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524 results on '"Sikka, Kapil"'

13. Utility of an in-house real-time PCR in whole blood samples as a minimally invasive method for early and accurate diagnosis of invasive mould infections.

Author

Pandey, Mragnayani, Xess, Immaculata, Sachdev, Janya, Sharad, Neha, Gupta, Sonakshi, Singh, Gagandeep, Yadav, Renu Kumari, Rana, Bhaskar, Raj, Stephen, Ahmad, M.Nizam, Nityadarshini, Neha, Baitha, Upendra, Soneja, Manish, Shalimar, Prakash, Bindu, Sikka, Kapil, Mathur, Purva, Jyotsna, Viveka P., Kumar, Rakesh, Wig, Naveet, Gourav, Sudesh, Biswas, Ashutosh, and Thakar, Alok

Published
2024
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29. SMARCA4/BRG1-Deficient Sinonasal Carcinoma: Morphologic Spectrum of an Evolving Entity

Author

Kakkar, Aanchal, Ashraf, Subiyathul Farah, Rathor, Amber, Adhya, Amit Kumar, Mani, Suresh, Sikka, Kapil, and Jain, Deepali

Subjects
Immunohistochemistry -- Analysis, Nose cancer -- Care and treatment -- Genetic aspects, Keratin -- Analysis, Health
Abstract

* Context.--Molecular analysis of poorly differentiated/ undifferentiated sinonasal neoplasms has resulted in identification of a growing number of genetically defined tumors. SMARCA4-deficient sinonasal carcinoma is one such recently described entity that emerged from within sinonasal undifferentiated carcinoma (SNUC), neuroendocrine carcinoma (NEC), and teratocarcinosarcoma (TCS). Objective.--To identify SMARCA4-deficient sinonasal carcinomas from a large institutional cohort of poorly differentiated/undifferentiated carcinomas and evaluate their clinicopathologic features. Design.--SMARCA4/BRG1 immunohistochemistry was performed on all tumors diagnosed as SNUC, poorly differentiated carcinoma, NEC, and TCS during a 12-year period. SMARCA2/BRM and INSM1 immunostaining was performed in SMARCA4-deficient cases. Results.--Twelve SMARCA4-deficient sinonasal carcinomas were identified among 299 cases. Morphologically, 5 cases were large cell NEC, 2 cases were small cell NEC, and 5 were TCS. SMARCA4 loss was diffuse and complete in 10 cases, while 2 cases showed focal retention. Most cases showed diffuse cytokeratin staining accompanied by weak, usually focal staining for chromogranin and synaptophysin. INSM-1 showed negativity in most cases. All cases showed retained SMARCA2 expression. IDH1/2 mutation was absent in all cases analyzed. Four of 7 patients died of disease, and aggressive multimodality treatment provided better outcome. Conclusions.--SMARCA4-deficient sinonasal carcinomas are morphologically akin to sinonasal poorly differentiated NECs and TCS, display cytokeratin positivity and only focal staining for neuroendocrine markers, and have aggressive biological behavior. Inclusion of SMARCA4 in the immunohistochemical panel for diagnostic workup of all sinonasal NEC and TCS phenotypes will facilitate their early recognition. Comprehensive germline and somatic mutational analyses of these tumors are necessary for further insights into their molecular pathogenesis. (Arch Pathol Lab Med. 2022;146:1122-1130; doi: 10.5858/arpa.2021-0001-OA), The sinonasal tract harbors a diverse spectrum of high-grade neoplasms, many of which have considerable overlapping morphologic features owing to their poorly differentiated or undifferentiated appearance. (1,2) Some of these [...]

Published
2022
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32. Airway management, procedural data, and in-hospital mortality records of patients undergoing surgery for mucormycosis associated with coronavirus disease (COVID-19)

Author

Sirohiya, Prashant, Vig, Saurabh, Mathur, Tanmay, Meena, Jitendra Kumar, Panda, Smriti, Goswami, Gitartha, Gupta, Raghav, konkimalla, Abhilash, Kondamudi, Dheeraj, Gupta, Nishkarsh, Ratre, Brajesh Kumar, Singh, Ram, Kumar, Balbir, Pandit, Anuja, Sikka, Kapil, Thakar, Alok, and Bhatnagar, Sushma

Published
2022
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33. Tumours of Nose and Paranasal Sinuses

Author

Nayak, Gyan, Verma, Hitesh, Kumar, Rakesh, Mehta, Rupa, Singh, Nikhil, Thakur, Kuldeep, Sikka, Kapil, Kakkar, Anchal, Jain, Deepali, Verma, Hitesh, editor, and Thakar, Alok, editor

Published
2021
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38. Metagenomic insights into fungal community composition of the nasopharyngeal region of COVID‐19 associated mucormycosis patients from India

Author

Arunan, Bharathi, primary, Talukdar, Daizee, additional, Swain, Satish, additional, Varadarajan, Ashwin, additional, Sarda, Radhika, additional, Singh, Gagandeep, additional, Nischal, Neeraj, additional, Soneja, Manish, additional, Bakshi, Susmita, additional, Jana, Pradipta, additional, Tanwar, Subhash, additional, Sikka, Kapil, additional, Verma, Hitesh, additional, Subramanian, Arulselvi, additional, Xess, Immaculata, additional, Wig, Naveet, additional, Das, Bhabatosh, additional, and Ray, Animesh, additional

Published
2024
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43. Pre‐vascular Facial Nodes: Sentinel Station for Metastasis in Gingivobuccal Complex Cancers.

