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1. The Antibiotic Future

Author

Silver, Lynn L., Bernstein, P. R., Editorial Board Member, Georg, G. I., Editorial Board Member, Kobayashi, T., Editorial Board Member, Lowe, J. A., Editorial Board Member, Meanwell, N. A., Editorial Board Member, Saxena, A. K., Editorial Board Member, Stilz, U., Editorial Board Member, Supuran, C. T., Editorial Board Member, Zhang, A., Editorial Board Member, Fisher, Jed F., editor, Mobashery, Shahriar, editor, Miller, Marvin J., editor, Balibar, C. J., Book Editor, Basarab, G. S., Book Editor, Bush, K., Book Editor, Chang, M., Book Editor, Fisher, J. F., Book Editor, Lee, S. H., Book Editor, Malinverni, J. C., Book Editor, Meisel, J. E., Book Editor, Melander, C., Book Editor, Melander, R. J., Book Editor, Mobashery, S., Book Editor, Roemer, T., Book Editor, Shlaes, D. M., Book Editor, Silver, L. L., Book Editor, and Sutterlin, H. A., Book Editor

Published
2018
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4. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Author

Aboderin, Aaron Oladipo, Al-Abri, Seif Salem, Awang Jalil, Nordiah, Benzonana, Nur, Bhattacharya, Sanjay, Brink, Adrian John, Burkert, Francesco Robert, Cars, Otto, Cornaglia, Giuseppe, Dyar, Oliver James, Friedrich, Alex W, Gales, Ana C, Gandra, Sumanth, Giske, Christian Georg, Goff, Debra A, Goossens, Herman, Gottlieb, Thomas, Guzman Blanco, Manuel, Hryniewicz, Waleria, Kattula, Deepthi, Jinks, Timothy, Kanj, Souha S, Kerr, Lawrence, Kieny, Marie-Paule, Kim, Yang Soo, Kozlov, Roman S, Labarca, Jaime, Laxminarayan, Ramanan, Leder, Karin, Leibovici, Leonard, Levy-Hara, Gabriel, Littman, Jasper, Malhotra-Kumar, Surbhi, Manchanda, Vikas, Moja, Lorenzo, Ndoye, Babacar, Pan, Angelo, Paterson, David L, Paul, Mical, Qiu, Haibo, Ramon-Pardo, Pilar, Rodríguez-Baño, Jesús, Sanguinetti, Maurizio, Sengupta, Sharmila, Sharland, Mike, Si-Mehand, Massinissa, Silver, Lynn L, Song, Wonkeung, Steinbakk, Martin, Thomsen, Jens, Thwaites, Guy E, van der Meer, Jos WM, Van Kinh, Nguyen, Vega, Silvio, Villegas, Maria Virginia, Wechsler-Fördös, Agnes, Wertheim, Heiman Frank Louis, Wesangula, Evelyn, Woodford, Neil, Yilmaz, Fidan O, Zorzet, Anna, Tacconelli, Evelina, Carrara, Elena, Savoldi, Alessia, Harbarth, Stephan, Mendelson, Marc, Monnet, Dominique L, Pulcini, Céline, Kahlmeter, Gunnar, Kluytmans, Jan, Carmeli, Yehuda, Ouellette, Marc, Outterson, Kevin, Patel, Jean, Cavaleri, Marco, Cox, Edward M, Houchens, Chris R, Grayson, M Lindsay, Hansen, Paul, Singh, Nalini, Theuretzbacher, Ursula, and Magrini, Nicola

Published
2018
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9. Antibacterial Agents That Inhibit Lipid a Biosynthesis

Author

Onishi, H. Russell, Pelak, Barbara A., Gerckens, Lynn S., Silver, Lynn L., Kahan, Frederick M., Chen, Meng-Hsin, Patchett, Arthur A., Galloway, Susan M., Hyland, Sheryl A., and Anderson, Matt S.

Published
1996

10. Reply to Kaye and Belley, “Third-Generation Cephalosporin-Resistant Enterobacterales Are Critical Priority Pathogens, Too!”

