179 results on '"Si-qi Liu"'
Search Results
2. Estimated glomerular filtration rate partially recovered in patients without Hypertriglyceridemia during Tenofovir disoproxil fumarate treatment
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Ya-ru Pan, Si-qi Liu, Yi-shan He, Yuan Xue, Jian Wang, Rui Huang, Chao Wu, Jian-chun Lu, and Long-gen Liu
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Tenofovir disoproxil fumarate ,dyslipidemia ,renal dysfunction ,hypertriglyceridemia ,triglyceride ,Medicine - Abstract
AbstractBackground Decrease in estimated glomerular filtration rate (eGFR) during Tenofovir disoproxil fumarate (TDF) treatment remains a concern, and few patients experience partial recovery of eGFR. This study aimed to investigate the risk factors for eGFR recovery in patients with and without hypertriglyceridemia.Methods A total of 203 patients with chronic HBV infection were prospectively recruited and followed up for three years. Data were collected at baseline, first, second, and third years during TDF treatment.Results Most patients achieved normal ALT (80.0% vs. 82.5%) and undetectable HBV DNA (95.0% vs. 95.6%) in both groups (p > 0.05). For patients with hypertriglyceridemia, eGFR and cholesterol did not change significantly during the 3-year follow-up, while triglyceride (TG) decreased significantly in the first year and persisted at a lower level in the subsequent two years. For patients without hypertriglyceridemia, eGFR declined significantly in the first year of treatment, then gradually recovered during the subsequent two years, and eGFR was negatively correlated with TG at the four time points. Fifteen (15/183, 8.2%) patients without hypertriglyceridemia experienced eGFR partial recovery in the third year. Univariate and multivariate analyses showed that baseline eGFR
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- 2023
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3. External-field regulated superatoms
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Si-Qi Liu, De-Kang Li, Jun Li, Hao Wang, Yun-Ting Bu, Jie Su, Jing Chen, and Shi-Bo Cheng
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Superatoms ,external-field regulated strategies (EFRS) ,atomic clusters ,superhalogen ,superalkali ,Physics ,QC1-999 - Abstract
ABSTRACTAs a special class of stable atomic clusters, the superatom has become an exciting research topic in recent decades. They can mimic the chemistry and physics of individual atoms in the periodic table and find potential applications in a variety of fields. Traditional strategies for superatom design, however, have their own limitations. Herein, we review recent progress in the discovery of novel methodologies for superatom design, namely external-field regulated strategies (EFRS). We begin with a description of the basic concept of the superatom and the conventional electron-counting rules for superatom design, followed by a discussion of recent exploration about external-field regulated superatoms, where the oriented external electric field (OEEF), the ligand field, and the solvent field are presented. In the concluding section, we discuss the benefits and challenges of the EFRS together with some future research topics.
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- 2023
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4. The negative association between serum albumin levels and coronary heart disease risk in adults over 45 years old: a cross-sectional survey
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Xin-zheng Hou, En-qi Liu, Si-qi Liu, Hao Lv, Hua-feng Cui, and Jing Han
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Medicine ,Science - Abstract
Abstract This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. This cross-sectional study used the non-institutionalized US population from the National Health and Nutrition Examination Survey (NHANES 2011–2018) as the sample source. Multiple logistic regression was performed to evaluate the association between serum albumin levels and CHD risk. Smooth curve fitting was performed to explore potential nonlinear relationships. When nonlinear relationships were found, a recursive algorithm was used to calculate inflection points. Additionally, a piecewise logistic regression model was constructed. After adjusting for confounders, multiple logistic regression and smooth curve fitting indicated an inverse association between serum albumin levels and CHD risk [OR = 0.970, 95% CI = (0.948, 0.992)]. Subgroup analysis revealed that the negative correlation was statistically significant in the population of female patients, over 60 years, with hypertension, without diabetes. There was a correlation between serum albumin levels and CHD risk. Lower serum albumin levels were associated with a higher CHD risk.
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- 2023
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5. Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study
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Xue-han Zhu, Ning-ning Tao, Qian-yun Zhang, Wan-mei Song, Qi-qi An, Si-qi Liu, Yi-fan Li, Fei Long, and Huai-chen Li
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Diagnostic delay ,Pulmonary tuberculosis ,Trend ,Poor prognosis ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Tuberculosis (TB) is one of the main infectious diseases that seriously threatens global health, while diagnostic delay (DD) and treatment dramatically threaten TB control. Methods Between 2005 and 2017 in Shandong, China, we enrolled pulmonary tuberculosis (PTB) patients with DD. DD trends were evaluated by Joinpoint regression, and associations between PTB patient characteristics and DD were estimated by univariate and multivariate logistic regression. The influence of DD duration on prognosis and sputum smear results were assessed by Spearman correlation coefficients. Results We identified 208,822 PTB cases with a median DD of 33 days (interquartile range (IQR) 18–63). The trend of PTB with DD declined significantly between 2009 and 2017 (annual percent change (APC): − 4.0%, P = 0.047, 2009–2013; APC: − 6.6%, P = 0.001, 2013–2017). Patients aged > 45 years old (adjusted odds ratio (aOR): 1.223, 95% confidence interval (CI) 1.189–1.257, 46–65 years; aOR: 1.306, 95% CI 1.267–1.346, > 65 years), farmers (aOR: 1.520, 95% CI 1.447–1.596), and those with a previous treatment history (aOR: 1.759, 95% CI 1.699–1.821) were prone to developing long DD (> 30 days, P
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- 2022
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6. Association between body mass index and newly diagnosed drug-resistant pulmonary tuberculosis in Shandong, China from 2004 to 2019
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Wan-mei Song, Jing Guo, Ting-ting Xu, Shi-jin Li, Jin-yue Liu, Ning-ning Tao, Yao Liu, Qian-yun Zhang, Si-qi Liu, Qi-qi An, Yi-fan Li, Chun-bao Yu, Ji-hua Dong, and Huai-chen Li
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Tuberculosis ,Drug resistance ,Body mass index ,Overweight ,Underweight ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Drug-resistant tuberculosis (DR-TB), obesity, and malnutrition are growing public health problems in the world. However, little has discussed the impact of different BMI status on the emergence of TB drug resistance. We aimed to explore the drug-resistant profiles of DR-TB and its clinical predictors among underweight, overweight or obesity population. Methods 8957 newly diagnosed TB cases with drug susceptibility results and BMI data in Shandong China, from 2004 to 2019 were enrolled. Multivariable and univariable logistic regression models were applied to investigate the impact of BMI on different drug-resistance. Clinical predicators and drug-resistant profiles of DR-TB among obesity, underweight, normal TB group were also described. Results Among 8957 TB cases, 6417 (71.64%) were normal weight, 2121 (23.68%) were underweight, 373 (4.16%) were overweight, and 46 (0.51%) were obese. The proportion of drug resistance and co-morbidity among normal weight, underweight, overweight, obese TB groups were 18.86%/18.25%/20.38%/23.91% (DR-TB), 11.19%/11.74%/9.65%/17.39% (mono-resistant tuberculosis, MR-TB), 3.41%/3.06%/5.36%/0.00% (multidrug resistant tuberculosis, MDR-TB), 4.21%/3.39%/5.36%/6.52% (polydrug resistant tuberculosis, PDR-TB), 10.57%/8.44%/19.57%/23.91% (co-morbidity), respectively. Compared with normal weight group, underweight were associated with lower risk of streptomycin-related resistance (OR 0.844, 95% CI 0.726–0.982), but contributed to a higher risk of MR-TB (isoniazid) (odds ratio (OR) 1.347, 95% CI 1.049–1.730; adjusted OR (aOR) 1.31, 95% CI 1.017–1.686), P
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- 2021
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7. SARS-CoV-2 Structural Proteins Modulated Blood-Testis Barrier-Related Proteins through Autophagy in the Primary Sertoli Cells
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Kai Kang, Yao-Dan Ma, Si-Qi Liu, Ri-Wei Huang, Jin-Jun Chen, Li-Long An, and Jiang Wu
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SARS-CoV-2 ,blood-testis barrier ,autophagy ,Sertoli cells ,junction protein ,immune factor ,Microbiology ,QR1-502 - Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disrupts the blood-testis barrier (BTB), resulting in alterations in spermatogenesis. However, whether BTB-related proteins (such as ZO-1, claudin11, N-cadherin, and CX43) are targeted by SARS-CoV-2 remains to be clarified. BTB is a physical barrier between the blood vessels and the seminiferous tubules of the animal testis, and it is one of the tightest blood-tissue barriers in the mammalian body. In this study, we investigated the effects of viral proteins, via ectopic expression of individual viral proteins, on BTB-related proteins, the secretion of immune factors, and the formation and degradation of autophagosomes in human primary Sertoli cells. Our study demonstrated that ectopic expression of viral E (envelope protein) and M (membrane protein) induced the expressions of ZO-1 and claudin11, promoted the formation of autophagosomes, and inhibited autophagy flux. S (spike protein) reduced the expression of ZO-1, N-cadherin, and CX43, induced the expression of claudin11, and inhibited the formation and degradation of autophagosomes. N (nucleocapsid protein) reduced the expression of ZO-1, claudin11, and N-cadherin. All the structural proteins (SPs) E, M, N, and S increased the expression of the FasL gene, and the E protein promoted the expression and secretion of FasL and TGF-β proteins and the expression of IL-1. Blockage of autophagy by specific inhibitors resulted in the suppression of BTB-related proteins by the SPs. Our results indicated that SARS-CoV-2 SPs (E, M, and S) regulate BTB-related proteins through autophagy.
