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2. OC.15.2 SMALL BOWEL CARCINOMAS MAY COMPLICATE COELIAC DISEASE DESPITE STRICT ADHERENCE TO GLUTEN-FREE DIET: A CASE SERIES FROM THE SMALL BOWEL CANCER ITALIAN CONSORTIUM

Author

Bianchi, P.I., primary, Vanoli, A., additional, Lenti, M., additional, Guerini, C., additional, Arpa, G., additional, Quaquarini, E., additional, Aronico, N., additional, Grillo, F., additional, Nesi, G., additional, Furlan, D., additional, Latella, G., additional, Sessa, F., additional, Mescoli, C., additional, Rugge, M., additional, Ferrero, S., additional, Macciomei, M., additional, Santini, D., additional, Volta, U., additional, De Giorgio, R., additional, Caio, G., additional, Calabro, A., additional, Ciacci, C., additional, D'Armiento, M., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Florena, A., additional, Ciardi, A., additional, Elli, L., additional, Vecchi, M., additional, Zingone, F., additional, Reggiani Bonetti, L., additional, Astegiano, M., additional, Sandri, G., additional, Silano, M., additional, Usai, P., additional, Perfetti, V., additional, Giannone, A., additional, Barresi, V., additional, Ciccocioppo, R., additional, Biletta, E., additional, Corazza, G., additional, and Di Sabatino, A., additional

Published
2023
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3. PC.01.9 HYPOMETHYLATION OF LINE-1 IN SMALL BOWEL CARCINOMAS AND COELIAC DISEASE

Author

Guerini, C., primary, Bianchi, P.I., additional, Libera, L., additional, Vanoli, A., additional, Arpa, G., additional, Aronico, N., additional, Furlan, D., additional, Grillo, F., additional, Nesi, G., additional, Sampietro, G., additional, Ardizzone, S., additional, Fociani, P., additional, Fiocca, R., additional, Latella, G., additional, Sessa, F., additional, D'Errico, A., additional, Malvi, D., additional, Mescoli, C., additional, Rugge, M., additional, Ferrero, S., additional, Poggioli, G., additional, Rizzello, F., additional, Macciomei, M., additional, Santini, D., additional, Volta, U., additional, De Giorgio, R., additional, Caio, G., additional, Calabro, A., additional, Ciacci, C., additional, D'Armiento, M., additional, Rizzo, A., additional, Solina, G., additional, Tonelli, F., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Florena, A., additional, Biancone, L., additional, Monteleone, G., additional, Caronna, R., additional, Ciardi, A., additional, Elli, L., additional, Caprioli, F., additional, Vecchi, M., additional, D'Inca, R., additional, Zingone, F., additional, D'Odorico, A., additional, Oreggia, B., additional, Reggiani Bonetti, L., additional, Astegiano, M., additional, Cantoro, L., additional, Papi, C., additional, Sandri, G., additional, Silano, M., additional, Usai, P., additional, Perfetti, V., additional, Quaquarini, E., additional, Giannone, A., additional, Orlandi, A., additional, Barresi, V., additional, Ciccocioppo, R., additional, Amodeo, G., additional, Biletta, E., additional, and Di Sabatino, A., additional

Published
2023
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4. T.05.10 CLINICAL HETEROGENEITY OF ADULT COELIAC DISEASE ACCORDING TO THE AGE AT ONSET: AN ITALIAN MULTICENTRIC STUDY

Author

Latorre, M.A., primary, Bianchi, P., additional, Lenti, M., additional, Aronico, N., additional, Petrucci, C., additional, D'Agate, C., additional, Neri, M., additional, Volta, U., additional, Mumolo, M., additional, Astegiano, M., additional, Calabro, A., additional, Zingone, F., additional, Latella, G., additional, Di Sario, A., additional, Carroccio, A., additional, Ciacci, C., additional, Luzza, F., additional, Bagnato, C., additional, Fantini, M., additional, Elli, L., additional, Cammarota, G., additional, Gasbarrini, A., additional, Portincasa, P., additional, Quatraccioni, C., additional, Iannelli, C., additional, Vecchione, N., additional, Broglio, G., additional, Ianiro, G., additional, Marsilio, I., additional, Bibbo, S., additional, Marinoni, B., additional, Tomaselli, D., additional, Abenavoli, L., additional, Pilia, R., additional, Santacroce, G., additional, Lynch, E., additional, Carrieri, A., additional, Mansueto, P., additional, Gabba, M., additional, Alunno, G., additional, Rossi, C., additional, Onnis, F., additional, Efthymakis, K., additional, Cesaro, N., additional, Vernero, M., additional, Baiano Svizzero, F., additional, Silano, M., additional, Klersy, C., additional, Corazza, G., additional, and Di Sabatino, A., additional

