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19 results on '"Siegel, Lori S."'

1. Crohn's disease shared decision making intervention leads to more patients choosing combination therapy: a cluster randomised controlled trial

Author

Zisman‐Ilani, Yaara, primary, Thompson, Kimberly D., additional, Siegel, Lori S., additional, Mackenzie, Todd, additional, Crate, Damara J., additional, Korzenik, Joshua R., additional, Melmed, Gil Y., additional, Kozuch, Patricia, additional, Sands, Bruce E., additional, Rubin, David T., additional, Regueiro, Miguel D., additional, Cross, Raymond, additional, Wolf, Douglas C., additional, Hanson, John S., additional, Schwartz, Ronald M., additional, Vrabie, Raluca, additional, Kreines, Michael D., additional, Scherer, Timothy, additional, Dubinsky, Marla C., additional, and Siegel, Corey A., additional

Published
2022
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3. Crohn's disease shared decision making intervention leads to more patients choosing combination therapy: a cluster randomised controlled trial.

Author

Zisman‐Ilani, Yaara, Thompson, Kimberly D., Siegel, Lori S., Mackenzie, Todd, Crate, Damara J., Korzenik, Joshua R., Melmed, Gil Y., Kozuch, Patricia, Sands, Bruce E., Rubin, David T., Regueiro, Miguel D., Cross, Raymond, Wolf, Douglas C., Hanson, John S., Schwartz, Ronald M., Vrabie, Raluca, Kreines, Michael D., Scherer, Timothy, Dubinsky, Marla C., and Siegel, Corey A.

Subjects
CROHN'S disease, DECISION making, MEDICATION therapy management, DISEASE duration, DISEASE management, DISEASE complications
Abstract

Summary: Background: Crohn's disease requires effective patient‐clinician communication for successful illness and medication management. Shared decision making (SDM) has been suggested to improve communication around early intensive therapy. However, effective evidence‐based SDM interventions for Crohn's disease are lacking, and the impact of SDM on Crohn's disease decision making and choice of therapy is unclear. Aim: To test the impact of SDM on choice of therapy, quality of the decision and provider trust compared to standard Crohn's disease care. Methods: We conducted a multi‐site cluster randomised controlled trial in 14 diverse gastroenterology practices in the US. Results: A total of 158 adult patients with Crohn's disease within 15 years of their diagnosis, with no prior Crohn's disease complications, and who were candidates to receive immunomodulators or biologics, participated in the study. Among these, 99 received the intervention and 59 received standard care. Demographics were similar between groups, although there were more women assigned to standard care, and a slightly shorter disease duration among those in the intervention group. Participants in the intervention group more frequently chose combination therapy (25% versus 5% control, p < 0.001), had a significantly lower decisional conflict (p < 0.05) and had greater trust in their provider (p < 0.05). Conclusions: With rapidly expanding medication choices for Crohn's disease and slow uptake of early intensive therapy, SDM can personalise treatment strategies and has the potential to move the field of Crohn's disease management forward with an ultimate goal of consistently treating this disease early and intensively in appropriate patients. Trial Registration: Evaluating a Shared Decision Making Program for Crohn's Disease, ClinicalTrials.gov Identifier NCT02084290 https://clinicaltrials.gov/ct2/show/NCT02084290. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Performance Characteristics of a Clinical Decision Support Tool for Disease Complications in Crohn’s Disease

Author

Siegel, Corey A, primary, Siegel, Lori S, additional, Dubinsky, Marla C, additional, Targan, Stephan, additional, Braun, Jonathan, additional, Landers, Carol, additional, Bilsborough, Janine, additional, Princen, Fred, additional, Lasch, Karen, additional, Candela, Ninfa, additional, McGovern, Dermot P B, additional, and Dervieux, Thierry, additional

Published
2021
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6. Ratcheting ambition to limit warming to 1.5 °C–trade-offs between emission reductions and carbon dioxide removal

Author

Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology. Institute for Data, Systems, and Society, Sloan School of Management, Jones, Andrew, Sterman, John, Holz, Christian, Siegel, Lori S, Johnston, Eleanor, Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology. Institute for Data, Systems, and Society, Sloan School of Management, Jones, Andrew, Sterman, John, Holz, Christian, Siegel, Lori S, and Johnston, Eleanor

