743 results on '"Silvestris, N"'
Search Results
2. Survival analysis of the metastatic cohort of Italian Association of Medical Oncology (AIOM) GARIBALDI survey
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Reni, M., Giommoni, E., Bergamo, F., Cavanna, L., Simionato, F., Spada, M., Di Marco, M., Bernardini, I., Cordio, S.S., Latiano, T., Spallanzani, A., Silvestris, N., Cardellino, G.G., Bonomi, M., Milella, M., Luchena, G., Tamburini, E., Macchini, M., Orsi, G., Modesti, M., Procaccio, L., Santoni, A., De Simone, I., Caldirola, L., Galli, F., and Pinto, C.
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- 2024
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3. Predictors of thyroid adverse events during cancer immunotherapy: a real-life experience at a single center
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Ruggeri, R. M., Spagnolo, C. C., Alibrandi, A., Silvestris, N., Cannavò, S., and Santarpia, M.
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- 2023
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4. A 1-year follow-up study on checkpoint inhibitor-induced colitis: results from a European consortium
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Mengoli, C., Aronico, N., Lepore, F., Broglio, G., Merli, S., Natalello, G., Alimenti, E., Scalvini, D., Muscarella, S., Agustoni, F., Pagani, A., Chiellino, S., Corallo, S., Musella, V., Cannizzaro, R., Vecchi, M., Caprioli, F., Gabbiadini, R., Dal Buono, A., Premoli, A., Locati, L.D., Buda, A., Contaldo, A., Schiepatti, A., Biagi, F., Morano, D., Cucè, M., Kotsakis, A., De Lisi, G., Lenti, M.V., Ribaldone, D.G., Borrelli de Andreis, F., Vernero, M., Barberio, B., De Ruvo, M., Savarino, E.V., Kav, T., Blesl, A., Franzoi, M., Gröchenig, H.P., Pugliese, D., Ianiro, G., Porcari, S., Cammarota, G., Gasbarrini, A., Spagnuolo, R., Ellul, P., Foteinogiannopoulou, K., Koutroubakis, I., Argyriou, K., Cappello, M., Jauregui-Amezaga, A., Demarzo, M.G., Silvestris, N., Armuzzi, A., Sottotetti, F., Bertani, L., Festa, S., Eder, P., Pedrazzoli, P., Lasagna, A., Vanoli, A., Gambini, G., Santacroce, G., Rossi, C.M., Delliponti, M., Klersy, C., Corazza, G.R., and Di Sabatino, A.
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- 2024
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5. Diabetes management in cancer patients. An Italian Association of Medical Oncology, Italian Association of Medical Diabetologists, Italian Society of Diabetology, Italian Society of Endocrinology and Italian Society of Pharmacology multidisciplinary consensus position paper
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Silvestris, N., Franchina, T., Gallo, M., Argentiero, A., Avogaro, A., Cirino, G., Colao, A., Danesi, R., Di Cianni, G., D’Oronzo, S., Faggiano, A., Fogli, S., Giuffrida, D., Gori, S., Marrano, N., Mazzilli, R., Monami, M., Montagnani, M., Morviducci, L., Natalicchio, A., Ragni, A., Renzelli, V., Russo, A., Sciacca, L., Tuveri, E., Zatelli, M.C., Giorgino, F., and Cinieri, S.
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- 2023
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6. MiRNA dysregulation underlying common pathways in type 2 diabetes and cancer development: an Italian Association of Medical Oncology (AIOM)/Italian Association of Medical Diabetologists (AMD)/Italian Society of Diabetology (SID)/Italian Society of Endocrinology (SIE)/Italian Society of Pharmacology (SIF) multidisciplinary critical view
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Natalicchio, A., Montagnani, M., Gallo, M., Marrano, N., Faggiano, A., Zatelli, M.C., Mazzilli, R., Argentiero, A., Danesi, R., D’Oronzo, S., Fogli, S., Giuffrida, D., Gori, S., Ragni, A., Renzelli, V., Russo, A., Franchina, T., Tuveri, E., Sciacca, L., Monami, M., Cirino, G., Di Cianni, G., Colao, A., Avogaro, A., Cinieri, S., Silvestris, N., and Giorgino, F.
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- 2023
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7. Vaccination for seasonal influenza, pneumococcal infection and SARS-CoV-2 in patients with solid tumors: recommendations of the Associazione Italiana di Oncologia Medica (AIOM)
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Pedrazzoli, P., Lasagna, A., Cassaniti, I., Piralla, A., Squeri, A., Bruno, R., Sacchi, P., Baldanti, F., Di Maio, M., Beretta, G.D., Cinieri, S., and Silvestris, N.
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- 2023
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8. Vaccination for herpes zoster in patients with solid tumors: a position paper on the behalf of the Associazione Italiana di Oncologia Medica (AIOM)
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Pedrazzoli, P., Lasagna, A., Cassaniti, I., Ferrari, A., Bergami, F., Silvestris, N., Sapuppo, E., Di Maio, M., Cinieri, S., and Baldanti, F.
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- 2022
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9. The molecular profiling of solid tumors by liquid biopsy: a position paper of the AIOM–SIAPEC-IAP–SIBioC–SIC–SIF Italian Scientific Societies
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Russo, A., Incorvaia, L., Del Re, M., Malapelle, U., Capoluongo, E., Gristina, V., Castiglia, M., Danesi, R., Fassan, M., Giuffrè, G., Gori, S., Marchetti, A., Normanno, N., Pinto, C., Rossi, G., Santini, D., Sartore-Bianchi, A., Silvestris, N., Tagliaferri, P., Troncone, G., Cinieri, S., and Beretta, G.D.
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- 2021
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10. Early prediction of pancreatic cancer from new-onset diabetes: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)/Società Italiana Endocrinologia (SIE)/Società Italiana Farmacologia (SIF) multidisciplinary consensus position paper
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Gallo, M., Adinolfi, V., Morviducci, L., Acquati, S., Tuveri, E., Ferrari, P., Zatelli, M.C., Faggiano, A., Argentiero, A., Natalicchio, A., D'Oronzo, S., Danesi, R., Gori, S., Russo, A., Montagnani, M., Beretta, G.D., Di Bartolo, P., Silvestris, N., and Giorgino, F.
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- 2021
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11. Antineoplastic dosing in overweight and obese cancer patients: an Associazione Italiana Oncologia Medica (AIOM)/Associazione Medici Diabetologi (AMD)/Società Italiana Endocrinologia (SIE)/Società Italiana Farmacologia (SIF) multidisciplinary consensus position paper
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Silvestris, N., Argentiero, A., Natalicchio, A., D'Oronzo, S., Beretta, G.D., Acquati, S., Adinolfi, V., Di Bartolo, P., Danesi, R., Faggiano, A., Ferrari, P., Gallo, M., Gori, S., Morviducci, L., Russo, A., Tuveri, E., Zatelli, M.C., Montagnani, M., and Giorgino, F.
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- 2021
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12. Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in older patients: A subgroup analysis from the TOSCA trial
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Bilancia, D., Rosati, G., Montesarchio, V., Iaffaioli, R.V., Nasti, G., Daniele, B., Zagonel, V., Lonardi, S., Pella, N., Aprile, G., Pasini, F., Marchetti, Roma P., Romiti, A., Ciuffreda, L., Ferrari, D., Foa, P., Zaniboni, A., Labianca, R., Mosconi, S., Sobrero, A., Bidoli, P., Cazzaniga, M., Beretta, G.D., Corsi, D.C., Cortesi, E., Barni, S., Petrelli, F., Allione, P., D'Arco, A.M., Valmadre, G., Piazza, E., Veltri, E., Ramus, G. Vietti, Giustini, L., Tumulo, S., Cascinu, S., Granetto, C., Testore, F., Giordano, M., Moroni, M., Di Seri, M., Nuzzo, A., Angelelli, L., Gori, S., Farina, G., Aglietta, M., Franchi, R., Comandé, M., Giordani, P., Tonini, G., Bucci, E., Ballestrero, A., Benasso, M., Graiff, C., Bravi, S., Caffo, O., Silva, R.R., Frontini, L., Rota, S., Cozzi, L., Cantore, M., Maiello, E., Cinieri, S., Silvestris, N., Romito, S., Gebbia, V., Banzi, M., Santoro, A., Artioli, F., Mattioli, R., Contu, A., Di Costanzo, F., Leonardi, F., Cavanna, L., Passalacqua, R., Amoroso, D., Sozzi, P., D'Amico, M., Amadori, D., Frassineti, L., Turci, D., Ravaioli, A., Pasquini, E., Gambi, A., Faedi, M., Cruciani, G., Bajetta, E., Di Bartolomeo, M., Gianni, L., Ronzoni, M., Ionta, M.T., Massidda, B., Scartozzi, M., Zampino, M.G., Bochicchio, A.M., Ciarlo, A., Di Leo, A., Frustaci, S., Rangoni, G., Arizzoia, A., Pavesi, L., Verusio, C., Pinotti, G., Iop, A., De Placido, S., Carlomagno, C., Adamo, V., Ficorella, C., Natale, D., Greco, E., Rulli, E., Galli, F., Poli, D., Porcu, L., Torri, V., Rosati, Gerardo, Lonardi, Sara, Galli, Fabio, Di Bartolomeo, Maria, Ronzoni, Monica, Zampino, Maria G., Banzi, Maria, Zaniboni, Alberto, Pasini, Felice, Bozzarelli, Silvia, Garattini, Silvio K., Ferrari, Daris, Montesarchio, Vincenzo, Mambrini, Andrea, Ciuffreda, Libero, Galli, Francesca, Pusceddu, Valeria, Carlomagno, Chiara, Bidoli, Paolo, Amoroso, Domenico, Bochicchio, Anna M., Frassineti, Luca, Corsi, Domenico, Bilancia, Domenico, Pastorino, Alessandro, De Stefano, Alfonso, and Labianca, Roberto
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- 2021
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13. COVID-19 infection in cancer patients: what has been the contribution of Associazione Italiana Oncologia Medica (AIOM) to oncological care since the beginning of the first pandemic wave?
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Silvestris, N., Di Maio, M., Russo, A., Chiari, R., De Giorgi, U., Del Mastro, L., Giuffrida, D., La Verde, N., Perrone, F., Tucci, M., Beretta, G.D., and Cinieri, S.