Published
2023
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6. Policy implementation and priorities to create healthy food environments using the Healthy Food Environment Policy Index (Food-EPI): A pooled level analysis across eleven European countries

Author

Pineda, E, Poelman, Mp, Aaspõllu, A, Bica, M, Bouzas, C, Carrano, E, De Miguel-Etayo, P, Djojosoeparto, S, Blenkuš, Mg, Graca, P, Geffert, K, Hebestreit, A, Helldan, A, Henjum, S, Huseby, C, Gregório, Mj, Kamphuis, C, Laatikainen, T, Løvhaug, Al, Leydon, C, Luszczynska, A, Mäki, P, Martínez, Ja, Raulio, S, Romaniuk, P, Roos, G, Salvador, C, Sassi, F, Silano, M, Sotlar, I, Specchia, Maria Lucia, de Arriaga, Mt, Terragni, L, Torheim, Le, Tur, Ja, von Philipsborn, P, Harrington, Jm, Vandevijvere, S, Specchia ML (ORCID:0000-0002-3859-4591), Pineda, E, Poelman, Mp, Aaspõllu, A, Bica, M, Bouzas, C, Carrano, E, De Miguel-Etayo, P, Djojosoeparto, S, Blenkuš, Mg, Graca, P, Geffert, K, Hebestreit, A, Helldan, A, Henjum, S, Huseby, C, Gregório, Mj, Kamphuis, C, Laatikainen, T, Løvhaug, Al, Leydon, C, Luszczynska, A, Mäki, P, Martínez, Ja, Raulio, S, Romaniuk, P, Roos, G, Salvador, C, Sassi, F, Silano, M, Sotlar, I, Specchia, Maria Lucia, de Arriaga, Mt, Terragni, L, Torheim, Le, Tur, Ja, von Philipsborn, P, Harrington, Jm, Vandevijvere, S, and Specchia ML (ORCID:0000-0002-3859-4591)

Abstract

Background: Food environments have been recognised as highly influential on population diets. Government policies have great potential to create healthy food environments to promote healthy diets. This study aimed to evaluate food environment policy implementation in European countries and identify priority actions for governments to create healthy food environments. Methods: The Healthy Food Environment Policy Index (Food-EPI) was used to evaluate the level of food environment policy and infrastructure support implementation in Estonia, Finland, Germany, Ireland, Italy, the Netherlands, Norway, Poland, Portugal, Slovenia, and Spain in 2019-2021. Evidence of implementation of food environment policies was compiled in each country and validated by government officials. National experts evaluated the implementation of policies and identified priority recommendations. Findings: Finland had the highest proportion (32%, n = 7/22) of policies shaping food environments with a "high" level of implementation. Slovenia and Poland had the highest proportion of policies rated at very low implementation (42%, n = 10/24 and 36%, n = 9/25 respectively). Policies regarding food provision, promotion, retail, funding, monitoring, and health in all policies were identified as the most important gaps across the European countries. Experts recommended immediate action on setting standards for nutrients of concern in processed foods, improvement of school food environments, fruit and vegetable subsidies, unhealthy food and beverage taxation, and restrictions on unhealthy food marketing to children. Interpretation: Immediate implementation of policies and infrastructure support that prioritize action towards healthy food environments is urgently required to tackle the burden of obesity and diet-related non-communicable diseases in Europe

Published
2022

7. P301 Non-familial small bowel carcinomas in Crohnʼs disease: clinico-pathological, molecular and prognostic features

Author

Di Sabatino, A., Vanoli, A., Furlan, D., Giuffrida, P., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabrò, A., Tonelli, F., Volta, U., Santini, D., Caio, G., Elli, L., Ferrero, S., Latella, G., Ciardi, A., Solina, G., Rizzo, A., Ciacci, C., DʼArmiento, F.P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Reggiani Bonetti, L., Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M.C., DʼIncà, R., Perfetti, V., Sandri, G., Silano, M., Florena, A.M., Giannone, A.G., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Manca, R., Martino, M., Trapani, D., Cerutti, R., Alberizzi, P., Riboni, R., Sessa, F., Paulli, M., Solcia, E., and Corazza, G.R.