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- 2023
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8. Using a risk model for probability of cancer in pulmonary nodules
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Si‐Qi Liu, Xiao‐Bin Ma, Wan‐Mei Song, Yi‐Fan Li, Ning Li, Li‐Na Wang, Jin‐Yue Liu, Ning‐Ning Tao, Shi‐Jin Li, Ting‐Ting Xu, Qian‐Yun Zhang, Qi‐Qi An, Bin Liang, and Huai‐Chen Li
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decision tree ,logistics regression ,lung cancer ,pulmonary nodules ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Considering the high morbidity and mortality of lung cancer and the high incidence of pulmonary nodules, clearly distinguishing benign from malignant lung nodules at an early stage is of great significance. However, determining the kind of lung nodule which is more prone to lung cancer remains a problem worldwide. Methods A total of 480 patients with pulmonary nodule data were collected from Shandong, China. We assessed the clinical characteristics and computed tomography (CT) imaging features among pulmonary nodules in patients who had undergone video‐assisted thoracoscopic surgery (VATS) lobectomy from 2013 to 2018. Preliminary selection of features was based on a statistical analysis using SPSS. We used WEKA to assess the machine learning models using its multiple algorithms and selected the best decision tree model using its optimization algorithm. Results The combination of decision tree and logistics regression optimized the decision tree without affecting its AUC. The decision tree structure showed that lobulation was the most important feature, followed by spiculation, vessel convergence sign, nodule type, satellite nodule, nodule size and age of patient. Conclusions Our study shows that decision tree analyses can be applied to screen individuals for early lung cancer with CT. Our decision tree provides a new way to help clinicians establish a logical diagnosis by a stepwise progression method, but still needs to be validated for prospective trials in a larger patient population.
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- 2021
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9. Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020
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Yi-Fan Li, Yao Liu, Qi Fu, Wan-mei Song, Jin-yue Liu, Qian-yun Zhang, Ting-ting Xu, Shi-jin Li, Qi-qi An, Si-qi Liu, Huai-chen Li, Ning Ning Tao, Xue-han Zhu, Chun-bao Yu, and Jihua Dong
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Medicine - Abstract
Objectives To investigate the independent and collective impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis (TB).Design This was a retrospective cohort study.Setting Shandong, China.Participants Patients with newly diagnosed TB from 1 January 2004 to 31 December 2020 were collected. Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information on drug susceptibility testing results, smoking or drinking habits; bacteriological identification as non-tuberculous mycobacteria.Primary and secondary outcome measures Patients were classified into four groups including smokers only (G1), drinker only (G2), smoker +drinker (G3), non-smoker +non-drinker group (G0). We described the drug-resistant profiles, clinical factors and calculated the ORs of different drug-resistance among G1, G2, G3, compared with G0 through univariate and multivariate logistics regression models.Results Of the 7996 TB cases enrolled, the proportions of G1, G2, G3 and G0 were 8.25%, 3.89%, 16.46% and 71.40%, respectively. The rates of drug-resistant (DR)-TB, mono-resistant TB, multidrug resistant (MDR)-TB, polydrug resistant TB in G1, G2, G3 and G0 were 19.24%/16.4%/17.33%/19.08%, 11.52%/8.68%/10.94%/11.63%, 3.03%/2.57%/2.96%/3.66% and 4.70%/4.82%/3.34%/ 4.08%, respectively. G3 had a higher risk of MDR1: isoniazid +rifampin (adjusted OR (aOR)=1.91, 95% CI: 1.036 to 3.532), but had a lower risk of DR-TB (aOR=0.84, 95% CI: 0.71 to 0.99), rifampin-related resistance (aOR=0.68, 95% CI: 0.49 to 0.93), streptomycin-related resistance (aOR=0.82, 95% CI: 0.68 to 0.99), ethambutol-related resistance (aOR=0.57, 95% CI: 0.34 to 0.95), MDR3: isoniazid +rifampin+streptomycin (aOR=0.41, 95% CI: 0.19 to 0.85), any isoniazid +streptomycin resistance (aOR=0.85, 95% CI: 0.71 to 1.00). However, there were no significant differences between G1 and G0, G2 and G0 in all drug-resistant subtypes. Those patients with cavity had a higher risk of DR-TB among G3 (OR=1.35, 95% CI: 1.01 to 1.81).Conclusion Although we did not found an independent impact of alcohol drinking or tobacco smoking on TB drug-resistance, respectively, these two habits had a combined effect on TB drug-resistance.
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- 2022
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10. A review of anomalous refractive and reflective metasurfaces
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Si-qi Liu, Zhen-yu Ma, Jian Pei, Qing-bin Jiao, Lin Yang, Wei Zhang, Hui Li, Yu-hang Li, Yu-bo Zou, and Xin Tan
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Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Abnormal refraction and reflection refers to the phenomenon in which light does not follow its traditional laws of propagation and instead is subject to refraction and reflection at abnormal angles that satisfy a generalization of Snell’s law. Metasurfaces can realize this phenomenon through appropriate selection of materials and structural design, and they have a wide range of potential applications in the military, communications, scientific, and biomedical fields. This paper summarizes the current state of research on abnormal refractive and reflective metasurfaces and their application scenarios. It discusses types of abnormal refractive and reflective metasurfaces based on their tuning modes (active and passive), their applications in different wavelength bands, and their future development. The technical obstacles that arise with existing metasurface technology are summarized, and prospects for future development and applications of abnormal refractive and reflective metasurfaces are discussed.
