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1. Association of SCN1A Polymorphisms rs3812718 and rs2298771 with Epilepsy.

Author

Katsarou, Martha-Spyridoula, Siatouni, Anna, Tsikrika, Danae, Kokkiou, Elena, Stefanatou, Maria, Verentzioti, Anastasia, Alexoudi, Athanasia, Gatzonis, Stylianos, Drakoulis, Nikolaos, and Papasavva, Maria

Subjects
*SEIZURES (Medicine), *VOLTAGE-gated ion channels, *SINGLE nucleotide polymorphisms, *EPILEPSY, *ACTION potentials, *SODIUM channels
Abstract

Background/Objectives: Epilepsy is a brain disease with both environmental and genetic inputs. Ion channel dysfunction seems to be of great significance for abnormal neuronal behavior during epileptic seizures. Within neurons, the voltage-gated sodium channels are crucial proteins contributing to the initiation and propagation of action potentials. The voltage-gated sodium channel α subunit 1 (SCN1A) gene encodes for the α subunit of a voltage-gated ion channel. The aim of the study was to investigate the relation of two common SCN1A variants, i.e., rs3812718 and rs2298771, with distinct epileptic phenotypes in a South-Eastern European population. Methods: DNA was extracted from 214 unrelated participants with focal onset, focal to bilateral tonic–clonic, or generalized onset epileptic seizures and genotyped using real-time PCR (LightSNiP assays) followed by melting curve analysis. Statistical analysis of the results was performed using IBM SPSS Statistics software (version 29.0 for Windows). Results: Genotype frequency distribution analysis indicated an association for the A-allele-containing genotypes of both rs3812718 and rs2298771 polymorphisms of SCN1A with generalized onset seizures and focal to bilateral tonic–clonic seizures versus focal onset seizures. Conclusions: Consequently, the study provides evidence that supports a potential association of the investigated SCN1A polymorphisms with distinct seizure subtype susceptibility in South-Eastern Europeans. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Circulating miR‐146a and miR‐134 in predicting drug‐resistant epilepsy in patients with focal impaired awareness seizures

Author

Leontariti, Maria, primary, Avgeris, Margaritis, additional, Katsarou, Martha‐Spyridoula, additional, Drakoulis, Nikolaos, additional, Siatouni, Anna, additional, Verentzioti, Anastasia, additional, Alexoudi, Athanasia, additional, Fytraki, Aggeliki, additional, Patrikelis, Panayiotis, additional, Vassilacopoulou, Dido, additional, Gatzonis, Stylianos, additional, and Sideris, Diamantis C., additional

Published
2020
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9. Variables affecting factors associated with primary headache

Author

Alexoudi, Athanasia Politis, Konstadinos Moukidou, Anthi and Tsatovidou, Rebekka Ververaki, Sarantoula Tavernarakis, Antonios and Siatouni, Anna Verentzioti, Anastasia Mitsikostas, Dimos and Gatzonis, Stylianos

Abstract

Primary headache syndromes' development is associated with biological, psychological and social parameters. Factors such as daily habits, behavioral characteristics and sleep disorders also play an important role. We aim to identify the variables which affect the above factors. The study included 111 patients affected by primary headache. The patients were stratified into subgroups according to gender, age, occupation and headache type. Women attained higher scores than men in three of the evaluation rating scales and lower scores in the severity of dependence scale. Occupation was associated with SF36 and Hamilton anxiety scale. Unemployed had higher scores in Hamilton anxiety. Migraineurs and occupied individuals have lower SF36 scores. Women are associated with depression, anxiety and higher disability derived from headache. Men are more prone to dependence on opioids. Unemployment was linked with anxiety and well-being. The migraneurs presented a decreased level of quality of life.

Published
2018

10. Bruising following natalizumab infusion for relapsing-remitting multiple sclerosis: a case report

Author

Gatzonis Stylianos and Siatouni Anna

Subjects
Medicine
Abstract

Abstract Introduction Natalizumab is a new treatment for relapsing-remitting multiple sclerosis. Because of limited experience of this treatment, medical professionals must be alert to possible side effects. Case presentation We present a 34-year-old Caucasian woman with relapsing-remitting multiple sclerosis. She developed bruises on her legs after the first and second administrations of the new monoclonal antibody, natalizumab. Clinical and laboratory investigations revealed no hematological abnormalities. At the time of writing, she has remained on natalizumab treatment without any further side effects. Conclusion In our patient, bruises on the lower extremities may be a benign side effect of natalizumab. This is the first documented incidence of this side effect, and the patient did not require discontinuation of natalizumab treatment.

