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2. Non-Invasive Imaging in Coronary Syndromes: Recommendations of The European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration with The American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance

Author

Edvardsen, Thor, Asch, Federico M., Davidson, Brian, Delgado, Victoria, DeMaria, Anthony, Dilsizian, Vasken, Gaemperli, Oliver, Garcia, Mario J., Kamp, Otto, Lee, Daniel C., Neglia, Danilo, Neskovic, Aleksandar N., Pellikka, Patricia A., Plein, Sven, Sechtem, Udo, Shea, Elaine, Sicari, Rosa, Villines, Todd C., Lindner, Jonathan R., and Popescu, Bogdan A.

Published
2022
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3. A randomized multicenter trial on a lung ultrasound–guided treatment strategy in patients on chronic hemodialysis with high cardiovascular risk

Author

Zoccali, Carmine, Torino, Claudia, Mallamaci, Francesca, Sarafidis, Pantelis, Papagianni, Aikaterini, Ekart, Robert, Hojs, Radovan, Klinger, Marian, Letachowicz, Krzysztof, Fliser, Danilo, Seiler-Mußler, Sarah, Lizzi, Fabio, Wiecek, Andrzej, Miskiewicz, Agata, Siamopoulos, Kostas, Balafa, Olga, Slotki, Itzchak, Shavit, Linda, Stavroulopoulos, Aristeidis, Covic, Adrian, Siriopol, Dimitrie, Massy, Ziad A., Seidowsky, Alexandre, Battaglia, Yuri, Martinez-Castelao, Alberto, Polo-Torcal, Carolina, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Fiaccadori, Enrico, Regolisti, Giuseppe, Hannedouche, Thierry, Bachelet, Thomas, Jager, Kitty J., Dekker, Friedo W., Tripepi, Rocco, Tripepi, Giovanni, Gargani, Luna, Sicari, Rosa, Picano, Eugenio, and London, Gérard Michel

Published
2021
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5. Inflammation is an amplifier of lung congestion by high lv filling pressure in hemodialysis patients: a longitudinal study

Author

Torino, Claudia, Gargani, Luna, Sicari, Rosa, Letachowicz, Krzysztof, Ekart, Robert, Fliser, Danilo, Covic, Adrian, Siamopoulos, Kostas, Stavroulopoulos, Aristeidis, Massy, Ziad A., Fiaccadori, Enrico, Regolisti, Giuseppe, Bachelet, Thomas, Slotki, Itzchak, Martinez-Castelao, Alberto, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Hannedouche, Thierry, Wiecek, Andrzej, Sarafidis, Pantelis, Battaglia, Yuri, Prohić, Nejra, Klinger, Marian, Hojs, Radovan, Seiler-Mußler, Sarah, Lizzi, Fabio, Siriopol, Dimitrie, Balafa, Olga, Shavit, Linda, Loutradis, Charalampos, Seidowsky, Alexandre, Tripepi, Rocco, Mallamaci, Francesca, Tripepi, Giovanni, Picano, Eugenio, London, Gérard Michel, and Zoccali, Carmine

Published
2020
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6. Inflammation is an amplifier of lung congestion by high lv filling pressure in hemodialysis patients: a longitudinal study

Author

Torino, Claudia, Gargani, Luna, Sicari, Rosa, Letachowicz, Krzysztof, Ekart, Robert, Fliser, Danilo, Covic, Adrian, Siamopoulos, Kostas, Stavroulopoulos, Aristeidis, Massy, Ziad A., Fiaccadori, Enrico, Regolisti, Giuseppe, Bachelet, Thomas, Slotki, Itzchak, Martinez-Castelao, Alberto, Coudert-Krier, Marie-Jeanne, Rossignol, Patrick, Hannedouche, Thierry, Wiecek, Andrzej, Sarafidis, Pantelis, Battaglia, Yuri, Prohić, Nejra, Klinger, Marian, Hojs, Radovan, Seiler-Mußler, Sarah, Lizzi, Fabio, Siriopol, Dimitrie, Balafa, Olga, Shavit, Linda, Loutradis, Charalampos, Seidowsky, Alexandre, Tripepi, Rocco, Mallamaci, Francesca, Tripepi, Giovanni, Picano, Eugenio, London, Gérard Michel, and Zoccali, Carmine