Published
2017
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8. Implementation level of best practice policies by Italian Government for healthier food environments: Healthy Food Environment Policy Index (Food-EPI)

Author

Zace, D, Di Pilla, A, Silano, M, Carini, E, Cacciatore, P, Frisicale, EM, Vandevijvere, S, Sassi, F, and Specchia, ML

Abstract

Background. This work aims to identify policies implemented for healthy food environments in Italy within The Healthy Food Environment Policy Index (Food-EPI) project. Methods. Food-EPI tool, which includes two components, thirteen domains and fifty good practice indicators, was adapted for the Italian context. Evidence for implementation was gathered and summarized for all fifty indicators from data sources such as governmental websites, non-government organizations publications and websites and via direct contact with Government officials. Results. The highest level of evidence was found within five domains: food composition (2/2 indicators), labelling (3/4), promotion (4/5), provision (4/5) and leadership (5/5). The domains with less identified evidence were food prices (1/4), food in retail (0/4), trade and investment (0/2) and platforms and interaction (1/4). Conclusions. The evidence summarization and the upcoming stakeholders’ meeting to rate the level of implementation for each indicator in Italy have the potential to improve Government commitment to shape healthier food environments.

Published
2022

9. POS1192 BEHAVIOR AND FEELINGS OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS DURING LOCKDOWN MEASURES FOR THE COVID-19 OUTBREAK

Author

De Marchi, G., primary, Azzolina, D., additional, Maresio, E., additional, Colatutto, D., additional, Binutti, M., additional, Monte, M., additional, Gallipoli, S., additional, Zobec, F., additional, Palese, A., additional, Silano, M., additional, De Vita, S., additional, Gregori, D., additional, and Quartuccio, L., additional

Published
2021
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10. Autophagy suppresses the pathogenic immune response to dietary antigens in cystic fibrosis

Author

Villella, V. R., Esposito, S., Ferrari, E., Monzani, R., Tosco, A., Rossin, F., Castaldo, A., Silano, M., Marseglia, G. L., Romani, L., Barlev, N. A., Piacentini, M., Raia, V., Kroemer, G., Maiuri, L., IRCCS San Raffaele Scientific Institute [Milan, Italie], Università degli studi di Napoli Federico II, Università degli Studi di Roma Tor Vergata [Roma], Istituto Superiore di Sanita [Rome], Università degli Studi di Perugia (UNIPG), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Gustave Roussy (IGR), Service de biologie [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Villella, Vr, Esposito, S, Ferrari, E, Monzani, R, Tosco, A, Rossin, F, Castaldo, A, Silano, M, Marseglia, Gl, Romani, L, Barlev, Na, Piacentini, M, Raia, V, Kroemer, G, Maiuri, L, IRCSS San Raffaele Scientific Institute [Milan, Italie], École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)

Subjects
Heterozygote, Settore BIO/06, Cystic Fibrosis, AUTOIMMUNITY, Cysteamine, Cystic Fibrosis Transmembrane Conductance Regulator, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Article, Gliadin, EPITHELIAL STRESS, ACTIVATION, Mice, INFLAMMATION, GTP-Binding Proteins, Autophagy, Animals, Humans, TISSUE TRANSGLUTAMINASE, Protein Glutamine gamma Glutamyltransferase 2, lcsh:QH573-671, Mice, Knockout, Transglutaminases, lcsh:Cytology, Homozygote, CELIAC-DISEASE, Epithelial Cells, TRIGGERS, digestive system diseases, Peptide Fragments, Mice, Inbred C57BL, T-CELLS, [SDV.IMM]Life Sciences [q-bio]/Immunology, Cytokines, GLIADIN, CYSTEAMINE, Beclin-1, Caco-2 Cells
Abstract

International audience; Under physiological conditions, a finely tuned system of cellular adaptation allows the intestinal mucosa to maintain the gut barrier function while avoiding excessive immune responses to non-self-antigens from dietary origin or from commensal microbes. This homeostatic function is compromised in cystic fibrosis (CF) due to loss-of-function mutations in the CF transmembrane conductance regulator (CFTR). Recently, we reported that mice bearing defective CFTR are abnormally susceptible to a celiac disease-like enteropathy, in thus far that oral challenge with the gluten derivative gliadin elicits an inflammatory response. However, the mechanisms through which CFTR malfunction drives such an exaggerated response to dietary protein remains elusive. Here we demonstrate that the proteostasis regulator/transglutaminase 2 (TGM2) inhibitor cysteamine restores reduced Beclin 1 (BECN1) protein levels in mice bearing cysteamine-rescuable F508del-CFTR mutant, either in homozygosis or in compound heterozygosis with a null allele, but not in knock-out CFTR mice. When cysteamine restored BECN1 expression, autophagy was increased and gliadin-induced inflammation was reduced. The beneficial effects of cysteamine on F508del-CFTR mice were lost when these mice were backcrossed into a Becn1 haploinsufficient/autophagy-deficient background. Conversely, the transfection-enforced expression of BECN1 in human intestinal epithelial Caco-2 cells mitigated the pro-inflammatory cellular stress response elicited by the gliadin-derived P31-43 peptide. In conclusion, our data provide the proof-of-concept that autophagy stimulation may mitigate the intestinal malfunction of CF patients.

