus found on bedrock in the Rio Tocantins, representing an extension of the distribution of the genus. Also, a multigene phylogeny is presented to evaluate the taxonomic position of this species concerning congeners. The new species differs from all congeners by (1) hypertrophied odontodes on cheeks reaching beyond the cleithrum, (2) a supraoccipital crest conspicuously elevated, (3) a supraorbital crest slightly convex, (4) oblique bars on the anterior part of the body, (5) a dark E‐shaped mark on the snout, (6) three oblique dark bars on the anterior part of the body and horizontal vermicular bars from the pectoral girdle to the posterior insertion of the dorsal fin, (7) a thin light gray bar on the posterior of the head extending across the branchial opening, (8) a tan background color, (9) a developed suspensorium with a diminished appendix in the metapterygoid, and (10) a dentary plate robust significantly fused with the angulo‐articular bone. The molecular phylogenetic results show the new species forming a group with Hypancistrus zebra (Brazilian Shield—Rio Xingu) as a clade, a sister group of a monophyletic group consisting of all congeners from the Río Orinoco. [ABSTRACT FROM AUTHOR]

Upper Crossed Syndrome (UCS), described by Vladimir Janda, is characterized by postural changes involving the cervical spine and trunk, leading to biomechanical limitations and cervicoscapulobrachial pain. This study proposes a mesotherapy protocol, termed the 8:1 block, to address cervicoscapulobrachialgia by targeting the scapulae and associated musculature. The scapula, central to shoulder girdle kinematics, often exhibits dyskinesis and muscular imbalances, notably the pattern referred to as scapular upper trapping (SUT). SUT involves scapular elevation, medial rotation, and shoulder protraction, contributing to cervicobrachial pain. The protocol includes a comprehensive assessment of muscle tone changes and biomechanical considerations, highlighting the importance of the scapula in upper limb movement and posture. Key anatomical changes involve tightened upper trapezius, levator scapulae, and pectoralis minor muscles, with weakened middle trapezius and serratus anterior. The mesotherapy approach targets these imbalances through specific injection points to alleviate muscle tension and correct postural deviations. Case studies from our clinic demonstrate the protocol's effectiveness in reducing pain and restoring scapular biomechanics. Patients reported significant improvements in pain relief and functional outcomes, underscoring the clinical utility of the 8:1 block in treating cervicoscapulobrachialgia. This protocol offers a feasible, cost-effective intervention that enhances the efficacy of traditional therapeutic exercises by addressing underlying muscular and biomechanical dysfunctions. In conclusion, the 8:1 block mesotherapy protocol provides a novel approach to managing cervicoscapulobrachial pain by focusing on scapular biomechanics and muscle tension. Further studies are needed to validate these findings and refine the protocol for broader clinical application. [ABSTRACT FROM AUTHOR]

Scapula shape is highly variable across humans and appears to be sexually dimorphic—differing significantly between biological males and females. However, previous investigations of sexual dimorphism in scapula shape have not considered the effects of allometry (the relationship between size and shape). Disentangling allometry from sexual dimorphism is necessary because apparent sex‐based differences in shape could be due to inherent differences in body size. This study aimed to investigate sexual dimorphism in scapula shape and examine the role of allometry in sex‐based variation. We used three‐dimensional geometric morphometrics with Procrustes ANOVA to quantify scapula shape variation associated with sex and size in 125 scapulae. Scapula shape significantly differed between males and females, and males tended to have larger scapulae than females for the same body height. We found that males and females exhibited distinct allometric relationships, and sexually dimorphic shape changes did not align with male‐ or female‐specific allometry. A secondary test revealed that sexual dimorphism in scapula shape persisted between males and females of similar body heights. Overall, our findings indicate that there are sex‐based differences in scapula shape that cannot be attributed to size‐shape relationships. Our results shed light on the potential role of sexual selection in human shoulder evolution, present new hypotheses for biomechanical differences in shoulder function between sexes, and identify relevant traits for improving sex classification accuracy in forensic analyses. [ABSTRACT FROM AUTHOR]

BACKGROUND: Parsonage-Turner syndrome (PTS) is a rare brachial neuritis of sudden onset resulting in constant, severe shoulder girdle pain followed by weakness and sensory deficits. The complex presentation often results in delayed diagnosis or misdiagnosis. This case report provides insight into a comprehensive approach to diagnosing PTS. CASE PRESENTATION: A 50-year-old man began experiencing severe left shoulder pain 48 hours before seeking medical treatment. OUTCOME AND FOLLOW-UP: The lack of conclusive findings during the physical therapy evaluation prompted a magnetic resonance imaging that revealed PTS. The patient reported full resolution of symptoms within 12 months. DISCUSSION: Severe pain, neurological weakness, and sensory changes led to the initial suspicion of a rotator cuff tear and brachial plexus injury, and a magnetic resonance imaging was recommended. This case study adds to the body of evidence emphasizing the importance of differential diagnosis in patients with neuromusculoskeletal involvement. JOSPT Cases 2024;4(4):1-4. Epub 18 September 2024. doi:10.2519/josptcases.2024.0038 [ABSTRACT FROM AUTHOR]

Wheelchair basketball players often develop shoulder pain due to repetitive wheelchair propulsion motion. Wheelchair propulsion involves two phases, push and recovery, with several different muscles simultaneously active in each phase. Although differences in the coordinated activity of multiple muscles may influence the mechanism of injury occurrence, there have been no studies investigating muscle synergy in wheelchair propulsion motion. Twelve healthy adult males with no previous wheelchair driving experience were included. The surface electromyography data of 10 muscles involved in shoulder joint movements were measured during a 20 m wheelchair propulsion motion. Muscle synergies were extracted using non-negative matrix factorization analysis of the electromyography data. Four muscle synergies were identified during wheelchair propulsion. Synergy 1 reflects propulsion through shoulder flexion and elbow flexion, while Synergy 2 involves shoulder flexion and elbow extension. Synergy 3 describes shoulder extension returning the upper limb, which has moved forward during the push, back to its original position, and Synergy 4 relates to stabilize the shoulder girdle during the recovery phase. This study is the first to explore muscle synergy during wheelchair propulsion, and the data from healthy participants without disabilities or pain will provide a baseline for future comparisons with data from wheelchair basketball players. [ABSTRACT FROM AUTHOR]

