Search

Your search keyword '"Siede W"' showing total 280 results
Start Over Author "Siede W"
280 results on '"Siede W"'

3. Postersitzung 2: Das metastasierte Prostatakarzinom

Author

die urologische Arbeitsgruppe Süd-Ost Niederlande, Seitz, G., Kolles, H., Niemeyer, A.-H., Wernert, N., Dhom, G., Allhoff, E., Franzen, W., Engelking, R., Csapo, Z., Weißmüller, J., Sigel, A., Oremek, G., Seiffert, U. B., Siede, W. H., Kirsten, R., Heinert, G., Breul, J., Kreuzfelder, E., Behrendt, J., Kirchheimer, J. C., Christ, G., Pflüger, H., Binder, B. R., Helpap, B., Abadi, H.-Al, Nagel, R., Wallenberg Pachaly, H. V., Gatto, M., Fernandez del Moral, P., Hoefakker, J. W., Debruyne, F. M. J., Kramer, W., Sandow, J., Althoff, P.-H., Balducci, M., Jonas, D., Bergner, S., Ringert, R. H., Rössler, W., Wieland, W., Tischer, F., Peters, H.-P., Wirth, M., Grups, J., Heckl, W., Frohmüller, H., Walther, R., Schrott, K. M., Petrow, V., Frankenschmidt, A., Sommerkamp, H., Wenderoth, U. K., Frohneberg, D., Elsäßer, E., Hautmann, R., Elsäßer, A., Jacobi, G. H., and Ackermann, Rolf, editor

Published
1988
Full Text
View/download PDF

4. Nephrologie

Author

Burghardt, W., Wernze, H., Tittor, W., Knebel, L., Tschöpe, W., Potempa, J., Ritz, E., Sprenger, K. B. G., Krivan, V., Geiger, H., Franz, H. E., Rumpf, K. W., Kaiser, H., Goebel, H.-H., Wagner, H. A., Ullmann, B., Scheler, F., Niese, D., Dreßen, P., Hiester, E., Gilsdorf, K., Schmidt, R. E., Dengler, H. J., Schauder, P., Schröder, K., Herbertz, L., Matthaei, D., Henning, H. V., Langenbeck, U., Heidemann, H., Kirch, W., Gerkens, J., Branch, R., Grützmacher, P., Siede, W., Peschke, B., Riepenhausen, J., Buck, M., Schoeppe, W., Passlick, J., Frank, A., Berger, M., Grabensee, B., Cremer, W., Graben, N., Krieger, K. P., Boesken, W. H., Hörth, G., Maas, D., Schollmeyer, P., Heidbreder, E., Dorer, J., Hörl, W. H., Heidland, A., Kopsa, H., Czech, W., Schmidt, P., Zazgornik, J., Balcke, P., Minar, E., Deutsch, E., Quintes, W., Kuhn, F.-P., Geisler-Quintes, A., Weber, M., Keidel, E., Köhler, H., Reinhard, U., Mikulla, A., Schwarz, A., Seyfert, S., Keller, F., Molzahn, M., Neumayer, H.-H., Gregor, M., Wagner, K., Pickartz, H., Sörensen, R., Riecken, E.-O., Tscholakoff, D., Marosi, L., Czembirek, H., Mann, H., Maurin, N., Ziegan, R., Stiller, S., Arnold, W., Renschin, G., Dormeyer, H. H., Meyer zum Büschenfelde, K.-H., Königshausen, T., Hein, D., Wanzlick, J., Steinhauer, H. B., Günter, B., Klehr, H. U., von Burgsdorff, H. H., Kaschell, H. J., Münch, H. G., Castro, L. A., Hillebrand, G., Schneider, B., Land, W., Gurland, H. J., Scharf, R. E., Grzibiela, W., Hartmann, B., Schnurr, E., Schneider, W., Trengut, H., Nyman, U., Hildell, J., Husberg, B., Schulz, E., Dennin, R. H., Sack, K., Herhahn, J., Hoyer, J., and Schlegel, Bernhard, editor

Published
1983
Full Text
View/download PDF

21. Structural aspects of polycyclic aromatic carcinogen-damaged DNA and its recognition by NER proteins

Author

Siede, Wolfram, Kow, Yoke Wah, Doetsch, Paul W, Siede, W ( Wolfram ), Kow, Y W ( Yoke Wah ), Doetsch, P W ( Paul W ), Geacintov, Nicolas, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Patel, Dinshaw, Broyde, Suse, Siede, Wolfram, Kow, Yoke Wah, Doetsch, Paul W, Siede, W ( Wolfram ), Kow, Y W ( Yoke Wah ), Doetsch, P W ( Paul W ), Geacintov, Nicolas, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Patel, Dinshaw, and Broyde, Suse

Published
2006

36. Influence of different inhibitors on the activity of the RAD54 dependent step of DNA repair in Saccharomyces cerevisiae.

Author

Siede, W., Obermaier, Sabine, and Eckardt, Friederike

Abstract

The recombinagenic pathway of DNA repair in yeast was characterized by the effect of different inhibitors on the temperature-dependent survival after γ-irradiation in haploid cells of the thermoconditional mutant rad54-3. Blocking protein synthesis with cycloheximide in replicating cells caused partial inhibiton of the RAD54 dependent function but some repair activity remained detectable. This indicates that γ-rays can induce RAD54 activity above some constitutive level of function. Inhibition of DNA replication by hydroxyurea efficiently blocked the RAD54 dependent function in stationary-phase cells but not in logarithmic-phase cells. In logarithmic-phase cells, we found a strong inhibitory effect of caffeine on the RAD54 mediated repair process. [ABSTRACT FROM AUTHOR]

Published
1985
Full Text
View/download PDF

40. Regulation of the RAD2 gene of Saccharomyces cerevisiae.

Author

Siede, W., Robinson, G. W., Kalainov, D., Malley, T., and Friedberg, E. C.