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- 2021
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14. OC.04.7: A ONE-YEAR FOLLOW-UP STUDY ON CHECKPOINT INHIBITORINDUCED COLITIS: RESULTS FROM A EUROPEAN CONSORTIUM
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Lenti, M.V., primary, Broglio, G., additional, Ribaldone, D.G., additional, Schiepatti, A., additional, Vernero, M., additional, Cosentino, F., additional, Blesl, A., additional, Buda, A., additional, Croitoru, A., additional, Del Buono, A., additional, Aranzazu Jaurgeu, A., additional, Lasagna, A., additional, Carvalho, D., additional, Pugliese, D., additional, Langholz, E., additional, Dahl, E., additional, Savarino, E.V., additional, Agustoni, F., additional, De Andreis, F. Borrelli, additional, Caprioli, F., additional, Schaik, F., additional, Sottotetti, F., additional, Cammarota, G., additional, Ianiro, G., additional, Gröchenig, H.P., additional, Koutroubakis, I., additional, Geldolf, J., additional, Argyriou, K., additional, Foteinogiannopolou, K., additional, Bertani, L., additional, Lobaton Ortega, T., additional, Cappello, M., additional, Delliponti, M., additional, Demarzo, M.G., additional, Truyens, M., additional, Silvestris, N., additional, Ellul, J., additional, Cannizzaro, R., additional, Gabbiadini, R., additional, Pedrazzoli, P., additional, Spagnuolo, R., additional, Saglio, S., additional, Stroie, T.G., additional, Natalello, G., additional, Varallo, M., additional, La Torre, M.A., additional, Petrucci, C., additional, Klersey, C., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
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- 2024
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15. Synthesis and biological evaluation of N-biphenyl-nicotinic based moiety compounds: A new class of antimitotic agents for the treatment of Hodgkin Lymphoma
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Porcelli, L., Stolfa, D., Stefanachi, A., Di Fonte, R., Garofoli, M., Iacobazzi, R.M., Silvestris, N., Guarini, A., Cellamare, S., and Azzariti, A.
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- 2019
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16. Immune inflammation indicators in anal cancer patients treated with concurrent chemoradiation: training and validation cohort with online calculator (ARC: Anal Cancer Response Classifier)
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Casadei-Gardini A, Montagnani F, Casadei C, Arcadipane F, Andrikou K, Aloi D, Prete AA, Zampino MG, Argentiero A, Pugliese G, Martini S, Iorio GC, Scartozzi M, Mistrangelo M, Fornaro L, Cassoni P, Marisi G, Dell'Acqua V, Ravenda PS, Lonardi S, Silvestris N, De Bari B, Ricardi U, Cascinu S, and Franco P
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NLR ,PLR ,SII ,Anal cancer ,prognostic factors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Andrea Casadei-Gardini,1 Francesco Montagnani,2 Chiara Casadei,1 Francesca Arcadipane,3 Kalliopi Andrikou,4 Deborah Aloi,5 Alessandra Anna Prete,6,7 Maria Giulia Zampino,8 Antonella Argentiero,9 Giuseppe Pugliese,4 Stefania Martini,10 Giuseppe Carlo Iorio,10 Mario Scartozzi,11 Massimiliano Mistrangelo,12 Lorenzo Fornaro,13 Paola Cassoni,14 Giorgia Marisi,15 Veronica Dell’Acqua,16 Paola Simona Ravenda,8 Sara Lonardi,6 Nicola Silvestris,7 Berardino De Bari,5 Umberto Ricardi,3 Stefano Cascinu,4 Pierfrancesco Franco91Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy; 2Oncology Department, SOC Oncology, ASL (Health Local Authority), Biella, Italy; 3Department of Oncology, Radiation Oncology, AOU Città della Salute e della Scienza, Turin, Italy; 4Department of Hematology and Oncology, University of Modena and Reggio Emilia, Modena, Italy; 5Radiation Oncology Department, Centre Hospitalier Régional Universitaire “Jean Minjoz”, Besançon Cedex, France; 6Unit of Medical Oncology 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto, IRCCS, Padua, Italy; 7Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I University Hospital, Rome, Italy; 8Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IRCCS, Milan, Italy; 9Medical Oncology Unit, Cancer Institute Giovanni Paolo II, Bari, Italy; 10Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy; 11Department of Medical Oncology, University of Cagliari, Cagliari, Italy; 12Department of Surgical Sciences, University of Turin, Turin, Italy; 13Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana University, Pisa, Italy; 14Department of Medical Sciences, Pathology Unit, University of Turin, Turin, Italy; 15Biosciences Laboratory, Istituto Scientifico Romagnolo per Lo Studio e La Cura Dei Tumori (IRST) IRCCS, Meldola, Italy; 16Department of Radiotherapy, IRCCS, European Institute of Oncology, Milan, ItalyBackground: In anal cancer, there are no markers nor other laboratory indexes that can predict prognosis and guide clinical practice for patients treated with concurrent chemoradiation. In this study, we retrospectively investigated the influence of immune inflammation indicators on treatment outcome of anal cancer patients undergoing concurrent chemoradiotherapy.Methods: All patients had a histologically proven diagnosis of squamous cell carcinoma of the anal canal/margin treated with chemoradiotherapy according to the Nigro’s regimen. Impact on prognosis of pre-treatment systemic index of inflammation (SII) (platelet x neutrophil/lymphocyte), neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were analyzed.Results: A total of 161 consecutive patients were available for the analysis. Response to treatment was the single most important factor for progression-free survival (PFS) and overall survival (OS). At univariate analysis, higher SII level was significantly correlated to lower PFS (p
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- 2019
17. Bone metastases in biliary cancers: A multicenter retrospective survey
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Santini, D, Brandi, G, Aprile, G, Russano, M, Cereda, S, Leone, F, Lonardi, S, Fornaro, L, Scartozzi, M, Silvestris, N, Barni, S, Pantano, F, Vincenzi, B, Palloni, A, Frega, G, Casagrande, M, Ferrari, L, Dadduzio, V, Intini, R, Filippi, R, Vasile, E, Vivaldi, C, Faloppi, L, Brunetti, O, Reni, M, Aglietta, M, and Tonini, G
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- 2018
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18. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019
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Tran, K, Lang, J, Compton, K, Xu, R, Acheson, A, Henrikson, H, Kocarnik, J, Penberthy, L, Aali, A, Abbas, Q, Abbasi, B, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdoli, G, Abdulkadir, H, Abedi, A, Abegaz, K, Abidi, H, Aboagye, R, Abolhassani, H, Absalan, A, Abtew, Y, Abubaker Ali, H, Abu-Gharbieh, E, Achappa, B, Acuna, J, Addison, D, Addo, I, Adegboye, O, Adesina, M, Adnan, M, Adnani, Q, Advani, S, Afrin, S, Afzal, M, Aggarwal, M, Ahinkorah, B, Ahmad, A, Ahmad, R, Ahmad, S, Ahmadi, S, Ahmed, H, Ahmed, L, Ahmed, M, Ahmed Rashid, T, Aiman, W, Ajami, M, Akalu, G, Akbarzadeh-Khiavi, M, Aklilu, A, Akonde, M, Akunna, C, Al Hamad, H, Alahdab, F, Alanezi, F, Alanzi, T, Alessy, S, Algammal, A, Al-Hanawi, M, Alhassan, R, Ali, B, Ali, L, Ali, S, Alimohamadi, Y, Alipour, V, Aljunid, S, Alkhayyat, M, Al-Maweri, S, Almustanyir, S, Alonso, N, Alqalyoobi, S, Al-Raddadi, R, Al-Rifai, R, Al-Sabah, S, Al-Tammemi, A, Altawalah, H, Alvis-Guzman, N, Amare, F, Ameyaw, E, Aminian Dehkordi, J, Amirzade-Iranaq, M, Amu, H, Amusa, G, Ancuceanu, R, Anderson, J, Animut, Y, Anoushiravani, A, Anoushirvani, A, Ansari-Moghaddam, A, Ansha, M, Antony, B, Antwi, M, Anwar, S, Anwer, R, Anyasodor, A, Arabloo, J, Arab-Zozani, M, Aremu, O, Argaw, A, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Aruleba, R, Aryannejad, A, Asaad, M, Asemahagn, M, Asemi, Z, Asghari-Jafarabadi, M, Ashraf, T, Assadi, R, Athar, M, Athari, S, Atout, M, Attia, S, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awedew, A, Awoke, M, Awoke, T, Ayala Quintanilla, B, Ayana, T, Ayen, S, Azadi, D, Azadnajafabad, S, Azami-Aghdash, S, Azanaw, M, Azangou-Khyavy, M, Azari Jafari, A, Azizi, H, Azzam, A, Babajani, A, Badar, M, Badiye, A, Baghcheghi, N, Bagheri, N, Bagherieh, S, Bahadory, S, Baig, A, Baker, J, Bakhtiari, A, Bakshi, R, Banach, M, Banerjee, I, Bardhan, M, Barone-Adesi, F, Barra, F, Barrow, A, Bashir, N, Bashiri, A, Basu, S, Batiha, A, Begum, A, Bekele, A, Belay, A, Belete, M, Belgaumi, U, Bell, A, Belo, L, Benzian, H, Berhie, A, Bermudez, A, Bernabe, E, Bhagavathula, A, Bhala, N, Bhandari, B, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, V, Bhuyan, S, Bibi, S, Bilchut, A, Bintoro, B, Biondi, A, Birega, M, Birhan, H, Bjorge, T, Blyuss, O, Bodicha, B, Bolla, S, Boloor, A, Bosetti, C, Braithwaite, D, Brauer, M, Brenner, H, Briko, A, Briko, N, Buchanan, C, Bulamu, N, Bustamante-Teixeira, M, Butt, M, Butt, N, Butt, Z, Caetano dos Santos, F, Camera, L, Cao, C, Cao, Y, Carreras, G, Carvalho, M, Cembranel, F, Cerin, E, Chakraborty, P, Charalampous, P, Chattu, V, Chimed-Ochir, O, Chirinos-Caceres, J, Cho, D, Cho, W, Christopher, D, Chu, D, Chukwu, I, Cohen, A, Conde, J, Cortes, S, Costa, V, Cruz-Martins, N, Culbreth, G, Dadras, O, Dagnaw, F, Dahlawi, S, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Danielewicz, A, Dao, A, Darvishi