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Luma de O Comini,1 Laura C de Oliveira,1 Luiza D Borges,1 Heloísa H Dias,1 Clara R S Batistelli,1 Luciana S da Silva,2 Tiago R Moreira,3 Rodrigo G da Silva,4 Rosângela M M Cotta1 1Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil; 2Medicine School, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil; 3Department of Nursing and Medicine, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil; 4Clinical Director of the Hemodialysis Service, São João Batista Hospital, Viçosa, Minas Gerais, BrasilCorrespondence: Luma de O CominiDepartment of Nutrition and Health, Federal University of Viçosa, Viçosa, Annex Building of the Biological Sciences Center II, University Campus, s/nº. Sala 101. Federal University of Viçosa, Viçosa, MG CEP: 36570-900, BrazilTel +55 31 3612-7538Fax +55 31 3612-5187Email lumacominiufv@gmail.comPurpose: To identify the associations between MetS and its components and chronic kidney disease (CKD) in a population with arterial hypertension (AH), or diabetes mellitus (DM) accompanied by the Primary Health Care (PHC).Patients and methods: A cross-sectional study with 788 individuals diagnosed with AH and/or DM followed by PHC of Viçosa, Brazil. Anthropometric, biochemical and clinical measures were performed for the diagnosis of MetS and CKD. MetS was identified using the NCEP-ATPIII criteria. CKD was identified by estimating the glomerular filtration rate using the CKD-EPI equation. Logistic regression models were used to estimate the chances of CKD associated with MetS and its components and specific combinations of components.Results: The prevalence of MetS reported in the population was 65.4%, that of hidden CKD was 15.4%. The prevalence of CKD among participants with MetS was 75.2%. The most prevalent component of MetS in the population was AH (96.7%). Elevated fasting blood glucose, central obesity, and reduced HDL-c were significantly associated with an increased chance of CKD (OR = 2.80, 95% CI 1.76–4.45, OR = 1.68, 95% CI, 05–2.71, OR = 1.61, CI 95% 1.03–2.50, respectively). For the multivariate adjustment, the participants with MetS were 2 times more likely to have CKD than those without MetS (OR = 2.07; 95% CI, 1.25–3.44). The combination of three components of MetS high blood pressure, abdominal obesity and elevated fasting blood glucose and the combination of four components of MetS high blood pressure, reduced HDL-c, high fasting blood glucose and abdominal obesity were associated with increased odds of CKD (OR = 2.67, CI 95% 1.70–4.20, OR = 2.50, CI 95% 1.55–4.02, respectively).Conclusion: MetS, as well as its individual or combined components were independently associated with CKD in the population with AH and/or DM accompanied by PHC.Keywords: high blood pressure, abdominal obesity, hypertriglyceridemia, fasting blood glucose, HDL-c, estimated glomerular filtration rate

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The aim of this systematic review was to synthesize the available literature on pretreatment factors, from a patient-centered perspective, that predict successful orthodontic treatment. Systematic and unrestricted searches were conducted across the electronic MEDLINE, Embase, Web-of-Science, Scopus, Cochrane Library, and LILACS/Bireme databases. Grey literature was also searched to identify potential studies. Qualitative assessments of the role of patient-centered pretreatment factors in orthodontic treatment success (adherence, satisfaction, and discontinuation rates) were evaluated and synthesized. Study selection and data extraction were performed independently by two reviewers. A total of sixteen studies were included. Three main domains related to the patient emerged as positive predictors of orthodontic treatment success: previous patterns of social behavior, attitudes of parents/caregivers, and reasonable motivation. Certain personality traits were associated with both positive and negative levels of adherence and treatment satisfaction. The evidence did not support the notion that the impact of malocclusion on aesthetic self-perception could serve as an indicator of cooperation, satisfaction, or discontinuation rates related to orthodontic treatment. Positive social behavior patterns and parental/caregiver attitudes, along with realistic prior motivation toward treatment goals, were found to be reliable predictors of orthodontic treatment success. Additionally, some personality traits were found to be associated with successful treatment outcomes. However, the evidence did not support the impact of malocclusion on self-perceived aesthetics as an indicator of compliance and satisfaction levels with orthodontic treatment.