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- 2022
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11. Population aging and trends of pulmonary tuberculosis incidence in the elderly
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Shi-jin Li, Yi-fan Li, Wan-mei Song, Qian-yun Zhang, Si-qi Liu, Ting-ting Xu, Qi-qi An, Jin-yue Liu, and Huai-chen Li
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Aging ,Pulmonary tuberculosis ,Incidence ,Join-point regression model ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background To explore population aging and the epidemic trend of pulmonary tuberculosis (PTB) in the elderly, and provide a basis for the prevention and control of pulmonary tuberculosis among the elderly. Methods We collected clinical information of 239,707 newly active PTB patients in Shandong Province from 2005 to 2017. We analyzed and compared the clinical characteristics, reported incidence and temporal trend of PTB among the elderly group (≥60 years) and the non-elderly group (
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- 2021
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12. Association between economic development level and tuberculosis registered incidence in Shandong, China
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Qian-yun Zhang, Dong-mei Yang, Lin-qing Cao, Jin-yue Liu, Ning-ning Tao, Yi-fan Li, Yao Liu, Wan-mei Song, Ting-ting Xu, Shi-jin Li, Qi-qi An, Si-qi Liu, Lei Gao, Wan-yan Song, and Huai-chen Li
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Tuberculosis ,Registered incidence ,Economic development ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Tuberculosis (TB) is one of the major infectious diseases that seriously endanger people’s health. In Shandong province, the relationship between the level of economic development and TB incidence has not been studied. This study aims to provide more research basis for the government to prevent and control TB by exploring the impact of different economic factors on TB incidence. Methods By constructing threshold regression model (TRM), we described the extent to which different economic factors contribute to TB registered incidence and differences in TB registered incidence among seventeen cities with different levels of economic development in Shandong province, China, during 2006–2017. Data were retrieved from the China Information System for Disease Control and Prevention. Results Per capita medical expenditure (regression coefficient, -0.0314462; SD, 0.0079305; P > |t|, 0.000) and per capita savings (regression coefficient, 0.0001924; SD, 0.0000566; P > |t|, 0.001) passed the significance test at the level of 1%.They are the two economic indicators that have the greatest impact on TB registered incidence. Through the threshold test, we selected the per capita savings as the threshold variable. In the three stages of per capita savings (33,835.5391 CNY), rural per capita income always has a significant negative impact on the TB registered incidence (The regression coefficients are − 0.0015682, − 0.0028132 and − 0.0022253 respectively. P is 0.007,0.000 and 0.000 respectively.).In cities with good economies, TB registered incidence was 38.30% in 2006 and dropped to 25.10% by 2017. In cities with moderate economies, TB registered incidence peaked in 2008 at 43.10% and dropped to 27.1% by 2017.In poorer cities, TB registered incidence peaked in 2008 at 56.30% and dropped to 28.9% in 2017. Conclusion We found that per capita savings and per capita medical expenditure are most closely related to the TB incidence. Therefore, relevant departments should formulate a more complete medical system and medical insurance policy to effectively solve the problem of “difficult and expensive medical treatment”. In order to further reduce the TB incidence, in addition to timely and accurate diagnosis and treatment, it is more important for governments to increase investment in medicine and health care.
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- 2020
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13. Ambient air pollutants, diabetes and risk of newly diagnosed drug-resistant tuberculosis
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Wan-mei Song, Yi Liu, Qian-yun Zhang, Si-qi Liu, Ting-ting Xu, Shi-jin Li, Qi-qi An, Jin-yue Liu, Ning-ning Tao, Yao Liu, Chun-Bao Yu, Cui-xiang Yu, Yi-fan Li, and Huai-chen Li
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Primary drug resistance ,Tuberculosis ,Ambient air pollution ,Diabetes ,Risk factor ,Environmental pollution ,TD172-193.5 ,Environmental sciences ,GE1-350 - Abstract
Background: Drug-resistant tuberculosis (DR-TB), diabetes and exposure to air pollution are thought to be important threat to human health, but no studies have explored the effects of ambient air pollutants on DR-TB when adjusting diabetes status so far. Methods: We performed a study among 3759 newly diagnosed TB cases with drug-susceptibility testing results, diabetes status, and individual air pollution data in Shandong from 2015 to 2019. Generalized linear mixed models (GLMM) including three models (Model 1: without covariates, Model 2: adjusted by diabetes status only, Model 3: with all covariates) were applied. Results: Of 3759 TB patients enrolled, 716 (19.05%) were DR-TB, and 333 (8.86%) had diabetes. High exposure to O3 was associated with an increased risk of RFP-resistance (Model 2 or 3: odds ratio (OR) = 1.008, 95% confidence intervals (CI): 1.002–1.014), ethambutol-resistance (Model 3: OR = 1.015, 95%CI: 1.004–1.027) and any rifampicin+streptomycin resistance (Model 1,2,3: OR = 1.01, 95%CI: 1.002–1.018) at 90 days. In contrast, NO2 was associated with a reduced risk of DR-TB (Model 3: OR = 0.99, 95%CI: 0.981–0.999) and multidrug-resistant TB (MDR-TB) (Model 3: OR = 0.977, 95%CI: 0.96–0.994) at 360 days. Additionally, SO2 (Model 1, 2, 3: OR = 0.987, 95%CI: 0.977–0.998) showed a protective effect on MDR-TB at 90 days. PM2.5 (90 days, Model 2: OR = 0.991, 95%CI: 0.983–0.999), PM10 (360 days, Model 2: OR = 0.992, 95%CI: 0.985–0.999) had protective effects on any RFP+SM resistance. Conclusions: O3 contributed to an elevated risk of TB resistance but PM2.5, PM10, SO2, NO2 showed an inverse effect. Air pollutants may affect the development of drug resistance among TB cases by adjusting the status of diabetes.
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- 2021
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14. COVID-19 and Tuberculosis Coinfection: An Overview of Case Reports/Case Series and Meta-Analysis
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Wan-mei Song, Jing-yu Zhao, Qian-yun Zhang, Si-qi Liu, Xue-han Zhu, Qi-qi An, Ting-ting Xu, Shi-jin Li, Jin-yue Liu, Ning-ning Tao, Yao Liu, Yi-fan Li, and Huai-chen Li
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COVID-19 ,tuberculosis ,co-infection ,clinical features ,risk factors ,Medicine (General) ,R5-920 - Abstract
Background: Coronavirus disease 2019 (COVID-19) and tuberculosis (TB) are two major infectious diseases posing significant public health threats, and their coinfection (aptly abbreviated COVID-TB) makes the situation worse. This study aimed to investigate the clinical features and prognosis of COVID-TB cases.Methods: The PubMed, Embase, Cochrane, CNKI, and Wanfang databases were searched for relevant studies published through December 18, 2020. An overview of COVID-TB case reports/case series was prepared that described their clinical characteristics and differences between survivors and deceased patients. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) for death or severe COVID-19 were calculated. The quality of outcomes was assessed using GRADEpro.Results: Thirty-six studies were included. Of 89 COVID-TB patients, 19 (23.46%) died, and 72 (80.90%) were male. The median age of non-survivors (53.95 ± 19.78 years) was greater than that of survivors (37.76 ± 15.54 years) (p < 0.001). Non-survivors were more likely to have hypertension (47.06 vs. 17.95%) or symptoms of dyspnea (72.73% vs. 30%) or bilateral lesions (73.68 vs. 47.14%), infiltrates (57.89 vs. 24.29%), tree in bud (10.53% vs. 0%), or a higher leucocyte count (12.9 [10.5–16.73] vs. 8.015 [4.8–8.97] × 109/L) than survivors (p < 0.05). In terms of treatment, 88.52% received anti-TB therapy, 50.82% received antibiotics, 22.95% received antiviral therapy, 26.23% received hydroxychloroquine, and 11.48% received corticosteroids. The pooled ORs of death or severe disease in the COVID-TB group and the non-TB group were 2.21 (95% CI: 1.80, 2.70) and 2.77 (95% CI: 1.33, 5.74) (P < 0.01), respectively.Conclusion: In summary, there appear to be some predictors of worse prognosis among COVID-TB cases. A moderate level of evidence suggests that COVID-TB patients are more likely to suffer severe disease or death than COVID-19 patients. Finally, routine screening for TB may be recommended among suspected or confirmed cases of COVID-19 in countries with high TB burden.
