Search

Your search keyword '"Shutt, Kathleen A."' showing total 301 results
Start Over Author "Shutt, Kathleen A."
301 results on '"Shutt, Kathleen A."'

3. Geotemporal Analysis ofNeisseria meningitidis Clones in the United States: 2000–2005

Author

Wiringa, Ann E, Shutt, Kathleen A, Marsh, Jane W, Cohn, Amanda C, Messonnier, Nancy E, Zansky, Shelley M, Petit, Susan, Farley, Monica M, Gershman, Ken, Lynfield, Ruth, Reingold, Arthur, Schaffner, William, Thompson, Jamie, Brown, Shawn T, Lee, Bruce Y, and Harrison, Lee H

Subjects
Microbiology, Biological Sciences, Biomedical and Clinical Sciences, Immunization, Vaccine Related, Prevention, Aetiology, 2.2 Factors relating to the physical environment, Infection, Bacterial Outer Membrane Proteins, Clone Cells, Epidemiological Monitoring, Gene Expression, Humans, Meningococcal Infections, Multilocus Sequence Typing, Neisseria meningitidis, Retrospective Studies, Serotyping, Spatio-Temporal Analysis, United States, General Science & Technology
Abstract

BackgroundThe detection of meningococcal outbreaks relies on serogrouping and epidemiologic definitions. Advances in molecular epidemiology have improved the ability to distinguish unique Neisseria meningitidis strains, enabling the classification of isolates into clones. Around 98% of meningococcal cases in the United States are believed to be sporadic.MethodsMeningococcal isolates from 9 Active Bacterial Core surveillance sites throughout the United States from 2000 through 2005 were classified according to serogroup, multilocus sequence typing, and outer membrane protein (porA, porB, and fetA) genotyping. Clones were defined as isolates that were indistinguishable according to this characterization. Case data were aggregated to the census tract level and all non-singleton clones were assessed for non-random spatial and temporal clustering using retrospective space-time analyses with a discrete Poisson probability model.ResultsAmong 1,062 geocoded cases with available isolates, 438 unique clones were identified, 78 of which had ≥2 isolates. 702 cases were attributable to non-singleton clones, accounting for 66.0% of all geocoded cases. 32 statistically significant clusters comprised of 107 cases (10.1% of all geocoded cases) were identified. Clusters had the following attributes: included 2 to 11 cases; 1 day to 33 months duration; radius of 0 to 61.7 km; and attack rate of 0.7 to 57.8 cases per 100,000 population. Serogroups represented among the clusters were: B (n = 12 clusters, 45 cases), C (n = 11 clusters, 27 cases), and Y (n = 9 clusters, 35 cases); 20 clusters (62.5%) were caused by serogroups represented in meningococcal vaccines that are commercially available in the United States.ConclusionsAround 10% of meningococcal disease cases in the U.S. could be assigned to a geotemporal cluster. Molecular characterization of isolates, combined with geotemporal analysis, is a useful tool for understanding the spread of virulent meningococcal clones and patterns of transmission in populations.

Published
2013

4. Geotemporal analysis of Neisseria meningitidis clones in the United States: 2000-2005.

Author

Wiringa, Ann E, Shutt, Kathleen A, Marsh, Jane W, Cohn, Amanda C, Messonnier, Nancy E, Zansky, Shelley M, Petit, Susan, Farley, Monica M, Gershman, Ken, Lynfield, Ruth, Reingold, Arthur, Schaffner, William, Thompson, Jamie, Brown, Shawn T, Lee, Bruce Y, and Harrison, Lee H

Subjects
Clone Cells, Humans, Neisseria meningitidis, Meningococcal Infections, Bacterial Outer Membrane Proteins, Serotyping, Retrospective Studies, Gene Expression, United States, Multilocus Sequence Typing, Epidemiological Monitoring, Spatio-Temporal Analysis, General Science & Technology
Abstract