Pollination by honey bees (Apis mellifera) is crucial for maintaining biodiversity and crop yields. However, the widespread use of pesticides may threaten bees' survival by contaminating their resources. Lambda-cyhalothrin, a neurotoxic insecticide commonly used in agricultural pest control, poses particular risks. In insects, the midgut and fat body serve as primary barriers against xenobiotics, and exposure to these chemicals during larval development can impact adult bees. This study aimed to assess whether the residual concentration of lambda-cyhalothrin in pollen grains affects the midgut and fat body of larval A. mellifera workers after chronic exposure. The midgut epithelium of larvae exposed to a lambda-cyhalothrin-based insecticide exhibited autophagic vacuoles, apical cell protrusions, apocrine secretion, nuclear pyknosis, and high levels of polysaccharides and glycoconjugates in the cytoplasm, with smaller amounts in the brush border. Histochemical analysis revealed areas of vacuolation and damage to cell integrity in the midgut. In fat body cells, the insecticide increased polysaccharide storage and decreased lipid droplet diameter. Despite the histopathological damages, no effects were found in the larval development and adult emergence. These findings suggest the occurrence of apoptosis and autophagy in midgut cells and alterations in nutrient storage in the fat body of A. mellifera larvae exposed to the lambda-cyhalothrin-based insecticide, potentially impacting the physiology and development of this pollinator with possible effects on adult workers., (© The Author(s) 2025. Published by Oxford University Press on behalf of the Society of Environmental Toxicology and Chemistry. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Plants provide an abundant source of potential therapeutic agents, including a diverse array of compounds, such as cyclotides, which are peptides known for their antimicrobial activity. Cyclotides are multifaceted molecules with a wide range of biological activities. Their unique topology forms a head-to-tail cyclic structure reinforced by a cysteine knot, which confers chemical and thermal stability. These molecules can directly target membranes of infectious agents by binding to phosphatidylethanolamine in lipid membranes, leading to membrane permeabilization. Additionally, they function as carriers and cell-penetrating molecules, demonstrating antiviral, antibacterial, antifungal, and nematicidal properties. The structure of cyclotides is also amenable to chemical synthesis, facilitating drug design through residue substitutions or grafting of bioactive epitopes within the cyclotide scaffold to enhance peptide stability. In this review, we explore the multifunctionality of these biomolecules as anti-infective agents, emphasizing their potential as a novel class of antimicrobial drugs.

Background: This study aimed to assess the organization, infrastructure, workforce, and adherence to protocols in neurocritical care across low- and middle-income countries (LMICs), with the goal of identifying key gaps and opportunities for improvement., Methods: We conducted a cross-sectional survey of 408 health care providers from 42 LMICs. The survey collected data on the presence of dedicated neurointensive care units, workforce composition, access to critical care technologies, and adherence to evidence-based protocols. Data were analyzed using descriptive statistics, and comparisons were made across different geographical regions (East Asia and the Pacific, Europe and Central Asia, Latin America and the Caribbean, the Middle East and North Africa, and South Asia and sub-Saharan Africa) and economic strata [low-income countries (LICs), lower middle-income countries (LoMICs), and upper middle-income countries (UMICs)]., Results: Only 36.8% of respondents reported access to dedicated neurointensive care units: highest in the Middle East (100%), lowest in sub-Saharan Africa (11.5%), highest in LoMICs (42%), and lowest in LICs (13%). Access to critical care technologies, such as portable computed tomography scanners (9.3%; UMICs 11%, LICs 0%) and tele-intensive care unit services (14.9%; UMICs 19%, LICs 10%), was limited. Workforce shortages were evident, with many institutions relying on anesthesia residents for 24-h care. Adherence to protocols, including those for acute ischemic stroke (61.7%) and traumatic brain injury (55.6%), was highest in Latin America and the Caribbean (72% and 73%, respectively) and higher in UMICs (66% and 60%, respectively) but remained low in LICs (22% and 32%, respectively)., Conclusions: The study highlights critical gaps in infrastructure, workforce, and technology across LMICs, yet it also underscores the potential for improvement. Strategic investments in neurointensive care unit capacity, workforce development, and affordable technologies are an unmet need in resource-limited settings. These findings offer a road map for policymakers and global health stakeholders to prioritize neurocritical care and reduce the disparities in patient outcomes globally., Competing Interests: Conflicts of interest: None of the authors have any conflict of interest. Ethical Approval/Informed Consent: Ethical approval for this study was obtained from the Institute Ethics Committee (IEC) at the All India Institute of Medical Sciences, New Delhi, India. Participating institutes in the various low- and middle-income countries sought clearance from their respective ethics committees, facilitated by the national coordinators who received the final protocol, IEC approval letter, and related documents., (© 2025. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.)

