1. [Preparation and
- Author
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An-Hao, Huang, Shun-Ping, Han, Yan-Ping, Lu, Rui, Ma, Hang-Sheng, Zheng, and Fan-Zhu, Li
- Subjects
Dendrimers ,Drug Carriers ,Drug Delivery Systems ,Arsenic Trioxide ,Cell Line, Tumor ,Humans ,Glioma ,Polyethylene Glycols - Abstract
Arsenic trioxide (ATO) is an effective component of traditional Chinese medicine arsenic. The existing studies have shown its good inhibition and apoptosis ability on a variety of tumours. However, its toxicity and difficulties in the permeability into the blood brain barrier (BBB) has the limitation in the application of glioma treatment. Polyamide-amine dendrimer (PAMAM) is a synthetic polymer with many advantages, such as a good permeability, stability and biocompatibility. Additionally, the 5th generation of PAMAM is an ideal drug carrier due to its three-dimensional structure. In this study, the 5th generation of PAMAM co-modified with RGDyC and PEG, then confirmed by ¹H-NMR. The average particle size of nanoparticles was about 20 nm according to the nanoparticle size-potential analyser and transmission electron microscopy.
- Published
- 2017