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5 results on '"Shu Qiao, Yang"'

1. Black rice diet alleviates colorectal cancer development through modulating tryptophan metabolism and activating AHR pathway

Author

Ling Wang, Yi‐Xuan Tu, Lu Chen, Ke‐Chun Yu, Hong‐Kai Wang, Shu‐Qiao Yang, Yuan Zhang, Shuai‐Jie Zhang, Shuo Song, Hong‐Li Xu, Zhu‐Cheng Yin, Ming‐Qian Feng, Jun‐Qiu Yue, Xiang‐Hong Huang, Tang Tang, Shao‐Zhong Wei, Xin‐Jun Liang, and Zhen‐Xia Chen

Subjects
black rice diet, colorectal cancer, gut metabolites, gut microbiome, Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Consumption of dietary fiber and anthocyanin has been linked to a lower incidence of colorectal cancer (CRC). This study scrutinizes the potential antitumorigenic attributes of a black rice diet (BRD), abundantly rich in dietary fiber and anthocyanin. Our results demonstrate notable antitumorigenic effects in mice on BRD, indicated by a reduction in both the size and number of intestinal tumors and a consequent extension in life span, compared to control diet‐fed counterparts. Furthermore, fecal transplants from BRD‐fed mice to germ‐free mice led to a decrease in colonic cell proliferation, coupled with maintained integrity of the intestinal barrier. The BRD was associated with significant shifts in gut microbiota composition, specifically an augmentation in probiotic strains Bacteroides uniformis and Lactobacillus. Noteworthy changes in gut metabolites were also documented, including the upregulation of indole‐3‐lactic acid and indole. These metabolites have been identified to stimulate the intestinal aryl hydrocarbon receptor pathway, inhibiting CRC cell proliferation and colorectal tumorigenesis. In summary, these findings propose that a BRD may modulate the progression of intestinal tumors by fostering protective gut microbiota and metabolite profiles. The study accentuates the potential health advantages of whole‐grain foods, emphasizing the potential utility of black rice in promoting health.

Published
2024
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2. Male‐Biased Gut Microbiome and Metabolites Aggravate Colorectal Cancer Development

Author

Ling Wang, Yi‐Xuan Tu, Lu Chen, Yuan Zhang, Xue‐Ling Pan, Shu‐Qiao Yang, Shuai‐Jie Zhang, Sheng‐Hui Li, Ke‐Chun Yu, Shuo Song, Hong‐Li Xu, Zhu‐Cheng Yin, Jun‐Qiu Yue, Qian‐Lin Ni, Tang Tang, Jiu‐Liang Zhang, Min Guo, Shuai Zhang, Fan Yao, Xin‐Jun Liang, and Zhen‐Xia Chen

Subjects
colorectal cancer, fecal microbiota transplantation, gut microbiome, sexual dimorphism, Science
Abstract

Abstract Men demonstrate higher incidence and mortality rates of colorectal cancer (CRC) than women. This study aims to explain the potential causes of such sexual dimorphism in CRC from the perspective of sex‐biased gut microbiota and metabolites. The results show that sexual dimorphism in colorectal tumorigenesis is observed in both ApcMin/+ mice and azoxymethane (AOM)/dextran sulfate sodium (DSS)‐treated mice with male mice have significantly larger and more tumors, accompanied by more impaired gut barrier function. Moreover, pseudo‐germ mice receiving fecal samples from male mice or patients show more severe intestinal barrier damage and higher level of inflammation. A significant change in gut microbiota composition is found with increased pathogenic bacteria Akkermansia muciniphila and deplets probiotic Parabacteroides goldsteinii in both male mice and pseudo‐germ mice receiving fecal sample from male mice. Sex‐biased gut metabolites in pseudo‐germ mice receiving fecal sample from CRC patients or CRC mice contribute to sex dimorphism in CRC tumorigenesis through glycerophospholipids metabolism pathway. Sexual dimorphism in tumorigenesis of CRC mouse models. In conclusion, the sex‐biased gut microbiome and metabolites contribute to sexual dimorphism in CRC. Modulating sex‐biased gut microbiota and metabolites could be a potential sex‐targeting therapeutic strategy of CRC.