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- 2021
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15. Risk factors for drug-resistant tuberculosis, the association between comorbidity status and drug-resistant patterns: a retrospective study of previously treated pulmonary tuberculosis in Shandong, China, during 2004–2019
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Yi-Fan Li, Ning-ning Tao, Wan-mei Song, Jin-yue Liu, Qian-yun Zhang, Ting-ting Xu, Shi-jin Li, Qi-qi An, Si-qi Liu, and Huai-chen Li
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Medicine - Abstract
Objective This study was designed to identify the risk factors for drug-resistant tuberculosis (DR-TB) and the association between comorbidity and drug resistance among retreated pulmonary tuberculosis (PTB).Design A retrospective study was conducted among all the 36 monitoring sites in Shandong, China, over a 16-year period. Baseline characteristics were collected from the TB Surveillance System. Categorical variables were compared by Fisher’s exact or Pearson’s χ2 test. The risk factors for drug resistance were identified using univariable analysis and multivariable logistic models. The influence of comorbidity on different types of drug resistance was evaluated by performing multivariable logistic models with the covariates adjusted by age, sex, body mass index, drinking/smoking history and cavity.Results A total of 10 975 patients with PTB were recorded during 2004–2019, and of these 1924 retreated PTB were finally included. Among retreated PTB, 26.2% were DR-TB and 12.5% had comorbidity. Smoking (adjusted OR (aOR): 1.69, 95% CI 1.19 to 2.39), cavity (aOR: 1.55, 95% CI 1.22 to 1.97) and comorbidity (aOR: 1.44, 95% CI 1.02 to 2.02) were risk factors for DR-TB. Of 504 DR-TB, 9.5% had diabetes mellitus, followed by hypertension (2.0%) and chronic obstructive pulmonary disease (1.8%). Patients with retreated PTB with comorbidity were more likely to be older, have more bad habits (smoking, alcohol abuse) and have clinical symptoms (expectoration, haemoptysis, weight loss). Comorbidity was significantly associated with DR-TB (aOR: 1.44, 95% CI 1.02 to 2.02), overall rifampin resistance (aOR: 2.17, 95% CI 1.41 to 3.36), overall streptomycin resistance (aOR: 1.51, 95% CI 1.00 to 2.27) and multidrug resistance (aOR: 1.96, 95% CI 1.17 to 3.27) compared with pan-susceptible patients (p
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- 2021
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16. Metaproteomics Reveals Similar Vertical Distribution of Microbial Transport Proteins in Particulate Organic Matter Throughout the Water Column in the Northwest Pacific Ocean
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Ling-Fen Kong, Ke-Qiang Yan, Zhang-Xian Xie, Yan-Bin He, Lin Lin, Hong-Kai Xu, Si-Qi Liu, and Da-Zhi Wang
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particulate organic matter ,prokaryotic community ,metaproteomics ,transporter ,northwest Pacific Ocean ,Microbiology ,QR1-502 - Abstract
Solubilized particulate organic matter (POM) rather than dissolved organic matter (DOM) has been speculated to be the major carbon and energy sources for heterotrophic prokaryotes in the ocean. However, the direct evidence is still lack. Here we characterized microbial transport proteins of POM collected from both euphotic (75 m, deep chlorophyll maximum DCM, and 100 m) and upper-twilight (200 m and 500 m) zones in three contrasting environments in the northwest Pacific Ocean using a metaproteomic approach. The proportion of transport proteins was relatively high at the bottom of the euphotic zone (200 m), indicating that this layer was the most active area of microbe-driven POM remineralization in the water column. In the upper-twilight zone, the predicted substrates of the identified transporters indicated that amino acids, carbohydrates, taurine, inorganic nutrients, urea, biopolymers, and cobalamin were essential substrates for the microbial community. SAR11, Rhodobacterales, Alteromonadales, and Enterobacteriales were the key contributors with the highest expression of transporters. Interestingly, both the taxonomy and function of the microbial communities varied among water layers and sites with different environments; however, the distribution of transporter types and their relevant organic substrates were similar among samples, suggesting that microbial communities took up similar compounds and were functionally redundant in organic matter utilization throughout the water column. The similar vertical distribution of transport proteins from the euphotic zone to the upper twilight zone among the contrasting environments indicated that solubilized POM rather than DOM was the preferable carbon and energy sources for the microbial communities.
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- 2021
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17. Lineage Tracking the Generation of T Regulatory Cells From Microbial Activated T Effector Cells in Naïve Mice
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Kun Zhu, Chenfeng He, Si-Qi Liu, Mingjuan Qu, Tao Xie, Xiaofeng Yang, Lei Lei, Xiaobo Zhou, Lin Shi, Dan Zhang, Yanbin Cheng, Yae Sun, Huiqiang Zheng, Xiaonan Shen, Qijing Li, Ning Jiang, and Baojun Zhang
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tolerance ,inducible Tregs ,microbiota ,gut ,TCR repertoire ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Regulatory T cells (Tregs) are essential for the maintenance of gut homeostasis by suppressing conventional CD4+ helper T cells (Tconvs) that are activated by microbial antigens. Although thymus is the major source of the peripheral Tregs, peripheral conversion from Tconvs to Tregs have also been shown to occur under various experimental conditions. It remains less clear about the frequency of lineage conversion from Tconvs to Tregs in naïve animals. Here we used a newly established reporter system to track a group of post expansion Tregs (eTregs), which exhibited a stronger suppressive ability than the non-lineage marked Tregs. Notably, microbial antigens are the primary driver for the formation of eTregs. TCR repertoire analysis of Peyer's patch T cells revealed that eTregs are clonally related to Tconvs, but not to the non-lineage tracked Tregs. Adoptive transfer of Tconvs into lymphopenic hosts demonstrated a conversion from Tconvs to eTregs. Thus, our lineage tracking method was able to capture the lineage conversion from microbial activated effector T cells to Tregs in naïve animals. This study suggests that a fraction of clonally activated T cells from the natural T cell repertoire exhibits lineage conversion to Tregs in response to commensal microbes under homeostatic conditions.
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- 2020
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18. Fine regulation of ARF17 for anther development and pollen formation
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Bo Wang, Jing-Shi Xue, Ya-Hui Yu, Si-Qi Liu, Jia-Xin Zhang, Xiao-Zhen Yao, Zhi-Xue Liu, Xiao-Feng Xu, and Zhong-Nan Yang
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Anther ,Tapetum ,Male sterility ,ARF17 ,5mARF17 ,Botany ,QK1-989 - Abstract
Abstract Background In Arabidopsis, the tapetum and microsporocytes are critical for pollen formation. Previous studies have shown that ARF17 is expressed in microsporocytes and tetrads and directly regulates tetrad wall synthesis for pollen formation. ARF17 is the direct target of miR160, and promoterARF17::5mARF17 (5mARF17/WT) transgenic plants, which have five silent mutations within the miR160-complementary domain, are sterile. Results Here, we found that ARF17 is also expressed in the tapetum, which was defective in arf17 mutants. Compared with arf17 mutants, 5mARF17/WT plants had abnormal tapetal cells and tetrads but were less vacuolated in the tapetum. Immunocytochemical assays showed that the ARF17 protein over-accumulated in tapetum, microsporocytes and tetrads of 5mARF17/WT plants at early anther stages, but its expression pattern was not affected during anther development. 5mARF17 driven by its native promoter did not rescue the arf17 male-sterile phenotype. The expression of 5mARF17 driven by the tapetum-specific promoter A9 led to a defective tapetum and male sterility in transgenic plants. These results suggest that the overexpression of ARF17 in the tapetum and microsporocytes of 5mARF17/WT plants leads to male sterility. Microarray data revealed that an abundance of genes involved in transcription and translation are ectopically expressed in 5mARF17/WT plants. Conclusions Our work shows that ARF17 plays an essential role in anther development and pollen formation, and ARF17 expression under miR160 regulation is critical for its function during anther development.
