840 results on '"Silva MF"'
Search Results
2. ANÁLISE DE ALTERAÇÕES GENÔMICAS QUANTITATIVAS EM GENES APAGADORES (KDM1B E KDM7) EM LEUCEMIA LINFOBLÁSTICA AGUDA PEDIÁTRICA
- Author
-
Silva, ANDS, primary, Teixeira, EB, additional, Oliveira, MB, additional, Rotella, LB, additional, Viana, VBJ, additional, Silva, MF, additional, Gomes, JAB, additional, Wanderley, AV, additional, Oliveira, EHC, additional, and Khayat, AS, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Polymeric nanoparticles loaded with the 3,5,3´-triiodothyroacetic acid (Triac), a thyroid hormone: factorial design, characterization, and release kinetics
- Author
-
dos Santos KC, da Silva MF, Pereira-Filho ER, Fernandes JB, Polikarpov I, and Forim MR
- Subjects
Medical technology ,R855-855.5 ,Chemical technology ,TP1-1185 - Abstract
Karen C dos Santos,1 Maria Fatima GF da Silva,1 Edenir R Pereira-Filho,1 Joao B Fernandes,1 Igor Polikarpov,2 Moacir R Forim11Department of Chemistry, Federal University of Sao Carlos, Sao Carlos, 2Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Sao Paulo, BrazilAbstract: This present investigation deals with the development and optimization of polymeric nanoparticle systems loaded with 3,5,3´-triiodothyroacetic acid (Triac). A 211–6 fractional factorial design and another 22 factorial design were used to study the contrasts on particle size distribution, morphology, surface charge, drug content, entrapment efficiency, and in vitro drug release profiles. The independent variables were the concentration of Triac, type and quantity of both polymer and oil, quantity of Span™ 60 and Tween® 80, volume of solvent and water, and velocity of both magnetic stirring and the transfer of the organic phase into the aqueous solution. The results of optimized formulations showed a narrow size distribution with a polydispersity index lower than 0.200. The particle sizes were on average 159.6 nm and 285.6 nm for nanospheres and nanocapsules, respectively. The zeta potential was higher than 20 mV (in module) and the entrapment efficiency was nearly 100%. A high-performance liquid chromatography method was developed, validated, and efficiently applied to Triac quantification in colloidal suspension. The main independent variables were the type and quantity of the polymer and oil. In vitro drug release profile depicted several features to sustain Triac release. Different formulations showed various release rates indicating an interaction between Triac and other formulation compounds such as polymer and/or oil quantity. Two different models were identified (biexponential and monoexponential) that allowed the control of both the release rate and Triac concentration. Thus, the prepared nanoparticles described here may be of clinical importance in delivering Triac for thyroid treatment.Keywords: Triac, nanoparticles, optimization, factorial design of experiments, HPLC analytical method
- Published
- 2012
4. Analgésicos opioides disponíveis em Portugal aprovados para dor crónica
- Author
-
Valentim Maricoto Silva,MF and Aguilar Abrantes Nogueira,GM
- Subjects
Opioide ,analgésico ,Portugal ,analgesia ,dor - Abstract
RESUMO A prevalência de dor crónica na população portuguesa é de 37%, provocando limitações físicas, psicológicas, sociais e uma clara diminuição da qualidade de vida. Em alguns tipos de dor crónica, os analgésicos opioides mostraram-se como as únicas alternativas passíveis de proporcionar controlo de dor, devendo a terapêutica recorrendo a este grupo ser iniciada quando todas as outras opções falharam. Este artigo pretende rever as principais características dos analgésicos opioides, incluindo efeitos secundários e formas farmacêuticas disponíveis, tanto para terapêutica basal como de resgate.
- Published
- 2020
5. The Contribution of lincRNAs at the Interface between Cell Cycle Regulation and Cell State Maintenance
- Author
-
Biasini, A, Smith, AAT, Abdulkarim, B, da Silva, MF, Tan, JY, Marques, AC, Biasini, A, Smith, AAT, Abdulkarim, B, da Silva, MF, Tan, JY, and Marques, AC
- Abstract
Cell cycle progression is controlled by the interplay of established cell cycle regulators. Changes in these regulators' activity underpin differences in cell cycle kinetics between cell types. We investigated whether long intergenic noncoding RNAs (lincRNAs) contribute to embryonic stem cell cycle adaptations. Using single-cell RNA sequencing data for mouse embryonic stem cells (mESCs) staged as G1, S, or G2/M we found differentially expressed lincRNAs are enriched among cell cycle-regulated genes. These lincRNAs (CC-lincRNAs) are co-expressed with genes involved in cell cycle regulation. We tested the impact of two CC-lincRNA candidates and show using CRISPR activation that increasing their expression is associated with deregulated cell cycle progression. Interestingly, CC-lincRNAs are often differentially expressed between G1 and S, their promoters are enriched in pluripotency transcription factor (TF) binding sites, and their transcripts are frequently co-regulated with genes involved in the maintenance of pluripotency, suggesting a contribution of CC-lincRNAs to mESC cell cycle adaptations.
- Published
- 2020
6. Regulation of pannexin channels in the central nervous system by Src family kinases
- Author
-
Lohman, Alexander W., primary, Weilinger, Nicholas L., additional, Santos, Silva MF, additional, Bialecki, Jennifer, additional, Werner, Allison C., additional, Anderson, Connor L., additional, and Thompson, Roger J., additional
- Published
- 2019
- Full Text
- View/download PDF
7. Does comsumption of staining drinks compromise the result of tooth whitening?
- Author
-
Nogueira, JSP, primary, Lins-Filho, PC, additional, Dias, MF, additional, Silva, MF, additional, and Guimaraes, RP, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Regulation of pannexin channels in the central nervous system by Src family kinases
- Author
-
Allison C. Werner, Jennifer Bialecki, Nicholas L. Weilinger, Alexander W. Lohman, Connor L. Anderson, Roger J. Thompson, and Silva Mf Santos
- Subjects
0301 basic medicine ,Central Nervous System ,SRC Family Tyrosine Kinase ,Biology ,Connexon ,Connexins ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Animals ,Humans ,Src family kinase ,Phosphorylation ,Kinase ,General Neuroscience ,Tyrosine phosphorylation ,Pannexin ,Cell biology ,030104 developmental biology ,src-Family Kinases ,chemistry ,Membrane channel ,Protein Processing, Post-Translational ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modification of pannexins is complex, with phosphorylation emerging as a prominent form of functional regulation. While much is still not known regarding the specific kinases and modified amino acids, recent reports support a role for Src family tyrosine kinases (SFK) in regulating pannexin channel activity. This review outlines the current evidence supporting SFK-dependent pannexin phosphorylation in the CNS and examines the importance of these modifications in the healthy and diseased brain.
