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Abstract Background Despite ongoing research, the underlying causes of schizophrenia remain unclear. Aspartate and asparagine, essential amino acids, have been linked to schizophrenia in recent studies, but their causal relationship is still unclear. This study used a bidirectional two-sample Mendelian randomization (MR) method to explore the causal relationship between aspartate and asparagine with schizophrenia. Methods This study employed summary data from genome-wide association studies (GWAS) conducted on European populations to examine the correlation between aspartate and asparagine with schizophrenia. In order to investigate the causal effects of aspartate and asparagine on schizophrenia, this study conducted a two-sample bidirectional MR analysis using genetic factors as instrumental variables. Results No causal relationship was found between aspartate and schizophrenia, with an odds ratio (OR) of 1.221 (95%CI: 0.483–3.088, P-value = 0.674). Reverse MR analysis also indicated that no causal effects were found between schizophrenia and aspartate, with an OR of 0.999 (95%CI: 0.987–1.010, P-value = 0.841). There is a negative causal relationship between asparagine and schizophrenia, with an OR of 0.485 (95%CI: 0.262-0.900, P-value = 0.020). Reverse MR analysis indicates that there is no causal effect between schizophrenia and asparagine, with an OR of 1.005(95%CI: 0.999–1.011, P-value = 0.132). Conclusion This study suggests that there may be a potential risk reduction for schizophrenia with increased levels of asparagine, while also indicating the absence of a causal link between elevated or diminished levels of asparagine in individuals diagnosed with schizophrenia. There is no potential causal relationship between aspartate and schizophrenia, whether prospective or reverse MR. However, it is important to note that these associations necessitate additional research for further validation.

Mixed‐dimensional (0D, 1D, and 3D) heterostructures based on 2D layered materials have been proven as a promising candidate for future nanoelectronics and optoelectronics applications. In this work, it is demonstrated that 1D atomic chain based Se nanoplates (NPs) can be epitaxially grown on monolayer ReS2 by a chemical transport reaction, thereby creating an interesting mixed‐dimensional Se/ReS2 heterostructure. A unique epitaxial relationship is observed with the (110) planes of the Se NPs parallel to the corresponding ReS2 (010) planes. Experimental and theoretical studies reveal that the Se NPs could conjugate with underlying monolayer ReS2 via strong chemical hybridization at heterointerface, which is expected to originate from the intrinsic defects of ReS2. Remarkably, photodetectors based on Se/ReS2 heterostructures exhibit ultrahigh detectivity of up to 8 × 1012 Jones, and also show a fast response time of less than 10 ms. These results illustrate the great advantage of directly integrated 1D Se based nanostructure on planar semiconducting ReS2 films for optoelectronic applications. It opens up a feasible way to obtain mixed‐dimensional heterostructures with atomic interfacial contact by epitaxial growth. 1D atomic chain based Se nanoplates (NPs) are epitaxially grown on monolayer ReS2 to form an interesting mixed‐dimensional Se/ReS2 heterostructure. Experimental and theoretical studies reveal that the Se NPs are chemically hybridized with underlying monolayer ReS2 through intrinsic defects in ReS2. Photodetectors based on Se/ReS2 heterostructures exhibit ultrahigh detectivity and fast response time. [ABSTRACT FROM AUTHOR]