Published
2019

11. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability (Modern Pathology, (2020), 33, 7, (1398-1409), 10.1038/s41379-020-0497-0)

Author

Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Bonetti, L. R., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., and Di Sabatino, A.

Published
2020

16. OC.06.1 ROLE OF EXTRACELLULAR MICROVESICLES IN CELIAC DISEASE AS POTENTIAL PATHOGENETIC AGENTS AND BIOMARKERS OF INTESTINAL INFLAMMATION

Author

D'Ambrosio, A., primary, Cecchetti, S., additional, Margutti, P., additional, Vincentini, O., additional, Donato, G., additional, Zamboni, S., additional, Sassano, S., additional, Silano, M., additional, Greco, N., additional, Di Loreto, F., additional, Borghini, R., additional, and Picarelli, A.,, additional

Published
2020
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23. Programmed Cell Death Ligand-1 (PD-L1) Expression is Coupled with Microsatellite Instability in Non-Familial Small Bowel Carcinomas Associated or not with Coeliac Disease or Crohn's Disease: Results from the Small Bowel Cancer Italian Consortium

Author

Vanoli, A., Giuffrida, P., Martino, M., Persichella, A., Viglio, A., Furlan, D., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabro, A., Tonelli, F., Volta, U., Santini, D., Giacomo Caio, Elli, L., Ferrero, S., Latella, G., Ciardi, A., Caronna, R., Solina, G., Rizzo, A. G., Ciacci, C., D Armiento, F. P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Bonetti, L. Reggiani, Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M., D Inca, R., Perfetti, V., Sandri, G., Silano, M., Florena, A., Giannone, A., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Sessa, F., Solcia, E., Corazza, G. R., Paulli, M., and Di Sabatino, A.

Subjects
NO
Published
2018

26. Small bowel carcinomas in celiac or Crohn's disease: Distinctive histophenotypic, molecular and histogenetic patterns

Author

Vanoli, A., Di Sabatino, A., Martino, M., Klersy, C., Grillo, F., Mescoli, C., Nesi, G., Volta, U., Fornino, D., Luinetti, O., Fociani, P., Villanacci, V., D'Armiento, F. P., Cannizzaro, R., Latella, G., Ciacci, C., Biancone, L., Paulli, M., Sessa, F., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., Ardizzone, S., Astegiano, M., Caio, G., Calabro, A., Canzonieri, V., Cerutti, R., Ciardi, A., Coppola, L., D'Inca, R., Elli, L., Ferrero, S., Florena, A. M., Furlan, D., Giannone, A. G., Giuffrida, P., Macciomei, M. C., Maccioni, A., Monteleone, G., Migliora, P., Orlandi, A., Papi, C., Perfetti, V., Bonetti, L. R., Rizzo, A., Salemme, M., Sandri, G., Sampietro, G., Santeusanio, G., Santini, D., Silano, M., Solina, G., Tonelli, F., Trapani, D., Usai, P., Vanoli, Alessandro, Di Sabatino, Antonio, Martino, Michele, Klersy, Catherine, Grillo, Federica, Mescoli, Claudia, Nesi, Gabriella, Volta, Umberto, Fornino, Daniele, Luinetti, Ombretta, Fociani, Paolo, Villanacci, Vincenzo, D'Armiento, Francesco P., Cannizzaro, Renato, Latella, Giovanni, Ciacci, Carolina, Biancone, Livia, Paulli, Marco, Sessa, Fausto, Rugge, Massimo, Fiocca, Roberto, Corazza, Gino R., Solcia, Enrico, D'Armiento, Francesco P, and Corazza, Gino R

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Pathology, small bowel carcinoma, celiac disease, immunology, gastrointestinal cancer, Kaplan-Meier Estimate, Histogenesis, Biology, Small, Gastroenterology, Pathology and Forensic Medicine, NO, Surgical pathology, immunology, inflammatory bowel disease, 03 medical and health sciences, small bowel carcinoma, 0302 clinical medicine, Crohn Disease, Internal medicine, Intestine, Small, Intestinal Neoplasms, medicine, Carcinoma, Humans, 2734 small bowel carcinoma, coeliac disease, Crohn's disease, Proportional Hazards Models, Retrospective Studies, Crohn's disease, Settore MED/12 - Gastroenterologia, Celiac Disease, Female, Middle Aged, Microsatellite instability, Anatomical pathology, medicine.disease, digestive system diseases, Intestine, 030104 developmental biology, Dysplasia, 030220 oncology & carcinogenesis, Hematopathology, celiac disease
Abstract

Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (beta-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters. In addition, non-tumor mucosa of celiac and Crohn's disease patients was investigated for epithelial precursor changes (hyperplastic, metaplastic or dysplastic) to help clarify carcinoma histogenesis. When compared with non-glandular structure and non-intestinal phenotype, both glandular structure and intestinal phenotype were associated with a more favorable outcome at univariable or stage-and microsatellite instability/tumor-infiltrating lymphocyte-inclusive multivariable analysis. The prognostic power of histological structure was independent of the clinical groups while the non-intestinal phenotype, associated with poor outcome, was dominant among Crohn's disease-associated carcinoma. Both nuclear beta-catenin and SOX-9 were preferably expressed among celiac disease-associated carcinomas; however, they were devoid, per se, of prognostic value. We obtained findings supporting an origin of celiac disease-associated carcinoma in SOX-9-positive immature hyperplastic crypts, partly through flat beta-catenin-positive dysplasia, and of Crohn's disease-associated carcinoma in a metaplastic (gastric and/or pancreatobiliary-type) mucosa, often through dysplastic polypoid growths of metaplastic phenotype. In conclusion, despite their common origin in a chronically inflamed mucosa, celiac disease-associated and Crohn's disease-associated small bowel carcinomas differ substantially in histological structure, phenotype, microsatellite instability/tumor-infiltrating lymphocyte status, Wnt pathway activation, mucosal precursor lesions and prognosis.

Published
2017

28. OC.11.1 PROGRAMMED CELL DEATH LIGAND-1 (PD-L1) EXPRESSION IS COUPLED WITH MICROSATELLITE INSTABILITY IN NON-FAMILIAL SMALL BOWEL CARCINOMAS ASSOCIATED OR NOT WITH COELIAC DISEASE OR CROHN'S DISEASE: RESULTS FROM THE SMALL BOWEL CANCER ITALIAN CONSORTIUM

Author

Vanoli, A., primary, Giuffrida, P., additional, Martino, M., additional, Persichella, A., additional, Viglio, A., additional, Furlan, D., additional, Klersy, C., additional, Grillo, F., additional, Fiocca, R., additional, Mescoli, C., additional, Rugge, M., additional, Nesi, G., additional, Fociani, P., additional, Sampietro, G., additional, Ardizzone, S., additional, Luinetti, O., additional, Calabrò, A., additional, Tonelli, F., additional, Volta, U., additional, Santini, D., additional, Caio, G., additional, Elli, L., additional, Ferrero, S., additional, Latella, G., additional, Ciardi, A., additional, Caronna, R., additional, Solina, G., additional, Rizzo, A.G., additional, Ciacci, C., additional, D'Armiento, F.P., additional, Salemme, M., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Bonetti, L. Reggiani, additional, Biancone, L., additional, Monteleone, G., additional, Orlandi, A., additional, Santeusanio, G., additional, Macciomei, M., additional, D'Incà, R., additional, Perfetti, V., additional, Sandri, G., additional, Silano, M., additional, Florena, A., additional, Giannone, A., additional, Papi, C., additional, Coppola, L., additional, Usai, P., additional, Maccioni, A., additional, Astegiano, M., additional, Migliora, P., additional, Sessa, F., additional, Solcia, E., additional, Corazza, G.R., additional, Paulli, M., additional, and Di Sabatino, A., additional

Published
2018
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29. Erratum

Author

Baig, M.K., Larach, J.A., Chang, S., Long, C., Weiss, E.G., Nogueras, J.J., Wexner, S.D., Bouchoucha, M., Devroede, G., Dorval, E., Faye, A., Arhan, P., Arsac, M., Zbar, A.P., Oyetunji, R.O., Gill, R., D’Annibale, A., Morpurgo, E., Fiscon, V., Termini, B., Serventi, A., Sovernigo, G., Orsini, C., Fa-Si-Oen, P., van de Gender, P., Putter, H., Ectors, N., D’Hoore, A., Topal, B., Penninckx, F., Marques, C.F.S., Nahas, S.C., Nahas, C.S.R., Sobrado, Jr., C.W., Habr-Gama, A., Kiss, D.R., Verdaasdonk, E.G.G., Bueno de Mesquita, J.M., Stassen, L.P.S., Nano, M., Prunotto, M., Ferronato, M., Solej, M., Galloni, M., Pigot, F., Dao-Quang, M., Castinel, A., Juguet, F., Bouchard, D., Bockle, J., Allaert, F.A., de la Portilla, F., Zbar, A.P., Rada, R., Vega, J., Cisneros, N., Maldonado, V.H., Utrera, A., Espinosa, E., Trecca, A., Gaj, F., Di Lorenzo, G.P., Ricciardi, M.R., Silano, M., Bella, A., Sperone, M., Vorobiev, G.I., Tsarkov, P.V., and Sorokin, E.V.