Cheshmeh Soltani, R, Darwesh, A, Das, S, Davitoiu, D, Davtalab Esmaeili, E, De la Hoz, F, Debela, S, Dehghan, A, Demisse, B, Demisse, F, Denova-Gutierrez, E, Derakhshani, A, Derbew Molla, M, Dereje, D, Deribe, K, Desai, R, Desalegn, M, Dessalegn, F, Dessalegni, S, Dessie, G, Desta, A, Dewan, S, Dharmaratne, S, Dhimal, M, Dianatinasab, M, Diao, N, Diaz, D, Digesa, L, Dixit, S, Doaei, S, Doan, L, Doku, P, Dongarwar, D, dos Santos, W, Driscoll, T, Dsouza, H, Durojaiye, O, Edalati, S, Eghbalian, F, Ehsani-Chimeh, E, Eini, E, Ekholuenetale, M, Ekundayo, T, Ekwueme, D, El Tantawi, M, Elbahnasawy, M, Elbarazi, I, Elghazaly, H, Elhadi, M, El-Huneidi, W, Emamian, M, Engelbert Bain, L, Enyew, D, Erkhembayar, R, Eshetu, T, Eshrati, B, Eskandarieh, S, Espinosa-Montero, J, Etaee, F, Etemadimanesh, A, Eyayu, T, Ezeonwumelu, I, Ezzikouri, S, Fagbamigbe, A, Fahimi, S, Fakhradiyev, I, Faraon, E, Fares, J, Farmany, A, Farooque, U, Farrokhpour, H, Fasanmi, A, Fatehizadeh, A, Fatima, W, Fattahi, H, Fekadu, G, Feleke, B, Ferrari, A, Ferrero, S, Ferro Desideri, L, Filip, I, Fischer, F, Foroumadi, R, Foroutan, M, Fukumoto, T, Gaal, P, Gad, M, Gadanya, M, Gaipov, A, Galehdar, N, Gallus, S, Garg, T, Gaspar Fonseca, M, Gebremariam, Y, Gebremeskel, T, Gebremichael, M, Geda, Y, Gela, Y, Gemeda, B, Getachew, M, Ghaffari, K, Ghafourifard, M, Ghamari, S, Ghasemi Nour, M, Ghassemi, F, Ghimire, A, Ghith, N, Gholamalizadeh, M, Gholizadeh Navashenaq, J, Ghozy, S, Gilani, S, Gill, P, Ginindza, T, Gizaw, A, Glasbey, J, Godos, J, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Golitaleb, M, Gorini, G, Goulart, B, Grosso, G, Guadie, H, Gubari, M, Gudayu, T, Guerra, M, Gunawardane, D, Gupta, B, Gupta, S, Gupta, V, Gurara, M, Guta, A, Habibzadeh, P, Haddadi Avval, A, Hafezi-Nejad, N, Hajj Ali, A, Haj-Mirzaian, A, Halboub, E, Halimi, A, Halwani, R, Hamadeh, R, Hameed, S, Hamidi, S, Hanif, A, Hariri, S, Harlianto, N, Haro, J, Hartono, R, Hasaballah, A, Hasan, S, Hasani, H, Hashemi, S, Hassan, A, Hassanipour, S, Hayat, K, Heidari, G, Heidari, M, Heidarymeybodi, Z, Herrera-Serna, B, Herteliu, C, Hezam, K, Hiraike, Y, Hlongwa, M, Holla, R, Holm, M, Horita, N, Hoseini, M, Hossain, M, Hosseini, M, Hosseinzadeh, A, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Hugo, F, Humayun, A, Hussain, S, Hussein, N, Hwang, B, Ibitoye, S, Iftikhar, P, Ikuta, K, Ilesanmi, O, Ilic, I, Ilic, M, Immurana, M, Innos, K, Iranpour, P, Irham, L, Islam, M, Islam, R, Islami, F, Ismail, N, Isola, G, Iwagami, M, J, L, Jaiswal, A, Jakovljevic, M, Jalili, M, Jalilian, S, Jamshidi, E, Jang, S, Jani, C, Javaheri, T, Jayarajah, U, Jayaram, S, Jazayeri, S, Jebai, R, Jemal, B, Jeong, W, Jha, R, Jindal, H, John-Akinola, Y, Jonas, J, Joo, T, Joseph, N, Joukar, F, Jozwiak, J, Jurisson, M, Kabir, A, Kacimi, S, Kadashetti, V, Kahe, F, Kakodkar, P, Kalankesh, L, Kalhor, R, Kamal, V, Kamangar, F, Kamath, A, Kanchan, T, Kandaswamy, E, Kandel, H, Kang, H, Kanno, G, Kapoor, N, Kar, S, Karanth, S, Karaye, I, Karch, A, Karimi, A, Kassa, B, Katoto, P, Kauppila, J, Kaur, H, Kebede, A, 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F., Shaker E., Shannawaz M., Sharew M. M. S., Sharifi A., Sharifi-Rad J., Sharma P., Shashamo B. B., Sheikh A., Sheikh M., Sheikhbahaei S., Sheikhi R. A., Sheikhy A., Shepherd P. R., Shetty A., Shetty J. K., Shetty R. S., Shibuya K., Shirkoohi R., Shirzad-Aski H., Shivakumar K. M., Shivalli S., Shivarov V., Shobeiri P., Shokri Varniab Z., Shorofi S. A., Shrestha S., Sibhat M. M., Siddappa Malleshappa S. K., Sidemo N. B., Silva D. A. S., Silva L. M. L. R., Silva Julian G., Silvestris N., Simegn W., Singh A. D., Singh A., Singh G., Singh H., Singh J. A., Singh J. K., Singh P., Singh S., Sinha D. N., Sinke A. H., Siraj M. S., Sitas F., Siwal S. S., Skryabin V. Y., Skryabina A. A., Socea B., Soeberg M. J., Sofi-Mahmudi A., Solomon Y., Soltani-Zangbar M. S., Song S., Song Y., Sorensen R. J. D., Soshnikov S., Sotoudeh H., Sowe A., Sufiyan M. B., Suk R., Suleman M., Suliankatchi Abdulkader R., Sultana S., Sur D., Szocska M., Tabaeian S. P., Tabares-Seisdedos R., Tabatabaei S. M., Tabuchi T., Tadbiri H., Taheri E., Taheri M., Taheri Soodejani M., Takahashi K., Talaat I. M., Tampa M., Tan K. -K., Tat N. Y., Tat V. Y., Tavakoli A., Tehrani-Banihashemi A., Tekalegn Y., Tesfay F. H., Thapar R., Thavamani A., Thoguluva Chandrasekar V., Thomas N., Thomas N. K., Ticoalu J. H. V., Tiyuri A., Tollosa D. N., Topor-Madry R., Touvier M., Tovani-Palone M. R., Traini E., Tran M. T. N., Tripathy J. P., Ukke G. G., Ullah I., Ullah S., Unnikrishnan B., Vacante M., Vaezi M., Valadan Tahbaz S., Valdez P. R., Vardavas C., Varthya S. B., Vaziri S., Velazquez D. Z., Veroux M., Villeneuve P. J., Violante F. S., Vladimirov S. K., Vlassov V., Vo B., Vu L. G., Wadood A. W., Waheed Y., Walde M. T., Wamai R. G., Wang C., Wang F., Wang N., Wang Y., Ward P., Waris A., Westerman R., Wickramasinghe N. D., Woldemariam M., Woldu B., Xiao H., Xu S., Xu X., Yadav L., Yahyazadeh Jabbari S. H., Yang L., Yazdanpanah F., Yeshaw Y., Yismaw Y., Yonemoto N., Younis M. Z., Yousefi Z., Yousefian F., Yu C., Yu Y., Yunusa I., Zahir M., Zaki N., Zaman B. A., Zangiabadian M., Zare F., Zare I., Zareshahrabadi Z., Zarrintan A., Zastrozhin M. S., Zeineddine M. A., Zhang D., Zhang J., Zhang Y., Zhang Z. -J., Zhou L., Zodpey S., Zoladl M., Vos T., Hay S. I., Force L. M., and Murray C. J. L.
- Abstract
Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [2
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- 2022
19. Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Italian Scientific Societies
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Russo, A, Incorvaia, L, Capoluongo, E, Tagliaferri, P, Gori, S, Cortesi, L, Genuardi, M, Turchetti, D, De Giorgi, U, Di Maio, M, Barberis, M, Dessena, M, Del Re, M, Lapini, A, Luchini, C, Jereczek-Fossa, B, Sapino, A, Cinieri, S, Beretta, G, Bella, M, Bracarda, S, Colombo, N, Conteduca, V, Del Mastro, L, Galvano, A, Gristina, V, Guarneri, V, La Verde, N, Lorusso, D, Marchetti, P, Normanno, N, Ottini, L, Pensabene, M, Pignata, S, Procopio, G, Ricevuto, E, Silvestris, N, Tassone, P, Tucci, M, Donato, V, Carrara, S, Paiella, S, Gentilini, O, Gunelli, R, Nicolis, F, Buttitta, F, Colecchia, M, Fassan, M, Malapelle, U, Marchetti, A, Marchio, C, Scarpa, A, Truini, M, Zamboni, G, Gion, M, Trevisiol, C, Gronchi, A, Danesi, R, Di Marco, V, Carrera, P, Ghiorzo, P, Pasini, B, Varesco, L, Artibani, W, Ludovico, G, Campanella, O, Vatrano, S, Tagliafico, E, Russo A., Incorvaia L., Capoluongo E., Tagliaferri P., Gori S., Cortesi L., Genuardi M., Turchetti D., De Giorgi U., Di Maio M., Barberis M., Dessena M., Del Re M., Lapini A., Luchini C., Jereczek-Fossa B. A., Sapino A., Cinieri S., Beretta G., Bella M. A., Bracarda S., Colombo N., Conteduca V., Del Mastro L., Galvano A., Gristina V., Guarneri V., La Verde N., Lorusso D., Marchetti P., Normanno N., Ottini L., Pensabene M., Pignata S., Procopio G., Ricevuto E., Silvestris N., Tassone P., Tucci M., Donato V., Carrara S., Paiella S., Gentilini O., Gunelli R., Nicolis F., Buttitta F., Colecchia M., Fassan M., Malapelle U., Marchetti A., Marchio C., Scarpa A., Truini M., Zamboni G., Gion M., Trevisiol C., Gronchi A., Danesi R., Di Marco V., Carrera P., Ghiorzo P., Pasini B., Varesco L., Artibani W., Ludovico G., Campanella O., Vatrano S., Tagliafico E., Russo, A, Incorvaia, L, Capoluongo, E, Tagliaferri, P, Gori, S, Cortesi, L, Genuardi, M, Turchetti, D, De Giorgi, U, Di Maio, M, Barberis, M, Dessena, M, Del Re, M, Lapini, A, Luchini, C, Jereczek-Fossa, B, Sapino, A, Cinieri, S, Beretta, G, Bella, M, Bracarda, S, Colombo, N, Conteduca, V, Del Mastro, L, Galvano, A, Gristina, V, Guarneri, V, La Verde, N, Lorusso, D, Marchetti, P, Normanno, N, Ottini, L, Pensabene, M, Pignata, S, Procopio, G, Ricevuto, E, Silvestris, N, Tassone, P, Tucci, M, Donato, V, Carrara, S, Paiella, S, Gentilini, O, Gunelli, R, Nicolis, F, Buttitta, F, Colecchia, M, Fassan, M, Malapelle, U, Marchetti, A, Marchio, C, Scarpa, A, Truini, M, Zamboni, G, Gion, M, Trevisiol, C, Gronchi, A, Danesi, R, Di Marco, V, Carrera, P, Ghiorzo, P, Pasini, B, Varesco, L, Artibani, W, Ludovico, G, Campanella, O, Vatrano, S, Tagliafico, E, Russo A., Incorvaia L., Capoluongo E., Tagliaferri P., Gori S., Cortesi L., Genuardi M., Turchetti D., De Giorgi U., Di Maio M., Barberis M., Dessena M., Del Re M., Lapini A., Luchini C., Jereczek-Fossa B. A., Sapino A., Cinieri S., Beretta G., Bella M. A., Bracarda S., Colombo N., Conteduca V., Del Mastro L., Galvano A., Gristina V., Guarneri V., La Verde N., Lorusso D., Marchetti P., Normanno N., Ottini L., Pensabene M., Pignata S., Procopio G., Ricevuto E., Silvestris N., Tassone P., Tucci M., Donato V., Carrara S., Paiella S., Gentilini O., Gunelli R., Nicolis F., Buttitta F., Colecchia M., Fassan M., Malapelle U., Marchetti A., Marchio C., Scarpa A., Truini M., Zamboni G., Gion M., Trevisiol C., Gronchi A., Danesi R., Di Marco V., Carrera P., Ghiorzo P., Pasini B., Varesco L., Artibani W., Ludovico G., Campanella O., Vatrano S., and Tagliafico E.