Author

Kumar, Rajeev, Kondamudi, Dheeraj, Sagar, Prem, Khan, Maroof A., Kakkar, Aanchal, Manchanda, Smita, Bhalla, Ashu S., Sikka, Kapil, Singh, Chirom A., Kumar, Rakesh, and Thakar, Alok

Abstract

Background: Pre‐vascular facial nodes (PV‐FNs; perifacial lymph nodes) are supra‐mandibular lymph nodes above the inferior border of the mandible. These are not part of routine neck dissection done for OCSCC. These lymph nodes can be sentinel station for metastatic lymph nodes from gingivobuccal complex cancers and are missed during routine neck dissection. It is imperative to include this sentinel station in routine neck dissection to prevent nodal recurrences. Materials and Methods: One hundred thirty‐seven patients with GBCC (T1–T4) were prospectively recruited between May 2020 and June 2022 with the intent to evaluate the incidence of PV‐FN metastases and clinicopathological factors predicting them. Results: PV‐FN metastases were seen in 26 patients (18.9%; 26/137). The occult metastasis rate was 8.7% (12/137). On multivariate analysis, pathological T4 stage (pT4), LVE positivity, and intermediate‐high BGS were statistically significant predictors of PV‐FN metastases in our study. Conclusions: Incidence of PV‐FN metastasis is high (18.9%) in GBCC, which can be potentially the first sentinel station in the lymphatic drainage pattern for this sub‐site. Meticulous clearance of this nodal basin is of paramount importance during neck dissection to prevent nodal recurrences. Level of Evidence: 2 (CEBM‐Level of Evidence‐2.1) Laryngoscope, 135:148–152, 2025 [ABSTRACT FROM AUTHOR]

Published
2025
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47. Low-molecular-weight heparin salvage in pedicled flap reconstruction in head and neck: a prospective cohort study.

Author

Panda, Smriti, Gautam, Vimmi, Mitra, Sandipta, Singh, Chirom Amit, Mani, Suresh, Palreddy, Akshara, Kabilan, Yuvanesh, Konkimalla, Abhilash, Kondamudi, Dheeraj, Bagchi, Debadeep, Raveendran, Sarath, Sikka, Kapil, Kumar, Rajeev, Singh, Anup, and Thakar, Alok

Subjects
THROMBOEMBOLISM prevention, LOW-molecular-weight heparin, T-test (Statistics), SALVAGE therapy, HEAD & neck cancer, VEINS, NECROSIS, FISHER exact test, LOGISTIC regression analysis, PROBABILITY theory, TREATMENT effectiveness, CHI-squared test, MULTIVARIATE analysis, DESCRIPTIVE statistics, DALTEPARIN (Drug), SURGICAL flaps, LONGITUDINAL method, ENOXAPARIN, ODDS ratio, THROMBOEMBOLISM, STATISTICS, PLASTIC surgery, EVALUATION
Abstract

Objective: To determine if systemic administration of low-molecular-weight heparin impacts venous compromise in loco-regional flap reconstruction for head and neck subsites. Methods: This prospective study was conducted on patients who had developed features of venous compromise of the flap. The case group received low-molecular-weight heparin (dalteparin). Results: Of the 73 patients who developed venous congestion, low-molecular-weight heparin was administered in 47 patients. In the low-molecular-weight heparin subset, 23 patients had either reversal or non-progression of venous compromise (48.9 per cent). Of the patients who had no response to low-molecular-weight heparin rescue, complete necrosis was seen in 4 and partial flap necrosis was observed in 19. The corresponding numbers in the control group were 13 and 12, respectively (odds ratio 23.9, p = 0.002). Additionally, the low-molecular-weight heparin arm had a lower incidence of partial or complete flap necrosis (p = 0.002). Conclusion: Low-molecular-weight heparin salvage, when instituted early, is likely to result in a significant reduction in flap-related morbidity. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Distinct features of a peripheral T-helper subset that drives B cell response in dengue virus infection

Author

Gupta, Nimesh, primary, Ansari, Asgar, additional, Sachan, Shilpa, additional, Ahuja, Jatin, additional, Venkadesan, Sureshkumar, additional, Nikam, Bhushan, additional, Kumar, Vinod, additional, Jain, Shweta, additional, Singh, Bhanu, additional, Coshic, Poonam, additional, Sikka, Kapil, additional, Wig, Naveet, additional, Sette, Alessandro, additional, Weiskopf, Daniela, additional, Mohantay, Debasisa, additional, and Soneja, Manish, additional

Published
2024
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