Published
2009
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11. Depression and anxiety in epilepsy: the association with demographic and seizure-related variables

Author

Pseftogianni Dimitra, Loucaidis Panagiotis, Siatouni Anna, Fountoulakis Konstantinos N, Gatzonis Stergios-Stylianos, Kararizou Eleni, Triantafyllou Nikolaos I, Kimiskidis Vasilios K, Vlaikidis Nikolaos, and Kaprinis George S

Subjects
Psychiatry, RC435-571
Abstract

Abstract Background Depression and anxiety are common psychiatric symptoms in patients with epilepsy, exerting a profound negative effect on health-related quality of life. Several issues, however, pertaining to their association with psychosocial, seizure-related and medication factors, remain controversial. Accordingly, the present study was designed to investigate the association of interictal mood disorders with various demographic and seizure-related variables in patients with newly-diagnosed and chronic epilepsy. Methods We investigated 201 patients with epilepsy (51.2% males, mean age 33.2 ± 10.0 years, range 16–60) with a mean disease duration of 13.9 ± 9.5 years. Depression and anxiety were assessed in the interictal state with the Beck Depression Inventory, 21-item version (BDI-21) and the state and trait subscales of the State-Trait Anxiety Inventory (STAI-S and STAI-T), respectively. The association of mood disorders with various variables was investigated with simple and multiple linear regression analyses. Results High seizure frequency and symptomatic focal epilepsy (SFE) were independent determinants of depression, together accounting for 12.4% of the variation of the BDI-21. The STAI-S index was significantly associated with the type of epilepsy syndrome (SFE). Finally, high seizure frequency, SFE and female gender were independent determinants of trait anxiety accounting for 14.7% of the variation of the STAI-T. Conclusion Our results confirm the prevailing view that depression and anxiety are common psychological disorders in epileptics. It is additionally concluded that female gender, high seizure frequency and a symptomatic epilepsy syndrome are independent risk factors for the development of anxiety and/or depression.

Published
2007
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12. The challenges that parents of children with epilepsy face:A qualitative study

Author

Kampra, Matina, Tzerakis, Nikolas, Thomsen, Louise Lund Holm, Katsarou , Efstathia, Voudris, Konstantinos, D. Mastroyianni, Sotiria, Mouskou, Stella, S. Drossou , Kyriaki, Siatouni, Anna, and Gatzonis, Stylianos

Subjects
Epilepsi, forældre, barn, samtykke, kvalitativ forskning
Abstract

ObjectiveThis qualitative study explored the challenges that Greek parents/caregivers of children with controlled epilepsy (CwE) face regarding the disorder.MethodsInterviews were conducted based on open-ended questions guided by a review of the literature. A total of 91 parents/caregivers were recruited by neurologists at the neurology clinics of two Athens public hospitals. A hermeneutic phenomenological approach was used to explore parent/caregiver experiences. The data were grouped and analyzed through a textual interpretation.ResultsTwo key challenges were identified for parents of CwE: the disclosure of epilepsy and the absence of adequate information about coping with epilepsy. Parents in Greece were hesitant to reveal their child's epilepsy to school staff and their wider social milieu. Also, although satisfied with the patient-centered approach they experienced with their hospital doctor, parents/caregivers found that they needed more education about the existing sources of psychosocial and emotional support to cope with their child's epilepsy personally and as a family. Finally, the parents/caregivers who let their child know about the epilepsy and discussed the implications with the child found that parent–child communication improved.ConclusionThis study provides valuable insight into the impact of epilepsy on parents of CwE, which might help hospital and school staff support families with greater understanding, sensitivity, and skill. The findings suggest that Greek authorities should staff hospitals and schools with experts and more systematically advertise sources of information about epilepsy and ways to cope with it.

Published
2017

13. Epidemiology of first epileptic seizures in the northern Aegean island of Lesvos, Greece

Author

Verentzioti, Anastasia Stranjalis, George Kalamatianos, Theodosis Siatouni, Anna Sakas, Damianos E. Gatzonis, Stylianos

Abstract

We aimed at establishing the epidemiologic profile of first epileptic seizures (FES) in the Greek island of Lesvos. During a 1year period (01/06/2010 to 31/05/2011), cases of FES admitted to the Lesvos General Hospital/addressed by general practitioners/private neurologists were prospectively identified. A total of 45 cases (30 males and 15 females; mean age +/- SD of 59.4 +/- 28.4 and 58.9 +/- 26.8 years, respectively), were collected. The FES incidence rate was 52.1 (95% CI 37-67) per 105 persons. Provoked and unprovoked FES had an incidence of, 16.2 and 35.9 cases per 105 persons, respectively. Following age-adjustment to the 2000 US census population, incidence rates of FES (all types combined) were, 40.5 (95% CI 28-56) per 10(5) persons. Cerebrovascular disease (CVD) was the most prevalent etiologic factor. The present findings indicate a low-ranking incidence of FES in the studied population and highlight CVD as a leading causative factor.

