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389 results on '"Shuman C"'

1. Conduits to care: call lights and patients’ perceptions of communication

Author

Montie M, Shuman C, Galinato J, Patak L, Anderson CA, and Titler MG

Subjects
Nurse-patient communication, medical technology, quality of care, Medicine (General), R5-920
Abstract

Mary Montie,1 Clayton Shuman,1 Jose Galinato,1 Lance Patak,2 Christine A Anderson,1 Marita G Titler1 1Department of Systems, Populations, and Leadership, School of Nursing, University of Michigan, Ann Arbor, MI, 2Department of Anesthesiology and Pain Medicine, Seattle Children’s Hospital, Seattle, WA, USA Background: Call light systems remain the primary means of hospitalized patients to initiate communication with their health care providers. Although there is vast amounts of literature discussing patient communication with their health care providers, few studies have explored patients’ perceptions concerning call light use and communication. The specific aim of this study was to solicit patients’ perceptions regarding their call light use and communication with nursing staff. Methods: Patients invited to this study met the following inclusion criteria: proficient in English, been hospitalized for at least 24 hours, aged ≥21 years, and able to communicate verbally (eg, not intubated). Thirty participants provided written informed consent, were enrolled in the study, and completed interviews. Results: Using qualitative descriptive methods, five major themes emerged from patients’ perceptions (namely; establishing connectivity, participant safety concerns, no separation: health care and the call light device, issues with the current call light, and participants’ perceptions of “nurse work”). Multiple minor themes supported these major themes. Data analysis utilized the constant comparative methods of Glaser and Strauss. Discussion: Findings from this study extend the knowledge of patients’ understanding of not only why inconsistencies occur between the call light and their nurses, but also why the call light is more than merely a device to initiate communication; rather, it is a direct conduit to their health care and its delivery. Keywords: nurse–patient communication, medical technology, quality of care, qualitative research, patient safety, nurse work

Published
2017

2. Genetics Adviser: The development and usability testing of a new patient digital health application to support clinical genomic testing

Author

Clausen, M, Krishnapillai, S, Hirjikaka, D, Kodida, R, Shickh, S, Reble, E, Mighton, C, Sam, J, Adi-Wauran, E, Baxter, NN, Feldman, G, Glogowski, E, Lerner-Ellis, J, Scheer, A, Shastri-Estrada, S, Shuman, C, Armel, SR, Aronson, M, Graham, T, Panchal, S, Thorpe, KE, Carroll, JC, Eisen, A, Elser, C, Kim, RH, Faghfoury, H, Schrader, KA, Seto, E, Bombard, Y, Clausen, M, Krishnapillai, S, Hirjikaka, D, Kodida, R, Shickh, S, Reble, E, Mighton, C, Sam, J, Adi-Wauran, E, Baxter, NN, Feldman, G, Glogowski, E, Lerner-Ellis, J, Scheer, A, Shastri-Estrada, S, Shuman, C, Armel, SR, Aronson, M, Graham, T, Panchal, S, Thorpe, KE, Carroll, JC, Eisen, A, Elser, C, Kim, RH, Faghfoury, H, Schrader, KA, Seto, E, and Bombard, Y

Published
2024

6. Recommendations for the collection and synthesis of Antarctic Ice Sheet mass balance data

Author

Abdalati, W, Allison, I, Carsey, F, Casassa, G, Fily, M, Frezzotti, M, Flicker, HA, Genthon, C, Goodwin, I, Guo, Z, Hamilton, GS, Hindmarsh, RCA, Hulbe, CL, Jacka, TH, Jezek, KC, Kwok, R, Li, J, Nixdorf, U, Paltridge, G, Rignot, E, Ritz, C, Satow, K, Scambos, TA, Shuman, C, Skvarca, P, Takahashi, S, van de Wal, RSW, Vaughan, DG, Wang, WL, Warner, RC, Wingham, DJ, Young, NW, and Zwally, HJ

Subjects
Antarctica, ice sheet, ice shelf, ice mass balance, remote sensing, Networking & Telecommunications, Earth Sciences
Abstract

Recent unexpected changes in the Antarctic Ice Sheet, including ice sheet thinning, ice shelf collapse and changes in ice velocities, along with the recent realization that as much as one third of ice shelf mass loss is due to bottom melt, place a new urgency on understanding the processes involved in these changes. Technological advances, including very new or forthcoming satellite-based (e.g. ICESat, CryoSat) remote sensing missions, will improve our ability to make meaningful determinations of changes in Antarctic Ice Sheet mass balance. This paper is the result of a workshop held to develop a strategy for international collaboration aimed at the collection and synthesis of Antarctic Ice Sheet mass balance data, and at understanding the processes involved so that we might predict future change. Nine sets of recommendations are made, concerning the most important and sensitive measurements, temporal ranges and study areas. A final tenth recommendation calls for increased synthesis of ice sheet data and communication between the field measurement, satellite observation and modelling communities. © 2004 Published by Elsevier B.V.

Published
2004

8. Recent Drift and Evolution of Large Icebergs in the Southern Ocean

Author

Scardilli, A, Claus, F, Shuman, C. A, and Scambos, T

Subjects
Meteorology And Climatology
Abstract

Tabular icebergs are almost unique to the Southern Ocean because they originate from large ice shelves or ice tongues that are now nearly absent in the Northern Hemisphere. Their evolution from calving to drift to eventual disintegration illustrates many interesting aspects of both glaciology and oceanography. Several events in 2018 highlighted these iceberg processes.

Published
2019

10. Genetics Adviser: a protocol for a mixed-methods randomised controlled trial evaluating a digital platform for genetics service delivery

Author

Shickh, S, Hirjikaka, D, Clausen, M, Kodida, R, Mighton, C, Reble, E, Sam, J, Panchal, S, Aronson, M, Graham, T, Armel, SR, Glogowski, E, Elser, C, Eisen, A, Carroll, JC, Shuman, C, Seto, E, Baxter, NN, Scheer, A, Shastri-Estrada, S, Feldman, G, Thorpe, KE, Schrader, KA, Lerner-Ellis, J, Kim, RH, Faghfoury, H, Bombard, Y, Shickh, S, Hirjikaka, D, Clausen, M, Kodida, R, Mighton, C, Reble, E, Sam, J, Panchal, S, Aronson, M, Graham, T, Armel, SR, Glogowski, E, Elser, C, Eisen, A, Carroll, JC, Shuman, C, Seto, E, Baxter, NN, Scheer, A, Shastri-Estrada, S, Feldman, G, Thorpe, KE, Schrader, KA, Lerner-Ellis, J, Kim, RH, Faghfoury, H, and Bombard, Y

