Search

Your search keyword '"Siba, Peter"' showing total 1,286 results
Start Over Author "Siba, Peter"
1,286 results on '"Siba, Peter"'

1. Low knowledge of newborn danger signs among pregnant women in Papua New Guinea and implications for health seeking behaviour in early infancy – findings from a longitudinal study

Author

Eghrari, Donya, Scoullar, Michelle J. L., Wilson, Alyce N., Peach, Elizabeth, Elijah, Arthur, Melepia, Pele, SupSup, Hadlee, Vallely, Lisa M., Siba, Peter M., Kennedy, Elissa C., Vogel, Joshua P., Homer, Caroline S. E., Robinson, Leanne J., Fowkes, Freya J. I., Pomat, William, Crabb, Brendan S., Beeson, James G., and Morgan, Christopher J.

Published
2023
Full Text
View/download PDF

3. Mycoplasma genitalium in pregnancy, including specific co-infections, is associated with lower birthweight: A prospective cohort study

Author

Scoullar, Michelle J.L., primary, Melepia, Pele, additional, Peach, Elizabeth, additional, Fidelis, Ruth, additional, Supsup, Hadlee, additional, Davidson, Eliza M., additional, Boeuf, Philippe, additional, Bradshaw, Catriona S., additional, Fehler, Glenda, additional, Hezeri, Priscah, additional, Kabiu, Dukduk, additional, Elijah, Arthur, additional, Siba, Peter M., additional, Kennedy, Elissa C., additional, Umbers, Alexandra J., additional, Robinson, Leanne J., additional, Vallely, Andrew J., additional, Badman, Steven G., additional, Vallely, Lisa M., additional, Fowkes, Freya J.I., additional, Morgan, Christopher J., additional, Pomat, William, additional, Crabb, Brendan S., additional, and Beeson, James G., additional

Published
2024
Full Text
View/download PDF

4. Quantifying differences in iron deficiency-attributable anemia during pregnancy and postpartum

Author

Davidson, Eliza M., Scoullar, Michelle J.L., Peach, Elizabeth, Morgan, Christopher J., Melepia, Pele, Opi, D. Herbert, Supsup, Hadlee, Hezeri, Priscah, Philip, Wilson, Kabiu, Dukduk, Tokmun, Kerryanne, Suruka, Rose, Fidelis, Ruth, Elijah, Arthur, Siba, Peter M., Pomat, William, Kombut, Benishar, Robinson, Leanne J., Crabb, Brendan S., Kennedy, Elissa, Boeuf, Philippe, Simpson, Julie A., Beeson, James G., and Fowkes, Freya J.I.

Published
2023
Full Text
View/download PDF

5. Millennium Development Goals in Papua New Guinea: Towards Universal Education

Author

Pham, Nguyen Bang, Okely, Anthony D., Whittaker, Maxine, Siba, Peter, and Pomat, William

Abstract

Globally, about 175 million children have no access to universal education in 2017. Nearly, 16 million young children in East Asia and Pacific Region are not enrolled into school, accounting for 19% of children in pre- and primary school age. This paper analyses surveillance data, extracted from the integrated Health and Demographic Surveillance System (iHDSS) database, developed by Papua New Guinea Institute of Medical Research in the period 2011-2017 to assess the implementation of Millennium Development Goals associated with universal education in Papua New Guinea (PNG). Net enrolment rate in primary education was 58%. Only 28% of children aged 7 were enrolled in Grade 1, and only 7% of children aged 15 years reached Grade 8 in the school year 2015. Late enrolment into Grade 1 among children aged 7 years was identified as the main cause of low net enrolment rate, leading to low completion rate of primary education in the following years and affecting the overall quality of universal education. Despite the improvement in gender equality, males had better access to education services than females as reflected in high male-to-female student ratios among the schooling age population, 5-24 years, which increased from 108 at primary to 132 at secondary and 181 at tertiary education. Educational policy-makers and practitioners should take immediate actions to improve net enrolment in Grade 1 and completion rate at primary education, as well as gender equality in education in PNG.

Published
2020
Full Text
View/download PDF

6. Plasmodium vivax spleen-dependent genes encode antigens associated with cytoadhesion and clinical protection

Author

Fernandez-Becerra, Carmen, Bernabeu, Maria, Castellanos, Angélica, Correa, Bruna R., Obadia, Thomas, Ramirez, Miriam, Rui, Edmilson, Hentzschel, Franziska, López-Montañés, Maria, Ayllon-Hermida, Alberto, Martin-Jaular, Lorena, Elizalde-Torrent, Aleix, Siba, Peter, Vêncio, Ricardo Z., Arevalo-Herrera, Myriam, Herrera, Sócrates, Alonso, Pedro L., Mueller, Ivo, and del Portillo, Hernando A.