Background: This study was conducted in the Prof. Dr. Karl Arens Reserve, Corumbataí, São Paulo. The area is a Cerrado fragment, with no records of fire since 1962 and is characterised by the predominance of Cerradão phytophysiognomy. Although several studies have been conducted in the Reserve, there was no testimony material for some species in the Herbarium Rioclarense (HRCB), nor a list of vouchers for any taxon in the main publications. Thus, the objective of this work was to undertake a floristic survey of the woody species in the Reserve, based on herbarium specimens and fieldwork., New Information: The survey in HRCB recorded 510 exsiccatae belonging to 160 species and 44 families. We also conducted 24 fieldwork expeditions between 2019 and 2021 and recorded 118 species in 39 families. In total, 193 woody species were recorded for the Reserve in Corumbataí. Species such as Copaiferalangsdorffii and Myrcianeoclusiifolia had already been cited for the area, but there was no testimony material in the herbarium. Machaeriumnyctitans and Alchorneaglandulosa are examples of new records for the Reserve. Fabaceae, Asteraceae, Myrtaceae, Melastomataceae and Rubiaceae were the families with the greatest species diversity., (Lilian Silva Santos, Pedro Luís Rodrigues de Moraes.)

Trichuriasis, a well-known type of soil-transmitted helminthiasis, is a neglected gastrointestinal nematode disease predominantly affecting children in tropical regions and is caused by Trichuris trichiura. The potential zoonotic transmission of this disease is indicated by its presence in nonhuman primates. Chronic infection leads to mucosal damage, bacterial translocation, and intense inflammatory infiltration; however, the progression of these processes remains poorly understood. This study tracks the acute phase of experimental trichuriasis, providing detailed insights into nematode tissue migration stages, inflammatory infiltration, cytokine production, and 2D/3D imaging of the bacterial translocation process. We showed a mixed immune response (Th1, Th2, and Th17) initiated by larval-induced lesions in the intestine tissue and modulated by L4 larvae and adult worms in the cecum, with systemic changes observed in the mesenteric lymph nodes, peritoneal macrophages, and spleen. Despite the disruption of the intestinal mucosa within the first 10 days post-infection (d.p.i.), bacterial invasion becomes evident only after the development of the nematode into the L3 larval stage (17 d.p.i.), intensifying with lesions caused by the L4 larvae (22 d.p.i.) and adult worms (35 d.p.i.). Our multidimensional approach, which incorporates microscopy tools, micro-CT, physiological evaluations, tissue/organ assessments, and immunological parameters, demonstrates the ability of larvae to breach the intestinal mucosa, further indicating the timing of extensive bacterial infiltration. Additionally, a 3D animation illustrates how adult worm attachment mechanisms may facilitate bacterial translocation. This study provides significant insights into the immunological and pathological mechanisms of trichuriasis progression, highlighting the complex interplay among host immune responses, the gut microbiome, and parasite survival strategies, all of which are crucial aspects for future therapeutic development., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2025 de Oliveira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