Author

Butler, Mark S., primary, Gigante, Valeria, additional, Sati, Hatim, additional, Paulin, Sarah, additional, Al-Sulaiman, Laila, additional, Rex, John H., additional, Fernandes, Prabhavathi, additional, Arias, Cesar A., additional, Paul, Mical, additional, Thwaites, Guy E., additional, Czaplewski, Lloyd, additional, Alm, Richard A., additional, Lienhardt, Christian, additional, Spigelman, Melvin, additional, Silver, Lynn L., additional, Ohmagari, Norio, additional, Kozlov, Roman, additional, Harbarth, Stephan, additional, and Beyer, Peter, additional

Published
2022
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11. Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed

Author

Butler, Mark S., primary, Gigante, Valeria, additional, Sati, Hatim, additional, Paulin, Sarah, additional, Al-Sulaiman, Laila, additional, Rex, John H., additional, Fernandes, Prabhavathi, additional, Arias, Cesar A., additional, Paul, Mical, additional, Thwaites, Guy E., additional, Czaplewski, Lloyd, additional, Alm, Richard A., additional, Lienhardt, Christian, additional, Spigelman, Melvin, additional, Silver, Lynn L., additional, Ohmagari, Norio, additional, Kozlov, Roman, additional, Harbarth, Stephan, additional, and Beyer, Peter, additional

Published
2022
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14. Setting Our Sights on Infectious Diseases

Author

Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, De Rycker, Manu, Horn, David, Aldridge, Bree, Amewu, Richard K., Barry, Clifton E., Buckner, Frederick S., Cook, Sarah, Ferguson, Michael A. J., Gobeau, Nathalie, Herrmann, Jennifer, Herrling, Paul, Hope, William, Keiser, Jennifer, Lafuente-Monasterio, Maria Jose, Leeson, Paul D., Leroy, Didier, Manjunatha, Ujjini H., McCarthy, James, Miles, Timothy J., Mizrahi, Valerie, Moshynets, Olena, Niles, Jacquin, Overington, John P., Pottage, John, Rao, Srinivasa P. S., Read, Kevin D., Ribeiro, Isabela, Silver, Lynn L., Southern, Jen, Spangenberg, Thomas, Sundar, Shyam, Taylor, Caitlin, Van Voorhis, Wes, White, Nicholas J., Wyllie, Susan, Wyatt, Paul G., Gilbert, Ian H., Massachusetts Institute of Technology. Department of Civil and Environmental Engineering, De Rycker, Manu, Horn, David, Aldridge, Bree, Amewu, Richard K., Barry, Clifton E., Buckner, Frederick S., Cook, Sarah, Ferguson, Michael A. J., Gobeau, Nathalie, Herrmann, Jennifer, Herrling, Paul, Hope, William, Keiser, Jennifer, Lafuente-Monasterio, Maria Jose, Leeson, Paul D., Leroy, Didier, Manjunatha, Ujjini H., McCarthy, James, Miles, Timothy J., Mizrahi, Valerie, Moshynets, Olena, Niles, Jacquin, Overington, John P., Pottage, John, Rao, Srinivasa P. S., Read, Kevin D., Ribeiro, Isabela, Silver, Lynn L., Southern, Jen, Spangenberg, Thomas, Sundar, Shyam, Taylor, Caitlin, Van Voorhis, Wes, White, Nicholas J., Wyllie, Susan, Wyatt, Paul G., and Gilbert, Ian H.

Abstract

In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

Published
2020

15. Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Author

Wang, Jun, Soisson, Stephen M., Young, Katherine, Shoop, Wesley, Kodali, Srinivas, Galgoci, Andrew, Painter, Ronald, Parthasarathy, Gopalakrishnan, Tang, Yui S., Cummings, Richard, Ha, Sookhee, Dorso, Karen, Motyl, Mary, Jayasuriya, Hiranthi, Ondeyka, John, Herath, Kithsiri, Zhang, Chaowei, Hernandez, Lorraine, Allocco, John, Basilio, Angela, Tormo, Jose R., Genilloud, Olga, Vicente, Francisca, Pelaez, Fernando, Colwell, Lawrence, Lee, Sang Ho, Michael, Bruce, Felcetto, Thomas, Gill, Charles, Silver, Lynn L., Hermes, Jeffery D., Bartizal, Ken, Barrett, John, Schmatz, Dennis, Becker, Joseph W., Cully, Doris, and Singh, Sheo B.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Jun Wang (corresponding author) [1, 3]; Stephen M. Soisson [1, 3]; Katherine Young [1]; Wesley Shoop [1, 2]; Srinivas Kodali [1]; Andrew Galgoci [1]; Ronald Painter [1]; Gopalakrishnan Parthasarathy [...]

