1. Distribution of mediastinal lesions across multi-institutional, international, radiology databases
- Author
-
Yan Shen, Edward Z. Sanchez, Guillaume Chassagnon, Demetrius L. Dicks, Anja C. Roden, Marie-Pierre Revel, Giovanella Palmieri, Nicolas Girard, Wentao Fang, Ami N. Rubinowitz, Sarah M. Jenkins, Brett W. Carter, Robert J. Korst, Darin White, Conrad Falkson, Edith M. Marom, Samantha Sigurdson, Mattia Di Segni, Silvana Del Vecchio, Eyal Klang, Engjellush Shumeri, Margaret Ottaviano, Mirella Marino, Jane P. Ko, Grant M. Spears, Julian R. Molina, Sabrina Segreto, Jeanne B. Ackman, Frank C. Detterbeck, Roden, Ac, Fang, W, Shen, Y, Carter, Bw, White, Db, Jenkins, Sm, Spears, Gm, Molina, Jr, Klang, E, Segni, Md, Ackman, Jb, Sanchez, Ez, Girard, N, Shumeri, E, Revel M., -P, Chassagnon, G, Rubinowitz, A, Dicks, D, Detterbeck, F, Ko J., P, Falkson, Cb, Sigurdson, S, Segreto, S, Del Vecchio, S, Palmieri, G, Ottaviano, M, Marino, M, Korst, R, and Marom, Em
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,China ,medicine.medical_specialty ,Lung Neoplasms ,computer.software_genre ,Mediastinal Neoplasms ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Biopsy ,medicine ,Humans ,Retrospective Studies ,Database ,medicine.diagnostic_test ,business.industry ,Mediastinum ,Retrospective cohort study ,Nodule (medicine) ,Magnetic resonance imaging ,Thymus Neoplasms ,Europe ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Radiology ,Differential diagnosis ,medicine.symptom ,business ,Mediastinal Cyst ,computer - Abstract
Mediastinal lesions are uncommon; studies on their distribution are, in general, small and from a single institution. Furthermore, these studies are usually based on pathology or surgical databases and, therefore, miss many lesions that did not undergo biopsy or resection. Our aim was to identify the distribution of lesions in the mediastinum in a large international, multi-institutional cohort.At each participating institution, a standardized retrospective radiology database search was performed for interpretations of computed tomography, positron emission tomography-computed tomography, and magnetic resonance imaging scans including any of the following terms: "mediastinal nodule," "mediastinal lesion," "mediastinal mass," or "mediastinal abnormality" (2011-2014). Standardized data were collected. Statistical analysis was performed.Among 3308 cases, thymomas (27.8%), benign mediastinal cysts (20.0%), and lymphomas (16.1%) were most common. The distribution of lesions varied among mediastinal compartments; thymomas (38.3%), benign cysts (16.8%), and neurogenic tumors (53.9%) were the most common lesions in the prevascular, visceral, and paravertebral mediastinum, respectively (p0.001). Mediastinal compartment was associated with age; patients with paravertebral lesions were the youngest (p0.0001). Mediastinal lesions differed by continent or country, with benign cysts being the most common mediastinal lesions in the People's Republic of China, thymomas in Europe, and lymphomas in North America and Israel (p0.001). Benign cysts, thymic carcinomas, and metastases were more often seen in larger hospitals, whereas lymphomas and thymic hyperplasia occurred more often in smaller hospitals (p 0.01).Our study confirmed that the spectrum and frequency of mediastinal lesions depend on mediastinal compartment and age. This information provides helpful demographic data and is important when considering the differential diagnosis of a mediastinal lesion.
- Published
- 2020