This paper presents a recursive method for identifying extreme and superstable curves in the parameter space of dissipative one-dimensional maps. The method begins by constructing an Archimedean spiral with a constant arc length. Subsequently, it identifies extreme and superstable curves by calculating an observable ψ. The spiral is used to locate a region where ψ changes sign. When this occurs, a bisection method is applied to determine the first point on the desired superstable or extreme curve. Once the initial direction is established, the recursive method identifies subsequent points using an additional bisection method, iterating the process until the stopping conditions are met. The logistic-Gauss map demonstrates each step of the method, as it exhibits a wide variety of periodicity structures in the parameter space, including cyclic extreme and superstable curves, which contribute to the formation of period-adding structures. Examples of extreme and superstable curves obtained by the recursive method are presented. It is important to note that the proposed method is generalizable and can be adapted to any one-dimensional map., (© 2025 Author(s). Published under an exclusive license by AIP Publishing.)

This study aimed to characterize the employment status and work-related conditions of patients with advanced breast cancer (ABC) in Portugal and quantify the productivity costs of premature abandonment of the work market while evaluating strategies to promote employment. The analysis was based on a cumulative incidence model for estimation of ABC prevalence and on a cross-sectional study characterizing the employment status of patients with ABC. This study was conducted in Portuguese hospitals, between Nov2021-Dec2022 and included patients diagnosed with ABC for at least 6 months, aged 66 or less and consenting for a self-answered questionnaire regarding work status. A total of 2151 working-aged women were estimated to have ABC in 2019 in Portugal, with productivity costs amounting to 28,676,754€ over 2019-2021. 112 patients from 9 hospitals were included in the study, average age was 52yr, 48 % had a postsecondary educational degree level and 87 % reported having a paid job at the time of diagnosis, mostly full-time. At the time of the study, only 38 % of the patients maintained the job status. The remaining were unemployed (51 %), on medical leave (25 %) or retired (24 %). Stop working was a personal choice for only 5 %. A subsidized part-time employment regimen, despite increased government costs, would allow a reduction in productivity costs, leading to a positive balance of 2,431,329€ over the same period. This study suggests that the majority of patients with ABC abandon the labor market before the age of retirement. Flexible work arrangements would benefit the patient, the government and the society. '., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)

This study aims to enhance our understanding of the temporal and spatial processes scales governing the evolutionary diversification of Neotropical birds with Trans- and Cis-Andean populations of the species Attila spadiceus from South and Central America. Through a multilocus analysis of the mitochondrial (CytB and ND2) and nuclear genes (I7BF, I5BF, and G3PDH) of 41 samples representing six subspecies, we describe the existing molecular lineages of A. spadiceus , and estimate their demographic dynamics. We used Ecological Niche Modeling (ENM) with six different algorithms to predict the potential distribution of A. spadiceus in both present-day and past scenarios, examining the overlap climatic niche between Cis- and Trans-Andean lineages. The analysis confirms a relatively recent divergence of the Trans- and Cis-Andean lineages, at approximately 0.25 million years ago (Ma). The niche modeling supports the existence of a dynamic scenario of the expansion and retraction of forest corridors in northwestern South America during the last glaciation. This suggests that the earlier orogenesis of the Andes was not a primary determinant of this dichotomy. Additionally, the analysis of population dynamics indicated a trend of increasing population size starting at 0.05 Ma for both lineages. Our findings highlight the significance of Pleistocene Forest corridors north of the Andes as the key factor maintaining communication before the separation of the lineages, likely associated with the retraction of this forest. We highlight the absence of any significant differentiation between the disjunct Amazonian and Atlantic Forest populations, at both part of the Cis-Andean lineage. The phylogeographic profile of A. spadiceus diverges from the patterns observed in other Neotropical birds, which emphasizes the need for further research on the role of the forest corridors of the northern Andes as drivers of diversification, to provide comprehensive insights into the processes that led to the formation of the region's present-day avian diversity., Competing Interests: There are no conflicts of interest, and all authors are aware of the submission of the information disclosed in this work., (© 2025 The Author(s). Ecology and Evolution published by John Wiley & Sons Ltd.)