Published
2023
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3. Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post-pandemic period

Author

Bin Cao, Ying Mei Liu, Shu Qiao Yang, Chen Wang, Jiu Xin Qu, and Xiaomin Yu

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Incidence (epidemiology), Pneumonia severity index, virus diseases, medicine.disease, Intensive care unit, respiratory tract diseases, law.invention, Pneumonia, law, Internal medicine, Epidemiology, Pandemic, Cohort, Immunology, medicine, Flu season, Immunology and Allergy, business, Genetics (clinical)
Abstract

Introduction Comparisons of the characteristics between the influenza A (H1N1) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post-pandemic period are poorly understood. Objectives The aim of our research was to investigate clinical and immune response differences between patients with influenza A (H1N1) pdm09 pneumonia and seasonal influenza A (H3N2) pneumonia in the post-pandemic period. Methods During the first flu season in post-pandemic period, patients from Beijing Network for Adult Community-Acquired Pneumonia present A (H1N1) pdm09 or A (H3N2) influenza were compared concurrently in the aspects of clinical characteristics and inflammatory profile in acute phase. Result Patients with A (H1N1) pdm09 influenza pneumonia showed a close mean age to A (H3N2) pneumonia (51 ± 20 vs 53 ± 16, mean ± standard deviation, years) but tended to have more underlying diseases (32.8% vs 10%, P = 0.036). Although clinical characteristics were similar, no statistical difference were found in pneumonia severity index (PSI) score or intensive care unit admission rate or mortality, patients in A (H1N1) pdm09 cohort present higher levels of aspartate aminotransferase, lactase dehydrogenase (P = 0.006, 0.018, respectively) in blood and also longer duration of fever than A (H3N2) cohort. Levels of interleukin (IL)-10 and IL-12 (p70) were higher in A (H1N1) pdm09 cohort (P = 0.031, 0.047, respectively). Conclusios During the first post-pandemic flu season, patients with the A (H1N1) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than A (H3N2) pneumonia.

Published
2013

4. Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post-pandemic period

Author

Shu Qiao, Yang, Jiu Xin, Qu, Chen, Wang, Xiao Min, Yu, Ying Mei, Liu, and Bin, Cao

Subjects
Adult, Male, China, influenza A (H1N1) pdm09, Adolescent, post-pandemic, Incidence, Influenza A Virus, H3N2 Subtype, Pneumonia, Viral, virus diseases, Original Articles, Middle Aged, Real-Time Polymerase Chain Reaction, respiratory tract diseases, Young Adult, Influenza A Virus, H1N1 Subtype, seasonal influenza A (H3N2), Influenza, Human, Cytokines, Humans, RNA, Viral, pneumonia, Female, Pandemics
Abstract

Introduction Comparisons of the characteristics between the influenza A (H1N1) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post-pandemic period are poorly understood. Objectives The aim of our research was to investigate clinical and immune response differences between patients with influenza A (H1N1) pdm09 pneumonia and seasonal influenza A (H3N2) pneumonia in the post-pandemic period. Methods During the first flu season in post-pandemic period, patients from Beijing Network for Adult Community-Acquired Pneumonia present A (H1N1) pdm09 or A (H3N2) influenza were compared concurrently in the aspects of clinical characteristics and inflammatory profile in acute phase. Result Patients with A (H1N1) pdm09 influenza pneumonia showed a close mean age to A (H3N2) pneumonia (51 ± 20 vs 53 ± 16, mean ± standard deviation, years) but tended to have more underlying diseases (32.8% vs 10%, P = 0.036). Although clinical characteristics were similar, no statistical difference were found in pneumonia severity index (PSI) score or intensive care unit admission rate or mortality, patients in A (H1N1) pdm09 cohort present higher levels of aspartate aminotransferase, lactase dehydrogenase (P = 0.006, 0.018, respectively) in blood and also longer duration of fever than A (H3N2) cohort. Levels of interleukin (IL)-10 and IL-12 (p70) were higher in A (H1N1) pdm09 cohort (P = 0.031, 0.047, respectively). Conclusios During the first post-pandemic flu season, patients with the A (H1N1) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than A (H3N2) pneumonia.

Published
2012

5. [Epidemiological analysis of Mycoplasma pneumoniae acute infection in adults with community-acquired pneumonia]

Author

Jiu-xin, Qu, Li, Gu, Jiang, Wu, Xiao-li, Li, Jian-ping, Dong, Zeng-hui, Pu, Yan, Gao, Ming, Hu, Yong-xiang, Zhang, Feng, Gao, Ying-mei, Liu, Shu-qiao, Yang, Xiu-hong, Jin, Xiu-hong, Ma, Bin, Cao, and Chen, Wang

Subjects
Adult, Aged, 80 and over, Community-Acquired Infections, Male, China, Young Adult, Adolescent, Pneumonia, Mycoplasma, Humans, Female, Middle Aged, Aged
Published
2012

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