The evolution of limb reduction in squamates is a classic example of convergence, but the skeletal morphological patterns associated with it are underexplored. To provide insights on the biomechanical and developmental consequences of transitions to limb reduction, we use geometric morphometrics to examine the morphology of pectoral and pelvic girdles in 90 species of limb-reduced skinks and their fully limbed relatives. Clavicle shapes converge towards an acute anterior bend when forelimbs are lost but hindlimbs are retained—a morphology typical of sand-swimmers. This may either indicate functional adaptations to locomotion in fine substrates, or a developmental consequence of complete limb loss. The shape of limb-bearing elements of both girdles (coracoid and pelvis) instead closely mirrors limb reduction, becoming more simplified as undulation replaces limbed locomotion. Integration between girdles decreases in taxa lacking elements of the forelimbs but not hindlimbs, indicating differential selection on each girdle in response to distinct locomotory strategies. However, this pattern becomes less clear when considering phylogenetic history, perhaps because it is limited to one specific clade (Lerista). We show how the functional demands of locomotion can induce changes at different levels of organismal organization, including both external and internal structures. [ABSTRACT FROM AUTHOR]

This study comprehensively assesses various recurrent neural networks (RNNs) for decoding the elbow angle from electromyogram (EMG) signals, a crucial aspect in myoelectric interfaces. EMG signals from the shoulder girdle and arm were recorded during goal-directed reaching movements, and linear envelopes were continuously mapped to the elbow angle by three RNN architectures: nonlinear autoregressive exogenous (NARX), Elman, and long-term short memory (LSTM). All three approaches effectively captured the complex dynamics of the multi-input to a single-output regression problem. Regarding within-subject variability, the NARX, Elman, and LSTM demonstrated superior accuracy and robustness compared to dynamic feedforward neural networks like time-delay neural networks. Notably, there was no statistically significant distinction among NARX, Elman, and LSTM estimation performances. Elman and LSTM exhibited an advantage in decoding latent information dependencies through their context layers, leading to improved estimation performance in inter-subject variability analysis, particularly with increased training data volume and variability. Furthermore, the LSTM, with its complex architecture capable of learning long-term temporal dependencies, exhibited the highest performance among the considered RNNs. Consequently, selecting the optimal RNN structure is recommended based on the complexity of the data at hand. The RNN-based decoding model holds potential applications in prosthetics, robotic assistants, and exoskeletons, enabling intention detection and real-time assessment of active rehabilitation progress. [ABSTRACT FROM AUTHOR]

Background: Congenital shoulder dislocation due to shoulder girdle malformation is called true congenital shoulder dislocation. It is an extremely rare disorder as compared with traumatic dislocation or secondary to brachial plexus injury. Case presentation: We report a case of atraumatic true congenital shoulder dislocation, one of the few reported cases across the world. The baby was born of a preterm caesarean section at 30 weeks of gestation, ruling out any perinatal trauma. The baby presented with a lateral shoulder crease and reduced movements of the affected upper limb. The diagnosis was confirmed with radiographs and a sonography that ruled out physeal injury. Treatment involved prompt closed reduction and stabilization by swathing in an adducted internally rotated position for two weeks. Conclusion: Owing to the rarity of this condition, the case is being reported to be archived with a handful of other such cases. [ABSTRACT FROM AUTHOR]

The climbing perch (Anabas testudineus) is a freshwater fish that can withstand highly unfavorable environments and stay out of the water for extended periods. Its anatomical characteristics showed terrestrial adaptation and terrestrial locomotion properties enable the use of climbing perch as an animal model. Moreover, its bone and cartilage profiles at different stages are crucial to improving the anatomical information for the osteogenesis model candidate. The current study aimed to illustrate the skeletal profiles of juvenile and adult climbing perch with the whole staining method. The samples included two adults and two juvenile climbing perch from Daerah Istimewa Yogyakarta, Indonesia. The fish were euthanized using β-hydroxyethyl phenyl ether in a lethal dose. The skeleton was examined using the Alcian blue–Alizarin red whole staining, which revealed the bones and cartilage under the stereomicroscope. The result showed that the bone is the main skeleton. Cartilage was detected in the area surrounding the orbit in the adult climbing perch and in the pterotic, pterosphenoid, prootic, and distal end of the hypural, parhypural, and basal pectoral girdle in the juvenile climbing perch. Endochondral osteogenesis was found in juvenile to adult climbing perch. [ABSTRACT FROM AUTHOR]

Unexpectedly abundant remains of herbivorous therapsids in the Late Triassic strata of southern Poland have significantly supplemented knowledge of their evolution. The skeletal morphology of the Late Norian (or Rhaetian) dicynodont Lisowicia bojani supports its close relationship to the Carnian Woznikella , both known from the Polish part of the Germanic Basin. Three evolutionary lineages of dicynodonts—Laurasian–Gondwanan Rhadiodromus klimovi  → Jachaleria candelariensis lineage, Laurasian lineage Shaanbeikannemeyeria xilougouensis  → Lisowicia bojani , and the Gondwanan lineage Kannemeyeria simocephalus  → Dinodontosaurus brevirostris —are distinguished based on characters of cranial and postcranial elements. In the lineages characterized by the parietal oval in cross-section and the two distinct articulations on the sternum, there is a tendency to exclude the frontal from the orbital margin and to reduce the number of sacral vertebrae. In the lineage with the parietal narrow and triangular in cross-section, the frontal forms part of the orbit margin, there is a single joint on the sternum, and there is a tendency towards flattening the skull roof. In both lineages the shoulder girdle is convergently modified, the acromion process decreased, and joints on the sternum moved posteriorly. [ABSTRACT FROM AUTHOR]

Sarcoglycanopathies are among the most frequent and severe forms of autosomal recessive forms of limb-girdle muscular dystrophies (LGMDs) with childhood onset. Four subtypes are known: LGMDR3, LGMDR4, LGMDR5 and LGMDR6, which are caused, respectively, by mutations in the SGCA, SGCB, SGCG and SGCD genes. We present the clinical variability of LGMD 2C/R5 among a genetically homogeneous group of 57 patients, belonging to 35 pedigrees. Molecular genetic analysis showed that all 57 patients were homozygous for the C283Y variant. The muscles of the pelvic girdle and the trunk were affected early and were more severely affected, followed by the shoulder girdle. Macroglossia, hypertrophy of the calves, scapular winging and lumbar hyperlordosis were common in the ambulatory phase. A great intra and interfamilial variability in the clinical presentation of LGMD 2C/R5 was observed, despite having the same underlying molecular defect. Females demonstrated a relatively milder clinical course compared to males. Mean creatine phosphokinase (CK) CK levels were 20 times above normal values. Muscle computer tomography (CT) CT or MRIs showed earlier and more severe involvement of the flexor proximal limb muscles in comparison to extensor muscles. [ABSTRACT FROM AUTHOR]