- Published
- 2017
- Full Text
- View/download PDF
19. Western blot detection of PMI protein in transgenic rice
- Author
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Rui-juan RONG, Peng-cheng WU, Jin-ping LAN, Han-fu WEI, Jian WEI, Hao CHEN, Jia-nan SHI, Yu-jie HAO, Li-juan LIU, Shi-juan DOU, Li-yun LI, Lin WU, Si-qi LIU, Chang-cheng YIN, and Guo-zhen LIU
- Subjects
transgenic rice ,protein expression ,CaMV-35S promoter ,phosphomannose isomerase (PMI) ,Western blot ,Agriculture (General) ,S1-972 - Abstract
Phosphomannose isomerase (PMI) encoding gene manA is a desirable selective marker in transgenic research. Understanding of its expression patterns in transgenic plant and establishing highly sensitive detection method based on immunoassay have great impacts on the application of PMI. In this study, PMI-specific monoclonal antibodies were generated using recombinant protein as immunogen, and could be used in Western blot to detect as little as 0.5 ng His-tagged PMI protein or rice expressed PMI protein in sample accounted for 0.4% of single rice grain (about 0.08 mg). PMI protein driven by CaMV-35S promoter was detected in dozens of tested tissues, including root, stem, leaf, panicle, and seed at all developmental stages during rice growing, and PMI protein accounted for about 0.036% of total protein in the leaves at seedling stage. The established method potentially can be used to monitor PMI protein in rice grains.
- Published
- 2016
- Full Text
- View/download PDF
20. Hypoglycemic Effects of Oat Oligopeptides in High-Calorie Diet/STZ-Induced Diabetic Rats
- Author
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Jun-bo Wang, Xin-ran Liu, Si-qi Liu, Rui-xue Mao, Chao Hou, Na Zhu, Rui Liu, Hui-juan Ma, and Yong Li
- Subjects
oat oligopeptides ,hypoglycemic effect ,oral glucose tolerance test ,Organic chemistry ,QD241-441 - Abstract
The study was aimed to determine whether treatment with oat oligopeptides (OOPs) could modulate hyperglycemia related to type 2 diabetes mellitus (T2DM) in Sprague⁻Dawley (SD) rats. Diabetic SD rats modeling by a joint effect of high-calorie diet for 45 days and twice intraperitoneal injection of 30 mg/kg streptozotocin at one-week interval were observed with or without OOPs administration (0.25, 0.50, 1.00, and 2.00 g/kg Body Weight) for 12 weeks. Fasting blood glucose (FBG), oral glucose test tolerance (OGTT), serum insulin, level of antioxidant, and hepatic enzymes were measured. In addition, frequency of micturition was recorded in this study for the first time. It was observed that the administration of OOPs (2.00 g/kg Body Weight) resulted in a significant decrease (p < 0.05) in FBG since 6th week and a significant decrease (p < 0.05) in the OGTT-AUC on 6th and 10th week. In addition, the administration of OOPs (2.00 g/kg Body Weight) reduced HOMA-IR index and 24-h urine volume significantly (p < 0.05) whereas increased SOD activity significantly (p < 0.05). These results suggested that OOPs may have a hypoglycemic effect in diabetic rats.
- Published
- 2019
- Full Text
- View/download PDF
21. Robust Remote Photoplethysmography Estimation With Environmental Noise Disentanglement.
- Author
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Si-Qi Liu 0003 and Pong C. Yuen
- Published
- 2024
- Full Text
- View/download PDF
22. Learning Temporal Similarity of Remote Photoplethysmography for Fast 3D Mask Face Presentation Attack Detection.
- Author
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Si-Qi Liu 0003, Xiangyuan Lan, and Pong C. Yuen
- Published
- 2022
- Full Text
- View/download PDF
23. Inherent Consistent Learning for Accurate Semi-supervised Medical Image Segmentation.
- Author
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Ye Zhu, Jie Yang, Si-Qi Liu, and Ruimao Zhang
- Published
- 2023
- Full Text
- View/download PDF
24. Weakly Supervised rPPG Estimation for Respiratory Rate Estimation.
- Author
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Jingda Du, Si-Qi Liu 0003, Bochao Zhang, and Pong C. Yuen
- Published
- 2021
- Full Text
- View/download PDF
25. A General Remote Photoplethysmography Estimator with Spatiotemporal Convolutional Network.
- Author
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Si-Qi Liu 0003 and Pong C. Yuen
- Published
- 2020
- Full Text
- View/download PDF
26. Temporal Similarity Analysis of Remote Photoplethysmography for Fast 3D Mask Face Presentation Attack Detection.
- Author
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Si-Qi Liu 0003, Xiangyuan Lan, and Pong C. Yuen
- Published
- 2020
- Full Text
- View/download PDF
27. Multi-Channel Remote Photoplethysmography Correspondence Feature for 3D Mask Face Presentation Attack Detection.
- Author
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Si-Qi Liu 0003, Xiangyuan Lan, and Pong C. Yuen
- Published
- 2021
- Full Text
- View/download PDF
28. Recent Progress on Face Presentation Attack Detection of 3D Mask Attacks.
- Author
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Si-Qi Liu 0003, Pong C. Yuen, Xiaobai Li, and Guoying Zhao 0001
- Published
- 2019
- Full Text
- View/download PDF
29. Remote Photoplethysmography Correspondence Feature for 3D Mask Face Presentation Attack Detection.
- Author
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Si-Qi Liu 0003, Xiangyuan Lan, and Pong C. Yuen
- Published
- 2018
- Full Text
- View/download PDF
30. Hot spot-based engineering of ketopantoate hydroxymethyltransferase for the improvement of D-pantothenic acid production in Escherichia coli
- Author
-
Xue Cai, Xue Shi, Si-Qi Liu, Yu Qiang, Ji-Dong Shen, Bo Zhang, Zhi-Qiang Liu, and Yu-Guo Zheng
- Subjects
Bioengineering ,General Medicine ,Applied Microbiology and Biotechnology ,Biotechnology - Published
- 2023
31. An electrochemiluminescence aptasensor based on highly luminescent silver-based MOF and biotin–streptavidin system for mercury ion detection
- Author
-
Si-Qi Liu, Jing-Shuai Chen, Xing-Pei Liu, Chang-Jie Mao, and Bao-Kang Jin
- Subjects
Electrochemistry ,Environmental Chemistry ,Biochemistry ,Spectroscopy ,Analytical Chemistry - Abstract
Silver-based organic frameworks with high ECL activity were synthesized and applied for the first time to construct an ECL sensor. The detection limit was as low as 66 fM for mercury ion concentration in water.