Published
2009
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30. OC.10.4: Survival of Non-Familial Small Bowel Carcinomas Depends on the Underlying Intestinal Immune-Mediated Disorder

Author

Di Sabatino, A., primary, Vanoli, A., additional, Furlan, D., additional, Giuffrida, P., additional, Klersy, C., additional, Grillo, F., additional, Fiocca, R., additional, Mescoli, C., additional, Rugge, M., additional, Nesi, G., additional, Fociani, P., additional, Sampietro, G.M., additional, Ardizzone, S., additional, Luinetti, O., additional, Calabrò, A., additional, Tonelli, F., additional, Volta, U., additional, Santini, D., additional, Elli, L., additional, Ferrero, S., additional, Latella, G., additional, Ciardi, A., additional, Solina, G., additional, Rizzo, A., additional, Ciacci, C., additional, D’Armiento, F.P., additional, Villanacci, V., additional, Cannizzaro, R., additional, Canzonieri, V., additional, Reggiani Bonetti, L., additional, Biancone, L., additional, Monteleone, G., additional, Orlandi, A., additional, Santeusanio, G., additional, Macciomei, M.C., additional, D’Incà, R., additional, Perfetti, V., additional, Sandri, G., additional, Silano, M., additional, Giannone, A.G., additional, Papi, C., additional, Coppola, L., additional, Usai, P., additional, Maccioni, A., additional, Astegiano, M., additional, Migliora, P., additional, Manca, R., additional, Martino, M., additional, Trapani, D., additional, Cerutti, R., additional, Alberizzi, P., additional, Riboni, R., additional, Sessa, F., additional, Paulli, M., additional, Solcia, E., additional, and Corazza, G.R., additional

Published
2017
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35. Highly efficient gluten degradation by lactobacilli and fungal proteases during food processing: new perspectives for celiac disease

Author

Rizzello CG, De Angelis M, Di Cagno R, Camarca A, Silano M, Losito I, De Vincenzi M, De Bari MD, Palmisano F, Maurano F, Gianfrani C, and Gobbetti M.

Subjects
food and beverages
Abstract

Presently, the only effective treatment for celiac disease is a life-long gluten-free diet. In this work, we used a new mixture of selected sourdough lactobacilli and fungal proteases to eliminate the toxicity of wheat flour during long-time fermentation. Immunological (R5 antibody-based sandwich and competitive enzyme-linked immunosorbent assay [ELISA] and R5 antibody-based Western blot), two-dimensional electrophoresis, and mass spectrometry (matrix-assisted laser desorption ionization-time of flight, strong-cation-exchange-liquid chromatography/capillary liquid chromatography-electrospray ionization-quadrupole-time of flight [SCX-LC/CapLC-ESI-Q-TOF], and high-pressure liquid chromatography-electrospray ionization-ion trap mass spectrometry) analyses were used to determine the gluten concentration. Assays based on the proliferation of peripheral blood mononuclear cells (PBMCs) and gamma interferon production by PBMCs and intestinal T-cell lines (iTCLs) from 12 celiac disease patients were used to determine the protein toxicity of the pepsin-trypsin digests from fermented wheat dough (sourdough). As determined by R5-based sandwich and competitive ELISAs, the residual concentration of gluten in sourdough was 12 ppm. Albumins, globulins, and gliadins were completely hydrolyzed, while ca. 20% of glutenins persisted. Low-molecular-weight epitopes were not detectable by SCX-LC/CapLC-ESI-Q-TOF mass spectrometry and R5-based Western blot analyses. The kinetics of the hydrolysis of the 33-mer by lactobacilli were highly efficient. All proteins extracted from sourdough activated PBMCs and induced gamma interferon production at levels comparable to the negative control. None of the iTCLs demonstrated immunoreactivity towards pepsin-trypsin digests. Bread making was standardized to show the suitability of the detoxified wheat flour. Food processing by selected sourdough lactobacilli and fungal proteases may be considered an efficient approach to eliminate gluten toxicity.