- Published
- 2017
9. 1514 Worker health surveillance: challenges to make it happen
- Author
-
Mininel, VA, primary, da Silva, MF, additional, Camarotto, JA, additional, and Takahashi, MABC, additional
- Published
- 2018
- Full Text
- View/download PDF
10. Urinary tract infection related to hospitalized patients: A Review
- Author
-
de Siqueira e, Silva MF, primary, de Sena, FCR, additional, Agostinho, F, additional, Almeida Medeiros, KK, additional, and Miguel, CB, additional
- Published
- 2017
- Full Text
- View/download PDF
11. Effect of phenolic compounds present in Argentinian plant extracts on mycelial growth of the plant pathogen Botrytis cinerea Pers.
- Author
-
MV, Hapon, primary, Boiteux, JJ, additional, Fern醤dez, MA, additional, Lucero, G, additional, Silva, MF, additional, and Pizzuolo, PH, additional
- Published
- 2017
- Full Text
- View/download PDF
12. Determination of the motor unit behavior of lumbar erector spinae muscles through surface EMG decomposition technology in healthy female subjects
- Author
-
Silva, MF, Dias, JM, Pereira, LM, Mazuquin, BF, Lindley, S, Richards, J, Cardoso, JR, Silva, MF, Dias, JM, Pereira, LM, Mazuquin, BF, Lindley, S, Richards, J, and Cardoso, JR
- Abstract
Introduction: The aims of this study were to determine the motor unit behavior of the erector spinae muscles and to assess whether differences exist between the dominant/nondominant sides of the back muscles. Methods: Nine healthy women, aged 21.7 years (SD = 0.7), performed a back extension test. Surface electromyographic decomposition data were collected from both sides of the erector spinae and decomposed into individual motor unit action potential trains. The mean firing rate for each motor unit was calculated, and a regression analysis was performed against the corresponding recruitment thresholds. Results: The mean firing rate ranged from 15.9 to 23.9 pps and 15.8 to 20.6 pps on the dominant and nondominant sides, respectively. However, the early motor unit potentials of the nondominant lumbar erector spinae muscles were recruited at a lower firing rate. Conclusions: This technique may further our understanding of individuals with back pain and other underlying neuromuscular diseases. Muscle Nerve 55: 28–34, 2017.
- Published
- 2016
13. A auto-estima e o não-verbal dos pacientes com queimaduras
- Author
-
da Silva Mf and da Sliva Mj
- Subjects
Nonverbal communication ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Self-esteem ,medicine ,Burn center ,Psychiatry ,business ,General Nursing ,media_common ,Clinical psychology - Abstract
Esta pesquisa teve como objetivos identificar o grau de auto-estima dos pacientes do Ambulatório de Seqüelas de Queimaduras do HC-FMUSP e identificar os sinais não-verbais emitidos pelos pacientes, quando questionados sobre sua auto-estima. Realizado com 80 pacientes (54 mulheres e 26 homens) atendidos na unidade durante o mês de fevereiro de 2002, o projeto foi aprovado pelas Comissões de Ética em Pesquisa da EEUSP e do HC-FMUSP e as entrevistas individuais com os pacientes baseadas em uma escala para avaliação de auto-estima validada no Brasil e na classificação de sinais não-verbais proposta por Silva. Dentre os resultados, verificamos que 18,75% pacientes apresentam baixa auto-estima, 32,50% média auto-estima e 48,75% pacientes alta auto-estima. O complemento foi a função dos sinais não-verbais mais freqüente entre os pacientes.
- Published
- 2004
14. Combined use of a femtosecond laser and a microkeratome in obtaining thin grafts for Descemet stripping automated endothelial keratoplasty: an eye bank study
- Author
-
Murta, JN, Rosa, AM, Quadrado, MJ, Russo, AD, and Silva, MF
- Subjects
Queratoplastia Penetrante ,Queratoplastia Endotelial da Lâmina Limitante Posterior ,sense organs ,eye diseases - Abstract
Purpose: To evaluate the use of a femtosecond laser combined with a microkeratome in the preparation of posterior corneal disks for Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This experimental study involved ultrathin DSAEK tissue preparation of 22 donor corneas unsuitable for transplantation. The first cut was performed with an Intralase® FS60 laser and the second cut with a Moria CBm 300-µm microkeratome. The thickness of the first cut was modified for each cornea to obtain a final graft thickness of less than 110 µm. Precut and postcut central pachymetry were performed with an ultrasonic pachymeter. Central endothelial cell density (ECD) was calculated before and 24 hours after tissue preparation. Results: Final graft thickness was 105.0 ± 26.1 (SD) µm (range 65-117). The mean microkeratome head cut thickness was 324.5 ± 10.9 µm (range 310-345). Precut and postcut ECDs averaged 2250 ± 222 and 2093 ± 286 cells/mm2, respectively, representing 6.9% of cell loss. No corneas were perforated. Conclusion: Femtosecond FS60 lasers and Moria CBm 300-µm microkeratomes can be used sequentially to prepare consistently thin DSAEK grafts with no irregular cuts or cornea perforations.
- Published
- 2013
15. Femtosecond laser and microkeratome-assisted Descemet stripping endothelial keratoplasty: first clinical results
- Author
-
Rosa, AM, Silva, MF, Quadrado, MJ, Costa, E, Marques, I, and Murta, JN
- Subjects
Queratoplastia Penetrante ,Queratoplastia Endotelial da Lâmina Limitante Posterior ,sense organs ,eye diseases - Abstract
Purpose: To evaluate the use of a femtosecond laser combined with a microkeratome in the preparation of posterior corneal disks for Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: This experimental study involved ultrathin DSAEK tissue preparation of 22 donor corneas unsuitable for transplantation. The first cut was performed with an Intralase® FS60 laser and the second cut with a Moria CBm 300-µm microkeratome. The thickness of the first cut was modified for each cornea to obtain a final graft thickness of less than 110 µm. Precut and postcut central pachymetry were performed with an ultrasonic pachymeter. Central endothelial cell density (ECD) was calculated before and 24 hours after tissue preparation. Results: Final graft thickness was 105.0 ± 26.1 (SD) µm (range 65-117). The mean microkeratome head cut thickness was 324.5 ± 10.9 µm (range 310-345). Precut and postcut ECDs averaged 2250 ± 222 and 2093 ± 286 cells/mm2, respectively, representing 6.9% of cell loss. No corneas were perforated. Conclusion: Femtosecond FS60 lasers and Moria CBm 300-µm microkeratomes can be used sequentially to prepare consistently thin DSAEK grafts with no irregular cuts or cornea perforations.