Abstract

INTRODUCTION: The high demand for genetic tests and limited supply of genetics professionals has created a need for alternative service delivery models. Digital tools are increasingly being used to support multiple points in the genetic testing journey; however, none are transferable across multiple clinical specialties and settings nor do they encompass the entire trajectory of the journey. We aim to evaluate the effectiveness of the Genetics Adviser, an interactive, patient-facing, online digital health tool that delivers pre-test counselling, provides support during the waiting period for results, and returns results with post-test counselling, encompassing the entire patient genetic testing journey. METHODS AND ANALYSIS: We will compare the Genetics Adviser paired with a brief genetic counselling session to genetic counselling alone in a randomised controlled trial. One hundred and forty patients who previously received uninformative genetic test results for their personal and family history of cancer will be recruited from familial cancer clinics in Toronto and offered all clinically significant results from genomic sequencing. Participants randomised into the intervention arm will use the Genetics Adviser to learn about genomic sequencing, receive pre-test counselling, support during the waiting period and results, supplemented with brief counselling from a genetic counsellor. Participants in the control arm will receive standard pre-test and post-test counselling for genomic sequencing from a genetic counsellor. Our primary outcome is decisional conflict following pre-test counselling from the Genetics Adviser+genetic counsellor or counsellor alone. Secondary outcomes include: knowledge, satisfaction with decision-making, anxiety, quality of life, psychological impact of results, empowerment, acceptability and economic impact for patients and the health system. A subset of patients will be interviewed to assess user experience. ETHICS AND DISSEMINATION: This

Published
2022

15. Validation of the MODIS 'Clear-Sky' Surface Temperature of the Greenland Ice Sheet

Author

Hall, Dorothy K, Koenig, L. S, DiGirolamo, N. E, Comiso, J, and Shuman, C. A

Subjects
Earth Resources And Remote Sensing
Abstract

Surface temperatures on the Greenland Ice Sheet have been studied on the ground, using automatic weather station (AWS) data from the Greenland-Climate Network (GC-Net), and from analysis of satellite sensor data. Using Advanced Very High Frequency Radiometer (AVHRR) weekly surface temperature maps, warming of the surface of the Greenland Ice Sheet has been documented from 1981 to present. We extend and refine this record using higher-resolution Moderate-Resolution Imaging Spectroradiometer (MODIS) data from March 2000 to the present. To permit changes to be observed over time, we are developing a well-characterized monthly climate-data record (CDR) of the "clear-sky" surface temperature of the Greenland Ice Sheet using data from both the Terra and Aqua satellites. We use the MODIS ice-surface temperature (IST) algorithm. Validation of the CDR consists of several facets: 1) comparisons between the Terra and Aqua IST maps; 2) comparisons between ISTs and in-situ measurements; 3) comparisons between ISTs and AWS data; and 4) comparisons of ISTs with surface temperatures derived from other satellite instruments such as the Thermal Emission and Reflection Radiometer. In this work, we focus on 1) and 2) above. Surface temperatures on the Greenland Ice Sheet have been studied on the ground, using automatic weather station (AWS) data from the Greenland-Climate Network (GC-Net), and from analysis of satellite sensor data. Using Advanced Very High Frequency Radiometer (AVHRR) weekly surface temperature maps, warming of the surface of the Greenland Ice Sheet has been documented from 1981 to present. We extend and refine this record using higher-resolution Moderate-Resolution Imaging Spectroradiometer (MODIS) data from March 2000 to the present. To permit changes to be observed over time, we are developing a well-characterized monthly climate-data record (CDR) of the "clear-sky" surface temperature of the Greenland Ice Sheet using data from both the Terra and Aqua satellites. We use the MODIS ice-surface temperature (IST) algorithm. Validation of the CDR consists of several facets: 1) comparisons between the Terra and Aqua IST maps; 2) comparisons between ISTs and in-situ measurements; 3) comparisons between ISTs and AWS data; and 4) comparisons of ISTs with surface temperatures derived from other satellite instruments such as the Thermal Emission and Reflection Radiometer. In this work, we focus on 1) and 2) above. First we provide comparisons between Terra and Aqua swath-based ISTs at approximately 14:00 Local Solar Time, reprojected to 12.5 km polar stereographic cells. Results show good correspondence when Terra and Aqua data were acquired within 2 hrs of each other. For example, for a cell centered over Summit Camp (72.58 N, 38.5 W), the average agreement between Terra and Aqua ISTs is 0.74 K (February 2003), 0.47 K (April 2003), 0.7 K (August 2003) and 0.96 K (October 2003) with the Terra ISTs being generally lower than the Aqua ISTs. More precise comparisons will be calculated using pixel data at the swath level, and correspondence between Terra and Aqua IST is expected to be closer. (Because of cloud cover and other considerations, only a few common cloud-free swaths are typically available for each month for comparison.) Additionally, previous work comparing land-surface temperatures (LSTs) from the standard MODIS LST product and in-situ surface-temperature data at Summit Camp on the Greenland Ice Sheet show that Terra MODIS LSTs are about 3 K lower than in-situ temperatures at Summit Camp, during the winter of 2008-09. This work will be repeated using both Terra and Aqua IST pixel data (in place of LST data). In conclusion, we demonstrate that the uncertainties in the CDR will be well characterized as we work through the various facets of its validation.

Published
2011

16. A Climate-Data Record (CDR) of the 'Clear Sky' Surface Temperature of the Greenland Ice Sheet

Author

Hall, Dorothy K, Comiso, J. C, DiGirolamo, N. E, and Shuman, C. A

Subjects
Meteorology And Climatology
Abstract

To quantify the ice-surface temperature (IST) we are developing a climate-data record (CDR) of monthly IST of the Greenland ice sheet, from 1982 to the present using Advanced Very High Resolution Radiometer (AVHRR) and Moderate-Resolution Imaging Spectroradiometer (MODIS) data at 5-km resolution. "Clear-sky" surface temperature increases have been measured from the early 1980s to the early 2000s in the Arctic using AVHRR data, showing increases ranging from 0.57-0.02 (Wang and Key, 2005) to 0.72 0.10 deg C per decade (Comiso, 2006). Arctic warming has implications for ice-sheet mass balance because much of the periphery of the ice sheet is near 0 deg C in the melt season and is thus vulnerable to more extensive melting (Hanna et al., 2008). The algorithm used for this work has a long history of measuring IST in the Arctic with AVHRR (Key and Haefliger, 1992). The data are currently available from 1981 to 2004 in the AVHRR Polar Pathfinder (APP) dataset (Fowler et al., 2000). J. Key1NOAA modified the AVHRR algorithm for use with MODIS (Hall et al., 2004). The MODIS algorithm is now being processed over Greenland. Issues being addressed in the production of the CDR are: time-series bias caused by cloud cover, and cross-calibration between AVHRR and MODIS instruments. Because of uncertainties, time series of satellite ISTs do not necessarily correspond with actual surface temperatures. The CDR will be validated by comparing results with in-situ (see Koenig and Hall, in press) and automatic-weather station data (e.g., Shuman et al., 2001).