Four wild chelonians (two three-toed box turtles [Terrapene triunguis] and two red-eared sliders [Trachemys scripta elegans]) were presented to an academic wildlife rehabilitation center after presumably being hit by a car. Physical examinations revealed various carapace, bridge, and plastron fractures, as well as a lack of motor function of different limbs. A craniodorsal-caudoventral oblique view or caudodorsal-cranioventral oblique radiographic view made at 45° to the frontal plane (Cr45D-CdV and Cd45D-CrV oblique views, respectively), along with standard views (i.e., dorsoventral, right lateral, craniocaudal views), were performed. The oblique views allowed for visualization of different pectoral girdle or pelvic girdle fractures that were not visualized or clearly identified on the standard views. Based on the four clinical cases described here, the addition of Cr45D-CdV or Cd45D-CrV oblique views to the standard views may be beneficial, especially when advance imaging such as computed tomography is not available. These oblique views can be used to better assess chelonian pectoral and pelvic girdles because these structures are superimposed in standard radiographs. Future studies investigating the diagnostic accuracy of detecting pelvic and pectoral girdle fractures using these views are warranted. [ABSTRACT FROM AUTHOR]

The purpose of this research was to assess the inter and intra-tester reliability of a suspended platform and inline force transducer when assessing straight arm shoulder girdle strength. Fourteen male (n=9) and female (n=4) apparently healthy participants completed two testing sessions separated by 1 - 7 days, where they completed the athletic shoulder assessment protocol. Participants completed each position twice per testing session using the suspended testing platform. Results from the athletic shoulder test using the suspended platform showed high reliability when measured with Intra Class Correlation (average of >0.9) and Pearson's Correlation (average of >0.9). Relative typical error of the measurement method was <10% for intra-session reliability and <11% for inter-session reliability. The results of this study show that the use of a suspended platform and inline force transducer are a reliable tool to assess straight arm shoulder strength in multiple positions. For practitioners this can allow greater accessibility to assess straight arm shoulder strength assessment due to the ease of construction and lower cost of a suspended platform when compared to traditional force platforms. [ABSTRACT FROM AUTHOR]

Background: The diagnostic value of clinical rotator cuff (RC) tests is controversial, with only sparse evidence available about their anatomical specificity. We prospectively assessed regional RC muscle activation patterns by means of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) after the execution of common clinical RC tests. Methods: Ten healthy subjects (five males, five females) underwent three sessions of diffusion-weighted 3-T shoulder MRI before and after testing the supraspinatus (SSP, Jobe test, session 1), subscapularis (SSC, lift-off test, session 2, at least 1 week later), and infraspinatus muscle (ISP, external rotation test, session 3, another week later). IVIM parameters (perfusion fraction, f; pseudo-diffusion coefficient. D*; and their product, fD*) were measured in regions of interest placed in images of the SSP, SSC, ISP, and deltoid muscle. The Wilcoxon signed-rank test was used for group comparisons; p-values were adjusted using the Bonferroni correction. Results: After all tests, fD* was significantly increased in the respective target muscles (SSP, SSC, or ISP; p ≤ 0.001). After SSP testing, an additional significant increase of fD* was observed in the deltoid, the SSC, and the ISP muscle (p < 0.001). After the SSC and ISP tests, no significant concomitant increase of any parameter was observed in the other RC muscles. Conclusion: IVIM revealed varying activation patterns of RC muscles for different clinical RC tests. For SSP testing, coactivation of the deltoid and other RC muscles was observed, implying limited anatomical specificity, while the tests for the SSC and ISP specifically activated their respective target muscle. Relevance statement: Following clinical RC tests, IVIM MRI revealed that SSP testing led to shoulder muscle coactivation, while the SSC and ISP tests specifically activated the target muscles. Key Points: In this study, intravoxel incoherent motion MRI depicted muscle activation following clinical rotator cuff tests. After supraspinatus testing, coactivation of surrounding shoulder girdle muscles was observed. Subscapularis and infraspinatus tests exhibited isolated activation of their respective target muscles. [ABSTRACT FROM AUTHOR]

Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy, characterized by progressive and asymmetric muscle atrophy, primarily affecting muscles of the face, shoulder girdle, and upper arms before affecting muscles of the lower extremities with age and greater disease severity. FSHD is a disabling condition, and patients may also present with various extramuscular symptoms. FSHD is caused by the aberrant expression of double homeobox 4 (DUX4) in skeletal muscle, arising from compromised epigenetic repression of the D4Z4 array. DUX4 encodes the DUX4 protein, a transcription factor that activates myotoxic gene programs to produce the FSHD pathology. Therefore, sequence-specific oligonucleotides aimed at reducing DUX4 levels in patients is a compelling therapeutic approach, and one that has received considerable research interest over the last decade. This review aims to describe the current preclinical landscape of oligonucleotide therapies for FSHD. This includes outlining the mechanism of action of each therapy and summarizing the preclinical results obtained regarding their efficacy in cellular and/or murine disease models. The scope of this review is limited to oligonucleotide-based therapies that inhibit the DUX4 gene, mRNA, or protein in a way that does not involve gene editing. [ABSTRACT FROM AUTHOR]

(1) Background: Although most brachial plexus birth palsies show some spontaneous recovery, secondary operations are likely to follow. Accordingly, due to the loss of muscle innervation, the growth of the affected limb and the shoulder girdle is reduced. This is associated with pathological scapula positioning and rotation. The objective of this work was to clarify the relationship between length differences of the two clavicles and different types of scapular dyskinesia. (2) Methods: Twenty-five patients suffering from brachial plexus birth palsy were included in this retrospective study. There were eighteen female and seven male patients with a mean age of 10 years (2 to 23 years). CT scans of the thoracic cage, including both shoulder joints and both clavicles, were obtained preoperatively between 2010 and 2012. Radiographic measurements were taken of the axial plane and 3D reconstructions were produced. Functional evaluations of possible movement and scapular dyskinesia were performed. (3) Results: We found an increasing difference in the length of the clavicle (both in absolute and relative terms) in the children with more pronounced scapular dyskinesia. Additionally, with increasing clavicle length differences, the scapula was positioned in a deteriorated angle compared to the healthy side. Significant positive correlations were identified for the age and absolute difference of the clavicle length and the length and width of the scapula on the affected side. (4) Conclusion: Scapular dyskinesia, which is a common finding in brachial plexus birth palsy, is strongly related to reduced clavicle growth. Reduced clavicle length (which is a relatively easily examinable parameter) compared to the healthy side can be used to estimate the extent of scapular malpositioning on the thoracic cage. The extent and severity of scapular dyskinesia increases with augmented differences in the length of the clavicle. [ABSTRACT FROM AUTHOR]