Freshwater depletion becomes a significant challenge as the population grows and food demand rises. We evaluated the responses of lettuce cultivars ( Lactuca Sativa ) under saline stress in photosynthetic responses, production, and ion homeostasis. We used a randomized block design in a 3 × 5 factorial scheme with five replications-the first factor: three cultivars of curly lettuce: SVR 2005, Simpson, and Grand Rapids. The second factor consisted of five treatments: T1-control (water of 0.53 dS m -1 ); T2-saline stress (water of 4.0 dS m -1 ); T3-saline stress + ascorbic acid; T4-saline stress + gibberellic acid; and T5-saline stress + salicylic acid. The Grand Rapids lettuce cultivar tolerated water salinity, obtaining the highest production. The Simpson lettuce cultivar was sensitive to salinity, reducing biomass production under saline stress by 11.47% compared to Grand Rapids. Salicylic acid was more effective at mitigating saline stress in the Simpson lettuce cultivar than ascorbic and gibberellic acids, with a 24.85% increase in production compared to saline stress. The findings suggest that the Grand Rapids lettuce cultivar is more resilient to saline conditions, while salicylic acid can significantly enhance production in the sensitive Simpson cultivar under saline stress.

Purpose: To evaluate the molecular evolution of endoplasmic reticulum (ER) stress during colorectal cancer carcinogenesis., Methods: Fifty-six hairless mice were divided into two groups: control (no intervention); and carcinogenesis (treated with two doses of azoxymethane at 10 mg/kg during the third and the fourth week and dextran sodium sulfate at 2.5% for seven days in the second, fifth, and eighth week). Euthanasia occurred at the fifth, 10th, 15th, and 20th week. Colons were collected, and gene expression of ER stress markers (IRE1-α, PERK, ATF6, and CHOP) was assessed via real-time quantitative polymerase chain reaction., Results: ERN1 expression was significantly higher than the control at the 10th week (1.39 ± 0.16, p 0.05) and the 20th week (1.15 ± 0.04, p 0.01). ATF6 also showed elevated expression, significantly different at the 10th week (1.71 ± 0.29, p 0.05) and the 20th week (1.14 ± 0.06, p 0.05). PERK and CHOP expressions were significantly higher than the control in the 15th (PERK = 1.30 ± 0.12, CHOP = 1.48 ± 0.23) and 20th weeks (PERK = 1.63 ± 0.20, CHOP = 1.67 ± 0.22, p 0.05)., Conclusion: Upregulation of IRN1, PERK, ATF6, and CHOP demonstrates a strong ER stress response during colorectal cancer development.

Objective: to analyze the spatial-temporal pattern of childbirths and flow of postpartum women assisted at a regional reference maternity hospital., Methods: ecological study of 4,081 childbirths, between September 2018 and December 2021, at a public maternity hospital in the Baixo Tocantins region, Pará, Brazil. With data collected from five sources, a geographic database was constructed, and spatial analysis was used with Kernel density interpolator. Maps were generated using QGis/3.5 and TerraView/4.3, calculating chi-square (p<0.05)., Results: the highest concentrations of normal and cesarean childbirths were observed in Barcarena (n=2,558/62.68%), Abaetetuba (n=750/18.38%), Moju (n=363/8.89%) and Igarapé-Miri (n=219/5.37%). Among the municipalities in the region, ten had obstetric beds, totaling 210 beds. In this scenario, postpartum women traveled up to 288 km to reach the maternity hospital., Conclusions: long distances between certain municipalities of residence and maternity hospital, and low supply of obstetric beds, were identified as risk factors for unfavorable obstetric outcomes.