Published
2011

17. A Climate-Data Record of the 'Clear-Sky' Surface Temperature of the Greenland Ice Sheet

Author

Hall, D. K, Comiso, J. C, Digirolamo, N. E, Stock, L. V, Riggs, G. A, and Shuman, C. A

Subjects
Meteorology And Climatology
Abstract

We are developing a climate-data record (CDR of daily "clear-sky" ice-surface temperature (IST) of the Greenland Ice Sheet, from 1982 to the present using Advanced Very High Resolution Radiometer (AVHRR) (1982 - present) and Moderate-Resolution Imaging Spectroradiometer (MODIS) data (2000 - present) at a resolution of approximately 5 km. The CDR will be continued in the National Polar-orbiting Operational Environmental Satellite System Visible/Infrared Imager Radiometer Suite era. Two algorithms remain under consideration. One algorithm under consideration is based on the split-window technique used in the Polar Pathfinder dataset (Fowler et al., 2000 & 21007). Another algorithm under consideration, developed by Comiso (2006), uses a single channel of AVHRR data (channel 4) in conjunction with meteorological-station data to account for atmospheric effects and drift between AVHRR instruments. Known issues being addressed in the production of the CDR are: tune-series bias caused by cloud cover (surface temperatures can be different under clouds vs. clear areas) and cross-calibration in the overlap period between AVHRR instruments, and between AVHRR and MODIS instruments. Because of uncertainties, mainly due to clouds (Stroeve & Steffen, 1998; Wang and Key, 2005; Hall et al., 2008 and Koenig and Hall, submitted), time-series of satellite 1S'1" do not necessarily correspond to actual surface temperatures. The CDR will be validated by comparing results with automatic-,",eather station (AWS) data and with satellite-derived surface-temperature products. Regional "clear-sky" surface temperature increases in the Arctic, measured from AVHRR infrared data, range from 0.57+/-0.02 deg C (Wang and Key, 2005) to 0.72+/-0.10 deg C (Comiso, 2006) per decade since the early 1980s. Arctic warming has important implications for ice-sheet mass balance because much of the periphery of the Greenland Ice Sheet is already near 0 deg C during the melt season, and is thus vulnerable to rapid melting if temperatures continue to increase. References