BackgroundThe detection of meningococcal outbreaks relies on serogrouping and epidemiologic definitions. Advances in molecular epidemiology have improved the ability to distinguish unique Neisseria meningitidis strains, enabling the classification of isolates into clones. Around 98% of meningococcal cases in the United States are believed to be sporadic.MethodsMeningococcal isolates from 9 Active Bacterial Core surveillance sites throughout the United States from 2000 through 2005 were classified according to serogroup, multilocus sequence typing, and outer membrane protein (porA, porB, and fetA) genotyping. Clones were defined as isolates that were indistinguishable according to this characterization. Case data were aggregated to the census tract level and all non-singleton clones were assessed for non-random spatial and temporal clustering using retrospective space-time analyses with a discrete Poisson probability model.ResultsAmong 1,062 geocoded cases with available isolates, 438 unique clones were identified, 78 of which had ≥2 isolates. 702 cases were attributable to non-singleton clones, accounting for 66.0% of all geocoded cases. 32 statistically significant clusters comprised of 107 cases (10.1% of all geocoded cases) were identified. Clusters had the following attributes: included 2 to 11 cases; 1 day to 33 months duration; radius of 0 to 61.7 km; and attack rate of 0.7 to 57.8 cases per 100,000 population. Serogroups represented among the clusters were: B (n = 12 clusters, 45 cases), C (n = 11 clusters, 27 cases), and Y (n = 9 clusters, 35 cases); 20 clusters (62.5%) were caused by serogroups represented in meningococcal vaccines that are commercially available in the United States.ConclusionsAround 10% of meningococcal disease cases in the U.S. could be assigned to a geotemporal cluster. Molecular characterization of isolates, combined with geotemporal analysis, is a useful tool for understanding the spread of virulent meningococcal clones and patterns of transmission in populations.

Published
2013

9. Meningococcal Carriage Among Georgia and Maryland High School Students

Author

Harrison, Lee H., Shutt, Kathleen A., Arnold, Kathryn E., Stern, Eric J., Pondo, Tracy, Kiehlbauch, Julia A., Myers, Robert A., Hollick, Rosemary A., Schmink, Susanna, Vello, Marianne, Stephens, David S., Messonnier, Nancy E., Mayer, Leonard W., and Clark, Thomas A.

Published
2015

16. Changes in Neisseria meningitidis Disease Epidemiology in the United States, 1998–2007: Implications for Prevention of Meningococcal Disease

Author

Cohn, Amanda C., MacNeil, Jessica R., Harrison, Lee H., Hatcher, Cynthia, Theodore, Jordan, Schmidt, Mark, Pondo, Tracy, Arnold, Kathryn E., Baumbach, Joan, Bennett, Nancy, Craig, Allen S., Farley, Monica, Gershman, Ken, Petit, Susan, Lynfield, Ruth, Reingold, Arthur, Schaffner, William, Shutt, Kathleen A., Zell, Elizabeth R., Mayer, Leonard W., Clark, Thomas, Stephens, David, and Messonnier, Nancy E.

Published
2010

25. Whole-Genome Sequencing Surveillance and Machine Learning of the Electronic Health Record for Enhanced Healthcare Outbreak Detection

Author

Sundermann, Alexander J, primary, Chen, Jieshi, additional, Kumar, Praveen, additional, Ayres, Ashley M, additional, Cho, Shu Ting, additional, Ezeonwuka, Chinelo, additional, Griffith, Marissa P, additional, Miller, James K, additional, Mustapha, Mustapha M, additional, Pasculle, A William, additional, Saul, Melissa I, additional, Shutt, Kathleen A, additional, Srinivasa, Vatsala, additional, Waggle, Kady, additional, Snyder, Daniel J, additional, Cooper, Vaughn S, additional, Van Tyne, Daria, additional, Snyder, Graham M, additional, Marsh, Jane W, additional, Dubrawski, Artur, additional, Roberts, Mark S, additional, and Harrison, Lee H, additional

Published
2021
Full Text
View/download PDF

28. Evaluation of universal antenatal screening for Group B streptococcus

Author

Van Dyke, Melissa K., Phares, Christina R., Lynfield, Ruth, Thomas, Ann R., Arnold, Kathryn E., Craig, Allen S., Mohle-Boetani, Janet, Gershman, Ken, Schaffner, William, Petit, Susan, Zansky, Shelley M., Morin, Craig A., Spina, Nancy L., Wymore, Kathryn, Harrison, Lee H., Shutt, Kathleen A., Bareta, Joseph, Bulens, Sandra N., Zell, Elizabeth R., Schuchat, Anne, and Schrag, Stephanie J.