Published
2020

7. Mycoplasma genitalium and Other Reproductive Tract Infections in Pregnant Women, Papua New Guinea, 2015-2017

Author

Scoullar, Michelle J.L., Boeuf, Philippe, Peach, Elizabeth, Fidelis, Ruth, Tokmun, Kerryanne, Melepia, Pele, Elijah, Arthur, Bradshaw, Catriona S., Fehler, Glenda, Siba, Peter M., Erskine, Simon, Mokany, Elisa, Kennedy, Elissa, Umbers, Alexandra J., Luchters, Stanley, Robinson, Leanne J., Wong, Nicholas C., Vallely, Andrew J., Badman, Steven G., Vallely, Lisa M., Fowkes, Freya J.I., Morgan, Christopher, Pomat, William, Crabb, Brendan S., Beeson, James G., and Team, Healthy Mothers Healthy Babies Study

Subjects
Genital diseases, Female -- Causes of, Mycoplasma genitalium -- Health aspects, Mycoplasma infections -- Statistics -- Demographic aspects, Pregnant women -- Health aspects, Health
Abstract

Reproductive tract infections (RTIs), including sexually transmitted infections (STIs), are preventable and often curable health conditions. Public health officials consider Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum subspecies [...]

Published
2021
Full Text
View/download PDF

8. A genomic history of Aboriginal Australia

Author

Malaspinas, Anna-Sapfo, Westaway, Michael C, Muller, Craig, Sousa, Vitor C, Lao, Oscar, Alves, Isabel, Bergström, Anders, Athanasiadis, Georgios, Cheng, Jade Y, Crawford, Jacob E, Heupink, Tim H, Macholdt, Enrico, Peischl, Stephan, Rasmussen, Simon, Schiffels, Stephan, Subramanian, Sankar, Wright, Joanne L, Albrechtsen, Anders, Barbieri, Chiara, Dupanloup, Isabelle, Eriksson, Anders, Margaryan, Ashot, Moltke, Ida, Pugach, Irina, Korneliussen, Thorfinn S, Levkivskyi, Ivan P, Moreno-Mayar, J Víctor, Ni, Shengyu, Racimo, Fernando, Sikora, Martin, Xue, Yali, Aghakhanian, Farhang A, Brucato, Nicolas, Brunak, Søren, Campos, Paula F, Clark, Warren, Ellingvåg, Sturla, Fourmile, Gudjugudju, Gerbault, Pascale, Injie, Darren, Koki, George, Leavesley, Matthew, Logan, Betty, Lynch, Aubrey, Matisoo-Smith, Elizabeth A, McAllister, Peter J, Mentzer, Alexander J, Metspalu, Mait, Migliano, Andrea B, Murgha, Les, Phipps, Maude E, Pomat, William, Reynolds, Doc, Ricaut, Francois-Xavier, Siba, Peter, Thomas, Mark G, Wales, Thomas, Wall, Colleen Ma’run, Oppenheimer, Stephen J, Tyler-Smith, Chris, Durbin, Richard, Dortch, Joe, Manica, Andrea, Schierup, Mikkel H, Foley, Robert A, Lahr, Marta Mirazón, Bowern, Claire, Wall, Jeffrey D, Mailund, Thomas, Stoneking, Mark, Nielsen, Rasmus, Sandhu, Manjinder S, Excoffier, Laurent, Lambert, David M, and Willerslev, Eske

Subjects
Africa, Australia, Datasets as Topic, Desert Climate, Gene Flow, Genetics, Population, Genome, Human, Genomics, History, Ancient, Human Migration, Humans, Language, Native Hawaiian or Other Pacific Islander, New Guinea, Phylogeny, Population Dynamics, Racial Groups, Tasmania, General Science & Technology
Abstract

The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ~10-32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama-Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51-72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert.

Published
2016

9. Risk factors and knowledge associated with high unintended pregnancy rates and low family planning use among pregnant women in Papua New Guinea

Author

Peach, Elizabeth, Morgan, Christopher, Scoullar, Michelle J. L., Fowkes, Freya J. I., Kennedy, Elissa, Melepia, Pele, Homiehombo, Primrose, Au, Lucy, Luchters, Stanley, Umbers, Alexandra J., Vallely, Andrew, Vallely, Lisa M., Kelly-Hanku, Angela, Robinson, Leanne J., Crabb, Brendan S., Elijah, Arthur, Siba, Peter M., Pomat, William, and Beeson, James G.