The pediatric shoulder girdle is a complex anatomical structure uniting the upper extremity and trunk. The osseous structures, their articulations, and the surrounding soft tissue support structures (muscles, tendons, and ligaments) allow for a wide range of motion at the shoulder. Growth and maturation of the components at the shoulder girdle vary, particularly the osseous structures. This characteristic renders interpretation of imaging of the pediatric shoulder girdle more challenging because normal or variant anatomy can be confused for pathology. We review the physiologic growth and maturation of the shoulder girdle with special emphasis on the development of the bones and their articulations. The role of various imaging modalities and the common osseous and soft tissue variants in the pediatric shoulder are also discussed. [ABSTRACT FROM AUTHOR]

The diagnosis and treatment of non-unions still represents an interdisciplinary challenge. Therefore, prevention, early detection and specific treatment are of great importance. Non-unions of the upper extremities, although less common than that of the lower extremities, requires special attention for successful treatment due to the central role of the shoulder girdle and arm in day to day activities. Successful treatment of non-unions requires a comprehensive evaluation of the patient's medical history, a thorough clinical examination and in particular radiological imaging. In order to effectively treat the pseudarthrosis it is crucial to distinguish between pseudarthroses that are suspected to be due to infections and those that are not. This article presents a treatment algorithm for managing both pseudarthrosis due to infection and pseudarthrosis without infection in the upper extremities. [ABSTRACT FROM AUTHOR]

Recent fieldwork in the late Middle Jurassic Balabansai Formation of Kyrgyzstan has yielded a partial skeleton of a large theropod dinosaur. The material includes a few bones of the skull (postorbital, quadratojugal), dorsal and sacral vertebrae, fragments of the pectoral girdle and forelimbs, and an almost complete pelvic girdle and hindlimbs, and is here made the type of a new theropod taxon, Alpkarakush kyrgyzicus gen. et sp. nov. Alpkarakush can be diagnosed by an extremely developed orbital brow on the postorbital, a pneumatic opening leading into cavities in the neural arch from the centroprezygodiapophyseal fossa in the posterior dorsal vertebrae, an almost enclosed ventral sulcus in manual phalanx II-1, a narrow and deep intercondylar groove on the anterior side of the distal femur, and an epicondylar crest on the distal femur that is offset from the distal end. A second, fragmentary, and smaller specimen from the same site represents the same taxon. Based on long bone histology, the type of Alpkarakush represents a late subadult individual, whereas the smaller specimen is a juvenile, possibly indicating gregarious behaviour. Phylogenetic analysis places Alpkarakush in the Metriacanthosauridae, underlining the diversity and wide distribution of this clade in the Jurassic of Asia. [ABSTRACT FROM AUTHOR]

The morphological transformation of the pectoral/shoulder girdle is fundamental to the water-to-land transition in vertebrate evolution. Although previous studies have resolved the embryonic origins of tetrapod shoulder girdles, those of fish pectoral girdles remain uncharacterized, creating a gap in the understanding of girdle transformation mechanisms from fish to tetrapods. Here, we identify the embryonic origins of the zebrafish pectoral girdle, including the cleithrum as an ancestral girdle element lost in extant tetrapods. Our combinatorial approach of photoconversion and genetic lineage tracing demonstrates that cleithrum development combines four adjoining embryonic populations. A comparison of these pectoral girdle progenitors with extinct and extant vertebrates highlights that cleithrum loss, indispensable for neck evolution, is associated with the disappearance of its unique developmental environment at the head/trunk interface. Overall, our study establishes an embryological framework for pectoral/shoulder girdle formation and provides evolutionary trajectories from their origin in water to diversification on land. The embryonic origins of the pectoral girdle in fish remain unexplored. Here they show that the zebrafish pectoral girdle develops as an amalgam of four distinct cell populations. [ABSTRACT FROM AUTHOR]

Polymyalgia rheumatica (PMR) is an inflammatory disease common in people aged 50 years and older. This condition is characterized by the presence of pain and stiffness involving mainly the shoulder and pelvic girdle. Besides the frequent association with giant cell arteritis (GCA), several conditions may mimic PMR or present with PMR features. Since the diagnosis is basically clinical, an adequate diagnosis of this condition is usually required. Positron emission tomography/computed tomography (PET-CT) has proved to be a useful tool for the diagnosis of PMR. The use of 18F-FDG-PET imaging appears promising as it provides detailed information on inflammatory activity that may not be evident with traditional methods. However, since PET-CT is not strictly necessary for the diagnosis of PMR, clinicians should consider several situations in which this imaging technique can be used in patients with suspected PMR. [ABSTRACT FROM AUTHOR]

Aim: This study aimed to: (a) assess the relationships between climbing performance and finger and shoulder girdle muscle endurance; and (b) provide evidence on the validity of the specialized exercise tests used for the purpose. Materials and methods: 28 male sport climbers (climbing ability 23 ± 2.43 IRCRA scale) performed four tests muscle failure, including two-finger hang tests (using 2.5 and 4 cm holds) and two variants of pull-up exercises (classical pull-ups and a combination of dynamic and isometric actions - the so-called Edlinger). Climbing performance and test results were subjected to correlation, taxonomic and regression analysis. Results: The correlations between the results from all tests and climbing performance were notably strong (r between 0.54 and 0.61) and statistically significant (p, 0.05). The taxonomic analysis indicated that the two variants of each test type reflect two different latent variables 2.5 cm and 4 cm finger hang durations were highly correlated (r = 0.76, p, 0.01). A similar correlation was found between the results from the pull-up tests (r = 0.72, p, 0.01). Thus, the finger hang and pull-up test results were determined to a high extent (43% and 49%, respectively) by factors that cannot be assessed when only one test of each type is used. The regression model of the two-finger tests allowed individual endurance profiles to be assessed. Conclusions: The muscular endurance of the elbow flexors and shoulder girdle muscles predicts climbing performance within the specific sport level studied to a comparable degree as finger flexor endurance. The use of two variants of a test intended to assess one physical ability provided important details on a climber's fitness. [ABSTRACT FROM AUTHOR]

Background Dermatomyositis is an uncommon inflammatory disease that causes muscle weakness and a distinctive dermatological rash. The objective of this study is to record all clinical presentations in patients with dermatomyositis but mainly dermatological manifestations. Methods This case series descriptive study included 23 patients with dermatomyositis who were seen during the period from 2014-2023. A full history and clinical examination were carried out. All patients were referred from the Rheumatology and Pediatric Units after doing a full assessment and necessary investigations. Results The juvenile group peak consisted of 13 patients, their ages ranged from 3-15 years with a mean of 5 years, 6 males and 7 females. The main clinical picture was photosensitivity with distinctive heliotrope facial rash in all patients, and calcinosis cutis in 8 (61.53%) cases The adult group included 10 subjects, their ages ranged from 30-60 years with a mean of 47 years, 9 females and one male patient. The presenting picture was skin rash in a form of photosensitivity with characteristic heliotrope of the face and muscle weakness of shoulder and pelvic girdles in all cases. No malignancy was reported. Conclusion There was no significant difference between both genders in children, however, it was more prevalent in adult females. The presenting features in the juvenile group were photosensitivity, a heliotrope rash of the face and calcinosis cutis. While photosensitivity with heliotrope dermatitis of the face and muscle weakness was sever in adults. No malignancy was detected during follow-ups in any patient. [ABSTRACT FROM AUTHOR]