Published
2017

14. Variables Affecting Factors Associated with Primary Headache

Author

Alexoudi, Athanasia, primary, Politis, Konstadinos, additional, Moukidou, Anthi, additional, Tsatovidou, Rebekka, additional, Ververaki, Sarantoula, additional, Tavernarakis, Antonios, additional, Siatouni, Anna, additional, Verentzioti, Anastasia, additional, Mitsikostas, Dimos, additional, and Gatzonis, Stylianos, additional

Published
2018
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18. Verbal and Figural Fluency in Temporal Lobe Epilepsy: Does Hippocampal Sclerosis Affect Performance?

Author

Zalonis, Ioannis, primary, Christidi, Foteini, additional, Artemiadis, Artemios, additional, Psarros, Constantinos, additional, Papadopoulos, George, additional, Tsivgoulis, George, additional, Gatzonis, Stergios, additional, Siatouni, Anna, additional, Velonakis, Georgios, additional, Karavasilis, Efstratios, additional, Kararizou, Evangelia, additional, and Triantafyllou, Nikolaos, additional

Published
2017
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20. Dynamics of regional brain activity in epilepsy: a cross-disciplinary study on both intracranial and scalp-recorded epileptic seizures

Author

Minadakis, George Ventouras, Errikos Gatzonis, Stylianos D. and Siatouni, Anna Tsekou, Hara Kalatzis, Ioannis Sakas, Damianos E. Stonham, John

Abstract

Objective. Recent cross-disciplinary literature suggests a dynamical analogy between earthquakes and epileptic seizures. This study extends the focus of inquiry for the applicability of models for earthquake dynamics to examine both scalp-recorded and intracranial electroencephalogram recordings related to epileptic seizures. Approach. First, we provide an updated definition of the electric event in terms of magnitude and we focus on the applicability of (i) a model for earthquake dynamics, rooted in a nonextensive Tsallis framework, (ii) the traditional Gutenberg and Richter law and (iii) an alternative method for the magnitude-frequency relation for earthquakes. Second, we apply spatiotemporal analysis in terms of nonextensive statistical physics and we further examine the behavior of the parameters included in the nonextensive formula for both types of electroencephalogram recordings under study. Main results. We confirm the previously observed power-law distribution, showing that the nonextensive formula can adequately describe the sequences of electric events included in both types of electroencephalogram recordings. We also show the intermittent behavior of the epileptic seizure cycle which is analogous to the earthquake cycles and we provide evidence of self-affinity of the regional electroencephalogram epileptic seizure activity. Significance. This study may provide a framework for the analysis and interpretation of epileptic brain activity and other biological phenomena with similar underlying dynamical mechanisms.

Published
2014

24. Correspondence IJC-D-16-00080

Author

Mavrogeni, Sophie, primary, Ntoskas, Triantafylos, additional, Gialafos, Elias, additional, Karabela, Georgia, additional, Krommida, Maria, additional, Gatzonis, Stergios, additional, Siatouni, Anna, additional, Kolovou, Genovefa, additional, Zouvelou, Vasiliki, additional, and Stamboulis, Elefterios, additional

Published
2016
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27. Ictal Intracranial Recording from a 'Burned-Out Hippocampus'

Author

Gatzonis, Stylianos Siatouni, Anna Georgaculias, Nikos and Korfias, Stefanos Sakas, Damianos E.

Subjects
nervous system
Abstract

Objective: To present a case involving a discrepancy in the presurgical data of a patient suffering from pharmacoresistant mesial temporal lobe epilepsy. Clinical Presentation and Intervention: A 47-year-old, female patient with complex partial seizures since her twenties came to be evaluated in the Epilepsy Surgery Unit. The ictal electroencephalogram suggested a left temporal epileptogenic zone and the magnetic resonance image showed an abnormality in the right mesial temporal lobe. Intracranial monitoring revealed a pacemaker zone in the right hippocampus that discharged fast spreading to the left mesial temporal lobe, a phenomenon known as ‘burned-out hippocampus’. Conclusion: The intracranial recording, even though it is an invasive procedure, was necessary for the presurgical evaluation of our patient. This case demonstrates the risks of using surface electroencephalography to determine localization of epileptogenic zones. Copyright (C) 2012 S. Karger AG, Basel

Published
2013

31. Remission of drug-resistant epileptic psychosis following left selective amygdalohippocampectomy

Author

Angelopoulos, Elias Gatzonis, Stylianos Siatouni, Anna and Angelakis, Efthymios Sakas, Damianos E.