Abstract

Introduction: Since inflammation alters vascular permeability, including vascular permeability in the lung, we hypothesized that it can be an amplifier of lung congestion in a category of patients at high risk for pulmonary oedema like end stage kidney disease (ESKD) patients. Objective and methods: We investigated the effect modification by systemic inflammation (serum CRP) on the relationship between a surrogate of the filling pressure of the LV [left atrial volume indexed to the body surface area (LAVI)] and lung water in a series of 220 ESKD patients. Lung water was quantified by the number of ultrasound B lines (US-B) on lung US. Six-hundred and three recordings were performed during a 2-year follow up. Longitudinal data analysis was made by the Mixed Linear Model. Results: At baseline, 88 had absent, 101 had mild to moderate lung congestion and 31 severe congestion. The number of US B lines associated with LAVI (r= 0.23, P< 0.001) and serum CRP was a robust modifier of this relationship (P< 0.001). Similarly, in fully adjusted longitudinal analyses US-B lines associated with simultaneous estimates of LAVI (P= 0.002) and again CRP was a strong modifier of this relationship in adjusted analyses (P≤ 0.01). Overall, at comparable LAVI levels, lung congestion was more pronounced in inflamed than in non-inflamed patients. Conclusion: In ESKD systemic inflammation is a modifier of the relationship between LAVI, an integrate measure of LV filling pressure, and lung water. For any given pressure, lung water is increased with higher CRP levels, likely reflecting a higher permeability of the alveolar-capillary barrier.

Published
2024
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14. Prognostic Role of Sonographic Decongestion in Patients with Acute Heart Failure with Reduced and Preserved Ejection Fraction: A Multicentre Study

Author

Pugliese, Nicola R., primary, Mazzola, Matteo, additional, Bandini, Giulia, additional, Barbieri, Greta, additional, Spinelli, Stefano, additional, De Biase, Nicolò, additional, Masi, Stefano, additional, Moggi-Pignone, Alberto, additional, Ghiadoni, Lorenzo, additional, Taddei, Stefano, additional, Sicari, Rosa, additional, Pang, Peter S., additional, De Carlo, Marco, additional, and Gargani, Luna, additional

Published
2023
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15. Prognostic role of stress echocardiography in hypertrophic cardiomyopathy: The International Stress Echo Registry

Author

Ciampi, Quirino, Olivotto, Iacopo, Gardini, Chiara, Mori, Fabio, Peteiro, Jesus, Monserrat, Lorenzo, Fernandez, Xusto, Cortigiani, Lauro, Rigo, Fausto, Lopes, Luis Rocha, Cruz, Ines, Cotrim, Carlos, Losi, Mariangela, Betocchi, Sandro, Beleslin, Branko, Tesic, Milorad, Dikic, Ana Djordjevic, Lazzeroni, Ettore, Lazzeroni, Davide, Sicari, Rosa, and Picano, Eugenio

Published
2016
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16. A New Integrated Clinical-Biohumoral Model to Predict Functionally Significant Coronary Artery Disease in Patients With Chronic Chest Pain

Author

Caselli, Chiara, Rovai, Daniele, Lorenzoni, Valentina, Carpeggiani, Clara, Teresinska, Anna, Aguade, Santiago, Todiere, Giancarlo, Gimelli, Alessia, Schroeder, Stephen, Casolo, Giancarlo, Poddighe, Rosa, Pugliese, Francesca, Le Guludec, Dominique, Valente, Serafina, Sambuceti, Gianmario, Perrone-Filardi, Pasquale, Del Ry, Silvia, Marinelli, Martina, Nekolla, Stephan, Pietila, Mikko, Lombardi, Massimo, Sicari, Rosa, Scholte, Arthur, Zamorano, José, Kaufmann, Philipp A., Underwood, S. Richard, Knuuti, Juhani, Giannessi, Daniela, and Neglia, Danilo