Background: Acute peripheral neuropathy, also known as Parsonage-Turner syndrome or neuralgic amyotrophy, mostly affects the upper brachial plexus trunks, which include the shoulder girdle. It is typically accompanied by abrupt, intense pain, weakness, and sensory disruption. The etiology and causes of this disease are still unknown because of its low prevalence, however viral reactions-induced inflammation is one of its frequent causes. Case presentation: Here, we introduce a professional wrestler patient who was diagnosed with PTS after vaccination and was treated, and we review some articles in this field. Conclusion: When it comes to shoulder-girdle complaints and pain, Parsonage-Turner syndrome can be a differential diagnosis. Corticosteroids during the acute period, followed by physical therapy, appear to be an efficient way to manage pain, inflammation, muscular atrophy, and the process of recovering to full nerve regeneration. [ABSTRACT FROM AUTHOR]

Aims: The suprascapular nerve is an ideal target for nerve blockade to alleviate shoulder pain given its widespread innervation to the shoulder girdle. To widen availability of this treatment, we investigate whether an anatomical landmark technique can be adopted by novice injectors to provide efficacious blockade. Methods: Five injectors were recruited with varying experience. 10 shoulders of Thiel embalmed cadavers were injected with blue dye. Written instructions and an illustration of the Dangoisse landmark technique were provided prior to injection. Cadavers were dissected and the presence or absence of dye staining reported by three observers and a consensus agreement reached. Results: Dissection demonstrated diffuse staining in the suprascapular fossa. 90% of shoulders had adequate staining of the suprascapular nerve directly, or distal branches, which would provide adequate anaesthesia. Inter-observer agreement was good (k = 0.73) for staining at the supraspinous fossa and excellent (k = 0.87) for staining distally. The technique was performed by novice injectors with a good success rate. Conclusion: This technique is reproducible by a range of clinicians to effectively provide anaesthesia of the SScN. Within a resource strained healthcare environment greater uptake of this technique is likely to be of benefit to a wider group of patients. [ABSTRACT FROM AUTHOR]

This study examines the ergonomics of the patient lifting motion often used by healthcare professionals, focusing on the shoulder area, as manual weight management is still an important part of daily work. Data acquisition was made with the 17 IMU sensors, Movella Xsens system. A total of 25 quality measurements were acquired for further data processing. A mathematical model with the defined assumptions is presented in this research calculating shoulder moment-kinematics. The load engagement profile was determined based on the hip extension as a variable size for different test subjects and trials. Shoulder flexion-extension range of motion (ROM) variance was estimated, determining each test subject's technique, together with shoulder moment and cumulative shoulder moment. Cumulative shoulder load varied from -31.46% to 27.78% from the mean shoulder moment value. During the estimated accumulation of a 5-year work span, the difference in worst to best techniques accumulated to 1.86 times. Recommendations on how the technique and the further scope of the research could be improved were given. [ABSTRACT FROM AUTHOR]

The noasaurid ceratosaur Kiyacursor longipes gen. et sp. nov. is described based on a fragmentary skeleton including cervical vertebra, pectoral girdle, humerus and hind limbs from the Lower Cretaceous (Aptian) Ilek Formation at Shestakovo 1 locality in Western Siberia, Russia. This is the first ceratosaur from the Early Cretaceous of Asia, extending the stratigraphic range of Ceratosauria by 40 Myr on that continent. Kiyacursor shares unique hind limb proportions with Elaphrosaurus and Limusaurus, suggesting improved cursorial ability. These taxa show an ostrich-like specialization of the pes, with a large third metatarsal and greatly reduced second metatarsal. By contrast, all other fast running non-avian theropod dinosaurs have an arctometatarsalian pes, with the third metatarsal strongly reduced proximally. The new taxon lived in the Early Cretaceous ecosystem containing a number of other Jurassic relics, such as stem salamanders, protosuchian and shartegosuchid crocodyliforms, tritylodontid synapsids and docodontan mammaliaforms. [ABSTRACT FROM AUTHOR]

Background: In patients with fibromyalgia, exercise and education are recommended to decrease pain level and improve pain management. The latest scientific evidence recommends to focus interventions on the upper limb. The aim of this pilot study was to compare the immediate effect of physical activity education vs. a control group on pain and muscle capacity in fibromyalgia patients. Method: Fifty-six participants with fibromyalgia were randomized into an experimental group and a control group. The intervention consisted in watching a five-minute video that provided information about fibromyalgia, pain, kinesiophobia and physical activity. The control group watched a neutral five-minute video about beavers in Quebec. Following the video, participants performed a muscular fatigue task consisting of a repeated unilateral shoulder abduction task. At baseline and following the muscular fatigue task, maximal voluntary contraction (MVC) in shoulder abduction was assessed as well as pain level and pressure pain threshold (PPT) in the upper limb. Electromyographic activity was also assessed for upper trapezius and middle deltoid muscles. Two-way repeated measures analysis of variance was used to compare the MVC, PPT, and pain level before and after the muscular fatigue task between groups. Results: The experimental group showed a significantly lower increase in pain than the control group in the middle deltoid muscle (p = 0.002) when assessed by verbal pain rating scale. No significant interaction or main effect of Group and Time were observed for the pain level at the upper trapezius and elbow extensor muscles nor for any of the PPT measures. According to electromyographic data, the median frequency values indicate that neither group experienced muscle fatigue during the repeated contraction task. Conclusions: The preliminary results suggest that a short physical activity education video positively influenced middle deltoid pain following repeated abduction in participants with fibromyalgia. Electromyographic analysis showed no evidence of objective muscle fatigue, suggesting that there might be a partial disconnection between the perception of muscle fatigue and the physiological biomarkers associated with muscle fatigue. [ABSTRACT FROM AUTHOR]