Published
2009

18. State of the Climate in 2018

Author

Arndt, D. S., Blunden, J., Dunn, R. J. H., Stanitski, D. M., Gobron, N., Willett, K. M., Sanchez-lugo, A., Berrisford, P., Morice, C., Nicolas, Jp, Carrea, L., Woolway, R. I., Merchant, C. J., Dokulil, M. T., De Eyto, E., Degasperi, C. L., Korhonen, J., Marszelewski, W., May, L., Paterson, A. M., Rusak, J. A., Schladow, S. G., Schmid, M., Verburg, P., Watanabe, S., Weyhenmeyer, G. A., King, A. D., Donat, M. G., Christy, J. R., Po-chedley, S., Mears, C. R., Haimberger, L., Covey, C., Randel, W., Noetzli, J., Biskaborn, B. K., Christiansen, H. H., Isaksen, K., Schoeneich, P., Smith, S., Vieira, G., Zhao, L., Streletskiy, D. A., Robinson, D. A., Pelto, M., Berry, D. I., Bosilovich, M. G., Simmons, A. J., Mears, C., Ho, S. P., Bock, O., Zhou, X., Nicolas, J, Vose, R. S., Adler, R., Gu, G., Becker, A., Yin, X, Tye, M. R., Blenkinsop, S., Durre, I., Ziese, M., Collow, A. B. Marquardt, Rustemeier, E., Foster, M. J., Di Girolamo, L., Frey, R. A., Heidinger, A. K., Sun-mack, S., Phillips, C., Menzel, W. P., Stengel, M., Zhao, G., Kim, H., Rodell, M., Li, B., Famiglietti, J. S., Scanlon, T., Van Der Schalie, R., Preimesberger, W., Reimer, C., Hahn, S., Gruber, A., Kidd, R., De Jeu, R. A. M., Dorigo, W. A., Barichivich, J., Osborn, T. J., Harris, I., Van Der Schrier, G., Jones, P. D., Miralles, D. G., Martens, B., Beck, H. E., Dolman, A. J., Jimenez, C., Mccabe, M. F., Wood, E. F., Allan, R., Azorin-molina, C., Mears, C. A., Mcvicar, T. R., Mayer, M., Schenzinger, V., Hersbach, H., Stackhouse, P. W., Jr., Wong, T., Kratz, D. P., Sawaengphokhai, P., Wilber, A. C., Gupta, S. K., Loeb, N. G., Dlugokencky, E. J., Hall, B. D., Montzka, S. A., Dutton, G., Muhle, J., Elkins, J. W., Miller, Br, Remy, S., Bellouin, N., Kipling, Z., Ades, M., Benedetti, A., Boucher, O., Weber, M., Steinbrecht, W., Arosio, C., Van Der A, R., Frith, S. M., Anderson, J., Coldewey-egbers, M., Davis, S., Degenstein, D., Fioletov, V. E., Froidevaux, L., Hubert, D., Long, C. S., Loyola, D., Rozanov, A., Roth, C., Sofieva, V., Tourpali, K., Wang, R., Wild, J. D., Davis, S. M., Rosenlof, K. H., Hurst, D. F., Selkirk, H. B., Vomel, H., Ziemke, J. R., Cooper, O. R., Flemming, J., Inness, A., Pinty, B., Kaiser, J. W., Van Der Werf, G. R., Hemming, D. L., Garforth, J., Park, T., Richardson, A. D., Rutishauser, T., Sparks, T. H., Thackeray, S. J., Myneni, R., Lumpkin, R., Huang, B., Kennedy, J., Xue, Y., Zhang, H. -m., Hu, C., Wang, M., Johnson, G. C., Lyman, J. M., Boyer, T., Cheng, L., Domingues, C. M., Gilson, J., Ishii, M., Killick, R. E., Monselesan, D., Purkey, S. G., Wijffels, S. E., Locarnini, R., Yu, L., Jin, X., Stackhouse, P. W., Kato, S., Weller, R. A., Thompson, P. R., Widlansky, M. J., Leuliette, E., Sweet, W., Chambers, D. P., Hamlington, B. D., Jevrejeva, S., Marra, J. J., Merrifield, M. A., Mitchum, G. T., Nerem, R. S., Kelble, C., Karnauskas, M., Hubbard, K., Goni, G., Streeter, C., Dohan, K., Franz, B. A., Cetinic, I., Karakoylu, E. M., Siegel, D. A., Westberry, T. K., Feely, R. A., Wanninkhof, R., Carter, B. R., Landschutzer, P., Sutton, A. J., Cosca, C., Trinanes, J. A., Baxter, S., Schreck, C., Bell, G. D., Mullan, A. B., Pezza, A. B., Coelho, C. A. S., Wang, B., He, Q., Diamond, H. J., Schreck, C. J., Blake, E. S., Landsea, C. W., Wang, H., Goldenberg, S. B., Pasch, R. J., Klotzbach, P. J., Kruk, M. C., Camargo, S. J., Trewin, B. C., Pearce, P. R., Lorrey, A. M., Domingues, R., Goni, G. J., Knaff, J. A., Lin, I. -i., Bringas, F., Richter-menge, J., Osborne, E., Druckenmiller, M., Jeffries, M. O., Overland, J. E., Hanna, E., Hanssen-bauer, I., Kim, S. -j., Walsh, J. E., Bhatt, U. S., Timmermans, M. -l., Ladd, C., Perovich, D., Meier, W., Tschudi, M., Farrell, S., Hendricks, S., Gerland, S., Haas, C., Krumpen, T., Polashenski, C., Ricker, R, Webster, M., Stabeno, P. J., Tedesco, M., Box, J. E., Cappelen, J., Fausto, R. S., Fettweis, X., Andersen, J. K., Mote, T., Smeets, C. J. P. P., Van As, D., Van De Wal, R. S. W., Romanovsky, V. E., Smith, S. L., Shiklomanov, N. I., Kholodov, A. L., Drozdov, D. S., Malkova, G. V., Marchenko, S. S., Jella, K. B., Mudryk, L., Brown, R., Derksen, C., Luojus, K., Decharme, B., Holmes, R. M., Shiklomanov, A. I., Suslova, A., Tretiakov, M., Mcclelland, J. W., Spencer, R. G. M., Tank, S. E., Epstein, H., Bhatt, U., Raynolds, M., Walker, D., Forbes, B., Phoenix, G., Bjerke, J., Tommervik, H., Karlsen, S. -r., Goetz, S., Jia, G., Bernhard, G. H., Grooss, J. -u., Ialongo, I., Johnsen, B., Lakkala, K., Manney, G. L., Mueller, R., Scambos, T., Stammerjohn, S., Clem, K. R., Barreira, S., Fogt, R. L., Colwell, S., Keller, L. M., Lazzara, M. A., Reid, P., Massom, R. A., Lieser, J. L., Meijers, A., Sallee, J. -b., Grey, A., Johnson, K., Arrigo, K., Swart, S., King, B., Meredith, M., Mazloff, M., Scardilli, A., Claus, F., Shuman, C. A., Kramarova, N., Newman, P. A., Nash, E. R., Strahan, S. E., Johnson, B., Pitts, M., Santee, M. L., Petropavlovskikh, I., Braathen, G. O., Coy, L., De Laat, J., Bissolli, P., Ganter, C., Li, T., Mekonnen, A., Gleason, K., Smith, A., Fenimore, C., Heim, R. R., Jr., Nauslar, N. J., Brown, T. J., Mcevoy, D. J., Lareau, N. P., Amador, J. A., Hidalgo, H. G., Alfaro, E. J., Calderon, B., Mora, N., Stephenson, T. S., Taylor, M. A., Trotman, A. R., Van Meerbeeck, C. J., Campbell, J. D., Brown, A., Spence, J., Martinez, R., Diaz, E., Marin, D., Hernandez, R., Caceres, L., Zambrano, E., Nieto, J., Marengo, J. A., Espinoza, J. C., Alves, L. M., Ronchail, J., Lavado-casimiro, J. W., Ramos, I., Davila, C., Ramos, A. M., Diniz, F. A., Aliaga-nestares, V., Castro, A. Y., Stella, J. L., Aldeco, L. S., Diaz, D. A. Campos, Misevicius, N., Kabidi, K., Sayouri, A., Elkharrim, M., Mostafa, A. E., Hagos, S., Feng, Z., Ijampy, J. A., Sima, F., Francis, S. D., Tsidu, G. Mengistu, Kruger, A. C., Mcbride, C., Jumaux, G., Dhurmea, K. R., Belmont, M., Rakotoarimalala, C. L., Labbe, L., Rosner, B., Benedict, I., Van Heerwaarden, C., Weerts, A., Hazeleger, W., Trachte, K., Zhu, Z., Zhang, P., Lee, T. C., Ripaldi, A., Mochizuki, Y., Lim, J. -y, Oyunjargal, L., Timbal, B., Srivastava, A. K., Revadekar, J. V., Rajeevan, M., Shimpo, A., Khoshkam, M., Kazemi, A. Fazl, Zeyaeyan, S., Lander, M. A., Mcgree, S., Tobin, S., Bettio, L., Arndt, D. S., Blunden, J., Dunn, R. J. H., Stanitski, D. M., Gobron, N., Willett, K. M., Sanchez-lugo, A., Berrisford, P., Morice, C., Nicolas, Jp, Carrea, L., Woolway, R. I., Merchant, C. J., Dokulil, M. T., De Eyto, E., Degasperi, C. L., Korhonen, J., Marszelewski, W., May, L., Paterson, A. M., Rusak, J. A., Schladow, S. G., Schmid, M., Verburg, P., Watanabe, S., Weyhenmeyer, G. A., King, A. D., Donat, M. G., Christy, J. R., Po-chedley, S., Mears, C. R., Haimberger, L., Covey, C., Randel, W., Noetzli, J., Biskaborn, B. K., Christiansen, H. H., Isaksen, K., Schoeneich, P., Smith, S., Vieira, G., Zhao, L., Streletskiy, D. A., Robinson, D. A., Pelto, M., Berry, D. I., Bosilovich, M. G., Simmons, A. J., Mears, C., Ho, S. P., Bock, O., Zhou, X., Nicolas, J, Vose, R. S., Adler, R., Gu, G., Becker, A., Yin, X, Tye, M. R., Blenkinsop, S., Durre, I., Ziese, M., Collow, A. B. Marquardt, Rustemeier, E., Foster, M. J., Di Girolamo, L., Frey, R. A., Heidinger, A. K., Sun-mack, S., Phillips, C., Menzel, W. P., Stengel, M., Zhao, G., Kim, H., Rodell, M., Li, B., Famiglietti, J. S., Scanlon, T., Van Der Schalie, R., Preimesberger, W., Reimer, C., Hahn, S., Gruber, A., Kidd, R., De Jeu, R. A. M., Dorigo, W. A., Barichivich, J., Osborn, T. J., Harris, I., Van Der Schrier, G., Jones, P. D., Miralles, D. G., Martens, B., Beck, H. E., Dolman, A. J., Jimenez, C., Mccabe, M. F., Wood, E. F., Allan, R., Azorin-molina, C., Mears, C. A., Mcvicar, T. R., Mayer, M., Schenzinger, V., Hersbach, H., Stackhouse, P. W., Jr., Wong, T., Kratz, D. P., Sawaengphokhai, P., Wilber, A. C., Gupta, S. K., Loeb, N. G., Dlugokencky, E. J., Hall, B. D., Montzka, S. A., Dutton, G., Muhle, J., Elkins, J. W., Miller, Br, Remy, S., Bellouin, N., Kipling, Z., Ades, M., Benedetti, A., Boucher, O., Weber, M., Steinbrecht, W., Arosio, C., Van Der A, R., Frith, S. M., Anderson, J., Coldewey-egbers, M., Davis, S., Degenstein, D., Fioletov, V. E., Froidevaux, L., Hubert, D., Long, C. S., Loyola, D., Rozanov, A., Roth, C., Sofieva, V., Tourpali, K., Wang, R., Wild, J. D., Davis, S. M., Rosenlof, K. H., Hurst, D. F., Selkirk, H. B., Vomel, H., Ziemke, J. R., Cooper, O. R., Flemming, J., Inness, A., Pinty, B., Kaiser, J. W., Van Der Werf, G. R., Hemming, D. L., Garforth, J., Park, T., Richardson, A. D., Rutishauser, T., Sparks, T. H., Thackeray, S. J., Myneni, R., Lumpkin, R., Huang, B., Kennedy, J., Xue, Y., Zhang, H. -m., Hu, C., Wang, M., Johnson, G. C., Lyman, J. M., Boyer, T., Cheng, L., Domingues, C. M., Gilson, J., Ishii, M., Killick, R. E., Monselesan, D., Purkey, S. G., Wijffels, S. E., Locarnini, R., Yu, L., Jin, X., Stackhouse, P. W., Kato, S., Weller, R. A., Thompson, P. R., Widlansky, M. J., Leuliette, E., Sweet, W., Chambers, D. P., Hamlington, B. D., Jevrejeva, S., Marra, J. J., Merrifield, M. A., Mitchum, G. T., Nerem, R. S., Kelble, C., Karnauskas, M., Hubbard, K., Goni, G., Streeter, C., Dohan, K., Franz, B. A., Cetinic, I., Karakoylu, E. M., Siegel, D. A., Westberry, T. K., Feely, R. A., Wanninkhof, R., Carter, B. R., Landschutzer, P., Sutton, A. J., Cosca, C., Trinanes, J. A., Baxter, S., Schreck, C., Bell, G. D., Mullan, A. B., Pezza, A. B., Coelho, C. A. S., Wang, B., He, Q., Diamond, H. J., Schreck, C. J., Blake, E. S., Landsea, C. W., Wang, H., Goldenberg, S. B., Pasch, R. J., Klotzbach, P. J., Kruk, M. C., Camargo, S. J., Trewin, B. C., Pearce, P. R., Lorrey, A. M., Domingues, R., Goni, G. J., Knaff, J. A., Lin, I. -i., Bringas, F., Richter-menge, J., Osborne, E., Druckenmiller, M., Jeffries, M. O., Overland, J. E., Hanna, E., Hanssen-bauer, I., Kim, S. -j., Walsh, J. E., Bhatt, U. S., Timmermans, M. -l., Ladd, C., Perovich, D., Meier, W., Tschudi, M., Farrell, S., Hendricks, S., Gerland, S., Haas, C., Krumpen, T., Polashenski, C., Ricker, R, Webster, M., Stabeno, P. J., Tedesco, M., Box, J. E., Cappelen, J., Fausto, R. S., Fettweis, X., Andersen, J. K., Mote, T., Smeets, C. J. P. P., Van As, D., Van De Wal, R. S. W., Romanovsky, V. E., Smith, S. L., Shiklomanov, N. I., Kholodov, A. L., Drozdov, D. S., Malkova, G. V., Marchenko, S. S., Jella, K. B., Mudryk, L., Brown, R., Derksen, C., Luojus, K., Decharme, B., Holmes, R. M., Shiklomanov, A. I., Suslova, A., Tretiakov, M., Mcclelland, J. W., Spencer, R. G. M., Tank, S. E., Epstein, H., Bhatt, U., Raynolds, M., Walker, D., Forbes, B., Phoenix, G., Bjerke, J., Tommervik, H., Karlsen, S. -r., Goetz, S., Jia, G., Bernhard, G. H., Grooss, J. -u., Ialongo, I., Johnsen, B., Lakkala, K., Manney, G. L., Mueller, R., Scambos, T., Stammerjohn, S., Clem, K. R., Barreira, S., Fogt, R. L., Colwell, S., Keller, L. M., Lazzara, M. A., Reid, P., Massom, R. A., Lieser, J. L., Meijers, A., Sallee, J. -b., Grey, A., Johnson, K., Arrigo, K., Swart, S., King, B., Meredith, M., Mazloff, M., Scardilli, A., Claus, F., Shuman, C. A., Kramarova, N., Newman, P. A., Nash, E. R., Strahan, S. E., Johnson, B., Pitts, M., Santee, M. L., Petropavlovskikh, I., Braathen, G. O., Coy, L., De Laat, J., Bissolli, P., Ganter, C., Li, T., Mekonnen, A., Gleason, K., Smith, A., Fenimore, C., Heim, R. R., Jr., Nauslar, N. J., Brown, T. J., Mcevoy, D. J., Lareau, N. P., Amador, J. A., Hidalgo, H. G., Alfaro, E. J., Calderon, B., Mora, N., Stephenson, T. S., Taylor, M. A., Trotman, A. R., Van Meerbeeck, C. J., Campbell, J. D., Brown, A., Spence, J., Martinez, R., Diaz, E., Marin, D., Hernandez, R., Caceres, L., Zambrano, E., Nieto, J., Marengo, J. A., Espinoza, J. C., Alves, L. M., Ronchail, J., Lavado-casimiro, J. W., Ramos, I., Davila, C., Ramos, A. M., Diniz, F. A., Aliaga-nestares, V., Castro, A. Y., Stella, J. L., Aldeco, L. S., Diaz, D. A. Campos, Misevicius, N., Kabidi, K., Sayouri, A., Elkharrim, M., Mostafa, A. E., Hagos, S., Feng, Z., Ijampy, J. A., Sima, F., Francis, S. D., Tsidu, G. Mengistu, Kruger, A. C., Mcbride, C., Jumaux, G., Dhurmea, K. R., Belmont, M., Rakotoarimalala, C. L., Labbe, L., Rosner, B., Benedict, I., Van Heerwaarden, C., Weerts, A., Hazeleger, W., Trachte, K., Zhu, Z., Zhang, P., Lee, T. C., Ripaldi, A., Mochizuki, Y., Lim, J. -y, Oyunjargal, L., Timbal, B., Srivastava, A. K., Revadekar, J. V., Rajeevan, M., Shimpo, A., Khoshkam, M., Kazemi, A. Fazl, Zeyaeyan, S., Lander, M. A., Mcgree, S., Tobin, S., and Bettio, L.