Published
2021
Full Text
View/download PDF

12. Defining malaria parasite population subdivisions, transmission dynamics and infection origins using SNP barcodes

Author

Harrison, G.L. Abby, primary, Mehra, Somya, additional, Razook, Zahra, additional, Tessier, Natacha, additional, Lee, Stuart, additional, Hetzel, Manuel W, additional, Tavul, Livingstone, additional, Laman, Moses, additional, Amato, Roberto, additional, Miotto, Olivo, additional, Makita, Leo, additional, Burke, Nicholas, additional, Jensen, Anne, additional, Kwiatkowski, Dominic, additional, Betuela, Inoni, additional, Siba, Peter M, additional, Bahlo, Melanie, additional, Mueller, Ivo, additional, and Barry, Alyssa E., additional

Published
2023
Full Text
View/download PDF

16. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Author

Abathina, Amadou, Abubakar, Ismaela, Achidi, Eric, Agbenyega, Tsiri, Aiyegbo, Mohammed, Akoto, Alex, Allen, Angela, Allen, Stephen, Amenga-Etego, Lucas, Amodu, Folakemi, Amodu, Olukemi, Anchang-Kimbi, Judith, Ansah, Nana, Ansah, Patrick, Ansong, Daniel, Antwi, Sampson, Anyorigiya, Thomas, Apinjoh, Tobias, Asafo-Agyei, Emmanuel, Asoala, Victor, Atuguba, Frank, Auburn, Sarah, Bah, Abdou, Bamba, Kariatou, Bancone, Germana, Band, Gavin, Barnwell, David, Barry, Abdoulaye, Bauni, Evasius, Besingi, Richard, Bojang, Kalifa, Bougouma, Edith, Bull, Susan, Busby, George, Camara, Abdoulie, Camara, Landing, Campino, Susana, Carter, Richard, Carucci, Dan, Casals-Pascual, Climent, Ceesay, Ndey, Ceesay, Pa, Chau, Tran, Chuong, Ly, Clark, Taane, Clarke, Geraldine, Cole-Ceesay, Ramou, Conway, David, Cook, Katharine, Cook, Olivia, Cornelius, Victoria, Corran, Patrick, Correa, Simon, Cox, Sharon, Craik, Rachel, Danso, Bakary, Davis, Timothy, Day, Nicholas, Deloukas, Panos, Dembele, Awa, deVries, Jantina, Dewasurendra, Rajika, Diakite, Mahamadou, Diarra, Elizabeth, Dibba, Yaya, Diss, Andrea, Djimdé, Abdoulaye, Dolo, Amagana, Doumbo, Ogobara, Doyle, Alan, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Dunstan, Sarah, Ebonyi, Augustine, Elhassan, Ahmed, Elhassan, Ibrahim, Elzein, Abier, Enimil, Anthony, Esangbedo, Pamela, Evans, Jennifer, Evans, Julie, Farrar, Jeremy, Fernando, Deepika, Fitzpatrick, Kathryn, Fullah, Janet, Garcia, Jacob, Ghansah, Anita, Gottleib, Michael, Green, Angie, Hart, Lee, Hennsman, Meike, Hien, Tran, Hieu, Nguyen, Hilton, Eliza, Hodgson, Abraham, Horstmann, Rolf, Hubbart, Christina, Hughes, Catherine, Hussein, Ayman, Hutton, Robert, Ibrahim, Muntaser, Ishengoma, Deus, Jaiteh, Jula, Jallow, Mariatou, Jallow, Muminatou, Jammeh, Kebba, Jasseh, Momodou, Jeffreys, Anna, Jobarteh, Amie, Johnson, Kimberly, Joseph, Sarah, Jyothi, Dushyanth, Kachala, David, Kamuya, Dorcas, Kanyi, Haddy, Karunajeewa, Harin, Karunaweera, Nadira, Keita, Momodou, Kerasidou, Angeliki, Khan, Aja, Kivinen, Katja, Kokwaro, Gilbert, Konate, Amadou, Konate, Salimata, Koram, Kwadwo, Kwiatkowski, Dominic, Laman, Moses, Le, Si, Leffler, Ellen, Lemnge, Martha, Lin, Enmoore, Ly, Alioune, Macharia, Alexander, MacInnis, Bronwyn, Mai, Nguyen, Makani, Julie, Malangone, Cinzia, Mangano, Valentina, Manjurano, Alphaxard, Manneh, Lamin, Manning, Laurens, Manske, Magnus, Marsh, Kevin, Marsh, Vicki, Maslen, Gareth, Maxwell, Caroline, Mbunwe, Eric, McCreight, Marilyn, Mead, Daniel, Mendy, Alieu, Mendy, Anthony, Mensah, Nathan, Michon, Pascal, Miles, Alistair, Miotto, Olivo, Modiano, David, Mohamed, Hiba, Molloy, Sile, Molyneux, Malcolm, Molyneux, Sassy, Moore, Mike, Moyes, Catherine, Mtei, Frank, Mtove, George, Mueller, Ivo, Mugri, Regina, Munthali, Annie, Mutabingwa, Theonest, Nadjm, Behzad, Ndi, Andre, Ndila, Carolyne, Newton, Charles, Niangaly, Amadou, Njie, Haddy, Njie, Jalimory, Njie, Madi, Njie, Malick, Njie, Sophie, Njiragoma, Labes, Nkrumah, Francis, Ntunthama, Neema, Nyika, Aceme, Nyirongo, Vysaul, O'Brien, John, Obu, Herbert, Oduro, Abraham, Ofori, Alex, Olaniyan, Subulade, Olaosebikan, Rasaq, Oluoch, Tom, Omotade, Olayemi, Oni, Olajumoke, Onykwelu, Emmanuel, Opi, Daniel, Orimadegun, Adebola, O'Riordan, Sean, Ouedraogo, Issa, Oyola, Samuel, Parker, Michael, Pearson, Richard, Pensulo, Paul, Peshu, Norbert, Phiri, Ajib, Phu, Nguyen, Pinder, Margaret, Pirinen, Matti, Plowe, Chris, Potter, Claire, Poudiougou, Belco, Puijalon, Odile, Quyen, Nguyen, Ragoussis, Ioannis, Ragoussis, Jiannis, Rasheed, Oba, Reeder, John, Reyburn, Hugh, Riley, Eleanor, Risley, Paul, Rockett, Kirk, Rodford, Joanne, Rogers, Jane, Rogers, William, Rowlands, Kate, Ruano-Rubio, Valentín, Sabally-Ceesay, Kumba, Sadiq, Abubacar, Saidy-Khan, Momodou, Saine, Horeja, Sakuntabhai, Anavaj, Sall, Abdourahmane, Sambian, David, Sambou, Idrissa, SanJoaquin, Miguel, Sepúlveda, Nuno, Shah, Shivang, Shelton, Jennifer, Siba, Peter, Silva, Nilupa, Simmons, Cameron, Simpore, Jaques, Singhasivanon, Pratap, Sinh, Dinh, Sirima, Sodiomon, Sirugo, Giorgio, Sisay-Joof, Fatoumatta, Sissoko, Sibiry, Small, Kerrin, Somaskantharajah, Elilan, Spencer, Chris, Stalker, Jim, Stevens, Marryat, Suriyaphol, Prapat, Sylverken, Justice, Taal, Bintou, Tall, Adama, Taylor, Terrie, Teo, Yik, Thai, Cao, Thera, Mahamadou, Titanji, Vincent, Toure, Ousmane, Troye-Blomberg, Marita, Usen, Stanley, Uyoga, Sophie, Vanderwal, Aaron, Wangai, Hannah, Watson, Renee, Williams, Thomas, Wilson, Michael, Wrigley, Rebecca, Yafi, Clarisse, Yamoah, Lawrence, Ndila, Carolyne M, Macharia, Alexander W, Nyutu, Gideon, Ojal, John, Shebe, Mohammed, Awuondo, Kennedy O, Mturi, Neema, Tsofa, Benjamin, Clark, Taane G, Kariuki, Silvia, Mackinnon, Margaret, Maitland, Kathryn, Kwiatkowski, Dominic P, Rockett, Kirk A, and Williams, Thomas N