Published
2007

38. Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis

Author

Di Simone, Nicoletta, De Spirito, Marco, Di Nicuolo, Fiorella, Tersigni, Chiara, Castellani, Roberta, Silano, M, Maulucci, Giuseppe, Papi, Massimiliano, Marana, R, Scambia, Giovanni, Gasbarrini, Antonio, Di Simone, Nicoletta (ORCID:0000-0003-1273-3335), De Spirito, Marco (ORCID:0000-0003-4260-5107), Maulucci, Giuseppe (ORCID:0000-0002-2154-319X), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Di Simone, Nicoletta, De Spirito, Marco, Di Nicuolo, Fiorella, Tersigni, Chiara, Castellani, Roberta, Silano, M, Maulucci, Giuseppe, Papi, Massimiliano, Marana, R, Scambia, Giovanni, Gasbarrini, Antonio, Di Simone, Nicoletta (ORCID:0000-0003-1273-3335), De Spirito, Marco (ORCID:0000-0003-4260-5107), Maulucci, Giuseppe (ORCID:0000-0002-2154-319X), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Scambia, Giovanni (ORCID:0000-0003-2758-1063), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion and characterized by circulating anti-transglutaminase type 2 (anti-TG2) autoantibodies. An epidemiological link between maternal CD and increased risk of pregnancy failure has been established; however, the mechanism underlying this association is still poorly understood. Because proper endometrial angiogenesis and decidualization are prerequisites for placental development, we investigated the effect of anti-TG2 antibodies on the process of endometrial angiogenesis. Binding of anti-TG2 antibodies to human endometrial endothelial cells (HEECs) was evaluated by ELISA. Angiogenesis was studied in vitro on HEECs and in vivo in a murine model. In particular, we investigated the effect of anti-TG2 antibodies on HEEC matrix metalloprotease-2 (MMP-2) activity by gelatin zymography, cytoskeletal organization and membrane properties by confocal microscopy, and activation of extracellular signal-regulated kinases (ERKs) and focal adhesion kinase (FAK) by Western blot analysis. Anti-TG2 antibodies bound to HEECs and decreased newly formed vessels both in vitro and in vivo. Anti-TG2 antibodies impaired angiogenesis by inhibiting the activation of MMP-2, disarranging cytoskeleton fibers, changing the physical and mechanical properties of cell membranes, and inhibiting the intracellular phosphorylation of FAK and ERK. Anti-TG2 antibodies inhibit endometrial angiogenesis affecting the TG2-dependent migration of HEECs and extracellular matrix degradation, which are necessary to form new vessels. Our results identify pathogenic mechanisms of placental damage in CD.

Published
2013

39. Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis

Author

De Spirito, Marco, Di Nicuolo, Fiorella, Tersigni, Chiara, Castellani, Roberta, Silano, M, Maulucci, Giuseppe, Papi, Massimiliano, Marana, Riccardo, Scambia, Giovanni, Gasbarrini, Antonio, De Spirito, Marco (ORCID:0000-0003-4260-5107), Maulucci, Giuseppe (ORCID:0000-0002-2154-319X), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Marana, Riccardo (ORCID:0000-0003-1616-7836), Scambia, Giovanni (ORCID:0000-0003-2758-1063), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), De Spirito, Marco, Di Nicuolo, Fiorella, Tersigni, Chiara, Castellani, Roberta, Silano, M, Maulucci, Giuseppe, Papi, Massimiliano, Marana, Riccardo, Scambia, Giovanni, Gasbarrini, Antonio, De Spirito, Marco (ORCID:0000-0003-4260-5107), Maulucci, Giuseppe (ORCID:0000-0002-2154-319X), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Marana, Riccardo (ORCID:0000-0003-1616-7836), Scambia, Giovanni (ORCID:0000-0003-2758-1063), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion and characterized by circulating anti-transglutaminase type 2 (anti-TG2) autoantibodies. An epidemiological link between maternal CD and increased risk of pregnancy failure has been established; however, the mechanism underlying this association is still poorly understood. Because proper endometrial angiogenesis and decidualization are prerequisites for placental development, we investigated the effect of anti-TG2 antibodies on the process of endometrial angiogenesis. Binding of anti-TG2 antibodies to human endometrial endothelial cells (HEECs) was evaluated by ELISA. Angiogenesis was studied in vitro on HEECs and in vivo in a murine model. In particular, we investigated the effect of anti-TG2 antibodies on HEEC matrix metalloprotease-2 (MMP-2) activity by gelatin zymography, cytoskeletal organization and membrane properties by confocal microscopy, and activation of extracellular signal-regulated kinases (ERKs) and focal adhesion kinase (FAK) by Western blot analysis. Anti-TG2 antibodies bound to HEECs and decreased newly formed vessels both in vitro and in vivo. Anti-TG2 antibodies impaired angiogenesis by inhibiting the activation of MMP-2, disarranging cytoskeleton fibers, changing the physical and mechanical properties of cell membranes, and inhibiting the intracellular phosphorylation of FAK and ERK. Anti-TG2 antibodies inhibit endometrial angiogenesis affecting the TG2-dependent migration of HEECs and extracellular matrix degradation, which are necessary to form new vessels. Our results identify pathogenic mechanisms of placental damage in CD.