Subjects
Chemoprevention -- Health aspects, Pregnant women -- Health aspects, Streptococcus agalactiae -- Diagnosis, Streptococcus agalactiae -- Care and treatment
Abstract

A study was conducted to as per national guidelines formulated in 2002 to screen pregnant women for colonization with group B streptococcus that could indicate the development of the disease in infants within a week after birth. Results revealed that universal screening proved to be useful in identifying mothers with group B streptococcus and could help in management of the condition in the newborns.

Published
2009

29. Effect of pneumococcal conjugate vaccine on pneumococcal meningitis

Author

Hsu, Heather E., Shutt, Kathleen A., Moore, Matthew R., Beall, Bernard W., Bennett, Nancy M., Craig, Allen S., Farley, Monica M., Jorgensen, James H., Lexau, Catherine A., Petit, Susan, Reingold, Arthur, Schaffner, William, Thomas, Ann, Whitney, Cynthia G., and Harrison, Lee H.

Subjects
Bacterial meningitis -- Prevention, Pneumococcal vaccine -- Health aspects, Pneumococcal vaccine -- Usage, Children -- Health aspects
Abstract

A study examined the effects of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) on pneumococcal meningitis among children and adults over several years. Results showed a decrease in rates of pneumococcal meningitis among adults and children since the introduction of PCV7.

Published
2009

30. Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive 'bundle' approach

Author

Muto, Carlene A., Blank, Mary Kathleen, Marsh, Jane W., Vergis, Emanuel N., O'Leary, Mary M., Shutt, Kathleen A., Pasculle, Anthony W., Pokrywka, Marian, Garcia, Juliet G., Posey, Kathy, Roberts, Terri L., Potoski, Brian A., Blank, Gary E., Simmons, Richard L., Veldkamp, Peter, Harrison, Lee H., and Paterson, David L.

Subjects
Epidemics -- Pennsylvania, Epidemics -- Control, Epidemics -- Research, Clostridium difficile -- Health aspects, Clostridium difficile -- Care and treatment, Clostridium difficile -- Prevention, Hospitals, University -- Services, Health, Health care industry
Published
2007

31. Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study

Author

Peleg, Anton Y., Husain, Shahid, Qureshi, Zubair A., Silveira, Fernanda P., Sarumi, Molade, Shutt, Kathleen A., Kwak, Eun J., and Paterson, David L.

Subjects
Organ transplant recipients -- Research, Actinomycetales infections -- Risk factors, Actinomycetales infections -- Patient outcomes, Actinomycetales infections -- Research, Health, Health care industry
Published
2007

32. Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibody

Author

Peleg, Anton Y., Husain, Shahid, Kwak, Eun J., Silveira, Fernanda P., Ndirangu, Magdaline, Tran, Jerry, Shutt, Kathleen A., Shapiro, Ron, Thai, Ngoc, Abu-Elmagd, Kareem, Mccurry, Kenneth R., Marcos, Amadeo, and Paterson, David L.

Subjects
Organ transplant recipients -- Drug therapy, Graft rejection -- Prevention, Graft rejection -- Research, Health, Health care industry
Published
2007

33. Epidemiological profile of linezolid-resistant coagulase-negative staphylococci

Author

Potoski, Brian A., Adams, Jennifer, Clarke, Lloyd, Shutt, Kathleen, Linden, Peter K., Baxter, Carla, Pasculle, A. William, Capitano, Blair, Peleg, Anton Y., Szabo, Dora, and Paterson, David L.

Subjects
Linezolid -- Complications and side effects, Linezolid -- Research, Staphylococcus -- Physiological aspects, Staphylococcus -- Analysis, Drug resistance in microorganisms -- Research, Health, Health care industry
Published
2006

34. Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001

Author

McEllistrem, M. Catherine, Adams, Jennifer M., Shutt, Kathleen, Sanza, Laurie T., Facklam, Richard R., Whitney, Cynthia G., Jorgensen, James H., and Harrison, Lee H.

Subjects
Drug therapy, Care and treatment, Health aspects, Streptococcus pneumoniae -- Care and treatment -- Health aspects, Children -- Health aspects, Erythromycin -- Drug therapy -- Health aspects
Abstract

After increasing from 1995 to 1999, invasive erythromycin-nonsusceptible Streptococcus pneumoniae rates per 100,000 decreased 53.6% in children from Baltimore, Maryland (USA) from 1999 to 2001, which was partially attributed to [...]