Facioscapulohumeral muscular dystrophy is a hereditary progressive myopathy caused by aberrant expression of the transcription factor DUX4 in skeletal muscle. No approved disease-modifying treatments are available for this disorder. We aimed to assess the safety and efficacy of losmapimod (a small molecule that inhibits p38α MAPK, a regulator of DUX4 expression, and p38β MAPK) for the treatment of facioscapulohumeral muscular dystrophy. We did a randomised, double-blind, placebo-controlled phase 2b trial at 17 neurology centres in Canada, France, Spain, and the USA. We included adults aged 18–65 years with type 1 facioscapulohumeral muscular dystrophy (ie, with loss of repression of DUX4 expression, as ascertained by genotyping), a Ricci clinical severity score of 2–4, and at least one skeletal muscle judged using MRI to be suitable for biopsy. Participants were randomly allocated (1:1) to either oral losmapimod (15 mg twice a day) or matching placebo for 48 weeks, via an interactive response technology system. The investigator, study staff, participants, sponsor, primary outcome assessors, and study monitor were masked to the treatment allocation until study closure. The primary endpoint was change from baseline to either week 16 or 36 in DUX4-driven gene expression in skeletal muscle biopsy samples, as measured by quantitative RT-PCR. The primary efficacy analysis was done in all participants who were randomly assigned and who had available data for assessment, according to the modified intention-to-treat principle. Safety and tolerability were assessed as secondary endpoints. This study is registered at ClinicalTrials.gov , number NCT04003974. The phase 2b trial is complete; an open-label extension is ongoing. Between Aug 27, 2019, and Feb 27, 2020, 80 people were enrolled. 40 were randomly allocated to losmapimod and 40 to placebo. 54 (68%) participants were male and 26 (33%) were female, 70 (88%) were White, and mean age was 45·7 (SD 12·5) years. Least squares mean changes from baseline in DUX4 - driven gene expression did not differ significantly between the losmapimod (0·83 [SE 0·61]) and placebo (0·40 [0·65]) groups (difference 0·43 [SE 0·56; 95% CI –1·04 to 1·89]; p=0·56). Losmapimod was well tolerated. 29 treatment-emergent adverse events (nine drug-related) were reported in the losmapimod group compared with 23 (two drug-related) in the placebo group. Two participants in the losmapimod group had serious adverse events that were deemed unrelated to losmapimod by the investigators (alcohol poisoning and suicide attempt; postoperative wound infection) compared with none in the placebo group. No treatment discontinuations due to adverse events occurred and no participants died during the study. Although losmapimod did not significantly change DUX4-driven gene expression, it was associated with potential improvements in prespecified structural outcomes (muscle fat infiltration), functional outcomes (reachable workspace, a measure of shoulder girdle function), and patient-reported global impression of change compared with placebo. These findings have informed the design and choice of efficacy endpoints for a phase 3 study of losmapimod in adults with facioscapulohumeral muscular dystrophy. Fulcrum Therapeutics. [ABSTRACT FROM AUTHOR]

The article presents an analysis of the muscle synergies involved in making ball throws in different directions and from different starting positions. The study involved 6 highly qualified athletes engaged in rhythmic gymnastics. Electromyograms of the superficial muscles of the upper extremities and trunk were recorded synchronously during the movements, as well as video capture of the movements of body segments. Synergy parameters were extracted from the recorded signals using factor analysis using the principal component method. It has been established that individuals who have mastered a complex motor skill can demonstrate similar motor control strategies. This is manifested in the structuring of intermuscular interaction in the form of two general modules, the degree of involvement of muscles in which is highly similar in the implementation of different motor tasks. The first muscle module implements active movement of the upper limb by jointly activating the muscles of the forearm, shoulder and upper shoulder girdle, and also provides stabilization of the position of the trunk by synchronizing the activity of the muscles of the back and abdomen. The second muscle module is specific and is mainly associated with high involvement in the synergy of the muscles of the upper shoulder girdle and forearm for the implementation of exercises performed without visual control, or from starting positions that limit the mobility of certain parts of the body. Thus, the solution to the problem of coordination of many elements of the motor system may consist not only in reducing the number of executive organs—muscles involved in control, but also in organizing control variables in the form of modules at the kinematic level and their stabilization through muscle synergies. [ABSTRACT FROM AUTHOR]

Background: Sprengel's deformity is a congenital abnormality of the shoulder girdle. Because scapular retraction, such as the Green procedure, is usually performed during childhood to improve esthetics and shoulder function, Sprengel's deformity is rarely found in older patients. Case presentation: We presented a unique case of a Japanese female cadaver with Sprengel's deformity at the age of 80 years. Anatomical dissection and radiological imaging revealed musculoskeletal anomalies associated with Sprengel's deformity, including Klippel–Feil syndrome, presence of an omovertebral bone, and absence of the trapezius muscle. In addition, bilateral cervical ribs were in contact with the brachial plexus. These anomalies may lead to numbness, pain, and limited range of motion of the neck and upper girdle with aging. Conclusions: Because most adult patients with Sprengel's deformity experience neck pain and limited movement of the shoulder, the presented case is a rare case of neglected Sprengel's deformity in an 80-year-old cadaver. [ABSTRACT FROM AUTHOR]

Objective: Documenting the movement of Channel Catfish Ictalurus punctatus through telemetry, where a transmitter tag is surgically implanted in the fish, can provide valuable insight into the species' spatial ecology and habitat use. However, since fish in the order Siluriformes can expel foreign objects such as tags from their body cavity, the utility of telemetry technology may be limited for Channel Catfish. This study aimed to determine (1) how quickly Channel Catfish reject tags that were surgically implanted into the body cavity, (2) if surgical implantation of transmitter tags causes mortality, and (3) what surgical method is best to minimize tag rejection and/or mortality. Methods: Three surgical trials were conducted on Channel Catfish (n = 24) using two tag implantation methods: a nontethered method, in which the tag was freely implanted into the body cavity, and a tethered method, where the tag was attached to the pectoral girdle. Fish were observed in the lab for 30 days for trials 1 and 2 and 225 days for trial 3 following tag implantation. Result: No complete tag rejections occurred during any of the three experimental trials. However, all five tethered fish experienced mortality during trial 3 (58-221 days postsurgery). Necropsies indicated that the tethered tagging method led to septicaemia infections and internal lacerations from the tether, which were not observed in the nontethered fish. Tags in the nontethered fish were in the process of being absorbed into the intestinal tract, which over time might have led to tag rejection. Conclusion: While rejection is possibly the end point of the nontethered tagging method, our results suggest it is nevertheless the better tagging method for Channel Catfish given higher survival. [ABSTRACT FROM AUTHOR]

Copyright of Zdravotnicke listy is the property of Alexander Dubcek University in Trencin, Faculty of Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the present work, regression equations were generated to estimate wet weight from total length and also to estimate wet weight and total length from skull and pectoral girdle bones length of Odontesthes nigricans. All regressions were statistically significant. No significant differences were found in the wet weight-total length relationship between males and females, showing a positive allometric growth between wet weight and total length. The equations obtained are a tool for research in trophic ecology, allowing a broader evaluation of the role of the lagoon silverside in the diet of piscivorous predators. [ABSTRACT FROM AUTHOR]