- Abstract
Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated with an increased risk for developing breast and ovarian cancers. Current evidence indicates that BRCA1/2 PVs are also associated with pancreatic cancer, and that BRCA2 PVs are associated with prostate cancer risk. The identification of carriers of constitutional PVs in the BRCA1/2 genes allows the implementation of individual and family prevention pathways, through validated screening programs and risk-reducing strategies. According to the relevant and increasing therapeutic predictive implications, the inclusion of BRCA testing in the routine management of patients with breast, ovarian, pancreatic and prostate cancers represent a key requirement to optimize medical or surgical therapeutic and prevention decision-making, and access to specific anticancer therapies. Therefore, accurate patient selection, the use of standardized and harmonized procedures, and adherence to homogeneous testing criteria, are essential elements to implement BRCA testing in clinical practice. This consensus position paper has been developed and approved by a multidisciplinary Expert Panel of 64 professionals on behalf of the AIOM–AIRO–AISP–ANISC–AURO–Fondazione AIOM–SIAPEC/IAP–SIBioC–SICO–SIF–SIGE–SIGU–SIU–SIURO–UROP Italian Scientific Societies, and a patient association (aBRCAdaBRA Onlus). The working group included medical, surgical and radiation oncologists, medical and molecular geneticists, clinical molecular biologists, surgical and molecular pathologists, organ specialists such as gynecologists, gastroenterologists and urologists, and pharmacologists. The manuscript is based on the expert consensus and reports the best available evidence, according to the current eligibility criteria for BRCA testing and counseling, it also harmonizes with current Italian National Guidelines and Clinical Recommendations.
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- 2022
20. Humoral and T-Cell Immune Response After 3 Doses of Messenger RNA Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines in Fragile Patients: The Italian VAX4FRAIL Study
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Corradini, P., Agrati, C., Apolone, G., Mantovani, A., Giannarelli, D., Marasco, V., Bordoni, V., Sacchi, A., Matusali, G., Salvarani, C., Zinzani, P. L., Mantegazza, R., Tagliavini, F., Lupo-Stanghellini, M. T., Ciceri, F., Damian, S., Uccelli, A., Fenoglio, D., Silvestris, N., Baldanti, F., Piaggio, G., Ciliberto, G., Morrone, A., Locatelli, Franco, Sinno, V., Rescigno, M., Costantini, M., Locatelli F. (ORCID:0000-0002-7976-3654), Corradini, P., Agrati, C., Apolone, G., Mantovani, A., Giannarelli, D., Marasco, V., Bordoni, V., Sacchi, A., Matusali, G., Salvarani, C., Zinzani, P. L., Mantegazza, R., Tagliavini, F., Lupo-Stanghellini, M. T., Ciceri, F., Damian, S., Uccelli, A., Fenoglio, D., Silvestris, N., Baldanti, F., Piaggio, G., Ciliberto, G., Morrone, A., Locatelli, Franco, Sinno, V., Rescigno, M., Costantini, M., and Locatelli F. (ORCID:0000-0002-7976-3654)
- Abstract
BACKGROUND: Patients with solid or hematological tumors or neurological and immune-inflammatory disorders are potentially fragile subjects at increased risk of experiencing severe coronavirus disease 2019 and an inadequate response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. METHODS: We designed a prospective Italian multicenter study to assess humoral and T-cell responses to SARS-CoV-2 vaccination in patients (n = 378) with solid tumors (ST), hematological malignancies (HM), neurological disorders (ND), and immunorheumatological diseases (ID). A group of healthy controls was also included. We analyzed the immunogenicity of the primary vaccination schedule and booster dose. RESULTS: The overall seroconversion rate in patients after 2 doses was 62.1%. Significantly lower rates were observed in HM (52.4%) and ID (51.9%) than in ST (95.6%) and ND (70.7%); a lower median antibody level was detected in HM and ID versus ST and ND (P < .0001). Similar rates of patients with a positive SARS-CoV-2 T-cell response were found in all disease groups, with a higher level observed in ND. The booster dose improved the humoral response in all disease groups, although to a lesser extent in HM patients, whereas the T-cell response increased similarly in all groups. In the multivariable logistic model, independent predictors of seroconversion were disease subgroup, treatment type, and age. Ongoing treatment known to affect the immune system was associated with the worst humoral response to vaccination (P < .0001) but had no effect on T-cell responses. CONCLUSIONS: Immunosuppressive treatment more than disease type per se is a risk factor for a low humoral response after vaccination. The booster dose can improve both humoral and T-cell responses.
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- 2023
21. Neutralizing antibodies to Omicron after the fourth SARS-CoV-2 mRNA vaccine dose in immunocompromised patients highlight the need of additional boosters
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Rescigno, M., Agrati, C., Salvarani, C., Giannarelli, D., Costantini, M., Mantovani, A., Massafra, R., Zinzani, P. L., Morrone, A., Notari, S., Matusali, G., Pinter, G. L., Uccelli, A., Ciliberto, G., Baldanti, F., Locatelli, Franco, Silvestris, N., Sinno, V., Turola, E., Lupo-Stanghellini, M. T., and Apolone, G.
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cross immunity ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,immunocompromised patients ,Immunology ,SARS-CoV-2 mRNA vaccine ,Immunology and Allergy ,Omicron neutralization ,T cell response ,humoral response - Abstract
IntroductionImmunocompromised patients have been shown to have an impaired immune response to COVID-19 vaccines.MethodsHere we compared the B-cell, T-cell and neutralizing antibody response to WT and Omicron BA.2 SARS-CoV-2 virus after the fourth dose of mRNA COVID-19 vaccines in patients with hematological malignancies (HM, n=71), solid tumors (ST, n=39) and immune-rheumatological (IR, n=25) diseases. The humoral and T-cell responses to SARS-CoV-2 vaccination were analyzed by quantifying the anti-RBD antibodies, their neutralization activity and the IFN-γ released after spike specific stimulation.ResultsWe show that the T-cell response is similarly boosted by the fourth dose across the different subgroups, while the antibody response is improved only in patients not receiving B-cell targeted therapies, independent on the pathology. However, 9% of patients with anti-RBD antibodies did not have neutralizing antibodies to either virus variants, while an additional 5.7% did not have neutralizing antibodies to Omicron BA.2, making these patients particularly vulnerable to SARS-CoV-2 infection. The increment of neutralizing antibodies was very similar towards Omicron BA.2 and WT virus after the third or fourth dose of vaccine, suggesting that there is no preferential skewing towards either virus variant with the booster dose. The only limited step is the amount of antibodies that are elicited after vaccination, thus increasing the probability of developing neutralizing antibodies to both variants of virus.DiscussionThese data support the recommendation of additional booster doses in frail patients to enhance the development of a B-cell response directed against Omicron and/or to enhance the T-cell response in patients treated with anti-CD20.
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- 2023
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22. Integrative characterization of pancreatic ductal adenocarcinoma with poorly cohesive / signet ring cells
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Luchini, Claudio, primary, Simbolo, M., additional, Silvestris, N., additional, Mafficini, A., additional, Maggino, L., additional, Malleo, G., additional, Mattiolo, P., additional, Salvia, R., additional, Lawlor, R., additional, and Scarpa, A., additional
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- 2022
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23. Vaccination for seasonal influenza in patients with cancer: recommendations of the Italian Society of Medical Oncology (AIOM)
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Pedrazzoli, P., Baldanti, F., Donatelli, I., Castrucci, M.R., Puglisi, F., Silvestris, N., and Cinieri, S.