- Published
- 2023
32. Precise determination of major and trace elements in micrometer-scale ilmenite lamellae in titanomagnetite using LA-ICP-MS technique: application of regression analysis to time-resolved signals
- Author
-
Si-Qi Liu, Shao-Yong Jiang, Wei Chen, Christina Yan Wang, Hui-Min Su, Yonghua Cao, Hao-Xiang Zhang, and Wen-Tian Li
- Subjects
General Chemical Engineering ,General Chemistry - Abstract
In this contribution, ilmenite lamellae intergrown with magnetite were selected as an example to describe a practical algorithm used to extract the chemical composition of binary mineral phases from mixed LA-ICP-MS signals.
- Published
- 2023
33. SARS-CoV-2 Structural Proteins Modulated Blood-Testis Barrier-Related Proteins through Autophagy in the Primary Sertoli Cells
- Author
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Wu, Kai Kang, Yao-Dan Ma, Si-Qi Liu, Ri-Wei Huang, Jin-Jun Chen, Li-Long An, and Jiang
- Subjects
SARS-CoV-2 ,blood-testis barrier ,autophagy ,Sertoli cells ,junction protein ,immune factor - Abstract
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disrupts the blood-testis barrier (BTB), resulting in alterations in spermatogenesis. However, whether BTB-related proteins (such as ZO-1, claudin11, N-cadherin, and CX43) are targeted by SARS-CoV-2 remains to be clarified. BTB is a physical barrier between the blood vessels and the seminiferous tubules of the animal testis, and it is one of the tightest blood-tissue barriers in the mammalian body. In this study, we investigated the effects of viral proteins, via ectopic expression of individual viral proteins, on BTB-related proteins, the secretion of immune factors, and the formation and degradation of autophagosomes in human primary Sertoli cells. Our study demonstrated that ectopic expression of viral E (envelope protein) and M (membrane protein) induced the expressions of ZO-1 and claudin11, promoted the formation of autophagosomes, and inhibited autophagy flux. S (spike protein) reduced the expression of ZO-1, N-cadherin, and CX43, induced the expression of claudin11, and inhibited the formation and degradation of autophagosomes. N (nucleocapsid protein) reduced the expression of ZO-1, claudin11, and N-cadherin. All the structural proteins (SPs) E, M, N, and S increased the expression of the FasL gene, and the E protein promoted the expression and secretion of FasL and TGF-β proteins and the expression of IL-1. Blockage of autophagy by specific inhibitors resulted in the suppression of BTB-related proteins by the SPs. Our results indicated that SARS-CoV-2 SPs (E, M, and S) regulate BTB-related proteins through autophagy.
- Published
- 2023
- Full Text
- View/download PDF
34. Table S2 from A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
- Author
-
Joseph A. D'Alessio, Glenn Dranoff, Joel P. Wagner, Kimberly Aardalen, Tiancen Hu, David A. Ruddy, Tomas Rejtar, William R. Tschantz, Katherine Seiss, Katie Russo, Markus Vogel, Sabine Deutsch, Srinivas Chakravarthy, Rajiv Chopra, Brian Granda, Casey Landry, Alyssa Grantham, and Si-Qi Liu
- Abstract
Table S2
- Published
- 2023
35. Supplementary Figures and Legends from A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
- Author
-
Joseph A. D'Alessio, Glenn Dranoff, Joel P. Wagner, Kimberly Aardalen, Tiancen Hu, David A. Ruddy, Tomas Rejtar, William R. Tschantz, Katherine Seiss, Katie Russo, Markus Vogel, Sabine Deutsch, Srinivas Chakravarthy, Rajiv Chopra, Brian Granda, Casey Landry, Alyssa Grantham, and Si-Qi Liu
- Abstract
Supplementary Figures and Legends
- Published
- 2023
36. Data from A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
- Author
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Joseph A. D'Alessio, Glenn Dranoff, Joel P. Wagner, Kimberly Aardalen, Tiancen Hu, David A. Ruddy, Tomas Rejtar, William R. Tschantz, Katherine Seiss, Katie Russo, Markus Vogel, Sabine Deutsch, Srinivas Chakravarthy, Rajiv Chopra, Brian Granda, Casey Landry, Alyssa Grantham, and Si-Qi Liu
- Abstract
CD3-bispecific antibodies represent an important therapeutic strategy in oncology. These molecules work by redirecting cytotoxic T cells to antigen-bearing tumor cells. Although CD3-bispecific antibodies have been developed for several clinical indications, cases of cancer-derived resistance are an emerging limitation to the more generalized application of these molecules. Here, we devised whole-genome CRISPR screens to identify cancer resistance mechanisms to CD3-bispecific antibodies across multiple targets and cancer types. By validating the screen hits, we found that deficiency in IFNγ signaling has a prominent role in cancer resistance. IFNγ functioned by stimulating the expression of T-cell killing–related molecules in a cell type–specific manner. By assessing resistance to the clinical CD3-bispecific antibody flotetuzumab, we identified core fucosylation as a critical pathway to regulate flotetuzumab binding to the CD123 antigen. Disruption of this pathway resulted in significant resistance to flotetuzumab treatment. Proper fucosylation of CD123 was required for its normal biological functions. In order to treat the resistance associated with fucosylation loss, flotetuzumab in combination with an alternative targeting CD3-bispecific antibody demonstrated superior efficacy. Together, our study reveals multiple mechanisms that can be targeted to enhance the clinical potential of current and future T-cell–engaging CD3-bispecific antibody therapies.
- Published
- 2023
37. Virasoro constraints for Drinfeld–Sokolov hierarchies and equations of Painlevé type
- Author
-
Si‐Qi Liu, Chao‐Zhong Wu, and Youjin Zhang
- Subjects
General Mathematics - Published
- 2022
38. Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo
- Author
-
Lei, Xuan, Jing-Hai, Hu, Ran, Bi, Si-Qi, Liu, and Chun-Xi, Wang
- Subjects
NF-kappa B ,Apoptosis ,General Medicine ,Mice ,Phosphatidylinositol 3-Kinases ,Urinary Bladder Neoplasms ,Complementary and alternative medicine ,Cell Line, Tumor ,Animals ,Humans ,Pharmacology (medical) ,Diterpenes ,Proto-Oncogene Proteins c-akt ,Cell Proliferation - Abstract
To explore the influences of andrographolide (Andro) on bladder cancer cell lines and a tumor xenograft mouse model bearing 5637 cells.For in vitro experiments, T24 cells were stimulated with Andro (0-40 µmol/L) and 5637 cells were stimulated with Andro (0 to 80 µmol/L). Cell growth, migration, and infiltration were assessed using cell counting kit-8, colony formation, wound healing, and transwell assays. Apoptosis rate was examined using flow cytometry. In in vivo study, the antitumor effect of Andro (10 mg/kg) was evaluated by 5637 tumor-bearing mice, and levels of nuclear factor κ B (NF- κ B) and phosphoinositide 3-kinase/AKT related-proteins were determined by immunoblotting.Andro suppressed growth, migration, and infiltraion of bladder cancer cells (P⩽0.05 or P⩽0.01). Additionally, Andro induced intrinsic mitochondria-dependent apoptosis in bladder cancer cell lines. Furthermore, Andro inhibited bladder cancer growth in mice (P⩽0.01). The expression of p65, p-AKT were suppressed by Andro treatment in vitro and in vivo (P⩽0.05 or P⩽0.01).Andrographolide inhibits proliferation and promotes apoptosis in bladder cancer cells by interfering with NF- κ B and PI3K/AKT signaling in vitro and in vivo.