- Published
- 2013
16. Optical- and x-ray-scattering studies of ionic ferrofluids ofMnFe2O4, γ-Fe2O3, andCoFe2O4
- Author
-
da Silva Mf and Figueiredo Neto Am
- Subjects
Ferrofluid ,Optics ,Birefringence ,Materials science ,Condensed matter physics ,Liquid crystal ,Scattering ,business.industry ,X-ray ,Ionic bonding ,business ,Magnetic liquids - Published
- 1993
17. HPV31 and HPV33 incidence in cervical samples from women in Recife, Brazil
- Author
-
Martins Db, P. M Felix, Katz Lm, Sergio Crovella, Antonio Carlos de Freitas, Willy Beçak, Lima Filho Jl, Bárbara Simas Chagas, Guimarães, P. M. Miranda, Angélica Alves Lima, Luiz Claudio Arraes, Baldez da Silva Mf, R.C. Stocco, M. F. P. T., Baldez da Silva, B. S., Chaga, V., Guimarãe, L. M. C., Katz, P. M., Felix, P. M., Miranda, A. A., Lima, L. C., Arrae, D. B. G., Martin, J. L., Lima Filho, R. C., Stocco, Crovella, Sergio, A. C., Freita, and W., Beçak
- Subjects
medicine.medical_specialty ,Ethnic group ,Prevalence ,Cervix Uteri ,Alphapapillomavirus ,Polymerase Chain Reaction ,Species Specificity ,Environmental health ,Epidemiology ,Genetics ,Medicine ,Humans ,Sex organ ,Molecular Biology ,Cervix ,Genotyping ,Cervical cancer ,business.industry ,Incidence (epidemiology) ,Alphapapillomaviru ,General Medicine ,medicine.disease ,Brazil ,Female ,medicine.anatomical_structure ,Immunology ,business ,Human - Abstract
Human papillomavirus (HPV) has been extensively studied concerning genomic structure, infection mechanisms, and diversity of types, as well as disease progression stages and development of vaccines. HPV type prevalence can differ in specific populations in different countries, according to ethnicity. This is the first report of an integrated project to evaluate the incidence of HPV types in different regions in Brazil in order to obtain data for vaccine development. Cervical samples were collected from women seen at a public hospital in Pernambuco, Northeast Brazil, for routine evaluation of genital alterations. Selection of the patients was random. There was a strong prevalence of HPV16 and a high incidence of HPV types 31 and 33. These data foster the discussion about the need to evaluate viral prevalence in each geographic region in order to develop targeted vaccine programs.
- Published
- 2009
18. Chapter 4 Alkyl, Aryl, Alkylarylquinoline, and Related Alkaloids
- Author
-
da Silva Mf, Vieria Pc, Soares Ms, and João B. Fernandes
- Subjects
Apiaceae ,Rutaceae ,biology ,Stereochemistry ,Zygophyllaceae ,Euphorbiaceae ,Rutoideae ,Proteobacteria ,Asteraceae ,biology.organism_classification ,Moraceae - Abstract
The Rutaceae continues to be the primary source of new alkyl-, aryl-, and alkylarylquinolin/ones. In the past 17 years, the overall distribution of these alkaloid types within the family has changed little since the chemosystematics reviews by Waterman (270), Mester (40), and da Silva et al. (279). Alkylquinolones dominate the reported isolations with about 51% of the total, with arylquinolones (16%), alkylquinolines (15%), alkylarylquinolines (11%), arylquinolines (3%), alkylarylquinolones (2%), and quinolines (2%) as the significant structural groups contributing to the remainder of this class of alkaloids. The alkyl-, aryl-, and alkylarylquinolin/one alkaloids occur in 50 species belonging to 24 genera and 6 subfamilies. Despite the intensive chemical exploration of many species from other plants in the Rutales family, but not in the family Rutaceae, the first alkaloid alkylquinolone from a simaroubaceous plant (160) was not reported until 1997. Although many additional alkaloids have been reported, some of new structural types (Bo.4), substantial biosynthetic work on plant-derived alkylquinolin/ones has not yet been carried out. The biosynthesis of some of these alkaloids in bacteria was firmly established as being derived from anthranilic acid. Outside of the Rutales, alkyl-, aryl-, and alkylarylquinolin/ones have not been found, except for simple quinoline (A.1; only one) and 2-methylquinoline derivatives in the Zygophyllaceae, and only an atypical quinolone derivative (Ao.1) in the Asteraceae family. A few 3-phenylquinolines (2), 3-(1H-indol-3-yl)quinoline (1), and quinoline-quinazoline (1) alkaloids have been reported from only a single genus in the Zygophyllaceae. Tryptophan-derived quinolines in higher plants are confined to a few 2-carboxylicquinolin/ones (6) and 4-carbaldehydequinolines (5); the former found in the Ephedraceae (5), Boraginaceae (1), Fagaceae (1), Ginkgoaceae (1), Plumbaginaceae (1), Solanaceae (1), and Apiaceae (1), and the latter in the Moraceae (3), Alliaceae (1), and Pontederiacae (1). The number of quinolones derived from glycine and a polyketide is also limited. 5-Alkyl-2-methylquinolin-4(1H)-ones (8) occur in the Euphorbiaceae, and 5-alkyaryl-2-methylquinolin-4(1H)-ones ((3) in the Sterculiaceae. Alkylquinolin/ones are well-known as typical alkaloids of three Proteobacteria and three Actinobacteria; the genus Pseudomonas yielded the majority (46%) of the total number of alkaloids reported (39). 2-Carboxylicquinolin/ones (4) and 4-carbaldehydequinolines (6) are minor constituents in both divisions of bacteria. More interesting are the quinolactacins (7), in which the second nitrogen is derived from L-valine or L-isoleucine, recently reported to occur only in the fungus Penicillium. Many of these diverse alkaloids have served directly as medicines or as lead compounds for the synthesis (258) of derivatives with an improved biological profile. It is apparent from the summary view of the alkyl-, aryl-, and alkylarylquinolin/ones reported in the Rutaceae that they help to confirm the affinity between Rutoideae tribes and provide firm support for placing the Spathelioideae and the Dictyolomatoideae close to the more primitive Zanthoxyleae tribe. On the other hand, the bacteria and fungi are needed for more substantial chemical studies. When more data become available, it is likely that useful systematic correlations will emerge. More detailed studies regarding the biosynthetic pathways of the alkyl-, aryl-, and alkylarylquinolin/ones in the Rutaceae and in bacteria are needed. Such studies would clarify the differences in the pathways based on their derivation from anthranilic acid in bacteria and in rutaceous plants. Finally, this survey indicates that the Rutaceae, and various bacterial and fungal species offer considerable potential for the discovery of new or known alkaloids with significant and possibly valuable biological activities.