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- 2014
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24. Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in older patients: A subgroup analysis from the TOSCA trial
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Rosati, G, Lonardi, S, Galli, F, Di Bartolomeo, M, Ronzoni, M, Zampino, M, Banzi, M, Zaniboni, A, Pasini, F, Bozzarelli, S, Garattini, S, Ferrari, D, Montesarchio, V, Mambrini, A, Ciuffreda, L, Pusceddu, V, Carlomagno, C, Bidoli, P, Amoroso, D, Bochicchio, A, Frassineti, L, Corsi, D, Bilancia, D, Pastorino, A, De Stefano, A, Labianca, R, Iaffaioli, R, Nasti, G, Daniele, B, Zagonel, V, Pella, N, Aprile, G, Marchetti, R, Romiti, A, Foa, P, Mosconi, S, Sobrero, A, Cazzaniga, M, Beretta, G, Cortesi, E, Barni, S, Petrelli, F, Allione, P, D'Arco, A, Valmadre, G, Piazza, E, Veltri, E, Ramus, G, Giustini, L, Tumulo, S, Cascinu, S, Granetto, C, Testore, F, Giordano, M, Moroni, M, Di Seri, M, Nuzzo, A, Angelelli, L, Gori, S, Farina, G, Aglietta, M, Franchi, R, Comande, M, Giordani, P, Tonini, G, Bucci, E, Ballestrero, A, Benasso, M, Graiff, C, Bravi, S, Caffo, O, Silva, R, Frontini, L, Rota, S, Cozzi, L, Cantore, M, Maiello, E, Cinieri, S, Silvestris, N, Romito, S, Gebbia, V, Santoro, A, Artioli, F, Mattioli, R, Contu, A, Di Costanzo, F, Leonardi, F, Cavanna, L, Passalacqua, R, Sozzi, P, D'Amico, M, Amadori, D, Turci, D, Ravaioli, A, Pasquini, E, Gambi, A, Faedi, M, Cruciani, G, Bajetta, E, Gianni, L, Ionta, M, Massidda, B, Scartozzi, M, Ciarlo, A, Di Leo, A, Frustaci, S, Rangoni, G, Arizzoia, A, Pavesi, L, Verusio, C, Pinotti, G, Iop, A, De Placido, S, Adamo, V, Ficorella, C, Natale, D, Greco, E, Rulli, E, Poli, D, Porcu, L, Torri, V, Rosati G., Lonardi S., Galli F., Di Bartolomeo M., Ronzoni M., Zampino M. G., Banzi M., Zaniboni A., Pasini F., Bozzarelli S., Garattini S. K., Ferrari D., Montesarchio V., Mambrini A., Ciuffreda L., Pusceddu V., Carlomagno C., Bidoli P., Amoroso D., Bochicchio A. M., Frassineti L., Corsi D., Bilancia D., Pastorino A., De Stefano A., Labianca R., Iaffaioli R. V., Nasti G., Daniele B., Zagonel V., Pella N., Aprile G., Marchetti R. P., Romiti A., Foa P., Mosconi S., Sobrero A., Cazzaniga M., Beretta G. D., Cortesi E., Barni S., Petrelli F., Allione P., D'Arco A. M., Valmadre G., Piazza E., Veltri E., Ramus G. V., Giustini L., Tumulo S., Cascinu S., Granetto C., Testore F., Giordano M., Moroni M., Di Seri M., Nuzzo A., Angelelli L., Gori S., Farina G., Aglietta M., Franchi R., Comande M., Giordani P., Tonini G., Bucci E., Ballestrero A., Benasso M., Graiff C., Bravi S., Caffo O., Silva R. R., Frontini L., Rota S., Cozzi L., Cantore M., Maiello E., Cinieri S., Silvestris N., Romito S., Gebbia V., Santoro A., Artioli F., Mattioli R., Contu A., Di Costanzo F., Leonardi F., Cavanna L., Passalacqua R., Sozzi P., D'Amico M., Amadori D., Turci D., Ravaioli A., Pasquini E., Gambi A., Faedi M., Cruciani G., Bajetta E., Gianni L., Ionta M. T., Massidda B., Scartozzi M., Ciarlo A., Di Leo A., Frustaci S., Rangoni G., Arizzoia A., Pavesi L., Verusio C., Pinotti G., Iop A., De Placido S., Adamo V., Ficorella C., Natale D., Greco E., Rulli E., Poli D., Porcu L., Torri V., Rosati, G, Lonardi, S, Galli, F, Di Bartolomeo, M, Ronzoni, M, Zampino, M, Banzi, M, Zaniboni, A, Pasini, F, Bozzarelli, S, Garattini, S, Ferrari, D, Montesarchio, V, Mambrini, A, Ciuffreda, L, Pusceddu, V, Carlomagno, C, Bidoli, P, Amoroso, D, Bochicchio, A, Frassineti, L, Corsi, D, Bilancia, D, Pastorino, A, De Stefano, A, Labianca, R, Iaffaioli, R, Nasti, G, Daniele, B, Zagonel, V, Pella, N, Aprile, G, Marchetti, R, Romiti, A, Foa, P, Mosconi, S, Sobrero, A, Cazzaniga, M, Beretta, G, Cortesi, E, Barni, S, Petrelli, F, Allione, P, D'Arco, A, Valmadre, G, Piazza, E, Veltri, E, Ramus, G, Giustini, L, Tumulo, S, Cascinu, S, Granetto, C, Testore, F, Giordano, M, Moroni, M, Di Seri, M, Nuzzo, A, Angelelli, L, Gori, S, Farina, G, Aglietta, M, Franchi, R, Comande, M, Giordani, P, Tonini, G, Bucci, E, Ballestrero, A, Benasso, M, Graiff, C, Bravi, S, Caffo, O, Silva, R, Frontini, L, Rota, S, Cozzi, L, Cantore, M, Maiello, E, Cinieri, S, Silvestris, N, Romito, S, Gebbia, V, Santoro, A, Artioli, F, Mattioli, R, Contu, A, Di Costanzo, F, Leonardi, F, Cavanna, L, Passalacqua, R, Sozzi, P, D'Amico, M, Amadori, D, Turci, D, Ravaioli, A, Pasquini, E, Gambi, A, Faedi, M, Cruciani, G, Bajetta, E, Gianni, L, Ionta, M, Massidda, B, Scartozzi, M, Ciarlo, A, Di Leo, A, Frustaci, S, Rangoni, G, Arizzoia, A, Pavesi, L, Verusio, C, Pinotti, G, Iop, A, De Placido, S, Adamo, V, Ficorella, C, Natale, D, Greco, E, Rulli, E, Poli, D, Porcu, L, Torri, V, Rosati G., Lonardi S., Galli F., Di Bartolomeo M., Ronzoni M., Zampino M. G., Banzi M., Zaniboni A., Pasini F., Bozzarelli S., Garattini S. K., Ferrari D., Montesarchio V., Mambrini A., Ciuffreda L., Pusceddu V., Carlomagno C., Bidoli P., Amoroso D., Bochicchio A. M., Frassineti L., Corsi D., Bilancia D., Pastorino A., De Stefano A., Labianca R., Iaffaioli R. V., Nasti G., Daniele B., Zagonel V., Pella N., Aprile G., Marchetti R. P., Romiti A., Foa P., Mosconi S., Sobrero A., Cazzaniga M., Beretta G. D., Cortesi E., Barni S., Petrelli F., Allione P., D'Arco A. M., Valmadre G., Piazza E., Veltri E., Ramus G. V., Giustini L., Tumulo S., Cascinu S., Granetto C., Testore F., Giordano M., Moroni M., Di Seri M., Nuzzo A., Angelelli L., Gori S., Farina G., Aglietta M., Franchi R., Comande M., Giordani P., Tonini G., Bucci E., Ballestrero A., Benasso M., Graiff C., Bravi S., Caffo O., Silva R. R., Frontini L., Rota S., Cozzi L., Cantore M., Maiello E., Cinieri S., Silvestris N., Romito S., Gebbia V., Santoro A., Artioli F., Mattioli R., Contu A., Di Costanzo F., Leonardi F., Cavanna L., Passalacqua R., Sozzi P., D'Amico M., Amadori D., Turci D., Ravaioli A., Pasquini E., Gambi A., Faedi M., Cruciani G., Bajetta E., Gianni L., Ionta M. T., Massidda B., Scartozzi M., Ciarlo A., Di Leo A., Frustaci S., Rangoni G., Arizzoia A., Pavesi L., Verusio C., Pinotti G., Iop A., De Placido S., Adamo V., Ficorella C., Natale D., Greco E., Rulli E., Poli D., Porcu L., and Torri V.
- Abstract
Background: Previous studies on oxaliplatin and fluoropyrimidines as adjuvant therapy in older patients with stage III colon cancer (CC) produced conflicting results. Patients and methods: We assessed the impact of age on time to tumour recurrence (TTR), disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS) in 2360 patients with stage III CC (1667 aged <70 years and 693 ≥ 70 years) randomised to receive 3 or 6 months of FOLFOX or CAPOX within the frame of the phase III, TOSCA study. Results: Older patients compared with younger ones presented more frequently an Eastern Cooperative Oncology Group performance status equal to 1 (10.5% vs 3.3%, p < 0.001), a greater number of right-sided tumours (40.9% vs 26.6%, p < 0.001), and were at higher clinical risk (37.2% vs 33.2%, p = 0.062). The treatments were almost identical in the two cohorts (p = 0.965). We found a greater proportion of dose reductions (46.7% vs 41.4%, p = 0.018), treatment interruptions (26.1% vs 19.3%, p < 0.001) and a higher proportion of recurrences (24.2% vs 20.3%, p = 0.033) in the older patients. The multivariable analysis of the TTR did not indicate a statistically significant effect of age (hazard ratio [HR]: 1.19; 95% confidence interval [CI]: 0.98–1.44; p = 0.082). The HR comparing older with younger patients was 1.34 (95% CI: 1.12–1.59; p = 0.001) for DFS, 1.58 (95% CI: 1.26–1.99; p < 0.001) for OS, and 1.28 (95% CI: 0.96–1.70; p = 0.089) for CSS. Conclusions: Worse prognostic factors and reduced treatment compliance have a negative impact on the efficacy of oxaliplatin-based adjuvant therapy in older patients.
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- 2021
25. P4.15B.03 Effects of Tai Chi and Qigong Interventions in Lung Cancer Patients: A Systematic Review
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Franchina, T., Franchina, V., Sapuppo, E., Tessitore, D., and Silvestris, N.
- Published
- 2024
- Full Text
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26. Natural history of bone metastasis in colorectal cancer: final results of a large Italian bone metastases study
- Author
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Santini, D., Tampellini, M., Vincenzi, B., Ibrahim, T., Ortega, C., Virzi, V., Silvestris, N., Berardi, R., Masini, C., Calipari, N., Ottaviani, D., Catalano, V., Badalamenti, G., Giannicola, R., Fabbri, F., Venditti, O., Fratto, M.E., Mazzara, C., Latiano, T.P., Bertolini, F., Petrelli, F., Ottone, A., Caroti, C., Salvatore, L., Falcone, A., Giordani, P., Addeo, R., Aglietta, M., Cascinu, S., Barni, S., Maiello, E., and Tonini, G.