- Published
- 2022
39. Metabolic tuning of a stable microbial community in the surface oligotrophic Indian Ocean revealed by integrated meta-omics
- Author
-
Zhang-Xian Xie, Ke-Qiang Yan, Ling-Fen Kong, Ying-Bao Gai, Tao Jin, Yan-Bin He, Ya-Yu Wang, Feng Chen, Lin Lin, Zhi-Long Lin, Hong-Kai Xu, Zong-Ze Shao, Si-Qi Liu, and Da-Zhi Wang
- Subjects
Aquatic Science ,Oceanography ,Ecology, Evolution, Behavior and Systematics ,Biotechnology - Abstract
Understanding the mechanisms, structuring microbial communities in oligotrophic ocean surface waters remains a major ecological endeavor. Functional redundancy and metabolic tuning are two mechanisms that have been proposed to shape microbial response to environmental forcing. However, little is known about their roles in the oligotrophic surface ocean due to less integrative characterization of community taxonomy and function. Here, we applied an integrated meta-omics-based approach, from genes to proteins, to investigate the microbial community of the oligotrophic northern Indian Ocean. Insignificant spatial variabilities of both genomic and proteomic compositions indicated a stable microbial community that was dominated by Prochlorococcus, Synechococcus, and SAR11. However, fine tuning of some metabolic functions that are mainly driven by salinity and temperature was observed. Intriguingly, a tuning divergence occurred between metabolic potential and activity in response to different environmental perturbations. Our results indicate that metabolic tuning is an important mechanism for sustaining the stability of microbial communities in oligotrophic oceans. In addition, integrated meta-omics provides a powerful tool to comprehensively understand microbial behavior and function in the ocean.
- Published
- 2022
40. A reliable calibration method for accurate determination of major and trace elements in fluorapatite by LA-ICP-MS without an internal standard
- Author
-
Hao-Xiang Zhang, Shao-Yong Jiang, Hui-Min Su, Si-Qi Liu, and Wen-Tian Li
- Subjects
Spectroscopy ,Analytical Chemistry - Abstract
During in situ determination of major and trace element concentrations of minerals by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), an internal standard is needed.
- Published
- 2022
41. Recent Progress on Face Presentation Attack Detection of 3D Mask Attack
- Author
-
Si-Qi Liu and Pong C. Yuen
- Published
- 2023
42. The negative association between serum albumin and coronary heart disease risk in adults over 45 years old: a cross-sectional survey
- Author
-
Xin-zheng Hou, En-qi Liu, Si-qi Liu, Hao Lv, Hua-feng Cui, and Jing Han
- Abstract
Objective: To explore the correlation between serum albumin and coronary heart disease (CHD) risk in adults over 45 years old.Methods: This cross-sectional study utilized the non-institutionalized US population from the National Health and Nutrition Examination Survey (NHANES 2011-2018) as the sample source. Multiple logistic regression was used to examine the association between serum albumin and CHD risk. Smooth curve fitting was performed to explore the potential nonlinear relationship. When the non-linear relationship was found, a recursive algorithm was used to calculate the inflection points, and a piecewise logistic regression model was constructed.Results: After adjusting for confounders, multiple logistic regression and smooth curve fitting indicated an inverse association between serum albumin and CHD risk [ OR=0.970, 95%CI= (0.948, 0.992)]. Subgroup analysis found this negative correlation was statistically significant in the population of females, over 60 years old, with hypertension and without diabetes.Conclusion: There is a correlation between serum albumin and CHD risk. Lower serum albumin levels are associated with higher CHD risk.
- Published
- 2022
43. Dynamic changes of estimated glomerular filtration rate are conversely related to triglyceride in non-overweight patients
- Author
-
Si-Qi Liu, Xiu-Jun Zhang, Yuan Xue, Rui Huang, Jian Wang, Chao Wu, Yi-Shan He, Ya-Ru Pan, and Long-Gen Liu
- Subjects
General Medicine - Abstract
Correlation between Triglyceride (TG) and estimated glomerular filtration rate (eGFR) remains largely unknown in overweight and non-overweight patients.To investigated the dynamic changes of eGFR and lipid profiles during 3-year tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B (CHB) and overweight.A total of 202 CHB patients who received TDF treatment at the Third People's Hospital of Changzhou (Changzhou, China) and Nanjing Drum Tower Hospital (Nanjing, China) between January 2016 and May 2018 were retrospectively enrolled. According to the body mass index (BMI) at the initiation of TDF treatment, CHB patients were divided into overweight (BMI ≥ 25 kg/mThere is no significant difference in hepatitis B virus DNA (HBV DNA) negativity and hepatitis Be antigen (HBeAg) loss between patients with overweight and non-overweight (bothDynamic changes in renal function were conversely related to TG during TDF treatment in patients with CHB and normal BMI, but not with overweight.
- Published
- 2022
44. Sm-Nd and U-Pb isotope behavior of REE-rich accessory minerals in pegmatite during overprinted metamorphic and hydrothermal events: Evidence from the Paleoproterozoic rare-earth pegmatite in the lesser Qinling district of China
- Author
-
Hao-Xiang Zhang, Shao-Yong Jiang, Si-Qi Liu, and Feng Yuan
- Subjects
Geochemistry and Petrology ,Geology - Published
- 2023
45. Using a risk model for probability of cancer in pulmonary nodules
- Author
-
Qi-qi An, Li-Na Wang, Wan-mei Song, Bin Liang, Yifan Li, Jin-yue Liu, Si-qi Liu, Shi-jin Li, Qian-yun Zhang, Ting-ting Xu, Xiao-Bin Ma, Ning Li, Huai-chen Li, and Ning-ning Tao
- Subjects
Adult ,Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Adolescent ,Decision tree ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Satellite Nodule ,decision tree ,medicine ,Humans ,pulmonary nodules ,Stage (cooking) ,Child ,Lung cancer ,RC254-282 ,Probability ,Retrospective Studies ,Lung ,business.industry ,logistics regression ,Infant, Newborn ,Infant ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cancer ,Nodule (medicine) ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,lung cancer ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Child, Preschool ,030220 oncology & carcinogenesis ,Multiple Pulmonary Nodules ,Female ,Original Article ,Radiology ,medicine.symptom ,business ,Decision tree model - Abstract
Background Considering the high morbidity and mortality of lung cancer and the high incidence of pulmonary nodules, clearly distinguishing benign from malignant lung nodules at an early stage is of great significance. However, determining the kind of lung nodule which is more prone to lung cancer remains a problem worldwide. Methods A total of 480 patients with pulmonary nodule data were collected from Shandong, China. We assessed the clinical characteristics and computed tomography (CT) imaging features among pulmonary nodules in patients who had undergone video‐assisted thoracoscopic surgery (VATS) lobectomy from 2013 to 2018. Preliminary selection of features was based on a statistical analysis using SPSS. We used WEKA to assess the machine learning models using its multiple algorithms and selected the best decision tree model using its optimization algorithm. Results The combination of decision tree and logistics regression optimized the decision tree without affecting its AUC. The decision tree structure showed that lobulation was the most important feature, followed by spiculation, vessel convergence sign, nodule type, satellite nodule, nodule size and age of patient. Conclusions Our study shows that decision tree analyses can be applied to screen individuals for early lung cancer with CT. Our decision tree provides a new way to help clinicians establish a logical diagnosis by a stepwise progression method, but still needs to be validated for prospective trials in a larger patient population., Considering the high morbidity and mortality of lung cancer and the high incidence of pulmonary nodules, it is of great significance to clearly distinguish between benign and malignant lung nodules at early stages. However, what kind of lung nodules are more prone to lung cancer is still a worldwide problem. In this study, 458 cases with pulmonary nodules data were collected from Shandong, China. We assessed the clinical characteristics and low‐dose computed tomography (LDCT) imaging features among pulmonary nodules in patients who had undergone video‐assisted thoracoscopic surgery (VATS) lobectomy from 2013 to 2018 to determine the machine learning models using multiple algorithms and select the best decision tree model. Our study shows that decision tree analyses can be applied to screen individuals for early lung cancer with CT. Our decision tree provides a new way to help clinicians establish a logical diagnosis by a stepwise progression method, but still needs to be validated for prospective trials in a larger patient population.