Published
2005

35. Correlating epidemiologic trends with the genotypes causing meningococcal disease, Maryland

Author

McEllistrem, M. Catherine, Kolano, John A., Pass, Margaret A., Caugant, Dominique A., Mendelsohn, Aaron B., Pacheco, Antonio Guilherme Fonseca, Shutt, Kathleen A., Razeq, Jafar, and Harrison, Lee H.

Subjects
Meningococcal infections -- Research
Abstract

During the 1990s in Maryland, the incidence of meningococcal infection increased among those 15-24 years of age, in large part because of serogroup C strains. The incidence of serogroup Y [...]

Published
2004

36. Leptospirosis in 'Eco-Challenge' athletes, Malaysian Borneo, 2000. (Research)

Author

Sejvar, James, Bancroft, Elizabeth, Winthrop, Kevin, Bettinger, Julie, Bajani, Mary, Bragg, Sandra, Shutt, Kathleen, Kaiser, Robyn, Marano, Nina, Popovic, Tanja, Tappero, Jordan, Ashford, David, Mascola, Laurene, Vugia, Duc, Perkins, Bradley, and Rosenstein, Nancy

Subjects
Case studies, Research, Leptospirosis -- Case studies -- Research
Abstract

Adventure travel is becoming more popular, increasing the likelihood of contact with unusual pathogens. We investigated an outbreak of leptospirosis in 'Eco-Challenge' multisport race athletes to determine illness etiology and [...]

Published
2003

37. Planning against biological terrorism: lessons from outbreak investigations. (Perspective)

Author

Ashford, David A., Kaiser, Robyn M., Bales, Michael E., Shutt, Kathleen, Patrawalla, Amee, McShan, Andre, Tappero, Jordan W., Perkins, Bradley A., and Dannenberg, Andrew L.

Subjects
United States. Centers for Disease Control and Prevention -- Investigations -- Safety and security measures -- Cases, Prevention, Cases, Safety and security measures, Investigations, Company legal issue, Epidemics -- Investigations -- United States -- Cases -- Prevention, Bioterrorism -- Safety and security measures -- Prevention -- Cases, Communicable diseases -- Investigations -- Safety and security measures -- Prevention -- Cases
Abstract

We examined outbreak investigations conducted around the world from 1988 to 1999 by the Centers for Disease Control and Prevention's Epidemic Intelligence Service. In 44 (4.0%) of 1,099 investigations, identified [...]

Published
2003

38. Whole-Genome Sequencing Surveillance and Machine Learning of the Electronic Health Record for Enhanced Healthcare Outbreak Detection.

Author

Sundermann, Alexander J, Chen, Jieshi, Kumar, Praveen, Ayres, Ashley M, Cho, Shu Ting, Ezeonwuka, Chinelo, Griffith, Marissa P, Miller, James K, Mustapha, Mustapha M, Pasculle, A William, Saul, Melissa I, Shutt, Kathleen A, Srinivasa, Vatsala, Waggle, Kady, Snyder, Daniel J, Cooper, Vaughn S, Tyne, Daria Van, Snyder, Graham M, Marsh, Jane W, and Dubrawski, Artur

Subjects
PUBLIC health surveillance, SEQUENCE analysis, CROSS infection, MACHINE learning, TERTIARY care, DATABASE management, EPIDEMICS, INFECTIOUS disease transmission, DESCRIPTIVE statistics, ELECTRONIC health records, ALGORITHMS
Abstract

Background Most hospitals use traditional infection prevention (IP) methods for outbreak detection. We developed the Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT), which combines whole-genome sequencing (WGS) surveillance and machine learning (ML) of the electronic health record (EHR) to identify undetected outbreaks and the responsible transmission routes, respectively. Methods We performed WGS surveillance of healthcare-associated bacterial pathogens from November 2016 to November 2018. EHR ML was used to identify the transmission routes for WGS-detected outbreaks, which were investigated by an IP expert. Potential infections prevented were estimated and compared with traditional IP practice during the same period. Results Of 3165 isolates, there were 2752 unique patient isolates in 99 clusters involving 297 (10.8%) patient isolates identified by WGS; clusters ranged from 2–14 patients. At least 1 transmission route was detected for 65.7% of clusters. During the same time, traditional IP investigation prompted WGS for 15 suspected outbreaks involving 133 patients, for which transmission events were identified for 5 (3.8%). If EDS-HAT had been running in real time, 25–63 transmissions could have been prevented. EDS-HAT was found to be cost-saving and more effective than traditional IP practice, with overall savings of $192 408–$692 532. Conclusions EDS-HAT detected multiple outbreaks not identified using traditional IP methods, correctly identified the transmission routes for most outbreaks, and would save the hospital substantial costs. Traditional IP practice misidentified outbreaks for which transmission did not occur. WGS surveillance combined with EHR ML has the potential to save costs and enhance patient safety. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

39. Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998. (Major Article)

Author

Morgan, Juliette, Bornstein, Shari L., Karpati, Adam M., Bruce, Michael, Bolin, Carole A., Austin, Constance C., Woods, Christopher W., Lingappa, Jairam, Langkop, Carl, Davis, Belinda, Graham, Donald R., Proctor, Mary, Ashford, David A., Bajani, Mary, Bragg, Sandra L., Shutt, Kathleen, Perkins, Bradley A., and Tappero, Jordan W.

Subjects
Leptospirosis -- Case studies, Drinking water -- Contamination, Health, Health care industry
Published
2002

41. Outbreak of Pseudomonas aeruginosa Infections from a Contaminated Gastroscope Detected by Whole Genome Sequencing Surveillance

Author

Sundermann, Alexander J, primary, Chen, Jieshi, additional, Miller, James K, additional, Saul, Melissa I, additional, Shutt, Kathleen A, additional, Griffith, Marissa P, additional, Mustapha, Mustapha M, additional, Ezeonwuka, Chinelo, additional, Waggle, Kady, additional, Srinivasa, Vatsala, additional, Kumar, Praveen, additional, Pasculle, A William, additional, Ayres, Ashley M, additional, Snyder, Graham M, additional, Cooper, Vaughn S, additional, Van Tyne, Daria, additional, Marsh, Jane W, additional, Dubrawski, Artur W, additional, and Harrison, Lee H, additional

Published
2020
Full Text
View/download PDF

43. Transmission Dynamics and Microevolution of Neisseria meningitidis During Carriage and Invasive Disease in High School Students in Georgia and Maryland, 2006–2007

Author

Mustapha, Mustapha M, primary, Marsh, Jane W, additional, Shutt, Kathleen A, additional, Schlackman, Jessica, additional, Ezeonwuka, Chinelo, additional, Farley, Monica M, additional, Stephens, David S, additional, Wang, Xin, additional, Van Tyne, Daria, additional, and Harrison, Lee H, additional

Published
2020
Full Text
View/download PDF

46. Toxic shock syndrome in the United States: surveillance update, 1979-1996

Author

Hajjeh, Rana A., Reingold, Arthur, Weil, Alexis, Shutt, Kathleen, Schuchat, Anne, and Perkins, Bradley A.

Subjects
Analysis, Research, Health aspects, Toxic shock syndrome -- Research, Menstruation disorders -- Analysis -- Research, Women's health -- Health aspects -- Analysis -- Research, Women -- Health aspects
Abstract

Menstrual toxic shock syndrome (TSS) emerged as a public health threat to women of reproductive age in 1979-80. We reviewed surveillance data for the period 1979 to 1996, when 5,296 [...]

Published
1999

47. Antigenic shift and increased incidence of meningococcal disease

Author

Harrison, Lee H., Jolley, Keith A., Shutt, Kathleen A., Marsh, Jane W., O'Leary, Mary, Sanza, Laurie Thomson, and Maiden, Martin C.J.

Subjects
Meningococcal infections -- Research, Meningococcal infections -- Physiological aspects, Neisseria meningitidis -- Health aspects, Neisseria meningitidis -- Physiological aspects, Antigenic determinants -- Evaluation, Health
Published
2006

50. Long-Acting Rilpivirine (RPV) Preexposure Prophylaxis Does Not Inhibit Vaginal Transmission of RPV-Resistant HIV-1 or Select for High-Frequency Drug Resistance in Humanized Mice

Author

Melody, Kevin, primary, Roy, Chandra N., additional, Kline, Christopher, additional, Cottrell, Mackenzie L., additional, Evans, Dwayne, additional, Shutt, Kathleen, additional, Pennings, Pleuni S., additional, Keele, Brandon F., additional, Bility, Moses, additional, Kashuba, Angela D. M., additional, and Ambrose, Zandrea, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results