- Published
- 2012
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27. T.06.2 MANAGEMENT AND OUTCOME OF CHECK-POINT INHIBITORINDUCED COLITIS: A MULTICENTRE RETROSPECTIVE STUDY
- Author
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Lenti, M.V., primary, Ribaldone, D.G., additional, Vernero, M., additional, De Andreis, F. Borrelli, additional, Savarino, E., additional, Zingone, F., additional, Sottotetti, F., additional, Cappello, M., additional, Brinch, D., additional, Silvestris, N., additional, Rossi, C.M., additional, Santacroce, G., additional, Klersy, C., additional, De Grazia, F., additional, Pagani, A., additional, Muscarella, S., additional, Brunetti, O., additional, De Ruvo, M., additional, Premoli, A., additional, Pedrazzoli, P., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
- Published
- 2022
- Full Text
- View/download PDF
28. The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
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Bhuyan, SS, Bibi, S, Bilchut, AH, Bintoro, BS, Biondi, A, Birega, MGB, Birhan, HE, Bjorge, T, Blyuss, O, Bodicha, BBA, Bolla, SR, Boloor, A, Bosetti, C, Braithwaite, D, Brauer, M, Brenner, H, Briko, AN, Briko, NI, Buchanan, CM, Bulamu, NB, Bustamante-Teixeira, MT, Butt, MH, Butt, NS, Butt, ZA, Caetano dos Santos, FL, Camera, LA, Cao, C, Cao, Y, Carreras, G, Carvalho, M, Cembranel, F, Cerin, E, Chakraborty, PA, Charalampous, P, Chattu, VK, Chimed-Ochir, O, Chirinos-Caceres, JL, Cho, DY, Cho, WCS, Christopher, DJ, Chu, D-T, Chukwu, IS, Cohen, AJ, Conde, J, Cortas, S, Costa, VM, Cruz-Martins, N, Culbreth, GT, Dadras, O, Dagnaw, FT, Dahlawi, SMA, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Danielewicz, A, An, TMD, Soltani, RDC, Darwesh, AM, Das, S, Davitoiu, DV, Esmaeili, ED, De la Hoz, FP, Debela, SA, Dehghan, A, Demisse, B, Demisse, FW, DenovaGutiA, E, Derakhshani, A, Molla, MD, Dereje, D, Deribe, KS, Desai, R, Desalegn, MD, Dessalegn, FN, Dessalegni, SAA, Dessie, G, Desta, AA, Dewan, SMR, Dharmaratne, SD, Dhimal, M, Dianatinasab, M, Diao, N, Diaz, D, Digesa, LE, Dixit, SG, Doaei, S, Linh, PD, Doku, PN, Dongarwar, D, dos Santos, WM, Driscoll, TR, Dsouza, HL, Durojaiye, OC, Edalati, S, Eghbalian, F, Ehsani-Chimeh, E, Eini, E, Ekholuenetale, M, Ekundayo, TC, Ekwueme, DU, El Tantawi, M, Elbahnasawy, MA, Elbarazi, I, Elghazaly, H, Elhadi, M, El-Huneidi, W, Emamian, MH, Bain, LE, Enyew, DB, Erkhembayar, R, Eshetu, T, Eshrati, B, Eskandarieh, S, Espinosa-Montero, J, Etaee, F, Etemadimanesh, A, Eyayu, T, Ezeonwumelu, IJ, Ezzikouri, S, Fagbamigbe, AF, Fahimi, S, Fakhradiyev, IR, Faraon, EJA, Fares, J, Farmany, A, Farooque, U, Farrokhpour, H, Fasanmi, AO, Fatehizadeh, A, Fatima, W, Fattahi, H, Fekadu, G, Feleke, BE, Ferrari, AA, Ferrero, S, Desideri, LF, Filip, I, Fischer, F, Foroumadi, R, Foroutan, M, Fukumoto, T, Gaal, PA, Gad, MM, Gadanya, MA, Gaipov, A, Galehdar, N, Gallus, S, Garg, T, Fonseca, MG, Gebremariam, YH, Gebremeskel, TG, Gebremichael, MA, Geda, YF, Gela, YY, Gemeda, BNB, Getachew, M, Getachew, ME, Ghaffari, K, Ghafourifard, M, Ghamari, S-H, Nour, MG, Ghassemi, F, Ghimire, A, Ghith, N, Gholamalizadeh, M, Navashenaq, JG, Ghozy, S, Gilani, SA, Gill, PS, Ginindza, TG, Gizaw, ATT, Glasbey, JC, Godos, J, Goel, A, Golechha, M, Goleij, P, Golinelli, D, Golitaleb, M, Gorini, G, Goulart, BNG, Grosso, G, Guadie, HA, Gubari, MIM, Gudayu, TW, Guerra, MR, Gunawardane, DA, Gupta, B, Gupta, S, Gupta, V, Gupta, VK, Gurara, MK, Guta, A, Habibzadeh, P, Avval, AH, Hafezi-Nejad, N, Ali, AH, Haj-Mirzaian, A, Halboub, ES, Halimi, A, Halwani, R, Hamadeh, RR, Hameed, S, Hamidi, S, Hanif, A, Hariri, S, Harlianto, N, Haro, JM, Hartono, RK, Hasaballah, A, Hasan, SMM, Hasani, H, Hashemi, SM, Hassan, AM, Hassanipour, S, Hayat, K, Heidari, G, Heidari, M, Heidarymeybodi, Z, Herrera-Serna, BY, Herteliu, C, Hezam, K, Hiraike, Y, Hlongwa, MM, Holla, R, Holm, M, Horita, N, Hoseini, M, Hossain, MM, Hossain, MBH, Hosseini, M-S, Hosseinzadeh, A, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Househ, M, Huang, J, Hugo, FN, Humayun, A, Hussain, S, Hussein, NR, Hwang, B-F, Ibitoye, SE, Iftikhar, PM, Ikuta, KS, Ilesanmi, OS, Ilic, IM, Ilic, MD, Immurana, M, Innos, K, Iranpour, P, Irham, LM, Islam, MS, Islam, RM, Islami, F, Ismail, NE, Isola, G, Iwagami, M, Merin, LJ, Jaiswal, A, Jakovljevic, M, Jalili, M, Jalilian, S, Jamshidi, E, Jang, S-I, Jani, CT, Javaheri, T, Jayarajah, UU, Jayaram, S, Jazayeri, SB, Jebai, R, Jemal, B, Jeong, W, Jha, RP, Jindal, HA, John-Akinola, YO, Jonas, JB, Joo, T, Joseph, N, Joukar, F, Jozwiak, JJ, Jarisson, M, Kabir, A, Kacimi, SEO, Kadashetti, V, Kahe, F, Kakodkar, PV, Kalankesh, LR, Kalhor, R, Kamal, VK, Kamangar, F, Kamath, A, Kanchan, T, Kandaswamy, E, Kandel, H, Kang, H, Kanno, GG, Kapoor, N, Kar, SS, Karanth, SD, Karaye, IM, Karch, A, Karimi, A, Kassa, BG, Katoto, PDMC, Kauppila, JH, Kaur, H, Kebede, AG, Keikavoosi-Arani, L, Kejela, GG, Bohan, PMK, Keramati, M, Keykhaei, M, Khajuria, H, Khan, A, Khan, AAK, Khan, EA, Khan, G, Khan, MN, Ab Khan, M, Khanali, J, Khatab, K, Khatatbeh, MM, Khatib, MN, Khayamzadeh, M, Kashani, HRK, Tabari, MAK, Khezeli, M, Khodadost, M, Kim, MS, Kim, YJ, Kisa, A, Kisa, S, Klugar, M, Klugarova, J, Kolahi, A-A, Kolkhir, P, Kompani, F, Koul, PA, Laxminarayana, SLK, Koyanagi, A, Krishan, K, Krishnamoorthy, Y, Bicer, BK, Kugbey, N, Kulimbet, M, Kumar, A, Kumar, GA, Kumar, N, Kurmi, OP, Kuttikkattu, A, La Vecchia, C, Lahiri, A, Lal, DK, Lam, J, Lan, Q, Landires, I, Larijani, B, Lasrado, S, Lau, J, Lauriola, P, Ledda, C, Lee, S-W, Lee, SWH, Lee, W-C, Lee, YY, Lee, YH, Legesse, SM, Leigh, J, Leong, E, Li, M-C, Lim, SS, Liu, G, Liu, J, Lo, C-H, Lohiya, A, Lopukhov, PD, Lorenzovici, L, Lotfi, M, Loureiro, JA, Lunevicius, R, Madadizadeh, F, Mafi, AR, Magdeldin, S, Mahjoub, S, Mahmoodpoor, A, Mahmoudi, M, Mahmoudimanesh, M, Mahumud, RA, Majeed, A, Majidpoor, J, Makki, A, Makris, KC, Rad, EM, Malekpour, M-R, Malekzadeh, R, Malik, AA, Mallhi, TH, Mallya, SD, Mamun, MA, Manda, AL, Mansour-Ghanaei, F, Mansouri, B, Mansournia, MA, Mantovani, LG, Martini, S, Martorell, M, Masoudi, S, Masoumi, SZ, Matei, CN, Mathews, E, Mathur, MR, Mathur, V, McKee, M, Meena, JK, Mehmood, K, Nasab, EM, Mehrotra, R, Melese, A, Mendoza, W, Menezes, RG, Mengesha, SD, Mensah, LG, Mentis, A-FA, Mera-Mamian, AYM, Meretoja, TJ, Merid, MW, Mersha, AG, Meselu, BT, Meshkat, M, Mestrovic, T, Jonasson, JM, Miazgowski, T, Michalek, IM, Mijena, GFW, Miller, TR, Mir, SA, Mirinezhad, SK, Mirmoeeni, S, Mirza-Aghazadeh-Attari, M, Mirzaei, H, Mirzaei, HR, Misganaw, AS, Misra, S, AbdulmuhsinMohammad, K, Mohammadi, E, Mohammadi, M, Mohammadian-Hafshejani, A, Mohammadpourhodki, R, Mohammed, A, Mohammed, S, Mohan, S, Mohseni, M, Moka, N, Mokdad, AH, Molassiotis, A, Molokhia, M, Momenzadeh, K, Momtazmanesh, S, Monasta, L, Mons, U, Al Montasir, A, Montazeri, F, Montero, A, Moosavi, MA, Moradi, A, Moradi, Y, Sarabi, MM, Moraga, P, Morawska, L, Morrison, SD, Morze, J, Mosapour, A, Mostafavi, E, Mousavi, SM, Isfahani, HM, Khaneghah, AM, Mpundu-Kaambwa, C, Mubarik, S, Mulita, F, Munblit, D, Munro, SB, Murillo-Zamora, E, Musa, J, Nabhan, AF, Nagarajan, AJ, Nagaraju, SP, Nagel, G, Naghipour, M, Naimzada, MD, Nair, TS, Naqvi, AA, Swamy, SN, Narayana, AI, Nassereldine, H, Natto, ZS, Nayak, BP, Ndejjo, R, Nduaguba, SO, Negash, WW, Nejadghaderi, SA, Nejati, K, Kandel, SN, Huy, VNN, Niazi, RK, Noor, NM, Noori, M, Noroozi, N, Nouraei, H, Nowroozi, A, Nunez-Samudio, V, Nzoputam, CI, Nzoputam, OJ, Oancea, B, Odukoya, OO, Oghenetega, OB, Ogunsakin, RE, Oguntade, AS, Oh, I-H, Okati-Aliabad, H, Okekunle, AP, Olagunju, AT, Olagunju, TO, Olakunde, BO, Olufadewa, II, Omer, E, Omonisi, AEE, Ong, S, Onwujekwe, OE, Orru, H, Otstavnov, SS, Oulhaj, A, Oumer, B, Owopetu, OF, Oyinloye, BE, Mahesh, PA, Padron-Monedero, A, Padubidri, JR, Pakbin, B, Pakshir, K, Pakzad, R, Palicz, T, Pana, A, Pandey, A, Pant, S, Pardhan, S, Park, E-K, Park, S, Patel, J, Pati, S, Paudel, R, Paudel, U, Paun, M, Toroudi, HP, Peng, M, Pereira, J, Pereira, RB, Perna, S, Perumalsamy, N, Pestell, RG, Pezzani, R, Piccinelli, C, Pillay, JD, Piracha, ZZ, Pischon, T, Postma, MJ, Langroudi, AP, Pourshams, A, Pourtaheri, N, Prashant, A, Qadir, MMF, Syed, ZQ, Rabiee, M, Rabiee, N, Radfar, A, Radhakrishnan, RA, Radhakrishnan, V, Raeisi, M, Rafiee, A, Rafiei, A, Raheem, N, Rahim, F, Rahman, MO, Rahman, M, Rahman, MA, Rahmani, AM, Rahmani, S, Rahmanian, V, Rajai, N, Rajesh, A, Ram, P, Ramezanzadeh, K, Rana, J, Ranabhat, K, Ranasinghe, P, Rao, CR, Rao, SJ, Rashedi, S, Rashidi, A, Rashidi, M-M, Ratan, ZA, Rawaf, DL, Rawaf, S, Rawal, L, Rawassizadeh, R, Razeghinia, MS, Rehman, AU, Rehman, IU, Reitsma, MB, Renzaho, AMN, Rezaei, M, Rezaei, N, Rezaei, S, Rezaeian, M, Rezapour, A, Riad, A, Rikhtegar, R, Rios-Blancas, M, Roberts, TJ, Rohloff, P, Romero-Rodriguez, E, Roshandel, G, Rwegerera, GM, Manjula, S, Saber-Ayad, MM, Saberzadeh-Ardestani, B, Sabour