Published
2018
Full Text
View/download PDF

26. Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Author

Abdel Hamid, Muzamil Mahdi, Abdelraheem, Mohamed Hassan, Acheampong, Desmond Omane, Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim, Andrianaranjaka, Voahangy, Aniebo, Ifeyinwa, Aninagyei, Enoch, Ansah, Felix, Ansah, Patrick, Apinjoh, Tobias, Arnaldo, Paulo, Ashley, Elizabeth, Auburn, Sarah, Awandare, Gordon, Ba, Hampate, Baraka, Vito, Barry, Alyssa, Bejon, Philip, Bertin, Gwladys, Boni, Maciej, Borrmann, Steffen, Bousema, Teun, Bouyou-Akotet, Marielle, Branch, Oralee, Bull, Peter, Cheah, Huch, Chindavongsa, Keobouphaphone, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David, Corredor, Vladimir, Courtier, Erin, Craig, Alister, d'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas, Denis, Brigitte, Dhorda, Mehul, Diakite, Mahamadou, Djimde, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen, Doumbia, Seydou, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego, Egwang, Thomas, Enosse, Sonia Maria Mauricio, Erko, Berhanu, Fairhurst, Rick, Faiz, Abdul, Fanello, Caterina, Fleharty, Mark, Forbes, Matthew, Fukuda, Mark, Gamboa, Dionicia, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Harrison, G, Healy, Sara Anne, Hendry, Jason, Hernandez-Koutoucheva, Anastasia, Hien, Tran Tinh, Hill, Catherine, Hombhanje, Francis, Hott, Amanda, Htut, Ye, Hussein, Mazza, Imwong, Mallika, Ishengoma, Deus, Jackson, Scott, Jacob, Chris, Jeans, Julia, Johnson, Kimberly, Kamaliddin, Claire, Kamau, Edwin, Keatley, Jon, Kochakarn, Theerarat, Konate, Drissa, Konaté, Abibatou, Kone, Aminatou, Kwiatkowski, Dominic, Kyaw, Myat, Kyle, Dennis, Lawniczak, Mara, Lee, Samuel, Lemnge, Martha, Lim, Pharath, Lon, Chanthap, Loua, Kovana, Mandara, Celine, Marfurt, Jutta, Marsh, Kevin, Maude, Richard James, Mayxay, Mayfong, Maïga-Ascofaré, Oumou, Miotto, Olivo, Mita, Toshihiro, Mobegi, Victor, Mohamed, Abdelrahim Osman, Mokuolu, Olugbenga, Montgomery, Jaqui, Morang'A, Collins Misita, Mueller, Ivo, Murie, Kathryn, Newton, Paul, Ngo Duc, Thang, Nguyen, Thuy, Nguyen, Thuy-Nhien, Nguyen Thi Kim, Tuyen, Nguyen Van, Hong, Noedl, Harald, Nosten, François, Noviyanti, Rintis, Ntui, Vincent Ntui-Njock, Nzila, Alexis, Ochola-Oyier, Lynette Isabella, Ocholla, Harold, Oduro, Abraham, Omedo, Irene, Onyamboko, Marie, Ouedraogo, Jean-Bosco, Oyebola, Kolapo, Oyibo, Wellington Aghoghovwia, Pearson, Richard, Peshu, Norbert, Phyo, Aung, Plowe, Christopher, Price, Ric, Pukrittayakamee, Sasithon, Quang, Huynh Hong, Randrianarivelojosia, Milijaona, Rayner, Julian, Ringwald, Pascal, Rosanas-Urgell, Anna, Rovira-Vallbona, Eduard, Ruano-Rubio, Valentin, Ruiz, Lastenia, Saunders, David, Shayo, Alex, Siba, Peter, Simpson, Victoria, Sissoko, Mahamadou, Smith, Christen, Su, Xin-Zhuan, Sutherland, Colin, Takala-Harrison, Shannon, Talman, Arthur, Tavul, Livingstone, Thanh, Ngo Viet, Thathy, Vandana, Thu, Aung Myint, Toure, Mahamoudou, Tshefu, Antoinette, Verra, Federica, Vinetz, Joseph, Wellems, Thomas, Wendler, Jason, White, Nicholas, Whitton, Georgia, Yavo, William, van der Pluijm, Rob, MalariaGEN, University of Khartoum, University of Cape Coast [Ghana], Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), The Wellcome Trust Sanger Institute [Cambridge], London School of Hygiene and Tropical Medicine [Fajara, Gambia], London School of Hygiene and Tropical Medicine (LSHTM), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), West African Centre for Cell Biology of Infectious Pathogens [Legon, Ghana] (WACCBIP), University of Ghana, Navrongo Health Research Centre [Navrongo, Ghana] (NHRC), Kenya Medical Research Institute (KEMRI), Texas Biomedical Research Institute [San Antonio, TX], Université d'Antananarivo, University of Buéa, Instituto Nacional de Saude [Maputo, Mozambique] (INS), Centre for Tropical Medicine and Global Health [Oxford, UK], Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford-University of Oxford, Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford-Mahidol University [Bangkok]-Wellcome Trust, Menzies School of Health Research [Australia], Charles Darwin University [Australia], Nuffield Department of Clinical Medicine [Oxford], University of Oxford, Institut de Recherche pour le Développement (IRD), Laboratory of Pathogen and Host Immunity [Montpellier] (LPHI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), and Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)

Subjects
data resource, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], plasmodium falciparum, genomics, malaria, Medicine (miscellaneous), genomic epidemiology, General Biochemistry, Genetics and Molecular Biology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Contains fulltext : 291985.pdf (Publisher’s version ) (Open Access) We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.

Published
2023

27. Insecticide-treated nets and malaria prevalence, Papua New Guinea, 2008-2014/Moustiquaires impregnees d'insecticides et prevalence du paludisme en Papouasie-Nouvelle-Guinee entre 2008 et 2014/Mosquiteros tratados con insecticida y prevalencia de la malaria, Papua Nueva Guinea, 2008-2014

Author

Hetzel, Manuel W., Pulford, Justin, Ura, Yangta, Jamea-Maiasa, Sharon, Tandrapah, Anthony, Tarongka, Nandao, Lorry, Lina, Robinson, Leanne J., Lilley, Ken, Makita, Leo, Siba, Peter M., and Mueller, Ivo

Subjects
Microscopy -- Usage, Infection -- Health aspects, Plasmodium falciparum -- Research, Malaria -- Health aspects -- Surveys -- Research, Health
Abstract

