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BACKGROUD: Colorectal cancer has an extremely high incidence and mortality rate, and early detection and treatment is important for health. METHODS: DEmiRNAs were searched for in different datasets. core DEmiRNAs were identified by one-factor cox analysis and target genes were predicted using targetscan and miRDB. Select intersections of target genes and DEmRNAs to identify key genes by survival analysis. RESULTS: Three miRNAs in COAD and two miRNAs in READ were identified as core DEmiRNAs. After searching for targeted mRNA and conducting survival and expression analysis, it was found that hsa-mir-296-TNSF15 and hsa-mir-744-TNSF15 are effective regulatory networks in colorectal cancer. CONCLUSION: This study identified hsa-mir-296-TNSF15 and hsa-mir-744-TNSF15 as effective regulatory networks related to the prognosis of colorectal cancer.

The root and rhizome of Litsea cubeba (Lour) Pers., named 'Dou-chi-jiang' in Chinese, has been traditionally used for treatment of cardiovascular and cerebrovascular diseases, rheumatic arthralgia, and other diseases in China. Aporphine alkaloids are its characteristic ingredients and responsible for its bioactivities, especially anti-inflammatory and analgesic effects. A sensitive and reliable high-performance liquid chromatography with diode array detection-tandem mass spectrometry method was developed for characterization and simultaneous determination of biological aporphine alkaloids in 'Dou-chi-jiang'. The optimized chromatographic conditions were performed on an Eclipse XDB C18 column with a gradient of acetonitrile/water containing 0.1% formic acid as the mass spectrometry mobile phase and acetonitrile/water containing 0.2% diethylamine (pH 3.10, adjusted by acetic acid) as the liquid chromatography mobile phase. The fragmentation pathways by loss of CO, ·CH3 , ·NH3 , and ·NH2 CH3 were detected as characteristic for aporphine alkaloids. Based on these characteristics, total 12 analogues were identified. The quantification method was validated in terms of linearity, precision, and accuracy for six major aporphine alkaloids, which was successfully applied for simultaneous determination in ten batches of samples. The established method is simple, rapid, and specific for characterization and quantitation of aporphine alkaloids in 'Dou-chi-jiang' and other traditional Chinese medicines rich in this kind of ingredient.

In many synchronous receivers, symbol timing synchronization is achieved through implementation of an analog phase locked loop (PLL). A phase detector and voltage-controlled oscillator drive a reference signal to be in phase with the received training sequence. Due to the quick phase convergence this option is attractive, however, limitations in pre-packaged hardware make this approach infeasible at times. This paper examines a configurable symbol synchronizer Based on Digital Phase Locked Loop (DPLL). We implement this method with FPGA. This method firstly gets the phase difference between the local synchronization signal and the received symbols by XOR. Then using the phase difference controls the counter. The counter controls the number of adding or deleting pulses in the corresponding gate. The synchronization time can be changed through setting of different K so as to achieve the purpose of fast bit synchronization. The paper shows the feasibility of this architecture can obviously decrease the synchronization time.

This paper implements the real-time face detection system with the Cascade Adaboost algorithm on the DSP platform (TMS320DM64 x ). Aiming at the feature extraction of the algorithm and cascade multiple classifiers, algorithm level optimization and implementation level optimization are proposed on DSP, such as floating-point to fixed-point Conversion (FFC), loop unrolling, software pipeline and linear assemble language optimization. The experimental result indicates that the system can detect any number of faces with any size at any position in a 320×240 image at a speed of 15 fps. The detection system can achieve a detection rate of 89.5%. The real-time face detection is implemented.

The first experimental results, to our knowledge, for the wavelength dependence of the electro-optic (EO) coefficients of a poled polymer film containing photochromic dyes are presented. The method used for measurement is based on the attenuated-total-reflection (ATR) technique. Initial results show that the electro-optic coefficients near absorption band decreases with the increases of light wavelength.