Published
2015
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19. Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome

Author

Myhre, Peder L., primary, Røsjø, Helge, additional, Sarvari, Sebastian I., additional, Ukkonen, Heikki, additional, Rademakers, Frank, additional, Engvall, Jan E., additional, Hagve, Tor-Arne, additional, Nagel, Eike, additional, Sicari, Rosa, additional, Zamorano, Jose L., additional, Monaghan, Mark, additional, D'hooge, Jan, additional, Edvardsen, Thor, additional, and Omland, Torbjørn, additional

Published
2022
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27. Non-Invasive Imaging in Coronary Syndromes: Recommendations of The European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration with The American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance

Author

Edvardsen, Thor, primary, Asch, Federico M., additional, Davidson, Brian, additional, Delgado, Victoria, additional, DeMaria, Anthony, additional, Dilsizian, Vasken, additional, Gaemperli, Oliver, additional, Garcia, Mario J., additional, Kamp, Otto, additional, Lee, Daniel C., additional, Neglia, Danilo, additional, Neskovic, Aleksandar N., additional, Pellikka, Patricia A., additional, Plein, Sven, additional, Sechtem, Udo, additional, Shea, Elaine, additional, Sicari, Rosa, additional, Villines, Todd C., additional, Lindner, Jonathan R., additional, and Popescu, Bogdan A., additional

Published
2022
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35. Non-invasive imaging in coronary syndromes: recommendations of the European Association of Cardiovascular Imaging and the American Society of Echocardiography, in collaboration with the American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance

Author

Edvardsen, Thor, primary, Asch, Federico M, additional, Davidson, Brian, additional, Delgado, Victoria, additional, DeMaria, Anthony, additional, Dilsizian, Vasken, additional, Gaemperli, Oliver, additional, Garcia, Mario J, additional, Kamp, Otto, additional, Lee, Daniel C, additional, Neglia, Danilo, additional, Neskovic, Aleksandar N, additional, Pellikka, Patricia A, additional, Plein, Sven, additional, Sechtem, Udo, additional, Shea, Elaine, additional, Sicari, Rosa, additional, Villines, Todd C, additional, Lindner, Jonathan R, additional, and Popescu, Bogdan A, additional

Published
2021
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44. Vascular Function Is Improved After an Environmental Enrichment Program