Introduction. Upper crossed syndrome (UCS) is a common musculoskeletal issue that includes the dysfunctional tone of the muscles in the shoulder girdle or cervicothoracic region. The objective of the current study is to compare the effects of muscle energy techniques with the National Academy of Sports Medicine-based exercise protocol on pain, range of motion, and disability in patients with UCS. Methods. it was a single-blinded randomised clinical trial carried out in the Physiotherapy department of the University of Lahore Teaching Hospital, Pakistan. Fifty patients with upper cross syndrome aged between 20 to 35 years were randomly allocated into two groups: group A (routine physical therapy combined with muscle energy techniques) and group B (routine physical therapy combined with the National Academy of Sports Medicine-based exercise protocol) for three sessions per week for total 8 weeks. data were collected at baseline, 4th, 8th, and 12th week for assessing the long-term effects of the treatment protocol as well. The Visual Analogue Scale, Neck disability index, and an inclinometer were used to measure the pain, disability, and range of motion of the cervical region, respectively. The data was analysed using SPSS version 23.0 (iBM, New York, USA). Results. out of 50 participants, 30 were male and 20 were female. The mean age of all the participants in experimental group A was 29.76 ± 2.89 and that in experimental group B was 30.56 ± 2.48. At the 4th, 8th, and 12th week, pain and disability were significantly (p-value < 0.05) reduced and cervical range of motion was significantly (p-value < 0.05) improved within both groups. After 8 weeks of treatment, a significant between-group difference was seen in favour of group A in terms of cervical range of motions (flexion, extension, rotation, and side bending) with p-values of less than 0.05 and in favour of group B in terms of pain (p-value 0.03) and disability (p-value 0.04) was seen. These differences were maintained at the 12th week follow-up as well. Conclusions. This study concluded that both NASM (National Academy of Sports Medicine-based exercise protocol) and METs (muscle energy techniques) are effective treatment options for people with upper cross syndrome. it was also concluded that METs are more effective in improving Range of motion (RoM), while the NASM-based exercise protocol is more effective in improving symptoms of pain and neck-related disability. [ABSTRACT FROM AUTHOR]

In tennis, the serve plays a key role in determining the success of a player. The speed of a serve is influenced by a multitude of interconnected skills and abilities. The objective of this study was to establish the correlation between the explosive strength of the throwing type, the grip strength and flexibility of the arms, and the shoulder girdle with the serve speed in young female tennis players. Additionally, the study aimed to develop a regression model that accurately predicts the serve speed by analyzing the interplay among these variables. The study was carried out on a group of 20 tennis players, who had an average age of 13.10 ± 0.74 years. Additionally, their height was recorded as 165.70 ± 4.90 cm, and their body mass was measured at 51.45 ± 5.84 kg. To assess the motor abilities of the upper extremities, four tests were used that aimed to measure the explosive strength of the throwing type; one test was for the strength of the hand and forearm muscles, and one test was for the flexibility of the arms and shoulder girdle. Of all the variables examined, the medicine ball throw shot put (MBTSP) (r = 0.75), overhead medicine ball throw (OMBT) (r = 0.70), and grip strength (GS) (r = 0.71) displayed a notable correlation with serve speed (p < 0.05). The results obtained from the multiple regression analysis indicate that the combination of selected predictors (MBTSP—medicine ball throw shot put, OMBT—overhead medicine ball throw and GS—grip strength) explained 75% of the variability in serve speed. Significantly, MBTSP surfaced as the predominant predictor, autonomously elucidating 51% of the variability in serve speed. The importance of improving the analyzed motor skills of young female tennis players to enhance their serve in terms of speed is emphasized by the findings of this research. [ABSTRACT FROM AUTHOR]

This article discusses a case of a 28-year-old woman with childhood-onset progressive skin fibrosis and joint immobility. The patient had been diagnosed with localized scleroderma and had tried various treatments without success. The diagnosis was eventually determined to be stiff skin syndrome (SSS), a rare disorder characterized by noninflammatory and progressive fibrosis of the skin. The article explores the clinical and histopathological features of SSS, as well as potential treatment options. [Extracted from the article]

This article is a case report on a Murrah buffalo that experienced dystocia, or difficulty in giving birth, due to acute dorsal deviation of the foetal head and neck along with bilateral shoulder flexion. The buffalo was presented to a veterinary clinic after failing to respond to manual foetal removal. The authors describe the clinical history, observations, and treatment of the case, which involved decapitation and disarticulation of the shoulder joint to relieve the dystocia. Dystocia is a major cause of reproductive complications in buffaloes, and foetal mal-disposition is a common cause. Different obstetrical operations, such as manual traction and fetotomy, are used to manage complicated cases. [Extracted from the article]

Objective: Unusual clinical course Background: Coracoid process fractures are uncommon and are often complicated by many types of shoulder girdle injuries. Previous reports have shown that osteosynthesis for isolated coracoid process fractures results in favorable outcomes and high bone union rates. However, owing to the rarity of coracoid process fractures combined with distal clavicle fractures, there are limited data to guide treatment strategies. We report a case of symptomatic nonunion despite performing osteosynthesis for fractures of the coracoid process and distal clavicle. Case Report: A 60-year-old man presented with left shoulder pain after falling from the back of a truck. Radiography and computed tomography (CT) findings revealed fractures of the left distal clavicle and coracoid process. We performed plate and costoclavicular fixation using a suture button for the distal clavicle fracture and cannulated cancellous screw fixation for the coracoid process fracture. However, the patient experienced severe pain around the coracoid and had limited shoulder range of motion 1 year postoperatively. CT revealed nonunion of the coracoid process, prompting a recommendation for surgery. However, despite severe persistent functional impairment, the patient refused surgery 1.5 years postoperatively. Conclusions: This case suggests the potential for symptomatic nonunion of the coracoid process when using a suture-button device for a distal clavicle fracture. To prevent postoperative nonunion of the coracoid process, postoperative CT evaluation is necessary. If a symptomatic delayed bone union of coracoid process is observed, considering early removal of the suture button is recommended. [ABSTRACT FROM AUTHOR]