Acute gastroenteritis (AG) is a major illness in early childhood. Recent studies suggest a potential association between human bocavirus (HBoV) and AG. HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family. This study aimed to describe the frequency of HBoV in Northern Brazil using samples from patients with AG collected between 2017 and 2022. Fecal samples obtained from the viral gastroenteritis surveillance network at the Evandro Chagas Institute (IEC) were analyzed. Fecal suspensions (20%) were prepared, and the viral genome was extracted. PCR and nested-PCR were employed to detect HBoV, followed by nucleotide sequencing to identify viral types. Out of 692 samples, HBoV positivity was detected in 9.2% of cases (64/692). Genotypes HBoV-1, HBoV-2, HBoV-3, and HBoV-4 were found in 42.5% (17/40), 22.5% (9/40), 32.5% (13/40), and 2.5% (1/40) of the specimens, respectively. Co-infections with HBoV and other enteric viruses occurred in 48.3% (31/64) of cases, with RVA being the most frequent (31.2%, 20/64). The study results underscore the importance of continuous monitoring and further research to better understand the seasonality, coinfection patterns, and genetic variability of HBoV.

Polymorphisms in the MBL2 gene exon 1 can decrease serum levels of mannose-binding lectin (MBL), increasing the risk of infection in immunocompromised individuals. This study evaluated the association between the polymorphism in exon 1 of the MBL2 gene, genotypes, serum MBL levels, and infection in 122 patients with acute lymphoid leukemia (ALL). The MBL*A allele exhibited the highest frequency (0.37) within the study population. The MBL*D (0.32) was the predominant variant. The combined frequency of O polymorphic alleles (either B or D) was 0.63. The frequencies of the A/A, A/O and O/O genotypes were 0.13, 0.49 and 0.38, respectively. All patients exhibited consistently low levels of serum MBL, irrespective of their exon 1 genotype. Parasitic infections (n = 103), bacterial (n = 69) and viral (n = 48). A/O genotype (0.49) had higher infection rates, A/A (0.13) had lower rates, and O/O showed increased viral susceptibility (OR: 0.37; 95% CI 0.13-1.06; p = 0.05). Our findings demonstrated that the study population were MBL-deficient, regardless of their MLB2 genotype. Individuals with the A/O genotype had more infections, while those with the O/O genotype appeared more susceptible to viral infections. These findings highlight the impact of MBL levels and genetic variants on infection susceptibility in ALL patients., Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Informed consent: Informed consent was obtained from all subjects involved in the study. Institutional review board statement: The study was approved by the Research Ethics Committee of HEMOAM under CAAE: 25710819.0.0000.0009, in accordance with the guidelines outlined in Resolution 466/2012 of the National Health Council (CNS) of Brazil., (© 2024. The Author(s).)

Background/objectives: The aim of this paper was to compare voice and speech characteristics between post-COVID-19 and control subjects. The hypothesis was that acoustic parameters of voice and speech may differentiate subjects infected by COVID-19 from control subjects. Additionally, we expected to observe the persistence of symptoms in women., Methods: In total, 134 subjects participated in the study, were selected for convenience and divided into two groups: 70 control subjects and 64 post-COVID-19 subjects, with an average time of 8.7 months after infection. The recordings were made using the SPIRA software (v.1.0.) on cell phones, based on three verbal tasks: sustained production of the vowel/a/, reading a sentence, and producing a rhyme. Acoustic analyses of speech and voice were carried out with the PRAAT software (v.4.3.18), based on the following parameters: total sentence duration, number of pauses, pause duration, f 0 , f 0 SD, jitter, shimmer, and harmonics-to-noise ratio (HNR)., Results: Regarding the acoustic characteristics of speech, there were no differences between the groups or between the sexes. Regarding the acoustic characteristics of voice, jitter, shimmer, and HNR, significant differences between the groups were found. Differences between sexes were observed in the following frequency-related parameters: f 0 , f 0 SD, and jitter., Conclusions: Some acoustic characteristics of the patients' voice may show a deteriorated condition even after exacerbation of the disease. These characteristics are compatible with some of the symptoms reported by post-COVID-19 subjects, such as the presence of tension and fatigue. These voice acoustic parameters could be used as biomarkers to screen voice disorders in long-COVID, using artificial intelligence (AI), accelerating the search for diagnosis by specialists.