Published
2019

19. Glacier Acceleration and Thinning after Ice Shelf Collapse in the Larsen B Embayment, Antarctica

Author

Scambos, T. A, Bohlander, J. A, Shuman, C. A, and Skvarca, P

Subjects
Geophysics
Abstract

Ice velocities derived from five Landsat 7 images acquired between January 2000 and February 2003 show a two- to six-fold increase in centerline speed of four glaciers flowing into the now-collapsed section of the Larsen B Ice Shelf. Satellite laser altimetry from ICEsat indicates the surface of Hektoria Glacier lowered by up to 38 +/- 6 m a six-month period beginning one year after the break-up in March 2002. Smaller elevation losses are observed for Crane and Jorum glaciers over a later 5-month period. Two glaciers south of the collapse area, Flask and Leppard, show little change in speed or elevation. Seasonal variations in speed preceding the large post-collapse velocity increases suggest that both summer melt percolation and changes in the stress field due to shelf removal play a major role in glacier dynamics.

Published
2004

20. Detailed ice loss pattern in the northern Antarctic Peninsula: widespread decline driven by ice front retreats

Author

Scambos, T. A., Berthier, E., Haran, T., Shuman, C. A., Cook, A. J., Ligtenberg, S. R M, Bohlander, J., Sub Dynamics Meteorology, Marine and Atmospheric Research, Sub Dynamics Meteorology, and Marine and Atmospheric Research

Subjects
lcsh:GE1-350, geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Ice stream, lcsh:QE1-996.5, Antarctic sea ice, 010502 geochemistry & geophysics, Glacier morphology, 01 natural sciences, Ice shelf, lcsh:Geology, Oceanography, 13. Climate action, Ice tongue, Sea ice, Cryosphere, Ice sheet, Geology, lcsh:Environmental sciences, 0105 earth and related environmental sciences, Water Science and Technology, Earth-Surface Processes
Abstract

The northern Antarctic Peninsula (nAP, < 66° S) is one of the most rapidly changing glaciated regions on earth, yet the spatial patterns of its ice mass loss at the glacier basin scale have to date been poorly documented. We use satellite laser altimetry and satellite stereo-image topography spanning 2001–2010, but primarily 2003–2008, to map ice elevation change and infer mass changes for 33 glacier basins covering the mainland and most large islands in the nAP. Rates of ice volume and ice mass change are 27.7± 8.6 km3 a−1 and 24.9± 7.8 Gt a−1, equal to −0.73 m a−1 w.e. for the study area. Mass loss is the highest for eastern glaciers affected by major ice shelf collapses in 1995 and 2002, where twelve glaciers account for 60% of the total imbalance. However, losses at smaller rates occur throughout the nAP, at both high and low elevation, despite increased snow accumulation along the western coast and ridge crest. We interpret the widespread mass loss to be driven by decades of ice front retreats on both sides of the nAP, and extended throughout the ice sheet due to the propagation of kinematic waves triggered at the fronts into the interior.