Background: The Limb Girdle Muscular Dystrophies (LGMDs) are characterized by progressive weakness of the shoulder and hip girdle muscles as a result of over 30 different genetic mutations. This study is designed to develop clinical outcome assessments across the group of disorders. Methods/design: The primary goal of this study is to evaluate the utility of a set of outcome measures on a wide range of LGMD phenotypes and ability levels to determine if it would be possible to use similar outcomes between individuals with different phenotypes. We will perform a multi-center, 12-month study of 188 LGMD patients within the established Genetic Resolution and Assessments Solving Phenotypes in LGMD (GRASP-LGMD) Research Consortium, which is comprised of 11 sites in the United States and 2 sites in Europe. Enrolled patients will be clinically affected and have mutations in CAPN3 (LGMDR1), ANO5 (LGMDR12), DYSF (LGMDR2), DNAJB6 (LGMDD1), SGCA (LGMDR3), SGCB (LGMDR4), SGCD (LGMDR6), or SGCG (LGMDR5, or FKRP-related (LGMDR9). Discussion: To the best of our knowledge, this will be the largest consortium organized to prospectively validate clinical outcome assessments (COAs) in LGMD at its completion. These assessments will help clinical trial readiness by identifying reliable, valid, and responsive outcome measures as well as providing data driven clinical trial decision making for future clinical trials on therapeutic agents for LGMD. The results of this study will permit more efficient clinical trial design. All relevant data will be made available for investigators or companies involved in LGMD therapeutic development upon conclusion of this study as applicable. Trial registration: Clinicaltrials.gov NCT03981289; Date of registration: 6/10/2019. [ABSTRACT FROM AUTHOR]

Introduction: Scapular anatomical neck fractures are among the most infrequent shoulder girdle fractures. Only seven radiologically confirmed cases of scapular anatomical neck fractures have been documented in the literature to date, of which only one case underwent delayed surgery. Case presentation: A 34-year-old male Persian patient with morbid obesity was diagnosed with a scapula anatomical neck fracture after a motor vehicle collision. The radiographic assessment of the patient indicated an increase in the scapular glenopolar angle (73.9°). Due to concurrent chest and head injuries, surgical intervention was deferred until 6 weeks following the injury. The posterolateral limited Dupont–Evrard approach was used because of the patient's extremely high body mass index. Two plates were utilized to achieve stable fixation of the glenoid neck fracture. Following a 1 year follow-up period, complete fracture union was successfully attained, resulting in a constant score of 79. Conclusions: The most accurate radiographic indicators of these fractures are a superior fracture line located laterally to the coracoid process, a small inferior spike, and an elevated glenopolar angle. The only tendon attached to the glenoid is the long head of the triceps, making these fractures unstable; therefore, surgery is required in the majority of instances. The small size of the fractured component makes stabilization more difficult. Overall, anatomical scapular neck fractures are extremely uncommon and distinguished from other scapular fractures by their unique radiological and biomechanical characteristics. This case highlights the challenges encountered when managing scapular fractures in patients with morbid obesity. The delayed surgical intervention and the choice of surgical approach tailored to the patient's specific anatomical and physiological considerations proved to be effective in achieving a favorable outcome. [ABSTRACT FROM AUTHOR]

Polymyalgia rheumatica is one of the most common inflammatory rheumatic conditions in older adults. The disease is characterized by pain and stiffness in the shoulder and pelvic girdle. Polymyalgia rheumatica is almost always observed in adults over the age of 50. The current article aimed to provide explanations for the age preference of polymyalgia rheumatica by reviewing the literature regarding disease etiology and pathogenesis. Potential factors related to the association between polymyalgia rheumatica and aging include immunosenescence/inflammaging, increased risk of infections by aging, endocrinosenescence, and age-related changes in gut microbiota. These factors and their potential contributions to immune-mediated inflammation will be discussed. [ABSTRACT FROM AUTHOR]

We report the first record of a species of Pareiorhaphis in the Manhuaçu River basin, an affluent to the right bank of the middle Doce River drainage in eastern Brazil. The description is based on a series of specimens recently collected and also on historical samples. All specimens were obtained from habitats with very strong water current running over flat bedrock. The new species is readily diagnosed from congeners by features related to the distinct morphology of lower lip papillae, unique pattern of plates covering the pectoral girdle between insertions of pectoral fins, and the lack of a maxillary barbel. In addition, the combination of longer snout, smaller orbital diameter, shape of the pectoral-fin spine, low number of dentary teeth, and lack of a dorsal-fin spinelet also distinguishes the new species from all species of Pareiorhaphis. The new species is further compared to Pareiorhaphis nasuta, P. scutula, P. proskynita, and P. vetula, congeners from the Doce River basin, and hypothesized to have traits that represent important adaptations for living in torrential habitats. [ABSTRACT FROM AUTHOR]

Many studies have described the muscle anatomy of the domestic fowl (Gallus gallus domesticus), a commonly used animal in developmental experiments. However, some major differences in terminology existed among studies, making it difficult to precisely discuss the muscle homologies between domestic fowl and other animals. In this study, the innervations of shoulder girdle muscles in five sides of the domestic fowl were elucidated and the homology of the shoulder girdle muscles between domestic fowl and other tetrapods was discussed using terminology that conforms to Nomina Anatomica Avium (1993). Unlike previous descriptions, the supracoracoideus, being developed in domestic fowl, is thought to have a different muscular origin from the deltoid muscle. The coracobrachialis cranialis, coracobrachialis caudalis and coracobrachialis muscles, previously described as the coracobrachialis muscle group, had different innervations; the coracobrachialis cranialis should be grouped with the deltoid muscles, and the coracobrachialis caudalis appears to belong to the pectoral muscle group. I propose that the subcoracoscapularis in domestic fowl, keeping the reptilian form, is divided into the subcoracoideus and subscapularis muscles. Based on the innervation, the subscapularis in domestic fowl is homologous with the subscapularis in reptiles and a major part of the subscapularis in mammals. Unlike the descriptions in previous studies, the scapulohumeralis cranialis and caudalis in the domestic fowl in this study, being innervated by the common branch, were found to have a close relationship with the subcoracoscapularis muscle. Based on the observations in this study, a new classification of the shoulder girdle muscles in domestic fowl is proposed. [ABSTRACT FROM AUTHOR]

An 81-year-old female was admitted to the Department of Internal Medicine with generalized weakness and arthralgia with a predilection to the spine and shoulder girdle, walking difficulty and mild memory loss of one week's duration. Symptomatology spontaneously resolved after two weeks of admission but recurred at follow-up along with a mixed disease impression, where an exhaustive list of diagnoses was ruled out. Polymyalgia rheumatica (PMR) is an aseptic inflammatory condition that may be diagnostically challenging, especially in patients with multiple comorbidities, and therefore, critical clinical thinking is imperative. Our case elucidated that the cornerstone of differential diagnosis and patient treatment is an excellent retrieval of medical history, in combination with reinforcement from the physical exam and radiological-laboratory work-up. [ABSTRACT FROM AUTHOR]

Copyright of Die Unfallchirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)