- Published
- 2007
19. Independent patterns of damage within magno-, parvo- and koniocellular pathways in Parkinson's disease
- Author
-
Silva, MF, Regateiro, FS, Forjaz, V, Januário, C, Freire-Gonçalves, A, and Castelo-Branco, M
- Subjects
genetic structures ,Perturbações da Visão ,Doença de Parkinson - Abstract
Sensory deficits have been documented in Parkinson's disease, in particular within the visual domain. However, ageing factors related to the brain and to neural and non-neural ocular structures could explain some of the previously reported results, in particular the claimed impairment within the koniocellular pathway. This study addressed visual impairment attributable to the magno- (luminance), parvo- (red-green) and koniocellular (blue-yellow) pathways in a population of Parkinson's disease patients. To avoid potentially confounding factors, all subjects underwent a full neurophthalmological assessment which led to exclusion of subjects with increased intraocular pressure, diabetes even in the absence of retinopathy, and ocular abnormalities (from a total of 72 patients' eyes, 12 were excluded). Both parvo- and koniocellular pathways were studied by means of contrast sensitivity (CS) measurements along protan, tritan and deutan axes and also by fitting chromatic discrimination ellipses using eight measured contrast axes. Magnocellular function was assessed, using stimuli that induce a frequency doubling illusion, in 17 locations in the fovea and periphery. Achromatic (luminance modulation) thresholds were significantly higher in Parkinson's disease both in foveal and peripheral locations. A significant impairment was observed along protan and deutan axes, but only marginally along the tritan axis. These results were corroborated by a significant elongation of chromatic discrimination ellipses in our Parkinson's disease group. Correlation analysis showed that achromatic and chromatic CS measures were independent, which implies that multiple visual pathways are affected independently in Parkinson's disease. Magnocellular impairment was significantly correlated with age and disease stage, in contrast to the measured chromatic deficits. We conclude that in Parkinson's disease, independent damage occurs in the early magno- and parvocellular pathways. Furthermore, traditional koniocellular probing strategies in Parkinson's disease may be confounded by ageing factors, which may reconcile the previously reported controversial findings concerning chromatic impairment in Parkinson's disease.
- Published
- 2005
20. Characterization of fatty acylcarnitines in rat hepatocytes in vitro
- Author
-
Aires, CC, Ruiter, J, de Almeida, IT, Duran, M, Wanders, RJ, Silva, MF, and Repositório da Universidade de Lisboa
- Subjects
Biochemistry & Molecular Biology - Abstract
Made available in DSpace on 2015-12-30T10:18:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2005
- Published
- 2005
21. A Probabilistic Investigation of Primary Consolidation Settlements of Subsea Structures
- Author
-
Silva, MF, primary, Begaj, L, additional, and Amodio, A, additional
- Full Text
- View/download PDF
22. Utilização de Projetos Terapêuticos Singulares no Enfrentamento às Doenças Crônicas não Transmissíveis: Relato de Experiência
- Author
-
SEVERO, AJ, primary, RIBEIRO, HMB, additional, CUNHA, JF, additional, SILVA, MF, additional, MOREIRA, PVL, additional, and PESSOA, TRRF, additional
- Published
- 2014
- Full Text
- View/download PDF
23. PReS-FINAL-2298: Biometrics of spleen and liver in patients with childhood-onset systemic lupus erythematosus
- Author
-
Campos, LM, primary, Silva, MF, additional, Tassetano, PF, additional, Alves, AG, additional, Rocha, SM, additional, Valente, M, additional, and Silva, CA, additional
- Published
- 2013
- Full Text
- View/download PDF
24. Is hepatic venous pressure gradient assessment required before liver resection in patients with cirrhosis and hepatocellular carcinoma?
- Author
-
Silva, MF, primary, Strasser, SI, additional, and Carrilho, FJ, additional
- Published
- 2013
- Full Text
- View/download PDF
25. Invasive aspergillosis: a severe infection in juvenile systemic lupus erythematosus patients
- Author
-
Silva, MF, primary, Ribeiro, AS, additional, Fiorot, FJ, additional, Aikawa, NE, additional, Lotito, AP, additional, Campos, LM, additional, Mauad, T, additional, and Silva, CA, additional
- Published
- 2012
- Full Text
- View/download PDF
26. Optical- and x-ray-scattering studies of ionic ferrofluids of MnFe2O4, gamma -Fe2O3, and CoFe2O4
- Author
-
da Silva MF and Figueiredo Neto AM
- Published
- 1993
27. Macrocrystalline silicon thin films prepared by RF reactive magnetron sputter deposition
- Author
-
Cerqueira, MF, primary, Andritschky, M, additional, Rebouta, L, additional, Ferreira, JA, additional, and da Silva, MF, additional
- Published
- 1995
- Full Text
- View/download PDF
28. Bioequivalence evaluation of single doses of two tramadol formulations: a randomized, open-label, two-period crossover study in healthy Brazilian volunteers.
- Author
-
Silva MF, Schramm SG, Kano EK, Mori Koono EE, Porta V, and dos Reis Serra CH
- Abstract
BACKGROUND: Tramadol is a well tolerated and effective analgesic used to treat moderate to severe pain. Several generic formulations of tramadol are available in Brazil; however, published information regarding their bioequivalence in the Brazilian population is not available. A study was designed for Brazilian regulatory authorities to allow marketing of a generic formulation. OBJECTIVE: The purpose of this study was to compare the bioequivalence of 2 commercial tablet preparations containing tramadol 100 mg marketed for use in Brazil. METHODS: A randomized, open-label, 2 x 2 crossover study was performed in healthy Brazilian volunteers under fasting conditions with a washout period of 12 days. Two tablet formulations of tramadol 100 mg (test and reference formulations) were administered as a single oral dose, and blood samples were collected over 24 hours. Tramadol plasma concentrations were quantified using a validated HPLC method. A plasma concentration-time profile was generated for each volunteer and then mean values were determined, from which C(max), T(max), AUC(0-infinity) k(e), and t(1/2) were calculated using a noncompartmental model. Bioequivalence between the products was determined by calculating 90% CIs for the ratios of C(max) AUC(0-t) and AUC(0-infinity), values for the test and reference products using log-transformed data. Tolerability was assessed by monitoring vital signs (temperature, blood pressure, heart rate), laboratory tests (hematology, blood biochemistry, hepatic function, urinalysis), and interviews with the volunteers before medication administration and every 2 hours during the study. RESULTS: Twenty-six healthy volunteers (13 men, 13 women) were enrolled in and completed the study. Mean (SD) age was 30 (6.8) years (range, 21-44 years), mean weight was 64 (8.3) kg (range, 53-79 kg), and mean height was 166 (6.4) cm (range, 155-178 cm). The 90% CIs for the ratios of Cmax (1.01-1.17), AUC(0-t) (1.00-1.13), and AUC(0-infinity). (1.00-1.14) values for the test and reference products fell within the interval of 0.80 to 1.25 proposed by most regulatory agencies, including the Brazilian regulatory body. No clinically important adverse effects were reported; only mild somnolence was reported by 4 volunteers and mild headaches by 5 volunteers, and there was no need to use medication to treat these symptoms. CONCLUSION: Pharmacokinetic analysis in these healthy Brazilian volunteers suggested that the test and reference formulations of tramadol 100-mg tablets met the regulatory requirements to assume bioequivalence based on the Brazilian regulatory definition. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
29. Combined ion bean and hyperfine interaction studies of LiNbO3 single crystals
- Author
-
Marques, Jg, Kling, A., Luis Rebouta, Da Silva, Mf, and Soares, Jc
30. Energy analysis of multi-legged locomotion systems
- Author
-
Silva, Mf, Machado, Jat, António Lopes, Berns, K., and Dillmann, R.