Objective To investigate changes in malaria prevalence in Papua New Guinea after the distribution of long-lasting Insecticide-treated nets, starting in 2004, and the introduction of artemisinin-based combination therapy in 2011. Methods Two malaria surveys were conducted in 2010-2011 and 2013-2014. They included 77 and 92 randomly selected villages, respectively. In each village, all members of 30 randomly selected households gave blood samples and were assessed for malaria infection by light microscopy. In addition, data were obtained from a malaria survey performed in 2008-2009. Results The prevalence of malaria below 1600 m in altitude decreased from 11.1% (95% confidence interval, CI: 8.5-14.3) in 2008-2009 to 5.1% (95% CI 3.6-7.4) in 2010-2011 and 0.9% (95% CI 0.6-1.5) in 2013-2014. Prevalence decreased with altitude. Plasmodium falciparum was more common than P. vivax overall, but not everywhere, and initially the prevalence of P. vivax infection decreased more slowly than P. falciparum infection. Malaria infections were clustered in households. In contrast to findings in 2008-2009, no significant association between net use and prevalence was found in the later two surveys. The prevalence of both fever and splenomegaly also decreased but their association with malaria infection became stronger. Conclusion Large-scale insecticide-treated net distribution was associated with an unprecedented decline in malaria prevalence throughout Papua New Guinea, including epidemic-prone highland areas.The decline was accompanied by broader health benefits, such as decreased morbidity. Better clinical management of nonmalarial fever and research into residual malaria transmission are required. Objectif Etudier les changements observes a legard de la prevalence du paludisme en Papouasie-Nouvelle-Gulnee suite a la distribution, depuis 2004, de moustiquaires impregnees d'Insecticides de longue duree et a l'introduction, depuis 2011, d'une combinaison therapeutique a base d'artemisinine. Methodes Deux enquetes portant sur le paludisme ont ete menees en 2010-2011 et 2013-2014. Elles incluaient respectivement 77 et 92 villages, selectionnes d'une maniere aleatoire. Dans chacun de ces villages, tous les membres de 30 foyers selectionnes aleatoirement ont donne des echantillons sanguins et ete soumis a un test de depistage de l'infection palustre par microscopie optique. Des donnees ont par ailleurs ete tirees d'une enquete sur le paludisme realisee en 2008-2009. Resultats La prevalencedu paludisme a moins de 1600 m d'altitude est passee de 11,1 % (intervalle de confiance, IC, a 95%: 8,5-14,3) en 2008-2009 a 5,1 % (IC a 95%: 3,6-7,4) en 2010-2011 et 0,9% (IC a 95%: 0,6-1,5) en 2013-2014. La prevalence diminuait avec l'altitude. Plasmodium falciparum n'etait pas systematiquement plus courant que R vivax, mais l'etait dans l'ensemble et, dans un premier temps, la prevalence de l'infection a R vivax a diminue plus lentement que la prevalence de l'Infection a P. falciparum. Les infections palustres ont ete regroupees par foyers. Contrairement a ce qu'indiquaient les resultats obtenus en 2008-2009, aucune correlation significative entre l'utilisation d'une moustiquaire et la prevalence n'a ete constatee dans le cadre des deux dernieres enquetes. Les prevalences de la fievre et de la splenomegalle ont egalement diminue, mais leur correlation avec l'infection palustre est devenue plus forte. Conclusion La distribution a grande echelle de moustiquaires impregnees d'insecticides a ete associee a un declin sans precedent de la prevalence du paludisme dans l'ensemble de la Papouasie-Nouvelle-Guinee, et notamment dans les reglons montagneuses sujettes aux epidemies. Ce declin s'est accompagne d'autres bienfaits sur la sante, et notamment d'une diminution de la morbidite. Il est necessaire d'ameliorer la prise en charge clinique de la fievre non palustre ainsi que les recherches sur la transmission residuelle du paludisme. Objetivo Investigar los cambios en la prevalencia de la malaria en Papua Nueva Guinea tras la distribucion de mosquiteros tratados con insecticida de larga duracion, a partir de 2004, y la introduccion de terapias combinadas basadas en la artemisinina en 2011. Metodos Se llevaron a cabo dos encuestas sobre la malaria en 2010-2011 y 2013-2014. Incluian 77y 92 aldeas seleccionadas al azar, respectivamente. En cada aldea, todos los miembros de 30 hogares seleccionados al azar dieron muestras de sangre y se evaluaron de infeccion de malaria con microscopio optico. Ademas, se obtuvieron datos de la encuesta sobre la malaria realizada en 2008-2009. Resultados La prevalencia de la malaria por debajo de 1600 m de altitud descendio del 11.1% (intervalo de confidencia (IC) del 95%: 8.5-14.3) en 2008-2009 al 5.1% (95% IC 3.6-7.4) en 2010-2011 y 0.9% (95% IC 0.6-1.5) en 2013-2014. La prevalencia descendia con la altitud. Plasmodium falciparum fue mas comun que P. vivax en general, pero no en todas partes e inicialmente la prevalencia de la infeccion P. vivax descendio mas lentamente que la infeccion P. falciparum. Las infecciones de malaria se agruparon en los hogares. Al contrario que los hallazgos en 2008-2009, no se encontro ninguna asociacion significativa entre el uso del mosquitero y la prevalencia en las dos ultimas encuestas. La prevalencia tanto de la fiebre como de la esplenomegalia tambien descendio, pero su asociacion con la infeccion de malaria se hizo mas fuerte. Conclusion La distribucion de mosquiteros tratados con insecticida a gran escala se asocio con un descenso sin precedentes en la prevalencia de la malaria en toda Papua Nueva Guinea, incluidas las areas altas con propension a causar epidemias. El descenso estuvo acompanado de beneficios saludables mas amplios, como el descenso de la morbilidad. Se requieren una mejor gestion clinica de la fiebre no relacionada con la malaria y la Investigacion de la transmision residual de la malaria., Introduction Historically, malaria has been endemic throughout Papua New Guinea, except in highland areas over 1600 m, where temperatures are low and there is no stable local transmission, though imported [...]