Published
2013

41. Anti-tissue transglutaminase antibodies from celiac patients are responsible for trophoblast damage via apoptosis in vitro

Author

Di Simone, Nicoletta, Silano, M, Castellani, Roberta, Di Nicuolo, Fiorella, D'Alessio, Maria Clara, Franceschi, Francesco, Tritarelli, Alessandra, Leone, Antonio Maria, Tersigni, Chiara, Gasbarrini, Giovanni Battista, Gentiloni Silveri, Nicolo', Caruso, Alessandro, Gasbarrini, Antonio, Di Simone, Nicoletta (ORCID:0000-0003-1273-3335), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Caruso, Alessandro (ORCID:0000-0002-4749-3207), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Di Simone, Nicoletta, Silano, M, Castellani, Roberta, Di Nicuolo, Fiorella, D'Alessio, Maria Clara, Franceschi, Francesco, Tritarelli, Alessandra, Leone, Antonio Maria, Tersigni, Chiara, Gasbarrini, Giovanni Battista, Gentiloni Silveri, Nicolo', Caruso, Alessandro, Gasbarrini, Antonio, Di Simone, Nicoletta (ORCID:0000-0003-1273-3335), Franceschi, Francesco (ORCID:0000-0001-6266-445X), Leone, Antonio Maria (ORCID:0000-0002-1276-9883), Caruso, Alessandro (ORCID:0000-0002-4749-3207), and Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)

Abstract

OBJECTIVES: The association between maternal celiac disease (CD) and both reduced fertility and increased risk of adverse pregnancy-related events has been long documented. However, no evidences are available regarding the pathogenic mechanisms of this link. The aim of this study was to determine whether anti-tissue transglutaminase (anti-tTG) antibodies are involved in the damage of trophoblastic cells in vitro . METHODS: Human primary trophoblastic cells, isolated from term placenta, were exposed to anti-tTG immunoglobulin G (IgG) antibodies, both commercially available and separated from sera of three untreated celiac women. The ability of anti-tTG antibodies to bind to trophoblastic cells, invasiveness of placental cells through a layer of extracellular matrix, and the activity of cellular matrix metalloprotease (MMP) and cellular apoptosis were evaluated, as indicators of trophoblast damage, by TdT-mediated dUTP digoxigenin nick end labeling (TUNEL) and annexin V expression. RESULTS: Anti-tTG IgG showed a specifi c dose- and time-dependent binding to human trophoblast. In addition, trophoblastic cells, after being exposed to anti-tTG IgG antibodies, both commercially available and separated from sera of celiac women, showed an impaired invasiveness, a decreased activity of cellular MMP, and a greater percentage of TUNEL positivity and annexin V positivity. CONCLUSIONS: We showed that the binding of anti-tTG antibodies to trophoblast might represent a key mechanism by which the embryo implantation and pregnancy outcome are impaired in untreated celiac pregnant women. Because healthy trophoblast development is essential for placental and fetal development, these data provide a novel mechanism for CD-induced infertility, early pregnancy loss, and intrauterine growth retardation.

Published
2010

42. ANTI-TISSUE TRANSGLUTAMINASE ANTIBODIES FROM CELIAC PATIENTS ARE RESPONSIBLE OF TROPHOBLAST DAMAGE VIA APOPTOSIS IN VITRO: A POSSIBLE ROLE FOR INFERTILITY, EARLY PREGNANCY LOSS AND INTRAUTERINE GROWTH RETARDATION?

Author

Franceschi, F., primary, Di Simone, N., additional, Roccarina, D., additional, Gigante, G., additional, Giupponi, B., additional, DeMarco, G., additional, Silano, M., additional, Castellani, R., additional, Di Nicuolo, F., additional, D'Alessio, M.C., additional, Tritarelli, A., additional, Leone, A.M., additional, Ojetti, V., additional, Gasbarrini, G., additional, Silveri, N. Gentiloni, additional, Caruso, A., additional, and Gasbarrini, A., additional

Published
2009
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