31. Performance analysis of multi-legged systems
- Author
-
Silva, Mf, Machado, Jat, António Lopes, and IEEE
32. Compositional study of (Pb,La)TiO3 thin films by Rutherford backscattering spectroscopy
- Author
-
Martin, Mj, Miguel Algueró, Calzada, Ml, Pardo, L., Da Silva, Mf, and Soares, Yjc
33. Quasi-periodic gaits in multi-legged robots
- Author
-
Silva, Mf, Machado, Jat, António Lopes, Bidaud, P., and Benamar, F.
34. Influence of temperature and pressure on the beryllium pebbles bedelectrical resistivity
- Author
-
Alves, E., Alves, Lc, Da Silva, Mf, Melo, Aa, Soares, Jc, and Scaffidi-Argentina, F.
35. Lattice location and annealing behavior of Mn implanted GaN
- Author
-
Liu, C., Eduardo Alves, Ramos, Ar, Da Silva, Mf, Soares, Jc, Matsutani, T., and Kiuchi, M.
36. High-T-c superconductors studies with radioactive ion beams at isolde
- Author
-
Correia, Jg, Alves, E., Amaral, Vs, Araujo, Jp, Bordet, P., Butz, T., Capponi, Jj, Ctortecka, B., Le Floch, S., Galindo, V., Gatt, R., Langouche, G., Loureiro, Sm, Lourenco, Aa, Marques, Jg, Melo, Aa, Papen, T., Ramos, Ar, Senateur, Jp, Da Silva, Mf, Soares, Jc, Sousa, Jb, Toulemonde, P., Troger, W., Vantomme, A., Wahl, U., and Weiss, F.
37. Oxidation resistance of (Ti,Al,Si)N coatings in air
- Author
-
Vaz, F., Luis Rebouta, Andritschky, M., and Da Silva, Mf
38. Sapphire (alpha-Al2O3) behaviour under heavy ion implantation
- Author
-
Eduardo Alves, Da Silva, Mf, Soares, Jc, and OECD
39. High-T-c superconductors studies with radioactive ion beams at isolde
- Author
-
Correia, Jg, Eduardo Alves, Amaral, Vs, Araujo, Jp, Bordet, P., Butz, T., Capponi, Jj, Ctortecka, B., Le Floch, S., Galindo, V., Gatt, R., Langouche, G., Loureiro, Sm, Lourenco, Aa, Marques, Jg, Melo, Aa, Papen, T., Ramos, Ar, Senateur, Jp, Da Silva, Mf, Soares, Jc, Sousa, Jb, Toulemonde, P., Troger, W., Vantomme, A., Wahl, U., Weiss, F., and OECD
40. Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women
- Author
-
José Luiz de Lima Filho, Rafael Lima Guimarães, Sergio Crovella, Antonio Carlos de Freitas, V.S. Guimaraes, Danielly Bruneska, Ludovica Segat, Maria Fernanda Piffer Tomasi Baldez da Silva, Lucas André Cavalcanti Brandão, Henrique Castelletti, Michele Milanese, Cintia Renata Costa Rocha, Luiz Claudio Arraes, Guimaraes, V, Guimaraes, R, Brandao, L, BALDEZ DA SILVA, Mf, Milanese, M, Segat, L, Castelletti, H, Bruneska, D, DE LIMA FILHO, Jl, DE FREITAS, Ac, Arraes, Lc, Rocha, C, and Crovella, Sergio
- Subjects
Adult ,Risk ,Adolescent ,Immunology ,Physiology ,Uterine Cervical Neoplasms ,Biology ,Mannose-Binding Lectin ,Uterine cancer ,Genotype ,medicine ,Immunology and Allergy ,Humans ,Genetic Predisposition to Disease ,Allele ,Human papillomavirus ,Promoter Regions, Genetic ,Mannan-binding lectin ,Human papillomavirus 16 ,Polymorphism, Genetic ,Haplotype ,Papillomavirus Infections ,HPV infection ,Case-control study ,General Medicine ,Sequence Analysis, DNA ,medicine.disease ,Case-Control Studies ,Female ,Brazil - Abstract
We studied the association between high-risk human papillomavirus (HPV) infection and MBL2 functional polymorphisms in a group of 180 high-risk HPV-infected women and 180 healthy control subjects. The most frequent high-risk HPV genotypes were 16 (47.2%), 31 (11.7%), 33 (5%), and 18 (2.2%), respectively. Of the 180 HPV-infected women, 99 presented with uterine cervical cancer and 81 did not. No differences in MBL2 genotype or in allelic or haplotype frequencies were found between HPV patients who developed cervical uterine cancer and those who did not. When considering combined genotypes grouped according to MBL production (designated as high, low, and deficient producers), we detected a significant difference between healthy controls and high-risk HPV-positive patients, the latter group showing increased frequencies of deficient-producer genotypes (14.4% vs 9.4% in the healthy control group, corrected p = 0.04). In conclusion, a correlation between MBL2 polymorphisms and high-risk HPV infection was found in this study.
- Published
- 2008
41. Influence of SARS-CoV-2 variants on COVID-19 epidemiological and clinical profiles: a comparative analysis of two waves of cases.