Published
2018

21. Interdisciplinary Determination of Ice Sheet Accumulation Patterns: Combined Atmospheric Modeling and Field and Remote Sensing Studies

Author

Shuman, C. A and Bindschadler, R. A

Subjects
Earth Resources And Remote Sensing
Abstract

This research is focusing on two related areas that are fundamental to the NASA PARCA (Program for Arctic Regional Climate Assessment) program. The primary research area is the determination of the amount, rate, and timing of accumulation at distributed sites in the dry snow zone of Greenland and evaluation of these results in light of accumulation modeling results. The secondary research area is the calibration of the isotope "thermometer" at these ice sheet sites as well as the determination of long-term temperature trends in Greenland.

Published
1999

22. A blood-based composite panel that screens Alzheimer’s disease

Author

Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li, and Jianping Jia

Subjects
Alzheimer’s disease, Mild cognitive impairment, Blood, Biomarker, Therapeutics. Pharmacology, RM1-950
Abstract

Abstract Background Blood tests would be much easier to implement in the clinical diagnosis of Alzheimer’s disease (AD) as minimally invasive measurements. Multiple inspection technologies promoted AD-associated blood biomarkers’ exploration. However, there was a lack of further screening and validation for these explored blood-based biomarkers. We selected four potential biomarkers to explore their plasma levels in AD and amnestic mild cognitive impairment (aMCI) and developed a composite panel for AD and aMCI screening. Method The plasma concentrations of soluble low-density lipoprotein receptor-associated protein 1 (sLRP1), Gelsolin (GSN), Kallikrein 4 (KLK4) and Caspase 3 were measured in the discovery and validation cohort. The receiver operating characteristic (ROC) curve was generated to assess the classification panel with the area under the curve (AUC). Results A total of 233 participants (26 CN, 27 aMCI, and 26 AD in the discovery cohort, and 51 CN, 50 aMCI, and 53 AD in the validation cohort) with complete data were included in the study. The plasma concentrations of sLRP1 and Caspase 3 were significantly decreased in AD and aMCI when compared with those in the CN group. Compared with the CN group, the concentrations of KLK4 and GSN were increased in AD, but not in MCI. Interestingly, one of four proteins, sLRP1 in plasma level was higher in Apolipoprotein E (APOE) ε4 non-carriers than that in APOE ε4 carriers, especially among CN and MCI. No significant difference was found between females and males in the plasma levels of four proteins. The composite panel is based on four blood biomarkers accurately classifying AD from CN (AUC = 0.903–0.928), and MCI from CN (AUC = 0.846–0.865). Moreover, dynamic changes in the plasma levels of four proteins exhibited a significant correlation with cognitive assessment. Conclusions Altogether, these findings indicate that the plasma levels of sLRP1, KLK4, GSN and Caspase 3 changed with the progression of AD. And their combination could be used to develop a panel for classifying AD and aMCI with high accuracy, which would provide an alternative approach for developing a blood-based test for AD and aMCI screening.

Published
2023
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24. Visual-Stratigraphic Dating of the GISP2 Ice Core: Basis, Reproducibility, and Application

Author

Alley, R. B, Shuman, C. A, Meese, D. A, Gow, A. J, Taylor, K. C, Cuffey, K. M, Fitzpatrick, J. J, Grootes, P. M, Zielinski, G. A, Ram, M, Spinelli, G, and Elder, B

Subjects
Oceanography
Abstract

Annual layers are visible in the Greenland Ice Sheet Project 2 ice core from central Greenland, allowing rapid dating of the core. Changes in bubble and grain structure caused by near-surface, primarily summertime formation of hoar complexes provide the main visible annual marker in the Holocene, and changes in "cloudiness" of the ice correlated with dustiness mark Wisconsinan annual cycles; both markers are evident and have been intercalibrated in early Holocene ice. Layer counts are reproducible between different workers and for one worker at different times, with 1% error over century-length times in the Holocene. Reproducibility is typically 5% in Wisconsinan ice-age ice and decreases with increasing age and depth. Cumulative ages from visible stratigraphy are not significantly different from independent ages of prominent events for ice older than the historical record and younger than approximately 50,000 years. Visible observations are not greatly degraded by "brittle ice" or many other core-quality problems, allowing construction of long, consistently sampled time series. High accuracy requires careful study of the core by dedicated observers.

Published
1997

25. Validity of the Temperature Reconstruction from Water Isotopes in Ice Cores

Author

Jouzel, J, Alley, R. B, Cuffey, K. M, Dansgaard, W, Grootes, P, Hoffmann, G, Johnsen, S. J, Koster, R. D, Peel, D, Shuman, C. A, Stievenard, M, Stuiver, M, and White, J

Subjects
Oceanography
Abstract

Well-documented present-day distributions of stable water isotopes (HDO and others) show the existence, in middle and high latitudes, of a linear relationship between the mean annual isotope content of precipitation (SD and 51"0) and the mean annual temperature at the precipitation site. Paleoclimatologists have used this relationship, which is particularly well obeyed over Greenland and Antarctica, to infer paleotemperatures from ice core data. There is, however, growing evidence that spatial and temporal isotope/ surface temperature slopes differ, thus complicating the use of stable water isotopes as paleothermometers. In this paper we review empirical estimates of temporal slopes in polar regions and relevant information that can be inferred from isotope models: simple, Rayleigh-type distillation models and (particularly over Greenland) general circulation models (GCMS) fitted with isotope tracer diagnostics. Empirical estimates of temporal slopes appear consistently lower than present-day spatial slopes and are dependent on the timescale considered. This difference is most probably due to changes in the evaporative origins of moisture, changes in the seasonality of the precipitation, changes in the strength of the inversion layer, or some combination of these changes. Isotope models have not yet been used to evaluate the relative influences of these different factors. The apparent disagreement in the temporal and spatial slopes clearly makes calibrating the isotope paleothermometer difficult. Nevertheless, the use of a (calibrated) isotope paleothermometer appears justified; empirical estimates and most (though not all) GCM results support the practice of interpreting ice core isotope records in terms of local temperature changes.