Author

Bruno, Rosa Maria, Stea, Francesco, Sicari, Rosa, Ghiadoni, Lorenzo, Taddei, Stefano, Ungar, Andrea, Bonuccelli, Ubaldo, Tognoni, Gloria, Cintoli, Simona, Del Turco, Serena, Sbrana, Silverio, Gargani, Luna, D'Angelo, Gennaro, Pratali, Lorenza, Berardi, Nicoletta, Maffei, Lamberto, Picano Eugenio, on behalf of Train the Brain Consortium. Full list of consortium members: Maffei L, Picano E, Andreassi MG, Angelucci A, Baldacci F, Baroncelli L, Begenisic T, Bellinvia PF, Berardi N, Biagi L, Bonaccorsi J, Bonanni E, Bonuccelli U, Borghini A, Braschi C, Broccardi M, Bruno RM, Caleo M, Carlesi C, Carnicelli L, Cartoni G, Cecchetti L, Cenni MC, Ceravolo R, Chico L, Cintoli S, Cioni G, Costa M, D’Angelo G, D’Ascanio P, De Nes M, Del Turco S, Di Coscio E, Di Galante M, di Lascio N, Faita F, Falorni I, Faraguna U, Fenu A, Fortunato L, Franco R, Gargani L, Gargiulo R, Ghiadoni L, Giorgi FS, Iannarella R, Iofrida C, Kusmic C, Limongi F, Maestri M, Maffei M, Maggi S, Mainardi M, Mammana L, Marabotti A, Mariotti V, Melissari E, Mercuri A, Molinaro S, Narducci R, Navarra T, Noale M, Pagni C, Palumbo S, Pasquariello R, Pellegrini S, Pietrini P, Pizzorusso T, Poli A, Pratali L, Retico A, Ricciardi E, Rota G, Sale A, Sbrana S, Scabia G, Scali M, Scelfo D, Sicari R, Siciliano G, Stea F, Taddei S, Tognoni G, Tonacci A, Tosetti M, Turchi S, Volpi L, Bruno, Rosa Maria, Stea, Francesco, Sicari, Rosa, Ghiadoni, Lorenzo, Taddei, Stefano, Ungar, Andrea, Bonuccelli, Ubaldo, Tognoni, Gloria, Cintoli, Simona, Del Turco, Serena, Sbrana, Silverio, Gargani, Luna, D'Angelo, Gennaro, Pratali, Lorenza, Berardi, Nicoletta, Maffei, Lamberto, Picano, Eugenio, on behalf of Train the Brain Consortium., Full list of consortium members: Maffei L, Picano, E, Andreassi, Mg, Angelucci, A, Baldacci, F, Baroncelli, L, Begenisic, T, Bellinvia, Pf, Berardi, N, Biagi, L, Bonaccorsi, J, Bonanni, E, Bonuccelli, U, Borghini, A, Braschi, C, Broccardi, M, Bruno, Rm, Caleo, M, Carlesi, C, Carnicelli, L, Cartoni, G, Cecchetti, L, Cenni, Mc, Ceravolo, R, Chico, L, Cintoli, S, Cioni, G, Costa, M, D’Angelo, G, D’Ascanio, P, De Nes, M, Del Turco, S, Di Coscio, E, Di Galante, M, di Lascio, N, Faita, F, Falorni, I, Faraguna, U, Fenu, A, Fortunato, L, Franco, R, Gargani, L, Gargiulo, R, Ghiadoni, L, Giorgi, F, Iannarella, R, Iofrida, C, Kusmic, C, Limongi, F, Maestri, M, Maffei, M, Maggi, S, Mainardi, M, Mammana, L, Marabotti, A, Mariotti, V, Melissari, E, Mercuri, A, Molinaro, S, Narducci, R, Navarra, T, Noale, M, Pagni, C, Palumbo, S, Pasquariello, R, Pellegrini, S, Pietrini, P, Pizzorusso, T, Poli, A, Pratali, L, Retico, A, Ricciardi, E, Rota, G, Sale, A, Sbrana, S, Scabia, G, Scali, M, Scelfo, D, Sicari, R, Siciliano, G, Stea, F, Taddei, S, Tognoni, G, Tonacci, A, Tosetti, M, Turchi, S, and Volpi, L

Subjects
Male, control groups, medicine.medical_specialty, Brachial Artery, Pulse Wave Analysis, 030204 cardiovascular system & hematology, 03 medical and health sciences, endothelial progenitor cell, 0302 clinical medicine, cognitive dysfunction, Internal medicine, medicine.artery, Internal Medicine, medicine, human, Brachial artery, Cognitive decline, humans, Pulse wave velocity, Aged, endothelial progenitor cells, Aged, 80 and over, Environmental enrichment, business.industry, control group, Area under the curve, Neuropsychology, Brain, vascular stiffness, Cognition, Middle Aged, medicine.disease, Exercise Therapy, Vasodilation, Cross-Sectional Studies, Cardiovascular Diseases, Cardiology, Female, Endothelium, Vascular, Alzheimer's disease, business, 030217 neurology & neurosurgery
Abstract