Published
2017

33. Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples

Author

MalariaGEN, Abdel Hamid, Muzamil Mahdi, Abdelraheem, Mohamed Hassan, Acheampong, Desmond Omane, Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim, Andrianaranjaka, Voahangy, Aniebo, Ifeyinwa, Aninagyei, Enoch, Ansah, Felix, Ansah, Patrick O, Apinjoh, Tobias, Arnaldo, Paulo, Ashley, Elizabeth, Auburn, Sarah, Awandare, Gordon A, Ba, Hampate, Baraka, Vito, Barry, Alyssa, Bejon, Philip, Bertin, Gwladys I, Boni, Maciej F, Borrmann, Steffen, Bousema, Teun, Bouyou-Akotet, Marielle, Branch, Oralee, Bull, Peter C, Cheah, Huch, Chindavongsa, Keobouphaphone, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David J, Corredor, Vladimir, Courtier, Erin, Craig, Alister, D'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas, Denis, Brigitte, Dhorda, Mehul, Diakite, Mahamadou, Djimde, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen, Doumbia, Seydou, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego F, Egwang, Thomas G, Enosse, Sonia Maria Mauricio, Erko, Berhanu, Fairhurst, Rick M, Faiz, Abdul, Fanello, Caterina A, Fleharty, Mark, Forbes, Matthew, Fukuda, Mark, Gamboa, Dionicia, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Harrison, GL Abby, Healy, Sara Anne, Hendry, Jason A, Hernandez-Koutoucheva, Anastasia, Hien, Tran Tinh, Hill, Catherine A, Hombhanje, Francis, Hott, Amanda, Htut, Ye, Hussein, Mazza, Imwong, Mallika, Ishengoma, Deus, Jackson, Scott A, Jacob, Chris G, Jeans, Julia, Johnson, Kimberly J, Kamaliddin, Claire, Kamau, Edwin, Keatley, Jon, Kochakarn, Theerarat, Konate, Drissa S, Konaté, Abibatou, Kone, Aminatou, Kwiatkowski, Dominic P, Kyaw, Myat P, Kyle, Dennis, Lawniczak, Mara, Lee, Samuel K, Lemnge, Martha, Lim, Pharath, Lon, Chanthap, Loua, Kovana M, Mandara, Celine I, Marfurt, Jutta, Marsh, Kevin, Maude, Richard James, Mayxay, Mayfong, Maïga-Ascofaré, Oumou, Miotto, Olivo, Mita, Toshihiro, Mobegi, Victor, Mohamed, Abdelrahim Osman, Mokuolu, Olugbenga A, Montgomery, Jaqui, Morang'a, Collins Misita, Mueller, Ivo, Murie, Kathryn, Newton, Paul N, Ngo Duc, Thang, Nguyen, Thuy, Nguyen, Thuy-Nhien, Nguyen Thi Kim, Tuyen, Nguyen Van, Hong, Noedl, Harald, Nosten, Francois, Noviyanti, Rintis, Ntui, Vincent Ntui-Njock, Nzila, Alexis, Ochola-Oyier, Lynette Isabella, Ocholla, Harold, Oduro, Abraham, Omedo, Irene, Onyamboko, Marie A, Ouedraogo, Jean-Bosco, Oyebola, Kolapo, Oyibo, Wellington Aghoghovwia, Pearson, Richard, Peshu, Norbert, Phyo, Aung P, Plowe, Christopher V, Price, Ric N, Pukrittayakamee, Sasithon, Quang, Huynh Hong, Randrianarivelojosia, Milijaona, Rayner, Julian C, Ringwald, Pascal, Rosanas-Urgell, Anna, Rovira-Vallbona, Eduard, Ruano-Rubio, Valentin, Ruiz, Lastenia, Saunders, David, Shayo, Alex, Siba, Peter, Simpson, Victoria J, Sissoko, Mahamadou S, Smith, Christen, Su, Xin-Zhuan, Sutherland, Colin, Takala-Harrison, Shannon, Talman, Arthur, Tavul, Livingstone, Thanh, Ngo Viet, Thathy, Vandana, Thu, Aung Myint, Toure, Mahamoudou, Tshefu, Antoinette, Verra, Federica, Vinetz, Joseph, Wellems, Thomas E, Wendler, Jason, White, Nicholas J, Whitton, Georgia, Yavo, William, Van Der Pluijm, Rob W, Amenga-Etego, Lucas [0000-0003-4468-0506], Anderson, Tim [0000-0002-0191-0204], Ansah, Patrick O [0000-0002-3214-5621], Ashley, Elizabeth [0000-0002-7620-4822], Ba, Hampate [0000-0002-9299-5775], Baraka, Vito [0000-0001-9694-9293], Bejon, Philip [0000-0002-2135-7549], Bertin, Gwladys I [0000-0002-2218-9591], Boni, Maciej F [0000-0002-0830-9630], Bousema, Teun [0000-0003-2666-094X], Chookajorn, Thanat [0000-0003-2876-6203], Claessens, Antoine [0000-0002-4277-0914], Conway, David J [0000-0002-8711-3037], Craig, Alister [0000-0003-0914-6164], D'Alessandro, Umberto [0000-0001-6341-5009], Day, Nicholas [0000-0003-2309-1171], Diakite, Mahamadou [0000-0002-4268-8857], Djimde, Abdoulaye [0000-0003-0062-2283], Dondorp, Arjen [0000-0001-5190-2395], Drakeley, Chris [0000-0003-4863-075X], Echeverry, Diego F [0000-0003-0301-4478], Erko, Berhanu [0000-0003-1685-752X], Faiz, Abdul [0000-0002-3460-7535], Fanello, Caterina A [0000-0003-1932-9562], Gamboa, Dionicia [0000-0002-1420-7729], Golassa, Lemu [0000-0002-1216-8711], Healy, Sara Anne [0000-0003-3078-6094], Ishengoma, Deus [0000-0003-2040-3416], Jackson, Scott A [0000-0002-3172-1607], Kamaliddin, Claire [0000-0001-8198-6235], Kamau, Edwin [0000-0002-5761-7883], Konate, Drissa S [0000-0002-4177-9642], Kwiatkowski, Dominic P [0000-0002-5023-0176], Kyle, Dennis [0000-0002-0238-965X], Lawniczak, Mara [0000-0002-3006-2080], Loua, Kovana M [0000-0003-0571-0944], Marsh, Kevin [0000-0001-8377-5466], Mayxay, Mayfong [0000-0002-6056-4516], Miotto, Olivo [0000-0001-8060-6771], Mita, Toshihiro [0000-0001-8180-2344], Mobegi, Victor [0000-0002-1962-5583], Morang'a, Collins Misita [0000-0002-6988-150X], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Ntui, Vincent Ntui-Njock [0000-0002-7532-9930], Oduro, Abraham [0000-0002-4191-7419], Onyamboko, Marie A [0000-0002-7501-5931], Ouedraogo, Jean-Bosco [0000-0003-0412-8733], Oyebola, Kolapo [0000-0002-1003-2570], Pearson, Richard [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Rosanas-Urgell, Anna [0000-0002-0432-5203], Shayo, Alex [0000-0002-7099-8537], Su, Xin-Zhuan [0000-0003-3246-3248], Vinetz, Joseph [0000-0001-8344-2004], Wellems, Thomas E [0000-0003-3899-8454], and Apollo - University of Cambridge Repository