Subjects
SACCHAROMYCES cerevisiae, MESSENGER RNA, SACCHAROMYCES, CELLS, SACCHAROMYCETACEAE, BIOCHEMICAL genetics, CELL division
Abstract

Regulation of the DNA damage-inducible RAD2 gene was investigated in yeast cells transformed with centromeric plasmids containing RAD2-lacZ fusion constructs. Deletion analysis defined several regions in the 350 bp region upstream of the translational start codon which are required for induction of β-galactosidase activity. No deletions resulted in constitutivety enhanced expression. We therefore conclude that induction of RAD2 by DNA-damaging agents is positively regulated. Two domains required for induction have a similar sequence and are located -70 and ∼140bp upstream of the major transcriptional start site. Four other sequence domains required for induction contain uninterrupted poly(dA) poly(dT) stretches 9–13 bp long. Deletion of some of these AT-rich domains also affects constitutive expression of RAD2. Expression of RAD2 is not cell-cycle-regulated in mitotic cells. However, meiosis is accompanied by increased steady-state levels of RAD2 mRNA in the absence of DNA damage. This enhanced transcription is not dependent on the presence of upstream sequences required for regulation of induction by DNA damage. Increased steady-state levels of RAD2 mRNA are induced by cycloheximide in asynchronousty dividing populations of cells, but not in non-replicating cells arrested in G1 phase of the cell cycle. Following exposure to u.v. irradiation induction is also dramatically reduced in non-replicating cells. [ABSTRACT FROM AUTHOR]

Published
1989
Full Text
View/download PDF

43. Die Behandlung der akuten Virus-Hepatitis mit Corticoid-Derivaten

Author

A Klamp and Siede W

Subjects
Hepatitis, medicine.medical_specialty, business.industry, Hepatitis A, General Medicine, Jaundice, medicine.disease, Gastroenterology, Pharmacotherapy, Prednisone, Internal medicine, medicine, Prednisolone, medicine.symptom, Viral hepatitis, Adverse effect, business, medicine.drug
Published
1960
Full Text
View/download PDF

45. Mutational inactivation of the Saccharomyces cerevisiae RAD4 gene in Escherichia coli

Author

Fleer, R, Siede, W, and Friedberg, E C

Abstract

The RAD4 gene of Saccharomyces cerevisiae is required for the incision of damaged DNA during nucleotide excision repair. When plasmids containing the wild-type gene were transformed into various Escherichia coli strains, transformation frequencies were drastically reduced. Most plasmids recovered from transformants showed deletions or rearrangements. A minority of plasmids recovered from E. coli HB101 showed no evidence of deletion or rearrangement, but when they were transformed into S. cerevisiae on centromeric vectors, little or no complementation of the UV sensitivity of rad4 mutants was observed. Deliberate insertional mutagenesis of the wild-type RAD4 allele before transformation of E. coli restored transformation to normal levels. Plasmids recovered from these transformants contained an inactive rad4 allele; however, removal of the inserted DNA fragment restored normal RAD4 function. These experiments suggest that expression of the RAD4 gene is lethal to E. coli and show that lethality can be prevented by inactivation of the gene before transformation. Stationary-phase cultures of some strains of E. coli transformed with plasmids containing an inactivated RAD4 gene showed a pronounced delay in the resumption of exponential growth, suggesting that the mutant (and, by inference, possibly wild-type) Rad4 protein interferes with normal growth control in E. coli. The rad4-2, rad4-3, and rad4-4 chromosomal alleles were leaky relative to a rad4 disruption mutant. In addition, overexpression of plasmid-borne mutant rad4 alleles resulted in partial complementation of rad4 strains. These observations suggest that the Rad4 protein is relatively insensitive to mutational inactivation.

Published
1987
Full Text
View/download PDF

47. Indications for an inducible component of error-prone DNA repair in yeast

Author

Siede, W. and Eckardt, F.

Abstract

In a thermoconditional mutant of mutagenic DNA repair (rev2(ts) = rad5-8) of Saccharomyces cerevisiae, recovery of survival and mutation frequencies can be monitored by incubating UV-irradiated cells in growth medium at a permissive temperature (23°C) before plating and a shift to restrictive temperature (36°C). Inhibition of protein synthesis with cycloheximide during incubation at permissive conditions blocks this REV2 dependent recovery process in stationary phase rev2(ts) cells, whereas it can be reduced but not totally abolished in exponentially growing cells. These results indicate a strict dependence on post-irradiation protein synthesis in stationary phase cells and argue for a considerable constitutive level and only limited inducibility in logarithmic phase cells. The UV inducibility of the REV2 coded function in stationary phase cells could be confirmed by analysis of the dose-response pattern of the his 5-2 reversion: in stationary phase rev2(ts) cells, the quadratic component of the biphasic linear-quadratic induction kinetics found at 23°C, which is interpreted as the consequence of induction of mutagenic repair, is eliminated at 36°C.

Published
1984

Catalog

Books, media, physical & digital resources
See catalog results