Environmental enrichment may slow cognitive decay possibly acting through an improvement in vascular function. Aim of the study was to assess the effects of a 7-month cognitive, social, and physical training program on cognitive and vascular function in patients with mild cognitive impairment. In a single-center, randomized, parallel-group study, 113 patients (age, 65–89 years) were randomized to multidomain training (n=55) or usual care (n=58). All participants underwent neuropsychological tests and vascular evaluation, including brachial artery flow-mediated dilation, carotid–femoral pulse wave velocity, carotid distensibility, and assessment of circulating hematopoietic CD34+ and endothelial progenitor cells. At study entry, an age-matched control group (n=45) was also studied. Compared with controls, patients had at study entry a reduced flow-mediated dilation (2.97±2.14% versus 3.73±2.06%; P =0.03) and hyperemic stimulus (shear rate area under the curve, 19.1±15.7 versus 25.7±15.1×10 −3 ; P =0.009); only the latter remained significant after adjustment for confounders ( P =0.03). Training improved Alzheimer disease assessment scale cognitive (training, 14.0±4.8 to 13.1±5.5; nontraining, 12.1±3.9 to 13.2±4.8; P for interaction visit×training=0.02), flow-mediated dilation (2.82±2.19% to 3.40±1.81%, 3.05±2.08% to 2.24±1.59%; P =0.006; P =0.023 after adjustment for diameter and shear rate area under the curve), and circulating hematopoietic CD34 + cells and prevented the decline in carotid distensibility (18.4±5.3 to 20.0±6.6, 23.9±11.0 to 19.5±7.1 Pa −1 ; P =0.005). The only clinical predictor of improvement of cognitive function after training was established hypertension. There was no correlation between changes in measures of cognitive and vascular function. In conclusion, a multidomain training program slows cognitive decline, especially in hypertensive individuals. This effect is accompanied by improved systemic endothelial function, mobilization of progenitor CD34 + cells, and preserved carotid distensibility. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01725178.

Published
2018

48. The multi-modality cardiac imaging approach to the Athleteʼs heart: an expert consensus of the European Association of Cardiovascular Imaging

Author

Galderisi, Maurizio, Cardim, Nuno, DʼAndrea, Antonello, Bruder, Oliver, Cosyns, Bernard, Davin, Laurent, Donal, Erwan, Edvardsen, Thor, Freitas, Antonio, Habib, Gilbert, Kitsiou, Anastasia, Plein, Sven, Petersen, Steffen E., Popescu, Bogdan A., Schroeder, Stephen, Burgstahler, Christof, Lancellotti, Patrizio, Sicari, Rosa, Muraru, Denisa, Lombardi, Massimo, Dulgheru, Raluca, and Gerche, Andre La

Published
2015
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49. Indications for cardiovascular magnetic resonance in children with congenital and acquired heart disease: an expert consensus paper of the Imaging Working Group of the AEPC and the Cardiovascular Magnetic Resonance Section of the EACVI

Author

Valsangiacomo Buechel, E.R., Grosse-Wortmann, L., Fratz, S., Eichhorn, J., Sarikouch, S., Greil, G.F., Beerbaum, P., Bucciarelli-Ducci, C., Bonello, B., Sieverding, L., Schwitter, J., Helbing, W.A., Galderisi, Maurizio, Miller, Owen, Sicari, Rosa, Simpson, John, Thaulow, Erik, Edvardsen, Thor, Brockmeier, Konrad, Qureshi, Shakeel, and Stein, Joerg

Published
2015
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50. Role of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of Cardiovascular Imaging Endorsed by the Saudi Heart Association

Author

Cardim, Nuno, Galderisi, Maurizio, Edvardsen, Thor, Plein, Sven, Popescu, Bogdan A., DʼAndrea, Antonello, Bruder, Oliver, Cosyns, Bernard, Davin, Laurent, Donal, Erwan, Freitas, Antonio, Habib, Gilbert, Kitsiou, Anastasia, Petersen, Steffen E., Schroeder, Stephen, Lancellotti, Patrizio, Camici, Paolo, Dulgheru, Raluca, Hagendorff, Andreas, Lombardi, Massimo, Muraru, Denisa, and Sicari, Rosa

Published
2015
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