Published
2006
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20. Setting Our Sights on Infectious Diseases

Author

De Rycker, Manu, primary, Horn, David, additional, Aldridge, Bree, additional, Amewu, Richard K., additional, Barry, Clifton E., additional, Buckner, Frederick S., additional, Cook, Sarah, additional, Ferguson, Michael A. J., additional, Gobeau, Nathalie, additional, Herrmann, Jennifer, additional, Herrling, Paul, additional, Hope, William, additional, Keiser, Jennifer, additional, Lafuente-Monasterio, Maria Jose, additional, Leeson, Paul D., additional, Leroy, Didier, additional, Manjunatha, Ujjini H., additional, McCarthy, James, additional, Miles, Timothy J., additional, Mizrahi, Valerie, additional, Moshynets, Olena, additional, Niles, Jacquin, additional, Overington, John P., additional, Pottage, John, additional, Rao, Srinivasa P. S., additional, Read, Kevin D., additional, Ribeiro, Isabela, additional, Silver, Lynn L., additional, Southern, Jen, additional, Spangenberg, Thomas, additional, Sundar, Shyam, additional, Taylor, Caitlin, additional, Van Voorhis, Wes, additional, White, Nicholas J., additional, Wyllie, Susan, additional, Wyatt, Paul G., additional, and Gilbert, Ian H., additional

Published
2019
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23. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Author

Tacconelli, Evelina, primary, Carrara, Elena, additional, Savoldi, Alessia, additional, Harbarth, Stephan, additional, Mendelson, Marc, additional, Monnet, Dominique L, additional, Pulcini, Céline, additional, Kahlmeter, Gunnar, additional, Kluytmans, Jan, additional, Carmeli, Yehuda, additional, Ouellette, Marc, additional, Outterson, Kevin, additional, Patel, Jean, additional, Cavaleri, Marco, additional, Cox, Edward M, additional, Houchens, Chris R, additional, Grayson, M Lindsay, additional, Hansen, Paul, additional, Singh, Nalini, additional, Theuretzbacher, Ursula, additional, Magrini, Nicola, additional, Aboderin, Aaron Oladipo, additional, Al-Abri, Seif Salem, additional, Awang Jalil, Nordiah, additional, Benzonana, Nur, additional, Bhattacharya, Sanjay, additional, Brink, Adrian John, additional, Burkert, Francesco Robert, additional, Cars, Otto, additional, Cornaglia, Giuseppe, additional, Dyar, Oliver James, additional, Friedrich, Alex W, additional, Gales, Ana C, additional, Gandra, Sumanth, additional, Giske, Christian Georg, additional, Goff, Debra A, additional, Goossens, Herman, additional, Gottlieb, Thomas, additional, Guzman Blanco, Manuel, additional, Hryniewicz, Waleria, additional, Kattula, Deepthi, additional, Jinks, Timothy, additional, Kanj, Souha S, additional, Kerr, Lawrence, additional, Kieny, Marie-Paule, additional, Kim, Yang Soo, additional, Kozlov, Roman S, additional, Labarca, Jaime, additional, Laxminarayan, Ramanan, additional, Leder, Karin, additional, Leibovici, Leonard, additional, Levy-Hara, Gabriel, additional, Littman, Jasper, additional, Malhotra-Kumar, Surbhi, additional, Manchanda, Vikas, additional, Moja, Lorenzo, additional, Ndoye, Babacar, additional, Pan, Angelo, additional, Paterson, David L, additional, Paul, Mical, additional, Qiu, Haibo, additional, Ramon-Pardo, Pilar, additional, Rodríguez-Baño, Jesús, additional, Sanguinetti, Maurizio, additional, Sengupta, Sharmila, additional, Sharland, Mike, additional, Si-Mehand, Massinissa, additional, Silver, Lynn L, additional, Song, Wonkeung, additional, Steinbakk, Martin, additional, Thomsen, Jens, additional, Thwaites, Guy E, additional, van der Meer, Jos WM, additional, Van Kinh, Nguyen, additional, Vega, Silvio, additional, Villegas, Maria Virginia, additional, Wechsler-Fördös, Agnes, additional, Wertheim, Heiman Frank Louis, additional, Wesangula, Evelyn, additional, Woodford, Neil, additional, Yilmaz, Fidan O, additional, and Zorzet, Anna, additional

Published
2018
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41. Discovery of FabH/FabF Inhibitors from Natural Products

