1. [Comparative analysis of associations of polymorphic genes F2, F5, GP1BA and ACE with the risk of stroke development in Russian and Ukrainian populations].
- Author
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Tupitsyna TV, Bondarenko EA, Kravchenko SA, Tatarskiĭ PF, Shepova IM, Shamalov NA, Kuznetsova SM, Shul'zhenko DV, Skvortsova VI, Slominskiĭ PA, Livshits LA, and Limborskaia SA
- Subjects
- Adult, Aged, Brain Ischemia genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Genetics, Population, Humans, Male, Middle Aged, Platelet Glycoprotein GPIb-IX Complex, Russia, Stroke genetics, Ukraine, White People genetics, Factor V genetics, Membrane Glycoproteins genetics, Peptidyl-Dipeptidase A genetics, Polymorphism, Genetic, Prothrombin genetics
- Abstract
The comparative analysis of the associations between G20210A polymorphism of F2 gene, G1691A polymorphism of F5 gene, -5T/C polymorphism of gene GP1BA, I/D polymorphism of gene ACE and the risk of development of the stroke in two ethnical samplings--Russian and Ukrainian populations--was conducted. It was shown that the patients of the Russian population with genotype DD have a higher level of the risk of ischemic stroke development (OR = 1.4, 95% CI [1.05; 1.78], p = 0.02), whereas genotypes I/I and I/D are associated with the lower level of risk of ischemic stroke (OR = 0.7, 95% CI [0.56; 0.95], p = 0.02). In the Ukrainian ethnical sampling, differences in distribution of genotypes and alleles frequencies between patients with stroke and healthy persons upon given polymorphic locus are not significant, and I/D polymorphism of gene ACE is not associated with the risk of development of the stroke (OR = 0.8, 95% CI [0.48; 1.32], p = 0.45). The G20210A polymorphism of gene F2, G1691A polymorphism of gene F5, -5T/C polymorphism of gene GP1BA are not associated with the risk of stroke in two ethnical samplings.
- Published
- 2013