- Author
-
Dos Santos PR, Dos Santos UR, de Santana Silva ÍTS, Fehlberg HF, Ferreira FB, Albuquerque GR, Mariano APM, da Silva MF, Lemos LS, Piton KA, de Melo Silva M, Fontana R, Guimarães Rocha Aguiar ER, Marin LJ, and Gadelha SR
- Subjects
- Humans, Male, Brazil epidemiology, Female, Cross-Sectional Studies, Adult, Middle Aged, Young Adult, Adolescent, Aged, Nasopharynx virology, Child, Child, Preschool, Aged, 80 and over, Infant, COVID-19 epidemiology, COVID-19 virology, SARS-CoV-2 genetics, SARS-CoV-2 isolation & purification
- Abstract
Background: The COVID-19 pandemic has been the most significant health challenge of the last century. Multiple and successive waves of COVID-19 cases, driven particularly by the emergence of new SARS-CoV-2 variants, have kept the world in a constant state of alert., Methods: We present an observational, descriptive, cross-sectional study aimed at identifying SARS-CoV-2 variants circulating during two local waves of COVID-19 cases in southern Bahia, Brazil (late 2021 and late 2022), and analyzing the association between the detected variants and the epidemiological and clinical characteristics of the disease. For this purpose, data and nasopharyngeal samples from individuals in southern Bahia, Brazil, with suspected COVID-19 were included. Viral detection was performed by RT-qPCR, and SARS-CoV-2 variants were identified by next-generation viral sequencing., Results: A total of 368 nasopharyngeal samples were tested. Approximately 23% of the samples from late 2021 tested positive for SARS-CoV-2, while in 2022, the positivity rate was about 56%. All sequenced samples from 2021 were identified as the Delta variant, while in 2022, all samples were classified as the Omicron variant. Overall, individuals who tested positive for SARS-CoV-2 in 2022 were younger than those who tested positive in 2021. Moreover, we observed significant differences in the clinical spectrum of SARS-CoV-2 infection when comparing the two periods. Individuals who presented with anosmia/ageusia were more likely to test positive for SARS-CoV-2 infection in 2021 but not in 2022. Additionally, fever, dry cough, pharyngalgia, headache, and rhinorrhea were more frequent among individuals infected with the Omicron variant than among those infected with the Delta variant., Conclusions: The profile of COVID-19 in southern Bahia differed when analyzing two distinct waves of the pandemic in the region. These differences are likely related to the variants, which may differ in transmissibility and virulence, thereby altering the dynamics of the pandemic. This underscores the importance of genomic surveillance in better understanding the behavior of viral infections., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
42. The Modulation of Growth and Metabolism in Solanum lycopersicum Contrast With the Leaf-Specific Regulation of Wild Tomato Species.
- Author
-
Siqueira JA, Martins AO, Wakin T, Silva MF, Batista-Silva W, Brito FAL, Zsögön A, Fernie AR, Nunes-Nesi A, and Araújo WL
- Abstract
Plant organs harbour diverse components that connect their physiology to the whole organism. The turnover of metabolites may be higher in some organs than in others, triggering differential growth patterns throughout the organism. We revealed that Solanum lycopersicum exhibits more coordinated growth and physiology across the entire plant compared to wild tomato species. Specifically, young leaves of S. lycopersicum develop more slowly than mature leaves, whereas wild species do not exhibit this pattern. Wild tomato Solanum pennellii displays young leaves with higher photosynthetic rates than mature leaves. Consequently, sucrose metabolism in S. pennellii is quite similar between young and mature leaves, while expression patterns of circadian clock genes differ significantly between leaves of different ages. Additionally, we demonstrated that introducing alleles related to tomato domestication into the wild tomato Solanum pimpinellifolium promotes coordinated growth between young and mature leaves, resulting in similar patterns to those observed in S. lycopersicum. Collectively, S. lycopersicum appears to exhibit more coordinated regulation of growth and metabolism, and understanding this process is likely fundamental to explaining its elevated harvest index., (© 2024 John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
43. Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway.
- Author
-
da Silva MF, Lins AA, Gomes MC, Marinho WPJ, de Araújo RSA, de Moura RO, Zhan P, Nascimento IJDS, and da Silva-Júnior EF
- Abstract
The term cancer is used to describe a complex pathology characterized by the uncontrollable proliferation of cells, which displays a fast metastatic spread, being a disease with difficult treatment. In this context, Phosphatidylinositol 3-kinase (PI3K) represents a promising pathway to be inhibited, aiming to develop anticancer agents, since it performs a pivotal role in regulating essential cellular processes, including cell proliferation, growth, autophagy, and apoptosis. In parallel, natural compounds can effectively represent a therapeutic strategy to fight against malignant cells. Then, compounds derived from various plant sources, such as flavonoids, terpenoids, alkaloids, coumarins, and lignans, have exhibited remarkable in vitro and in vivo anticancer properties. This review focused in the exploration of natural products targeting the PI3K/AKT/m-TOR signaling pathway, demonstrating that these compounds could even further investigated to reveal novel and effective anticancer drugs in the future., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2024
- Full Text
- View/download PDF
44. Sex, vaccination status, and comorbidities influence long COVID persistence.
- Author
-
Fuller T, Flores Mamani R, Ferreira Pinto Santos H, Melo Espíndola O, Guaraldo L, Lopes Melo C, Borges Da Silva MF, Amaral Calvet G, Soares Bastos L, Carvalho MS, and Brasil P
- Abstract
Background: There is interest in the public health impact of Long COVID, defined as symptoms that persist or begin after SARS-CoV-2 infection. We aimed to identify demographic and clinical risk factors associated with Long COVID over time in an Upper Middle-Income Country (UMIC) and potential biomarkers predictive of symptom trajectory., Methods: Prospective cohort study of adults with mild SARS-COV-2 during the Omicron period. We tracked symptom persistence and IgG antibody titers against the spike S1 subunit., Results: Of 383 participants, 276 had confirmed SARS-CoV-2 infection. Long COVID persisted for ≥ two months in 21 % and ≥ 12 months in 5 %. The most common symptoms were fatigue, upper respiratory symptoms, and myalgia/arthralgia: 15 % had fatigue for ≥ one month, 10 % for ≥ two months, and 5 % ≥ three months. Upper respiratory symptoms lasted ≥ one month in 17 %, ≥ two months in 7 %, and ≥ three months in 3 %. Fully 9 % reported myalgia/arthralgia lasting ≥ one month, 6 % ≥ two months, and 4 % ≥ three months. Risk factors for symptom persistence included female sex, not being fully vaccinated, and comorbidities. Participants experiencing persistent fatigue had lower anti-S1 IgG titers., Conclusions: In this population, symptom persistence declined after the acute phase, but 5 % of participants did not fully recover. Even in a population that was almost fully vaccinated, women, individuals with comorbidities, and the few remaining people who were unvaccinated were at greater risk for Long COVID. Immunoglobulins may have utility as a biomarker of Long COVID fatigue in this population., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
45. In people with shoulder pain, mobilisation with movement and exercise improves function and pain more than sham mobilisation with movement and exercise: a randomised trial.