Author

Young, Katherine, primary, Jayasuriya, Hiranthi, additional, Ondeyka, John G., additional, Herath, Kithsiri, additional, Zhang, Chaowei, additional, Kodali, Srinivas, additional, Galgoci, Andrew, additional, Painter, Ronald, additional, Brown-Driver, Vickie, additional, Yamamoto, Robert, additional, Silver, Lynn L., additional, Zheng, Yingcong, additional, Ventura, Judith I., additional, Sigmund, Janet, additional, Ha, Sookhee, additional, Basilio, Angela, additional, Vicente, Francisca, additional, Tormo, José Rubén, additional, Pelaez, Fernando, additional, Youngman, Phil, additional, Cully, Doris, additional, Barrett, John F., additional, Schmatz, Dennis, additional, Singh, Sheo B., additional, and Wang, Jun, additional

Published
2006
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43. Outbreak of Klebsiella pneumoniae Producing a New Carbapenem-Hydrolyzing Class A β-Lactamase, KPC-3, in a New York Medical Center

Author

Woodford, Neil, primary, Tierno, Philip M., additional, Young, Katherine, additional, Tysall, Luke, additional, Palepou, Marie-France I., additional, Ward, Elaina, additional, Painter, Ronald E., additional, Suber, Deborah F., additional, Shungu, Daniel, additional, Silver, Lynn L., additional, Inglima, Kenneth, additional, Kornblum, John, additional, and Livermore, David M., additional

Published
2004
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45. Novel illudins from Coprinopsis episcopalis (syn. Coprinus episcopalis), and the distribution of illudin-like compounds among filamentous fungi

Author

Gonzalez Del Val, Antonio, primary, Platas, Gonzalo, additional, Arenal, Francisco, additional, Orihuela, Juan Carlos, additional, Garcia, María, additional, Hernandez, Pilar, additional, Royo, Inmaculada, additional, De Pedro, Nuria, additional, Silver, Lynn L., additional, Young, Katherine, additional, Vicente, María Francisca, additional, and Pelaez, Fernando, additional

Published
2003
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48. Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III

Author

Ali, Amjad, primary, Aster, Susan D, additional, Graham, Donald W, additional, Patel, Gool F, additional, Taylor, Gayle E, additional, Tolman, Richard L, additional, Painter, Ronald E, additional, Silver, Lynn L, additional, Young, Katherine, additional, Ellsworth, Kenneth, additional, Geissler, Wayne, additional, and Harris, Georgianna S, additional

Published
2001
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49. Characterization of a Carbapenem-Hydrolyzing Enzyme, PoxB, in Pseudomonas aeruginosaPAO1

Author

Zincke, Diansy, Balasubramanian, Deepak, Silver, Lynn L., and Mathee, Kalai

Abstract

ABSTRACTPseudomonas aeruginosais an opportunistic pathogen often associated with severe and life-threatening infections that are highly impervious to treatment. This microbe readily exhibits intrinsic and acquired resistance to varied antimicrobial drugs. Resistance to penicillin-like compounds is commonplace and provided by the chromosomal AmpC β-lactamase. A second, chromosomally encoded β-lactamase, PoxB, has previously been reported in P. aeruginosa. In the present work, the contribution of this class D enzyme was investigated using a series of clean in-frame ampC, poxB, and oprDdeletions, as well as complementation by expression under the control of an inducible promoter. While poxBdeletions failed to alter β-lactam sensitivities, expression of poxBin ampC-deficient backgrounds decreased susceptibility to both meropenem and doripenem but had no effect on imipenem, penicillin, and cephalosporin MICs. However, when expressed in an ampCpoxB-deficient background, that additionally lacked the outer membrane porin-encoding gene oprD, PoxB significantly increased the imipenem as well as the meropenem and doripenem MICs. Like other class D carbapenem-hydrolyzing β-lactamases, PoxB was only poorly inhibited by class A enzyme inhibitors, but a novel non-β-lactam compound, avibactam, was a slightly better inhibitor of PoxB activity. In vitrosusceptibility testing with a clinical concentration of avibactam, however, failed to reduce PoxB activity against the carbapenems. In addition, poxBwas found to be cotranscribed with an upstream open reading frame, poxA, which itself was shown to encode a 32-kDa protein of yet unknown function.

Published
2015
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50. Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives

Author

Hammond, Gail G., primary, Huber, Joann L., additional, Greenlee, Mark L., additional, Laub, Joanne B., additional, Young, Katherine, additional, Silver, Lynn L., additional, Balkovec, James M., additional, Pryor, KellyAnn D., additional, Wu, Joseph K., additional, Leiting, Barbara, additional, Pompliano, David L., additional, and Toney, Jeffrey H., additional

Published
1999
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