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In order to identify disease biomarkers for the clinical and therapeutic management of autoimmune diseases such as systemic sclerosis (SSc) and undifferentiated connective tissue disease (UCTD), we have explored the setting of peripheral T regulatory (T reg) cells and assessed an expanded profile of autoantibodies in patients with SSc, including either limited (lcSSc) or diffuse (dcSSc) disease, and in patients presenting with clinical signs and symptoms of UCTD. A large panel of serum antibodies directed towards nuclear, nucleolar, and cytoplasmic antigens, including well-recognized molecules as well as less frequently tested antigens, was assessed in order to determine whether different antibody profiles might be associated with distinct clinical settings. Beside the well-recognized association between lcSSc and anti-centromeric or dcSSC and anti-topoisomerase-I antibodies, we found a significative association between dcSSc and anti-SRP or anti-PL-7/12 antibodies. In addition, two distinct groups emerged on the basis of anti-RNP or anti-PM-Scl 75/100 antibody production among UCTD patients. The levels of T reg cells were significantly lower in patients with SSc as compared to patients with UCTD or to healthy controls; in patients with lcSSc, T reg cells were inversely correlated to disease duration, suggesting that their levels may represent a marker of disease progression.

Sir, Breast cancer of the axillary extension is very infrequently diagnosed early on the tail of Spence – a peripheral extension of breast tissue with a duct system to the axilla – and is commonly confused with other axillary disease (1). We describe here a patient affected with breast cancer originating from the right axillary extension of the mammary tail of Spence, characterized by an unspecific clinical presentation.

Airbags are restraining safety devices, but their activation may sometimes induce injuries during road accidents. Rapid deceleration due to an impact causes the ignition of a sodium azide cartridge, which releases nitrogen gas to inflate the nylon rubber bag. Numerous high-temperature gases, sodium hydroxide, carbon dioxide, and various other metallic oxides are also released producing a corrosive alkaline aerosol. Cutaneous and extracutaneous injuries due to airbag deployment may occur. Cutaneous injuries are frequent, and consist of irritant dermatitis, and chemical and thermal burns. Furthermore, numerous kinds of traumatic lesions (abrasions, friction burns, and lacerations) may be observed. Extracutaneous damage may involve the eyes, ears, cardiovascular system, nerves, joints, and bones. The nature of airbag lesions, their frequency, and management are reported. Even though the majority of airbag lesions are minor and do not require hospitalization, correct diagnosis and the choice of the most suitable treatment are necessary.

Acroangiodermatitis is an angioproliferative disease characterized by pseudosarcomatous papules and plaques. It is often associated with different disorders like: chronic venous insufficiency, artero-venous malformations, artero-venous shunts, paralysed limb. In the case of amputation stumps the traumatic and suctional stimula may be the cause of this reactive pathology. We describe a case of acroangiodermatitis in an above-knee amputation stump in a 48-year-old-female affected by Down's syndrome.

ejd.2011.1271 Auteur(s) : Pietro DONATI1, Silvana TRINCONE2, Carlo COTA1, Francesca PAOLINI3, Aldo VENUTI3 venuti@ifo.it 1 Laboratory of Cutaneous Histopathology, San Gallicano Dermatologic Institute I.R.C.C.S, Via Chianesi, 53, 00144 Rome, Italy 2 Dermatology Department, San Gallicano Dermatologic Institute I.R.C.C.S, Via Chianesi, 53, 00144 Rome, Italy 3 Laboratory of Virology, Regina Elena National Cancer Institute, Via delle Messi d’Oro, 156, 00158 Rome, Italy A 63-year-old man presented with [...]

Air bags, fitted in the majority of new automobiles, are safety devices activated when a sudden deceleration causes the ignition of a propellant cartridge containing sodium azide. The bag is inflated by nitrogen liberated during the combustion. Deployment releases various high-temperature gases, including nitrogen and carbon dioxide, and produces sodium hydroxide, a highly irritant alkaline substance. In about 7%-8% of cases, air bags cause dermatologic injuries such as traumatic lesions, irritant dermatitis, and chemical and thermal burns. Nondermatologic lesions, such as ocular damage (alkali keratitis, corneal abrasions), ear lesions, bone fractures, and contusive damage can also be caused by air bag deployment.