Published
1997

26. Detection and Monitoring of Stratigraphic Markers and Temperature Trends at the Greenland Ice Sheet Project 2 Using Passive-Microwave Remote-Sensing Data

Author

Shuman, C. A, Alley, R. B, Fahnestock, M. A, Fawcett, P. J, Bondschadler, R. A, White, J. W. C, Grootes, P. M, Anandakrishnan, S, and Stearns, C. R

Subjects
Earth Resources And Remote Sensing
Abstract

Satellite passive-microwave sensors provide a sensitive means of studying ice-sheet surface processes that assists ice-core interpretation and can extend local observations across regional scales. Analysis of special sensor microwave/imager (SSM/I) brightness temperature (TB) data supports ice-core research in two specific ways. First, the summer hoar complex layers used to date the Holocene portion of the Greenland Ice Sheet Project 2 ice core can be defined temporally and spatially by SSM/I 37-GHz vertically (V) and horizontally (H) polarized B ratio (V/H) trends. Second, comparison of automatic weather station temperatures to SSM/I 37-GHz V TB data shows that they are an effective proxy temperature record in this region. Also, the TB data can be correlated with proxy temperature trends from stable-isotope-ratio (delta O-18 and delta-D) profiles from snow pits and this allows the assignment of dates to specific snow depths.

Published
1997

28. Comparison of virus-capsid mimicking biologic-shell based versus polymeric-shell nanoparticles for enhanced oral insulin delivery

Author

Zhixiang Cui, Shuman Cui, Lu Qin, Yalin An, Xin Zhang, Jian Guan, Tin Wui Wong, and Shirui Mao

Subjects
Oral insulin, Streptavidin, Virus-mimicking, Nanoparticles, Muco-penetrating, Mucus, Therapeutics. Pharmacology, RM1-950
Abstract

Virus-capsid mimicking mucus-permeable nanoparticles are promising oral insulin carriers which surmount intestinal mucus barrier. However, the impact of different virus-capsid mimicking structure remains unexplored. In this study, utilizing biotin grafted chitosan as the main skeleton, virus-mimicking nanoparticles endowed with biologic-shell (streptavidin coverage) and polymeric-shell (hyaluronic acid/alginate coating) were designed with insulin as a model drug by self-assembly processes. It was demonstrated that biologic-shell mimicking nanoparticles exhibited a higher intestinal trans-mucus (>80%, 10 min) and transmucosal penetration efficiency (1.6–2.2-fold improvement) than polymeric-shell counterparts. Uptake mechanism studies revealed caveolae-mediated endocytosis was responsible for the absorption of biologic-shell mimicking nanoparticles whereas polymeric-shell mimicking nanoparticles were characterized by clathrin-mediated pathway with anticipated lysosomal insulin digestion. Further, in vivo hypoglycemic study indicated that the improved effect of regulating blood sugar levels was virus-capsid structure dependent out of which biologic-shell mimicking nanoparticles presented the best performance (5.1%). Although the findings of this study are encouraging, much more work is required to meet the standards of clinical translation. Taken together, we highlight the external structural dependence of virus-capsid mimicking nanoparticles on the muco-penetrating and uptake mechanism of enterocytes that in turn affecting their in vivo absorption, which should be pondered when engineering virus-mimicking nanoparticles for oral insulin delivery.

Published
2023
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29. Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer’s disease

Author

Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, and Jianping Jia

Subjects
Familial Alzheimer’s disease, Gene mutation, Neuropsychology, Diffusion tensor imaging, Resting state functional MRI, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Neuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer’s disease (FAD). This study investigated the effects of APOEε4 and known pathogenic gene mutation on different cognitive domains and circuit imaging markers in preclinical FAD. Methods One hundred thirty-nine asymptomatic subjects in FAD families, including 26 APOEε4 carriers, 17 APP and 20 PS1 mutation carriers, and 76 control subjects, went through a series of neuropsychological tests and MRI scanning. Test scores and imaging measures including volumes, diffusion indices, and functional connectivity (FC) of frontostriatal and hippocampus to posterior cingulate cortex pathways were compared between groups and analyzed for correlation. Results Compared with controls, the APOEε4 group showed increased hippocampal volume and decreased FC of fronto-caudate pathway. The APP group showed increased recall scores in auditory verbal learning test, decreased fiber number, and increased radial diffusivity and FC of frontostriatal pathway. All three genetic groups showed decreased fractional anisotropy of hippocampus to posterior cingulate cortex pathway. These neuropsychological and imaging measures were able to discriminate genetic groups from controls, with areas under the curve from 0.733 to 0.837. Circuit imaging measures are differentially associated with scores in various cognitive scales in control and genetic groups. Conclusions There are neuropsychological and imaging changes in the preclinical stage of FAD, some of which are shared by APOEε4 and known pathogenic gene mutation, while some are unique to different genetic groups. These findings are helpful for the early identification of Alzheimer’s disease and for developing generalized and individualized prevention and intervention strategies.

Published
2023
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39. Phosphorus Addition Reduces Seedling Growth and Survival for the Arbuscular Mycorrhizal Tree Cinnamomum camphora (Lauraceae) and Ectomycorrhizal Tree Castanopsis sclerophylla (Fagaceae) in Fragmented Forests in Eastern China

Author

Jinliang Liu, Mengsi Zhou, Xue Li, Tianxiang Li, Haoyue Jiang, Luping Zhao, Shuman Chen, Jingying Tian, and Wenjuan Han

Subjects
phosphorus limitation, habitat loss, mycorrhizal symbiosis, subtropical, community dynamics, Botany, QK1-989
Abstract

Global changes in nutrient deposition rates and habitat fragmentation are likely to have profound effects on plant communities, particularly in the nutrient-limited systems of the tropics and subtropics. However, it remains unclear how increased phosphorus (P) supply affects seedling growth in P-deficient subtropical fragmented forests. To explore this, we applied P to 11 islands in a subtropical Chinese archipelago and examined the results in combination with a contemporary greenhouse experiment to test the influence of P addition on seedling growth and survival. We measured the growth (i.e., base area) and mortality rate of seedlings for one arbuscular mycorrhizal (AM) and one ectomycorrhizal (EcM) tree species separately and calculated their relative growth rate and mortality when compared with P addition and control treatment on each island. We also measured three functional traits and the biomass of seedlings in the greenhouse experiment. Results showed that P addition significantly increased the mortality of AM and EcM seedlings and reduced the growth rate of EcM seedlings. The relative growth rate of AM seedlings, but not EcM seedlings, significantly decreased as the island area decreased, suggesting that P addition could promote the relative growth rate of AM seedlings on larger islands. The greenhouse experiment showed that P addition could reduce the specific root length of AM and EcM seedlings and reduce the aboveground and total biomass of seedlings, indicating that P addition may affect the resource acquisition of seedlings, thereby affecting their survival and growth. Our study reveals the synergistic influence of habitat fragmentation and P deposition, which may affect the regeneration of forest communities and biodiversity maintenance in fragmented habitats.