, S, Saddik, B, Sadeghi, E, Saeb, MR, Saeed, U, Safaei, M, Safary, A, Sahebazzamani, M, Sahebkar, A, Sahoo, H, Sajid, MR, Salari, H, Salehi, S, Salem, MR, Salimzadeh, H, Samodra, YL, Samy, AM, Sanabria, J, Sankararaman, S, Sanmarchi, F, Santric-Milicevic, MM, Saqib, MAN, Sarveazad, A, Sarvi, F, Sathian, B, Satpathy, M, Sayegh, N, Schneider, IJC, Schwarzinger, M, Sekerija, M, Senthilkumaran, S, Sepanlou, SG, Seylani, A, Seyoum, K, Sha, F, Shafaat, O, Shah, PA, Shahabi, S, Shahid, I, Shahrbaf, MA, Shahsavari, HR, Shaikh, MA, Shaka, MF, Shaker, E, Shannawaz, M, Sharew, MMS, Sharifi, A, Sharifi-Rad, J, Sharma, P, Shashamo, BB, Sheikh, A, Sheikh, M, Sheikhbahaei, S, Sheikhi, RA, Sheikhy, A, Shepherd, PR, Shetty, A, Shetty, JK, Shetty, RS, Shibuya, K, Shirkoohi, R, Shirzad-Aski, H, Shivakumar, KM, Shivalli, S, Shivarov, V, Shobeiri, P, Varniab, ZS, Shorofi, SA, Shrestha, S, Sibhat, MM, Malleshappa, SS, Sidemo, NB, Silva, DAS, Silva, LMLR, Julian, GS, Silvestris, N, Simegn, W, Singh, AD, Singh, A, Singh, G, Singh, H, Singh, JA, Singh, JK, Singh, P, Singh, S, Sinha, DN, Sinke, AH, Siraj, MS, Sitas, F, Siwal, SS, Skryabin, VY, Skryabina, AA, Socea, B, Soeberg, MJ, Sofi-Mahmudi, A, Solomon, Y, Soltani-Zangbar, MS, Song, S, Song, Y, Sorensen, RJD, Soshnikov, S, Sotoudeh, H, Sowe, A, Sufiyan, MB, Suk, R, Suleman, M, Abdulkader, RS, Sultana, S, Sur, D, Szacska, M, Tabaeian, SP, Tabares-Seisdedos, R, Tabatabaei, SM, Tabuchi, T, Tadbiri, H, Taheri, E, Taheri, M, Soodejani, MT, Takahashi, K, Talaat, IM, Tampa, M, Tan, K-K, Tat, NY, Tat, VY, Tavakoli, A, Tehrani-Banihashemi, A, Tekalegn, Y, Tesfay, FH, Thapar, R, Thavamani, A, Chandrasekar, VT, Thomas, N, Thomas, NK, Ticoalu, JHV, Tiyuri, A, Tollosa, DN, Topor-Madry, R, Touvier, M, Tovani-Palone, MR, Traini, E, Mai, TNT, Tripathy, JP, Ukke, GG, Ullah, I, Ullah, S, Unnikrishnan, B, Vacante, M, Vaezi, M, Tahbaz, SV, Valdez, PR, Vardavas, C, Varthya, SB, Vaziri, S, Velazquez, DZ, Veroux, M, Villeneuve, PJ, Violante, FS, Vladimirov, SK, Vlassov, V, Vo, B, Vu, LG, Wadood, AW, Waheed, Y, Walde, MT, Wamai, RG, Wang, C, Wang, F, Wang, N, Wang, Y, Ward, P, Waris, A, Westerman, R, Wickramasinghe, ND, Woldemariam, M, Woldu, B, Xiao, H, Xu, S, Xu, X, Yadav, L, Jabbari, SHY, Yang, L, Yazdanpanah, F, Yeshaw, Y, Yismaw, Y, Yonemoto, N, Younis, MZ, Yousefi, Z, Yousefian, F, Yu, C, Yu, Y, Yunusa, I, Zahir, M, Zaki, N, Zaman, BA, Zangiabadian, M, Zare, F, Zare, I, Zareshahrabadi, Z, Zarrintan, A, Zastrozhin, MS, Zeineddine, MA, Zhang, D, Zhang, J, Zhang, Y, Zhang, Z-J, Zhou, L, Zodpey, S, Zoladl, M, Vos, T, Hay, S, Force, LM, and Murray, CJL
- Abstract
BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [2
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- 2022
29. Safety of third dose of COVID-19 vaccination in frail patients: Results from the prospective Italian VAX4FRAIL study
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Di Cosimo, S., Lupo-Stanghellini, M. T., Costantini, M., Mantegazza, R., Ciceri, F., Salvarani, C., Zinzani, P. L., Mantovani, A., Ciliberto, G., Uccelli, A., Baldanti, F., Apolone, G., Delcuratolo, S., Morrone, A., Locatelli, Franco, Agrati, C., Silvestris, N., Locatelli F. (ORCID:0000-0002-7976-3654), Di Cosimo, S., Lupo-Stanghellini, M. T., Costantini, M., Mantegazza, R., Ciceri, F., Salvarani, C., Zinzani, P. L., Mantovani, A., Ciliberto, G., Uccelli, A., Baldanti, F., Apolone, G., Delcuratolo, S., Morrone, A., Locatelli, Franco, Agrati, C., Silvestris, N., and Locatelli F. (ORCID:0000-0002-7976-3654)
- Abstract
Importance: Despite people with impaired immune competence due to an underlying disease or ongoing therapy, hereinafter frail patients, are (likely to be) the first to be vaccinated, they were usually excluded from clinical trials. Objective: To report adverse reactions of frail patients after receipt of the third dose (booster) administered after completion of a two-dose mRNA vaccination and to compare with those reported after the receipt of the first two doses. Design: A multicenter, observational, prospective study aimed at evaluating both the safety profile and the immune response of Pfizer-BioNTech or Moderna vaccines in frail patients. Setting: National Project on Vaccines, COVID-19 and Frail Patients (VAX4FRAIL) Participants: People consenting and included in the VAX4FRAIL trial. Exposure: A series of three doses of COVID-19 mRNA vaccination from the same manufacturer. Main outcome(s) and measure(s): Evaluation of a self-assessment questionnaire addressing a predefined list of eight symptoms on a five-item Likert scale. Symptoms were classified as severe if the patient rated them as severe or overwhelming. Results: Among 320 VAX4FRAIL participants diagnosed/treated for hematological malignancies (N=105; 32.8%), solid tumors (N=48; 15.0%), immune-rheumatological diseases (N=60; 18.8%), neurological diseases (N=107; 33.4%), and receiving the booster dose, 70.3% reported at least one loco-regional or systemic reactions. Adverse events were mostly mild or moderate, none being life-threatening. Only six of the 320 (1.9%) patients had their treatment postponed due to the vaccine. The safety profile of the booster compared to previously administered two doses showed a stable prevalence of patients with one or more adverse events (73.5%, 79.7% and 73.9% respectively), and a slightly increment of patients with one or more severe adverse events (13.4%, 13.9% and 19.2% respectively). Conclusions and relevance: The booster of the mRNA COVID-19 vaccine was safely adminis
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- 2022
30. mRNA-COVID19 Vaccination Can Be Considered Safe and Tolerable for Frail Patients
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Lupo-Stanghellini, M. T., Di Cosimo, S., Costantini, M., Monti, S., Mantegazza, R., Mantovani, A., Salvarani, C., Zinzani, P. L., Inglese, M., Ciceri, F., Apolone, G., Ciliberto, G., Baldanti, F., Morrone, A., Sinno, V., Locatelli, Franco, Notari, S., Turola, E., Giannarelli, D., Silvestris, N., Locatelli F. (ORCID:0000-0002-7976-3654), Lupo-Stanghellini, M. T., Di Cosimo, S., Costantini, M., Monti, S., Mantegazza, R., Mantovani, A., Salvarani, C., Zinzani, P. L., Inglese, M., Ciceri, F., Apolone, G., Ciliberto, G., Baldanti, F., Morrone, A., Sinno, V., Locatelli, Franco, Notari, S., Turola, E., Giannarelli, D., Silvestris, N., and Locatelli F. (ORCID:0000-0002-7976-3654)
- Abstract
Background: Frail patients are considered at relevant risk of complications due to coronavirus disease 2019 (COVID-19) infection and, for this reason, are prioritized candidates for vaccination. As these patients were originally not included in the registration trials, fear related to vaccine adverse events and disease worsening was one of the reasons for vaccine hesitancy. Herein, we report the safety profile of the prospective, multicenter, national VAX4FRAIL study (NCT04848493) to evaluate vaccines in a large trans-disease cohort of patients with solid or hematological malignancies and neurological and rheumatological diseases. Methods: Between March 3 and September 2, 2021, 566 patients were evaluable for safety endpoint: 105 received the mRNA-1273 vaccine and 461 the BNT162b2 vaccine. Frail patients were defined per protocol as patients under treatment with hematological malignancies (n = 131), solid tumors (n = 191), immune-rheumatological diseases (n = 86), and neurological diseases (n = 158), including multiple sclerosis and generalized myasthenia. The impact of the vaccination on the health status of patients was assessed through a questionnaire focused on the first week after each vaccine dose. Results: The most frequently reported moderate–severe adverse events were pain at the injection site (60.3% after the first dose, 55.4% after the second), fatigue (30.1%–41.7%), bone pain (27.4%–27.2%), and headache (11.8%–18.9%). Risk factors associated with the occurrence of severe symptoms after vaccine administration were identified through a multivariate logistic regression analysis: age was associated with severe fever presentation (younger patients vs. middle-aged vs. older ones), female individuals presented a higher probability of severe pain at the injection site, fatigue, headache, and bone pain; and the mRNA-1237 vaccine was associated with a higher probability of severe pain at the injection site and fever. After the first dose, patients presenting a se
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- 2022
31. Cisplatin, fotemustine and whole-brain radiotherapy in non-small cell lung cancer patients with asymptomatic brain metastases: A multicenter phase II study of the Gruppo Oncologico Italia Meridionale (GOIM 2603)
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Galetta, D., Gebbia, V., Silvestris, N., Ferraù, F., Carrozza, F., Cigolari, S., Russo, P., Calista, F., Adamo, V., and Colucci, G.
