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12. Investigation of protective effects of Erythrina velutinaextract against MMS induced damages in the root meristem cells of Allium cepa

Author

Silva, Deborah S.B.S., Barboza, Benhur, Garcia, Anuska C.F.S., Oliveira, Betejane de, Estevam, Charles S., Neto, Vitor A., Santos, Andre L.L.M., Dias, Antonio S., Scher, Ricardo, and Pantaleao, Silmara M.

Abstract

Erythrina velutinaWilld., Fabaceae, is a medicinal plant that can be found in the tropics and subtropics, including in the semi-arid northeastern Brazil. It is commonly used in folk medicine to treat anxiety, agitation and insomnia. E. velutinahas been known to present analgesic, anti-infl ammatory and antibacterial activities, however, it is unknown if this plant present a protective effect on DNA. We assessed the antigenotoxic effect of E. velutinaagainst the genotoxic effects induced by MMS in the root meristem cells of Allium cepa. Three concentrations of the aqueous extract (100, 200 and 400mg/L) of this medicinal plant were used in three different types of treatment (pre-, post- and simultaneous). The effects of the extracts on the root meristem cells of A. cepawere analyzed at both macroscopic and microscopic levels. Protective effects were observed at higher concentrations in pre-treatment and in simultaneous treatment. The results suggest that E. velutinamay present antigenotoxic properties and demonstrate its chemopreventive potential.

Published
2013
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