- Published
- 2021
46. Elucidating colony bloom formation mechanism of a harmful alga Phaeocystis globosa (Prymnesiophyceae) using metaproteomics
- Author
-
Hua-Min Cheng, Shu-Feng Zhang, Xiao-Lian Ning, Jian-Xiang Peng, Dong-Xu Li, Hao Zhang, Kun Zhang, Lin Lin, Si-Qi Liu, Walker O. Smith, and Da-Zhi Wang
- Subjects
Environmental Engineering ,Environmental Chemistry ,Pollution ,Waste Management and Disposal - Published
- 2023
47. Mineral associations and in-situ major and trace element compositions of dalyite from charoitites, Murun complex, Siberia
- Author
-
Emilia Yu. Dokuchits, Shao-Yong Jiang, Aleksandr S. Stepanov, Irina A. Zhukova, Tatiana A. Radomskaya, Hui-Min Su, and Si-Qi Liu
- Subjects
Geochemistry and Petrology ,Economic Geology ,Geology - Published
- 2023
48. A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy
- Author
-
Tomas Rejtar, Markus Vogel, Srinivas Chakravarthy, Joseph Anthony D'alessio, Katie Russo, Alyssa Grantham, David A. Ruddy, Sabine Deutsch, Si-Qi Liu, Katherine Seiss, Tiancen Hu, William R. Tschantz, Glenn Dranoff, Casey Landry, Rajiv Chopra, Joel Wagner, Brian Granda, and Kimberly Aardalen
- Subjects
0301 basic medicine ,Cancer Research ,CD3 Complex ,CD3 ,Immunology ,Cell ,Interleukin-3 Receptor alpha Subunit ,Antineoplastic Agents ,Lymphocyte Activation ,Article ,Interferon-gamma ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Mice, Inbred NOD ,Cell Line, Tumor ,Antibodies, Bispecific ,medicine ,Animals ,Humans ,Cytotoxic T cell ,CRISPR ,Clustered Regularly Interspaced Short Palindromic Repeats ,Fucosylation ,biology ,Cancer ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Immunotherapy ,Interleukin-3 receptor ,Antibody ,T-Lymphocytes, Cytotoxic - Abstract
CD3-bispecific antibodies represent an important therapeutic strategy in oncology. These molecules work by redirecting cytotoxic T cells to antigen-bearing tumor cells. Although CD3-bispecific antibodies have been developed for several clinical indications, cases of cancer-derived resistance are an emerging limitation to the more generalized application of these molecules. Here, we devised whole-genome CRISPR screens to identify cancer resistance mechanisms to CD3-bispecific antibodies across multiple targets and cancer types. By validating the screen hits, we found that deficiency in IFNγ signaling has a prominent role in cancer resistance. IFNγ functioned by stimulating the expression of T-cell killing–related molecules in a cell type–specific manner. By assessing resistance to the clinical CD3-bispecific antibody flotetuzumab, we identified core fucosylation as a critical pathway to regulate flotetuzumab binding to the CD123 antigen. Disruption of this pathway resulted in significant resistance to flotetuzumab treatment. Proper fucosylation of CD123 was required for its normal biological functions. In order to treat the resistance associated with fucosylation loss, flotetuzumab in combination with an alternative targeting CD3-bispecific antibody demonstrated superior efficacy. Together, our study reveals multiple mechanisms that can be targeted to enhance the clinical potential of current and future T-cell–engaging CD3-bispecific antibody therapies.
- Published
- 2021
49. Primary Drug-Resistance Pattern and Trend in Elderly Tuberculosis Patients in Shandong, China, from 2004 to 2019
- Author
-
Chun-Bao Yu, Huai-chen Li, Qi-qi An, Wan-mei Song, Ning-ning Tao, Ting-ting Xu, Yifan Li, Qian-yun Zhang, Shi-jin Li, Jin-yue Liu, Si-qi Liu, and Yao Liu
- Subjects
0301 basic medicine ,Pharmacology ,medicine.medical_specialty ,COPD ,Tuberculosis ,business.industry ,030106 microbiology ,Retrospective cohort study ,Drug resistance ,medicine.disease ,Comorbidity ,03 medical and health sciences ,0302 clinical medicine ,Infectious Diseases ,Internal medicine ,Diabetes mellitus ,Epidemiology ,medicine ,Sputum ,Pharmacology (medical) ,030212 general & internal medicine ,medicine.symptom ,business - Abstract
Background With an aging population, China is facing a huge burden of elderly patients with drug resistant tuberculosis (DR-TB), which has become a significant obstacle for the global TB control. There is still little study on DR-TB in the elderly in China so far. Thus, more research on the epidemiological characteristics and trend of primary DR-TB among the elderly will be necessary. Methods A retrospective study was conducted in Shandong, China from 2004 to 2019. We collected 12,661 primary TB cases, of which 4368 elderly (≥60 years) primary TB cases were involved. Clinical characteristics including age, sex, cavity, smoking, drinking, comorbidity and drug susceptibility data were collected from 36 TB prevention and control institutions of Shandong Province. Sputum samples were collected by each surveillance site, and examined in the TB Reference Laboratory of SPCH. Descriptive statistical analysis, chi-square and linear regression were used for analyzing. Results Among 4368 elderly patients with primary TB, the DR-TB and multi-resistant tuberculosis (MDR-TB) accounted for 17.19% and 2.29%, respectively. During 2004-2019, the proportions of MDR-TB, polydrug resistant tuberculosis (PDR-TB), rifampin (RFP)-resistance increased by 160.00%, 18.18%, 231.82%, respectively and the rate of DR-TB among elderly patients with primary cavitary TB increased by 255%. Among the elderly with primary DR-TB during 2004-2019, the proportion of male (from 85.19 to 89.06), cavity (from 7.41 to 46.88), RFP-resistance (from 3.70 to 21.88), and streptomycin (SM)-resistance (from 37.04 to 62.5) increased significantly (P
- Published
- 2020
50. Association of hemoglobin levels with bone mineral density in the thoracic and lumbar spine for adults over 18 years of age: a cross-sectional study
- Author
-
En Qi Liu, Xin Zheng Hou, Si Qi Liu, Jing Han, and Hao Lv
- Subjects
musculoskeletal diseases ,hemic and lymphatic diseases ,musculoskeletal system - Abstract
Aim:The overall object of this study is to find out the association between hemoglobin (HGB) and bone mineral density (BMD) in the lumbar and thoracic spine among adults over the age of 18.Methods:The current cross-sectional study used the non-institutionalised US population from the National Health and Nutrition Survey (NHANES) as the sample source. A multiple linear regression model and smoothed curve fitting were used to show the assessment of the relationship between hemoglobin and bone mineral density in the lumbar and thoracic spine, with analysis of subgroups according to gender and race.Results:After accounting for relevant confounders, HGB was negatively associated with bone mineral density in multiple regression models. In subgroup analyses stratified by sex or race, however, the relationship between HGB and thoracic spine BMD was only found in women and Mexican-Americans, and the association with lumbar spine BMD was present in males and females, Mexican-American and Non-Hispanic White. Among participants in other races and those whose race was not reported, the relationship between HGB with BMD in the lumbar spine and the thoracic spine showed an inverted U-shaped curve (turning point: HGB 11.9 g/dL).Conclusion: HGB was negatively associated with BMD in the lumbar spine and BMD in the thoracic spine. However, this significant correlation varies by gender and race.
- Published
- 2022
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