- Author
-
Baeske R, Hall T, Dall'Olmo RR, and Silva MF
- Subjects
- Humans, Middle Aged, Male, Female, Adult, Pain Measurement, Treatment Outcome, Movement physiology, Physical Therapy Modalities, Shoulder Pain therapy, Shoulder Pain rehabilitation, Exercise Therapy methods, Range of Motion, Articular physiology
- Abstract
Question: In people with shoulder pain, what is the effect of adding mobilisation with movement (MWM) to a standard exercise program on function and pain compared with sham MWM and the same exercise program?, Design: A randomised trial with concealed allocation, blinded outcome assessment and intention-to-treat analysis., Participants: Seventy people with chronic atraumatic rotator cuff related pain, with a mean age 48 years (SD 10)., Interventions: The experimental group received MWM plus exercise and the control group received sham MWM plus exercise. Treatments were delivered twice per week for 5 weeks., Outcome Measures: The primary outcome measures were function (0 to 100 Shoulder Pain and Disability Index) and pain (0 to 10 Numerical Pain Rating Scale). Secondary outcomes were self-efficacy, perceived improvement and active pain-free range of movement. Assessment time points were at baseline (week 0), the end of the treatment period (week 5) and a follow-up 1 month after the end of treatment (week 9)., Results: At week 5, the experimental group improved more than the control group in function (MD -15 points, 95% CI -24 to -7), pain at night (MD -2.1, 95% CI -3.1 to -1.1), pain on movement (MD -1.5, 95% CI -2.5 to -0.6) and active range of movement in flexion (MD 16 deg, 95% CI 1 to 30), abduction (MD 23 deg, 95% CI 6 to 40), external rotation (MD 11 deg, 95% CI 4 to 17) and hand behind back (MD 20 deg, 95% CI 8 to 32). At week 9, benefits were seen in the Shoulder Pain and Disability Index (MD -9 points, 95% CI -17 to -1), pain at night (MD -1.9, 95% CI -2.9 to -0.8) and on movement (MD -1.3, 95% CI-2.3 to -0.3). The effects of the experimental intervention on other outcomes were mostly unclear due to wide confidence intervals. Blinding was successful., Conclusions: Adding MWM to exercise improved function, pain and active range of movement in people with shoulder pain. These benefits were not placebo effects., Registration: NCT04175184., (Copyright © 2024 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
46. Microfiltered red-purple pitaya concentrate: A promising multifunctional food-derived colorant.
- Author
-
de Sousa Silva FT, da Rocha Viana JD, Gomes da Silva MF, Silvestre da Silva G, Florindo Guedes MI, de Lima Rebouças E, Apolinário da Silva AP, Coutinho MR, Wlisses da Silva A, Rodrigues de Souza AC, Zocolo GJ, Herbster Moura CF, and Dionísio AP
- Subjects
- Animals, Betalains pharmacology, Betalains chemistry, Hypoglycemic Agents pharmacology, Plant Extracts pharmacology, Plant Extracts chemistry, Color, Filtration methods, Nutritive Value, Fruit chemistry, Food Coloring Agents pharmacology, Food Coloring Agents chemistry, Cactaceae chemistry, Zebrafish
- Abstract
Red pitaya fruit has become a source of natural colorant, because it is rich in betalains, a pigment that imparts a red-purple color that interests the food and cosmetics industries. This fruit also possesses high nutritional value, with a range of bioactive compounds known to confer potential health benefits and prevent chronic diseases, such as diabetes, which makes it useful for use as pharmaceutical agents and dietary supplements. In order to improve its technological and biological effects, a concentration will be required. Thus, the microfiltration, followed by vacuum concentration, can be an interesting strategy for this purpose. This study aimed to explore tangential microfiltration to produce microfiltered material, which is an important step to obtain the microfiltered red-purple pitaya concentrate. Therefore, physicochemical and chemical characterization (including
1 H NMR analysis) and biological properties (toxicity and diabetes) of this concentrate were assessed, using adult zebrafish as a model. The results show that microfiltration was carried out efficiently, with an average consumption of 95.75 ± 3.13 and 74.12 ± 3.58 kW h m-3 , varying according to the material used ("unpeeled pitaya pulp" or "pitaya pulp with peel," respectively). The in vivo tests indicated non-toxicity and hypoglycemic effect of the concentrate, since the blood glucose levels were significantly lower in the zebrafish groups treated with this concentrate in comparison with that of control group. Thus, this study suggests the potential of microfiltered red-purple pitaya concentrate as a promising multifunctional food-derived colorant, exhibiting beneficial biological effects far beyond its attractive color. PRACTICAL APPLICATION: Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose has attracted attention as a potential source of natural colorants because of its red-purple skin and flesh color. In addition, this fruit has a range of bioactive compounds, which make it a valuable resource for providing potential health benefits and preventing chronic diseases such as diabetes. In this paper, the microfiltered red-purple pitaya concentrate showed beneficial biological effects far beyond its attractive color. Thus, this product can be considered a promising multifunctional food-derived colorant to use in the food, pharmaceutical, or cosmetics industries., (© 2024 Institute of Food Technologists.)- Published
- 2024
- Full Text
- View/download PDF
47. A network analysis of positive psychosocial factors and indication of suboptimal HIV care outcomes among Black women living with HIV.
- Author
-
Chuku CC, Silva MF, Lee JS, Reid R, Lazarus K, Carrico AW, and Dale SK
- Subjects
- Humans, Female, Cross-Sectional Studies, Adult, Middle Aged, Medication Adherence psychology, Viral Load, Posttraumatic Growth, Psychological, HIV Infections psychology, HIV Infections drug therapy, Social Support, Self Efficacy, Adaptation, Psychological, Black or African American psychology, Self Concept, Resilience, Psychological
- Abstract
Black women living with HIV (BWLWH) face barriers that impact health outcomes. However, positive psychosocial indicators may influence HIV care outcomes. Among this cross-sectional study of 119 BWLWH, a network analysis was utilized to examine relationships between positive psychosocial factors and HIV-related health outcomes. A preliminary polychoric analysis was conducted to examine correlations between the variables, and the network analyzed connections between resilience, self-efficacy, self-esteem, perceived social support, religious coping, post-traumatic growth, and an indicator variable for suboptimal HIV care outcomes (low medication adherence, detectable viral load, and missed HIV-related health visits) and determined the centrality measures within the network. Seven significant associations were found among the factors: self-efficacy and self-esteem, post-traumatic growth and resilience, post-traumatic growth and self-efficacy, post-traumatic growth and religious coping, perceived social support and resilience, self-esteem and resilience, self-esteem and perceived social support (bootstrapped 95% CI did not contain zero). Self-efficacy was the strongest indicator associated with the other factors. Although not statistically significant, the indicator for suboptimal HIV care outcomes was negatively associated with perceived social support and religious coping. Future interventions incorporating self-efficacy may be beneficial to the overall well-being of Black women.
