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7. Regenerative medicine for digestive fistulae therapy: Benefits, challenges and promises of stem/stromal cells and emergent perspectives via their extracellular vesicles

Author

Sebbagh, Anna C., primary, Rosenbaum, Boris, additional, Péré, Guillaume, additional, Alric, Hadrien, additional, Berger, Arthur, additional, Wilhelm, Claire, additional, Gazeau, Florence, additional, Mathieu, Noëlle, additional, Rahmi, Gabriel, additional, and Silva, Amanda K.A., additional

Published
2021
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8. Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”

Author

Silva, Amanda K.A., primary, Morille, Marie, additional, Piffoux, Max, additional, Arumugam, Surendar, additional, Mauduit, Phlippe, additional, Larghero, Jérôme, additional, Bianchi, Arnaud, additional, Aubertin, Kelly, additional, Blanc-Brude, Olivier, additional, Noël, Danièle, additional, Velot, Emilie, additional, Ravel, Célia, additional, Elie-Caille, Céline, additional, Sebbagh, Anna, additional, Boulanger, Chantal, additional, Wilhelm, Claire, additional, Rahmi, Gabriel, additional, Raymond-Letron, Isabelle, additional, Cherukula, Kondareddy, additional, Montier, Tristan, additional, Martinaud, Christophe, additional, Bach, Jean-Marie, additional, Favre-Bulle, Olivier, additional, Spadavecchia, Jolanda, additional, Jorgensen, Christian, additional, Menasché, Philippe, additional, Aussel, Clotilde, additional, Chopineau, Joël, additional, Mosser, Mathilde, additional, Ullah, Matti, additional, Sailliet, Nicolas, additional, Luciani, Nathalie, additional, Mathieu, Noëlle, additional, Rautou, Pierre-Emmanuel, additional, Brouard, Sophie, additional, Boireau, Wilfrid, additional, Jauliac, Sébastien, additional, Dedier, Marianne, additional, Trouvin, Jean-Hugues, additional, Gazeau, Florence, additional, Trouillas, Marina, additional, Peltzer, Juliette, additional, Monsel, Antoine, additional, and Banzet, Sébastien, additional

Published
2021
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13. Enhancing digestive fistula healing by the off-label use of a thermoresponsive vessel occluder polymer associated with esophageal stent placement: A case report

Author

Berger, Arthur, primary, Caudron, Eric, additional, Perrod, Guillaume, additional, Boucenna, Imane, additional, Gazeau, Florence, additional, Wilhelm, Claire, additional, Berger, Anne, additional, Clément, Olivier, additional, Cellier, Christophe, additional, Silva, Amanda K.A., additional, and Rahmi, Gabriel, additional

Published
2021
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16. Plasmodium falciparumsexual parasites develop in human erythroblasts and affect erythropoiesis

Author

Neveu, Gaëlle, Richard, Cyrielle, Dupuy, Florian, Behera, Prativa, Volpe, Fiona, Subramani, Pradeep Annamalai, Marcel-Zerrougui, Benjamin, Vallin, Patrice, Andrieu, Muriel, Minz, Aruna Mukti, Azar, Nabih, Martins, Rafael M., Lorthiois, Audrey, Gazeau, Florence, Lopez-Rubio, José-Juan, Mazier, Dominique, Silva, Amanda K.A., Satpathi, Sanghamitra, Wassmer, Samuel C., Verdier, Frédérique, and Lavazec, Catherine

Abstract

Plasmodium falciparumgametocytes, the sexual stage responsible for malaria parasite transmission from humans to mosquitoes, are key targets for malaria elimination. Immature gametocytes develop in the human bone marrow parenchyma, where they accumulate around erythroblastic islands. Notably though, the interactions between gametocytes and this hematopoietic niche have not been investigated. Here, we identify late erythroblasts as a new host cell for P falciparumsexual stages and show that gametocytes can fully develop inside these nucleated cells in vitro and in vivo, leading to infectious mature gametocytes within reticulocytes. Strikingly, we found that infection of erythroblasts by gametocytes and parasite-derived extracellular vesicles delay erythroid differentiation, thereby allowing gametocyte maturation to coincide with the release of their host cell from the bone marrow. Taken together, our findings highlight new mechanisms that are pivotal for the maintenance of immature gametocytes in the bone marrow and provide further insights on how Plasmodiumparasites interfere with erythropoiesis and contribute to anemia in malaria patients.

Published
2020
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