Objective: To evaluate the association between the severity of possible sleep bruxism (PSB) and possible awake bruxism (PAB) and attrition tooth wear facets (ATWF) in children/adolescents., Methods: Four hundred-thirty-four children/adolescents enrolled in schools in Lavras, Brazil, participated in this cross-sectional study. Caregivers answered a questionnaire about their childrens' PSB. Children/adolescents answered a questionnaire about the occurrence of PAB., Results: ATWF among individuals without PSB and PAB was lower than those with moderate/severe PSB ( p = 0.038) and moderate/severe PAB ( p = 0.003). ATWF in anterior teeth was lower among individuals without PSB compared to those with mild ( p = 0.015) and moderate/severe PSB ( p = 0.032). ATWF in posterior teeth was lower among individuals without PAB compared to those with mild ( p = 0.046) and moderate/severe PAB ( p = 0.017)., Conclusion: The number of attrition tooth wear facets is proportional to the severity of PSB and PAB.

Introduction: Carbapenemase-producing Enterobacterales (CPE) is a global threat. We evaluate the prevalence of CPE among isolates categorized as meropenem-susceptible, but that meet the European Committee on Antimicrobial Susceptibility Testing (EUCAST) screening cut-off values for carbapenemase detection, and analyze the susceptibility of these isolates to new available drugs., Methods: We analyzed 257 isolates from patients hospitalized in a tertiary hospital in Brazil, from July 2022 to April 2023. Only isolates that met the screening cut-off values established by EUCAST for detection of carbapenemases were analyzed (i.e. meropenem inhibition zones of 25-27mm by disk diffusion). The detection of carbapenemases was performed by immnunochromatographic testing and confirmed by high-resolution melting-PCR (HRM-qPCR)., Results: We identified 12 (4.7%) CPE including 7 KPC, 4 NDM, and 1 OXA-48-like. The isolates were susceptible to ceftazidime-avibactam (72.7%), meropenem-vaborbactam (100%), imipenem-relebactam (63.6%) and ceftolozane-tazobactam (36.4%)., Conclusion: We highlight the importance of tracking carbapenemases for epidemiological control and therapeutic guidance., (Copyright © 2024 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved.)

We report herein the case of a 41-year-old man operated on for a small inferior parietal lobule ganglioglioma with a sleep-awake-sleep protocol and language mapping to avoid major speech disorders. Postoperatively, however, writing disturbance was characterized by persistent graphemic errors that lasted for about 8 months. The topic is discussed in light of recent literature, exploring the possible relationship between writing difficulties and disconnections produced by a combination of resecting supramarginal gyrus components and interrupting arcuate fasciculus fibers. Awake mapping of eloquent structures is typically done using direct brain stimulation to maximize the extent of the resection while minimizing permanent neurological deficits. However, most intraoperative language tests focus on language skills such as oral and reading skills. Therefore, the detection of dysgraphia requires a high degree of attention from the surgical team and direct examination intra-and perioperatively. To this end, employing an intraoperative writing test during awake surgery may be considered. Advances in this field may aid in increasing the accuracy during parenchymal dissections, influencing the extent of the resection, improving the patient's functional prognosis and long-term quality of life., Competing Interests: Conflict of Interest Statement. The authors have no conflicts of interest to declare., (© 2025. The Author(s).)