Subjects
data resource, plasmodium falciparum, genomics, malaria, genomic epidemiology
Abstract

We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.

Published
2023

34. Additional file 1 of Low knowledge of newborn danger signs among pregnant women in Papua New Guinea and implications for health seeking behaviour in early infancy – findings from a longitudinal study

Author

Eghrari, Donya, Scoullar, Michelle J. L., Wilson, Alyce N., Peach, Elizabeth, Elijah, Arthur, Melepia, Pele, SupSup, Hadlee, Vallely, Lisa M., Siba, Peter M., Kennedy, Elissa C., Vogel, Joshua P., Homer, Caroline S. E., Robinson, Leanne J., Fowkes, Freya J. I., Pomat, William, Crabb, Brendan S., Beeson, James G., and Morgan, Christopher J.

Abstract

Additional file 1.

Published
2023
Full Text
View/download PDF

39. Population Structure and Migration in the Eastern Highlands of Papua New Guinea; a Region Impacted by the kuru Epidemic

Author

Quinn, Liam, primary, Moltke, Ida, additional, Whitfield, Jerome, additional, Alpers, Michael, additional, Campbell, Tracy, additional, Hummerich, Holger, additional, Pomat, William, additional, Siba, Peter, additional, Koki, George, additional, Collinge, John, additional, Hellenthal, Garrett, additional, and Mead, Simon, additional

Published
2022
Full Text
View/download PDF

41. A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies

Author

Chan, Jo-Anne, Howell, Katherine B., Langer, Christine, Maier, Alexander G., Hasang, Wina, Rogerson, Stephen J., Petter, Michaela, Chesson, Joanne, Stanisic, Danielle I., Duffy, Michael F., Cooke, Brian M., Siba, Peter M., Mueller, Ivo, Bull, Peter C., Marsh, Kevin, Fowkes, Freya J.I., and Beeson, James G.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results