Published
2023
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40. Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study

Author

Fang Ye, Xinying Gao, Zhiyi Wang, Shuman Cao, Guangcai Liang, Danni He, Zhitang Lv, Liming Wang, Pengfei Xu, and Qi Zhang

Subjects
Autism spectrum disorders, Gut microbiome, China, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5
Abstract

Background: Autism spectrum disorders (ASDs) are a set of complex neurobiological disorders. Growing evidence has shown that the microbiota that resides in the gut can modulate brain development via the gut–brain axis. However, direct clinical evidence of the role of the microbiota–gut–brain axis in ASD is relatively limited. Methods: A case-control study of 71 boys with ASD and 18 neurotypical controls was conducted at China-Japan Friendship Hospital. Demographic information and fecal samples were collected, and the gut microbiome was evaluated and compared by 16S ribosomal RNA gene sequencing and metagenomic sequencing. Results: A higher abundance of operational taxonomic units (OTUs) based on fecal bacterial profiling was observed in the ASD group. Significantly different microbiome profiles were observed between the two groups. At the genus level, we observed a decrease in the relative abundance of Escherichia, Shigella, Veillonella, Akkermansia, Provindencia, Dialister, Bifidobacterium, Streptococcus, Ruminococcaceae UCG_002, Megasphaera, Eubacterium_coprostanol, Citrobacter, Ruminiclostridium_5, and Ruminiclostridium_6 in the ASD cohort, while Eisenbergiella, Klebsiella, Faecalibacterium, and Blautia were significantly increased. Ten bacterial strains were selected for clinical discrimination between those with ASD and the neurotypical controls. The highest AUC value of the model was 0.947. Conclusion: Significant differences were observed in the composition of the gut microbiome between boys with ASD and neurotypical controls. These findings contribute to the knowledge of the alteration of the gut microbiome in ASD patients, which opens the possibility for early identification of this disease.

Published
2021
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41. The extreme melt across the Greenland ice sheet in 2012

Author

Nghiem, S. V., Hall, D. K., Mote, T. L., Tedesco, Marco, Albert, M. R., Keegan, K., Shuman, C. A., Neumann, G., and DiGirolamo, N. E.

Subjects
Meteorology, Meltwater, Earth temperature, Geology, Geomorphology, FOS: Earth and related environmental sciences, Climatic changes, Climatic geomorphology
Abstract

The discovery of the 2012 extreme melt event across almost the entire surface of the Greenland ice sheet is presented. Data from three different satellite sensors – including the Oceansat-2 scatterometer, the Moderate-resolution Imaging Spectroradiometer, and the Special Sensor Microwave Imager/Sounder – are combined to obtain composite melt maps, representing the most complete melt conditions detectable across the ice sheet. Satellite observations reveal that melt occurred at or near the surface of the Greenland ice sheet across 98.6% of its entire extent on 12 July 2012, including the usually cold polar areas at high altitudes like Summit in the dry snow facies of the ice sheet. This melt event coincided with an anomalous ridge of warm air that became stagnant over Greenland. As seen in melt occurrences from multiple ice core records at Summit reported in the published literature, such a melt event is rare with the last significant one occurring in 1889 and the next previous one around seven centuries earlier in the Medieval Warm Period. Given its rarity, the 2012 extreme melt across Greenland provides an exceptional opportunity for new studies in broad interdisciplinary geophysical research.

Published
2012
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42. 2001-2009 elevation and mass losses in the Larsen A and B embayments, Antarctic Peninsula

Author

Shuman, C. A., Berthier, Etienne, Scambos, T. A., NASA Goddard Space Flight Center (GSFC), Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), National Snow and Ice Data Center (NSIDC), University of Colorado [Boulder], Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience; We investigate the elevation and mass-balance response of tributary glaciers following the loss of the Larsen A and B ice shelves, Antarctic Peninsula (in 1995 and 2002 respectively). Our study uses MODIS imagery to track ice extent, and ASTER and SPOT5 digital elevation models (DEMs) plus ATM and ICESat laser altimetry to track elevation changes, spanning the period 2001-09. The measured Larsen B tributary glaciers (Hektoria, Green, Evans, Punchbowl, Jorum and Crane) lost up to 160 m in elevation during 2001-06, and thinning continued into 2009. Elevation changes were small for the more southerly Flask and Leppard Glaciers, which are still constrained by a Larsen B ice shelf remnant. In the northern embayment, continued thinning of >3 m/yr on Drygalski Glacier, 14 years after the Larsen A ice shelf disintegrated, suggests that mass losses for the exposed Larsen B tributaries will continue for years into the future. Grounded ice volume losses exceed 13 km3 for Crane Glacier and 30 km3 for the Hektoria-Green-Evans glaciers. The combined mean loss rate for 2001-06 is at least 11.2 Gt/yr. Our values differ significantly from published mass-budget-based estimates for these embayments, but are a reasonable fraction of GRACE-derived rates for the region (~40 Gt/yr).

Published
2011

43. The triggering of sub-glacial lake drainage during the rapid glacier drawdown: Crane Glacier, Antarctic Peninsula

Author

Scambos, T. A., Berthier, Etienne, Shuman, C. A., National Snow and Ice Data Center (NSIDC), University of Colorado [Boulder], Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), NASA Goddard Space Flight Center (GSFC), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography
Abstract

International audience; Ice surface altimetry from ICESat-1 and NASA aircraft altimeter overflights spanning 2002- 09 indicate that a region of lower Crane Glacier, Antarctic Peninsula, shows an unusual temporal pattern of elevation loss: a period of very rapid drawdown ( 91 m a -1 between September 2004 and September 2005) bounded by periods of large but more moderate rates (23 m a -1 until September 2004; 12 m a -1 after September 2005). The region of increased drawdown is 4.5 km 2.2 km based on satellite (ASTER and SPOT-5) stereo-image digital elevation model (DEM) differencing spanning the event. In a later differential DEM the anomalous drawdown feature is not seen. Bathymetry in Crane Glacier fjord reveals a series of flat-lying, formerly subglacial deeps interpreted as lake sediment basins. We conclude that the elevation-change feature resulted from drainage of a small, deep subglacial lake. We infer that the drainage event was induced by hydraulic forcing of subglacial water past a downstream obstruction. However, only a fraction of Crane Glacier's increase in flow speed that occurred near the time of lake drainage (derived from image feature tracking) appears to be directly attributable to the event; instead, retreat of the ice front off a subglacial ridge 6 km downstream of the lake is likely the dominant cause of renewed fast flow and more negative mass balance in the subsequent 4 years.

Published
2011

47. Detailed ice loss pattern in the northern Antarctic Peninsula: Widespread decline driven by ice front retreats

Author

Scambos, T. A., Berthier, E., Haran, T., Shuman, C. A., Cook, A. J., Ligtenberg, S. R M, Bohlander, J., Scambos, T. A., Berthier, E., Haran, T., Shuman, C. A., Cook, A. J., Ligtenberg, S. R M, and Bohlander, J.

Abstract

The northern Antarctic Peninsula (nAP, < 66° S) is one of the most rapidly changing glaciated regions on earth, yet the spatial patterns of its ice mass loss at the glacier basin scale have to date been poorly documented. We use satellite laser altimetry and satellite stereo-image topography spanning 2001-2010, but primarily 2003-2008, to map ice elevation change and infer mass changes for 33 glacier basins covering the mainland and most large islands in the nAP. Rates of ice volume and ice mass change are 27.7 ± 8.6 km3 a-1 and 24.9±7.8Gta-1, equal to -0.73 ma-1 w.e. for the study area. Mass loss is the highest for eastern glaciers affected by major ice shelf collapses in 1995 and 2002, where twelve glaciers account for 60% of the total imbalance. However, losses at smaller rates occur throughout the nAP, at both high and low elevation, despite increased snow accumulation along the western coast and ridge crest. We interpret the widespread mass loss to be driven by decades of ice front retreats on both sides of the nAP, and extended throughout the ice sheet due to the propagation of kinematic waves triggered at the fronts into the interior.

Published
2014

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