This study focuses on the analysis of a unique composition between two well-established models, known as the Logistic-Gauss map. The investigation cohesively transitions to an exploration of parameter space, essential for unraveling the complexity of dissipative mappings and understanding the intricate relationships between periodic structures and chaotic regions. By manipulating control parameters, our approach reveals intriguing patterns, with findings enriched by extreme orbits, trajectories that connect local maximum and minimum values of one-dimensional maps. This theory enhances our perception of structural organization and offers valuable perceptions of the system behaviors, contributing to an expanded understanding of chaos and periodicity in dynamic systems. The analysis reveals Complex Sets of Periodicity (CSP) in the parameter space, characterized by superstable curves that traverse their main bodies. The exploration of different combinations of parameters shows cascades of CSP structures with added periods and are organized based on extreme curves. This investigation offers valuable discoveries of the dynamics of dissipative mappings, opening avenues for future explorations in chaotic systems., (© 2025 Author(s). Published under an exclusive license by AIP Publishing.)

Maternal anxiety can have a significant impact on a child's behavior. This study aimed to investigate the association between maternal anxiety and externalizing and internalizing behavioral problems in their offspring. Data were utilized from 530 mothers and their 740 children participating in the 1993 Pelotas Birth Cohort and the 1993 Cohort-II study, respectively. Maternal anxiety was assessed at ages 18 and 22 using the Mini International Neuropsychiatric Interview (MINI). At age 22, mothers completed the Child Behavior Checklist (CBCL) to assess externalizing and internalizing behavior problems in their children (aged 16 months to 10 years). Two samples were analyzed: one included all children, and the other was a subsample that included only one child per mother. In one-child-per-mother sample, children of mothers with anxiety had 4.63 (95 % CI: 2.28; 6.97), 3.35 (95 % CI: 0.92; 5.77), and 4.97 (95 % CI: 2.51; 7.43) points higher scores on internalizing, externalizing, and total problem scales, respectively, compared to children of mothers without anxiety. When including all children, the differences were 2.68 (95 % CI: 0.93; 4.44), 2.63 (95 % CI: 0.73; 4.52), and 2.60 (95 % CI: 0.87; 4.34) points, respectively. Understanding the mechanisms underlying this association, emphasized by these findings, is crucial for promoting children's mental health and well-being, as well as developing effective interventions to support both mothers and children., Competing Interests: Declaration of competing interest All authors contributed to study design, data analysis, data interpretation, and drafting and revision of the manuscript, and gave final approval of the version to be submitted for publication. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. The authors declare no conflicts of interest., (Copyright © 2025 Elsevier B.V. All rights reserved.)

Eleven previously undescribed macrocyclic humulene sesquiterpenoids, dolichocarpols G-Q (1-11), five undescribed bicyclic, dolichocarpols R-V (12-16) and two undescribed norsesquiterpenes, dolichocarpols W-X (17-18) were isolated from the roots of Anaxagorea dolichocarpa. Their structures were unequivocally determined by the analysis of NMR, HRESIMS, and IR data, along with NMR and ECD quantum-mechanical calculations, followed by the application of the DP4+ method. Most compounds possess an ether bridge between different carbons, whereas compounds 13/14 and 15/16 are diastereomers isomerized at C-7/C-10 and at C-7/C-10/C-12, respectively. The antineuroinflammatory activity of compounds 1-18 was tested in an LPS/IFN-γ-stimulated BV2 microglial cell line. Compounds 1, 5, 8, 9 and 14 significantly reduced nitric oxide (NO) levels in a concentration-dependent manner (25-200 μM). Moreover, possible interactions between these bioactive compounds and inducible nitric oxide synthase (iNOS) were predicted via in silico studies. NO is known as an inflammatory mediator in neurodegenerative diseases; therefore, the effects of these compounds indicate their potential antineuroinflammatory activity., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier Ltd. All rights reserved.)