Abstract

Mitigation scenarios to limit global warming to 1.5 °C or less in 2100 often rely on large amounts of carbon dioxide removal (CDR), which carry significant potential social, environmental, political and economic risks. A precautionary approach to scenario creation is therefore indicated. This letter presents the results of such a precautionary modelling exercise in which the models C-ROADS and En-ROADS were used to generate a series of 1.5 °C mitigation scenarios that apply increasingly stringent constraints on the scale and type of CDR available. This allows us to explore the trade-offs between near-term stringency of emission reductions and assumptions about future availability of CDR. In particular, we find that regardless of CDR assumptions, near-term ambition increase ('ratcheting') is required for any 1.5 °C pathway, making this letter timely for the facilitative, or Talanoa, dialogue to be conducted by the UNFCCC in 2018. By highlighting the difference between net and gross reduction rates, often obscured in scenarios, we find that mid-term gross CO2emission reduction rates in scenarios with CDR constraints increase to levels without historical precedence. This in turn highlights, in addition to the need to substantially increase CO2reduction rates, the need to improve emission reductions for non-CO2greenhouse gases. Further, scenarios in which all or part of the CDR is implemented as non-permanent storage exhibit storage loss emissions, which partly offset CDR, highlighting the importance of differentiating between net and gross CDR in scenarios. We find in some scenarios storage loss trending to similar values as gross CDR, indicating that gross CDR would have to be maintained simply to offset the storage losses of CO2sequestered earlier, without any additional net climate benefit.

Published
2019

12. Su1312 A Validated Web-Based Patient Communication Tool to Display Individualized Crohn's Disease Predicted Outcomes Based on Clinical, Serologic and Genetic Variables

Author

Siegel, Corey A., primary, Horton, Henry, additional, Siegel, Lori S., additional, Thompson, Kimberly D., additional, Mackenzie, Todd, additional, Stewart, Sabrina K., additional, Rice, Philip, additional, Stempak, Joanne M., additional, Dezfoli, Seper, additional, Levy, Alexander N., additional, Baek, Michael D., additional, Milgrom, Raquel, additional, Dulai, Parambir S., additional, Silverberg, Mark S., additional, Dubinsky, Marla, additional, and McGovern, Dermot P., additional

Published
2014
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13. Predicting Crohn's Disease Post-Operative Recurrence Using Clinical, Endoscopic, Serologic and Genetic Factors

Author

Siegel, Corey A., primary, Fleshner, Phillip, additional, Siegel, Lori S., additional, Rotter, Jerome I., additional, Dubinsky, Marla, additional, Vasiliauskas, Eric A., additional, Ippoliti, Andrew, additional, Shih, David Q., additional, Melmed, Gil Y., additional, Landers, Carol J., additional, Haritunians, Talin, additional, Targan, Stephan R., additional, Taylor, Kent D., additional, and McGovern, Dermot P., additional

Published
2011
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15. Real-time tool to display the predicted disease course and treatment response for children with Crohnʼs disease

Author

Siegel, Corey A., primary, Siegel, Lori S., additional, Hyams, Jeffrey S., additional, Kugathasan, Subra, additional, Markowitz, James, additional, Rosh, Joel R., additional, Leleiko, Neal, additional, Mack, David R., additional, Crandall, Wallace, additional, Evans, Jonathan, additional, Keljo, David J., additional, Otley, Anthony R., additional, Oliva-Hemker, Maria, additional, Farrior, Sharmayne, additional, Langton, Christine R., additional, Wrobel, Iwona T., additional, Wahbeh, Ghassan, additional, Quiros, J. Antonio, additional, Silber, Gary, additional, Bahar, Ron J., additional, Sands, Bruce E., additional, and Dubinsky, Marla C., additional

Published
2011
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16. 1108 A Prediction Tool to Help Children with Crohn's Disease and Their Parents Understand Individualized Risks of Disease Complications and Response to Therapy

Author

Siegel, Corey A., primary, Siegel, Lori S., additional, Hyams, Jeffrey S., additional, Kugathasan, Subra, additional, Markowitz, James, additional, Rosh, Joel R., additional, Leleiko, Neal, additional, Mack, David R., additional, Crandall, Wallace, additional, Evans, Jonathan, additional, Keljo, David J., additional, Otley, Anthony R., additional, Oliva-Hemker, Maria, additional, Langton, Christine R., additional, Wrobel, Iwona T., additional, Wahbeh, Ghassan, additional, Quiros, Antonio, additional, Silber, Gary, additional, Bahar, Ron J., additional, Sands, Bruce E., additional, and Dubinsky, Marla, additional

Published
2009
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17. Adverse effects from environmental mercury loads on breeding common loons

Author

Evers, David C., primary, Savoy, Lucas J., additional, DeSorbo, Christopher R., additional, Yates, David E., additional, Hanson, William, additional, Taylor, Kate M., additional, Siegel, Lori S., additional, Cooley, John H., additional, Bank, Michael S., additional, Major, Andrew, additional, Munney, Kenneth, additional, Mower, Barry F., additional, Vogel, Harry S., additional, Schoch, Nina, additional, Pokras, Mark, additional, Goodale, Morgan W., additional, and Fair, Jeff, additional

Published
2007
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