- Published
- 2024
- Full Text
- View/download PDF
48. Epidemiology of the use of inferior vena cava filters in Brazil between 2008 and 2019.
- Author
-
Louzada ACS, Diamante Leiderman DB, Alexandrino da Silva MF, Cassino Portugal MF, Carlos de Campos Guerra J, Teivelis MP, and Wolosker N
- Subjects
- Humans, Brazil epidemiology, Time Factors, Female, Male, Middle Aged, Risk Factors, Aged, Treatment Outcome, Databases, Factual, Practice Patterns, Physicians' trends, Prosthesis Implantation adverse effects, Prosthesis Implantation instrumentation, Prosthesis Implantation mortality, Prosthesis Implantation trends, Adult, Retrospective Studies, Vena Cava Filters trends, Hospital Mortality, Pulmonary Embolism mortality, Pulmonary Embolism therapy
- Abstract
Objectives: The primary objective was to study the totality of inferior vena cava filter placements and their temporal and geographic distribution in the Brazilian Public Health System, which insures more than 160 million Brazilians. The secondary objective was to analyze in-hospital mortality after filter placement and deaths due to pulmonary embolism., Methods: Public and open data on in-hospital mortality due to pulmonary embolism and on rates of inferior vena cava filters placement, its associated diagnosis, and in-hospital mortality in Brazilian public hospitals between January 2008 and December 2019 were extracted from Ministry of Health databases., Results: A total of 9108 inferior vena cava filters were placed, 98.18% of which was therapeutic. We observed a significant increase in the use of these devices over the years, from 508 inferior vena cava filters placed in 2008 to 965 in 2019. In-hospital mortality rate in patients who received inferior vena cava filters was 6.21%, stable over time, and 96.64% of causes of these causes were attributed to venous thromboembolism. The in-hospital mortality rate due to pulmonary embolism, regardless of the placement of vena cava filters, has increased significantly., Conclusion: We observed a low but increasing rate of inferior vena cava filter placements in Brazil between 2008 and 2019, most indications were therapeutic. Our findings were heterogeneous across Brazilian regions and contrasted to those observed in the USA, which is likely due to cultural and socioeconomic factors., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
- Full Text
- View/download PDF
49. Sustainable synthesis pathways: Bacterial nanocellulose from lignocellulosic biomass for circular economy initiatives.
- Author
-
Rodrigues DM, da Silva MF, de Mélo AHF, Carvalho PH, Baudel HM, and Goldbeck R
- Subjects
- Hydrolysis, Fermentation, Gluconacetobacter xylinus metabolism, Polysaccharides chemistry, Polysaccharides metabolism, Lignin chemistry, Lignin metabolism, Cellulose chemistry, Cellulose metabolism, Biomass, Eucalyptus chemistry, Saccharum chemistry
- Abstract
The hydrothermal pretreatment process stands out as a pivotal step in breaking down the hemicellulosic fraction of lignocellulosic biomasses, such as sugarcane bagasse and eucalyptus sawdust. This pretreatment step is crucial for preparing these materials for subsequent processes, particularly in food applications. This technique aims to disintegrate plant wall components like cellulose, hemicellulose, and lignin, and facilitating access in later phases such as enzymatic hydrolysis, and ultimately making fermentable sugars available. In this study, sugarcane bagasse and eucalyptus sawdust biomass underwent hydrothermal pretreatment at specific conditions, yielding two key components: dry biomass and hemicellulose liquor. The primary focus was to assess the impact of hydrothermal pretreatment followed by enzymatic hydrolysis, using the Celic Ctec III enzyme cocktail, to obtain fermentable sugars. These sugars were then transformed into membranes via strain Gluconacetobacter xylinus bacterial biosynthesis. Notably, the addition of a nitrogen source significantly boosted production to 14.76 g/ in hydrolyzed sugarcane bagasse, underscoring its vital role in bacterial metabolism. Conversely, in hydrolyzed eucalyptus, nitrogen source inclusion unexpectedly decreased yield, highlighting the intricate interactions in fermentation media and the pivotal influence of nitrogen supplementation. Characterization of membranes obtained in synthetic and hydrolyzed media through techniques such as FEG-SEM, FTIR, and TGA, followed by mass balance assessment, gauged their viability on an industrial scale. This comprehensive study aimed not only to understand the effects of pretreatment and enzymatic hydrolysis but to also evaluate the applicability and sustainability of the process on a large scale, providing crucial insights into its feasibility and efficiency in practical food-related scenarios, utilizing nanocellulose bacterial (BNC) as a key component., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
50. Highly efficient Cu(II) coordination polymer catalyst for the conversion of hazardous volatile organic compounds.
- Author
-
Paul A, Liu P, G Mahmoud A, Rakočević L, C B A Alegria E, Khan RA, C Guedes da Silva MF, Wang Z, and J L Pombeiro A
- Subjects
- Catalysis, Coordination Complexes chemistry, Toluene chemistry, Copper chemistry, Polymers chemistry, Oxidation-Reduction, Volatile Organic Compounds chemistry
- Abstract
Three novel coordination polymers (CPs), namely [Cu(μ-1κO,2κN-L)
2 ]n (1), [Zn (μ-1κO,2κN-L)2 (H2 O)2 ]n (2) and [Cd (μ-1κOO',2κN-L)2 ]n (3) [where HL = 4-(pyrimidin-5-ylcarbamoyl)benzoic acid], were synthesized and characterized by elemental analysis, ATR-IR, TGA, XPS and single-crystal X-ray diffraction. Despite having the same organic ligand, the various metal cations had an impact in the subsequent frameworks. Hirshfeld surface analysis was performed to investigate the intermolecular interactions and to examine the stability of the crystal structures of the three polymers. Their catalytic performances were screened for the peroxidative oxidation of Volatile Organic Compounds (VOCs), with toluene and p-xylene selected as model substrates. Tert-butyl hydroperoxide (t-BuOOH or TBHP) (aq. 70 %) was employed as the oxidant. The catalytic oxidation of toluene yielded benzyl alcohol, benzaldehyde and benzoic acid. The copper CP 1 exhibited the highest total yield for toluene oxidation, reaching approximately 36% in an aqueous medium. For p-xylene oxidation, tolualdehyde, methylbenzyl alcohol, and toluic acid were produced as the primary products, accompanied by minor ones. The experiments were conducted under diverse conditions, manipulating key parameters such as the choice of solvent (water or acetonitrile), type of oxidant (t-BuOOH or H2 O2 ), the concentration of the oxidant and reaction temperature. In the presence of catalyst 1, a maximum total yield of ca. 80% was achieved for p-xylene oxidation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.