Abstract

We describe two female patients with drug-resistant mesial temporal lobe epilepsy and chronic drug-resistant psychosis. In both patients, MRI scans revealed left mesial temporal sclerosis. After clinical assessment, ictal video/EEG monitoring, and a neuropsychological evaluation including Wada testing, the patients underwent selective left amygdalohippocampectomy. Since the operation, the two patients have remained free of seizures for 17 and 15 months. During the same period, both patients have sustained a full remission of the psychosis. (C) 2008 Elsevier Inc. All rights reserved.

Published
2009

46. Depression and anxiety in epilepsy: the association with demographic and seizure-related variables

Author

Kimiskidis, Vasilios K, primary, Triantafyllou, Nikolaos I, additional, Kararizou, Eleni, additional, Gatzonis, Stergios-Stylianos, additional, Fountoulakis, Konstantinos N, additional, Siatouni, Anna, additional, Loucaidis, Panagiotis, additional, Pseftogianni, Dimitra, additional, Vlaikidis, Nikolaos, additional, and Kaprinis, George S, additional

Published
2007
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47. Ictal Intracranial Recording from a 'Burned-Out Hippocampus'.

Author

Gatzonis, Stylianos, Siatouni, Anna, Georgaculias, Nikos, Korfias, Stefanos, and Sakas, Damianos E.

Subjects
*EPILEPSY, *HIPPOCAMPUS (Brain), *SPASMS, *ELECTROENCEPHALOGRAPHY, *BRAIN diseases
Abstract

Objective: To present a case involving a discrepancy in the presurgical data of a patient suffering from pharmacoresistant mesial temporal lobe epilepsy. Clinical Presentation and Intervention: A 47-year-old, female patient with complex partial seizures since her twenties came to be evaluated in the Epilepsy Surgery Unit. The ictal electroencephalogram suggested a left temporal epileptogenic zone and the magnetic resonance image showed an abnormality in the right mesial temporal lobe. Intracranial monitoring revealed a pacemaker zone in the right hippocampus that discharged fast spreading to the left mesial temporal lobe, a phenomenon known as 'burned-out hippocampus'. Conclusion: The intracranial recording, even though it is an invasive procedure, was necessary for the presurgical evaluation of our patient. This case demonstrates the risks of using surface electroencephalography to determine localization of epileptogenic zones. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2012
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48. Pseudomigraine with transient neurological deficits and cerebrospinal fluid lymphocytosis or HaNDL syndrome: A case report with confusion and positive IgM antibodies to CMV in serum.

Author

Verentzioti, Anastasia, Tavernarakis, Antonios, Mamali, Margarita, Siatouni, Anna, and Gatzonis, Stylianos

Subjects
*LYMPHOCYTOSIS, *CEREBROSPINAL fluid, *LUMBAR puncture, *LYMPHOCYTES, *CHICKENPOX, *DISEASES, *COGNITION disorders, *CYTOMEGALOVIRUS diseases, *HEADACHE, *IMMUNOGLOBULINS, *LEUCOCYTE disorders, *SYNDROMES, *DISEASE complications, *PSYCHOLOGY
Abstract

An article presents a case study of an immunocompetent 28-year-old male with headache associated with neurologic deficits and cerebrospinal fluid lymphocytosis (HaNDL) syndrome who was admitted to the hospital with complains of vomiting, aggressiveness and acute confusional state. It mentions his treatment with lumbar puncture to analyze cerebrospinal fluid (CSF). It also cites a report on intermittent cerebellar syndrome with headache and mild pleocytosis of the CSF after varicella infection.

Published
2017
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49. Ictal intracranial recording from a 'burned-out hippocampus'.

Author

Gatzonis S, Siatouni A, Georgaculias N, Korfias S, and Sakas DE

Subjects
Electroencephalography, Epilepsies, Partial pathology, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Epilepsy, Temporal Lobe pathology, Hippocampus pathology
Abstract

Objective: To present a case involving a discrepancy in the presurgical data of a patient suffering from pharmacoresistant mesial temporal lobe epilepsy., Clinical Presentation and Intervention: A 47-year-old, female patient with complex partial seizures since her twenties came to be evaluated in the Epilepsy Surgery Unit. The ictal electroencephalogram suggested a left temporal epileptogenic zone and the magnetic resonance image showed an abnormality in the right mesial temporal lobe. Intracranial monitoring revealed a pacemaker zone in the right hippocampus that discharged fast spreading to the left mesial temporal lobe, a phenomenon known as 'burned-out hippocampus'., Conclusion: The intracranial recording, even though it is an invasive procedure, was necessary for the presurgical evaluation of our patient. This case demonstrates the risks of using surface electroencephalography to determine localization of epileptogenic zones., (Copyright © 2012 S. Karger AG, Basel.)

Published
2013
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