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- 2011
- Full Text
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32. Khorana score and thromboembolic risk in stage II–III colorectal cancer patients: a post hoc analysis from the adjuvant TOSCA trial
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Barni, S, Rosati, G, Lonardi, S, Pella, N, Banzi, M, Zampino, M, Dotti, K, Rimassa, L, Marchetti, P, Maiello, E, Artioli, F, Ferrari, D, Labianca, R, Bidoli, P, Zaniboni, A, Sobrero, A, Iaffaioli, V, De Placido, S, Frassineti, G, Ciarlo, A, Buonadonna, A, Silvestris, N, Piazza, E, Pavesi, L, Moroni, M, Clerico, M, Aglietta, M, Giordani, P, Galli, F, Petrelli, F, Barni S., Rosati G., Lonardi S., Pella N., Banzi M., Zampino M. G., Dotti K. F., Rimassa L., Marchetti P., Maiello E., Artioli F., Ferrari D., Labianca R., Bidoli P., Zaniboni A., Sobrero A., Iaffaioli V., De Placido S., Frassineti G. L., Ciarlo A., Buonadonna A., Silvestris N., Piazza E., Pavesi L., Moroni M., Clerico M., Aglietta M., Giordani P., Galli F., Petrelli F., Barni, S, Rosati, G, Lonardi, S, Pella, N, Banzi, M, Zampino, M, Dotti, K, Rimassa, L, Marchetti, P, Maiello, E, Artioli, F, Ferrari, D, Labianca, R, Bidoli, P, Zaniboni, A, Sobrero, A, Iaffaioli, V, De Placido, S, Frassineti, G, Ciarlo, A, Buonadonna, A, Silvestris, N, Piazza, E, Pavesi, L, Moroni, M, Clerico, M, Aglietta, M, Giordani, P, Galli, F, Petrelli, F, Barni S., Rosati G., Lonardi S., Pella N., Banzi M., Zampino M. G., Dotti K. F., Rimassa L., Marchetti P., Maiello E., Artioli F., Ferrari D., Labianca R., Bidoli P., Zaniboni A., Sobrero A., Iaffaioli V., De Placido S., Frassineti G. L., Ciarlo A., Buonadonna A., Silvestris N., Piazza E., Pavesi L., Moroni M., Clerico M., Aglietta M., Giordani P., Galli F., and Petrelli F.
- Abstract
Background: The risk of venous thromboembolic events (VTE) during adjuvant chemotherapy for colorectal cancer (CRC) is unknown. We aim to evaluate if the Khorana score (KS) can predict this risk, and if it represents a prognostic factor for overall survival (OS) through a post hoc analysis of the phase III TOSCA trial of different durations (3- versus 6-months) of adjuvant chemotherapy. Methods: A logistic regression model was used to test the associations between the risk of VTE and the KS. The results are expressed as odds ratios (OR) with 95% confidence intervals (95% CI). To assess the effect of the KS on OS, multivariable analyses using Cox regression models were performed. The results are expressed as hazard ratios (HR) with 95% CI. Results: Among 1380 CRC patients with available data, the VTE risk (n = 72 events: 5.2%) was similar in the two duration arms (5.5% versus 4.9%), with 0.2% of patients belonging to the high-risk KS group. Rates of VTE were similar in the low- and intermediate-risk groups (4.8% versus 6.4%). KS did not represent an independent predictive factor for VTE occurrence. Chemotherapy duration was not associated with VTE risk. In addition, KS was not prognostic for OS in multivariate analysis (HR: 0.92, 95% CI, 0.63–1.36; p = 0.6835). Conclusions: The use of the KS did not predict VTEs in a low–moderate thromboembolic risk population as CRC. These data did not support the use of KS to predict VTE during adjuvant chemotherapy, and suggest that other risk assessment models should be researched.
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- 2020
33. The role of PNI to predict survival in advanced hepatocellular carcinoma treated with Sorafenib
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Caputo F., Dadduzio V., Tovoli F., Bertolini G., Cabibbo G., Cerma K., Vivaldi C., Faloppi L., Rizzato M. D., Piscaglia F., Celsa C., Fornaro L., Marisi G., Conti F., Silvestris N., Silletta M., Lonardi S., Granito A., Stornello C., Massa V., Astara G., Delcuratolo S., Cascinu S., Scartozzi M., Casadei-Gardini A., Francesco Caputo,Vincenzo Dadduzio,Francesco Tovoli,Giulia Bertolini,Giuseppe Cabibbo,Krisida Cerma,Caterina Vivaldi,Luca Faloppi,Mario Domenico Rizzato,Fabio Piscaglia,Ciro Celsa,Lorenzo Fornaro,Giorgia Marisi,Fabio Conti,Nicola Silvestris,Marianna Silletta,Sara Lonardi,Alessandro Granito,Caterina Stornello,Valentina Massa,Giorgio Astara,Sabina Delcuratolo,Stefano Cascinu,Mario Scartozzi,Andrea Casadei-Gardini, Caputo, F., Dadduzio, V., Tovoli, F., Bertolini, G., Cabibbo, G., Cerma, K., Vivaldi, C., Faloppi, L., Rizzato, M. D., Piscaglia, F., Celsa, C., Fornaro, L., Marisi, G., Conti, F., Silvestris, N., Silletta, M., Lonardi, S., Granito, A., Stornello, C., Massa, V., Astara, G., Delcuratolo, S., Cascinu, S., Scartozzi, M., Casadei Gardini, A., Caputo F., Dadduzio V., Tovoli F., Bertolini G., Cabibbo G., Cerma K., Vivaldi C., Faloppi L., Rizzato M.D., Piscaglia F., Celsa C., Fornaro L., Marisi G., Conti F., Silvestris N., Silletta M., Lonardi S., Granito A., Stornello C., Massa V., Astara G., Delcuratolo S., Cascinu S., Scartozzi M., and Casadei-Gardini A.
- Subjects
RNA viruses ,Male ,Etiology ,Cancer Treatment ,Hepacivirus ,Kaplan-Meier Estimate ,Biochemistry ,Cohort Studies ,White Blood Cells ,Mathematical and Statistical Techniques ,Retrospective Studie ,Animal Cells ,Adult ,Aged ,Aged, 80 and over ,Antineoplastic Agents ,Carcinoma, Hepatocellular ,Female ,Humans ,Italy ,Liver Neoplasms ,Lymphocyte Count ,Middle Aged ,Prognosis ,Retrospective Studies ,Serum Albumin ,Sorafenib ,Nutrition Assessment ,Medicine and Health Sciences ,80 and over ,Lymphocytes ,Pathology and laboratory medicine ,Hepatitis C virus ,Liver Diseases ,Statistics ,Medical microbiology ,Oncology ,Liver Neoplasm ,Physical Sciences ,Viruses ,Medicine ,Pathogens ,Cellular Types ,Human ,Research Article ,Hepatitis B virus ,Immune Cells ,Science ,Immunology ,Gastroenterology and Hepatology ,Research and Analysis Methods ,Carcinomas ,Microbiology ,Albumins ,Gastrointestinal Tumors ,Statistical Methods ,Blood Cells ,Adult, Aged, 80 and over, Antineoplastic Agents, Carcinoma, Hepatocellular, Cohort Studies, Female, Humans, Italy, Kaplan-Meier Estimate, Liver Neoplasms, Lymphocyte Count, Male, Middle Aged, Prognosis, Retrospective Studies, Serum Albumin, Sorafenib, Nutrition Assessment ,Biology and life sciences ,Flaviviruses ,Carcinoma ,Viral pathogens ,Organisms ,Cancers and Neoplasms ,Proteins ,Hepatocellular ,Hepatocellular Carcinoma ,Cell Biology ,prognostic nutritional index (PNI), hepatocellular carcinoma (HCC), sorafenib., survival, mRECIST ,Hepatitis viruses ,Microbial pathogens ,Multivariate Analysis ,Cohort Studie ,Mathematics - Abstract
Background and aims The present study aims to investigate the role of the prognostic nutritional index (PNI) on survival in patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. Methods This multicentric study included a training cohort of 194 HCC patients and three external validation cohorts of 129, 76 and 265 HCC patients treated with Sorafenib, respectively. The PNI was calculated as follows: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (per mm3). Univariate and multivariate analyses were performed to investigate the association between the covariates and the overall survival (OS). Results A PNI cut-off value of 31.3 was established using the ROC analysis. In the training cohort, the median OS was 14.8 months (95% CI 12–76.3) and 6.8 months (95% CI 2.7–24.6) for patients with a high (>31.3) and low ( 70 years (p< 0.0038) were independent prognostic factors for OS. By performing the same multivariate analysis of the training cohort, the PNI 31.3 was found to be an independent prognostic factor for predicting OS in all the three validation cohorts. Conclusions PNI represents a prognostic tool in advanced HCC treated with first-line Sorafenib. It is readily available and low-cost, and it could be implemented in clinical practice in patients with HCC.
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- 2020
34. Update on capecitabine alone and in combination regimens in colorectal cancer patients
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Silvestris, N., Maiello, E., De Vita, F., Cinieri, S., Santini, D., Russo, A., Tommasi, S., Azzariti, A., Numico, G., Pisconti, S., Petriella, D., Lorusso, V., Millaku, A., and Colucci, G.
- Published
- 2010
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- View/download PDF
35. Lapatinib in breast cancer: clinical experiences and future perspectives
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Giampaglia, M., Chiuri, V.E., Tinelli, A., De Laurentiis, M., Silvestris, N., and Lorusso, V.
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- 2010
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36. Molecularly targeted endocrine therapies for breast cancer
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Orlando, L., Schiavone, P., Fedele, P., Calvani, N., Nacci, A., Rizzo, P., Marino, A., D'Amico, M., Sponziello, F., Mazzoni, E., Cinefra, M., Fazio, N., Maiello, E., Silvestris, N., Colucci, G., and Cinieri, S.
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- 2010
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37. Adjuvant colon cancer chemotherapy: where we are and where we'll go
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Lombardi, L., Morelli, F., Cinieri, S., Santini, D., Silvestris, N., Fazio, N., Orlando, L., Tonini, G., Colucci, G., and Maiello, E.
- Published
- 2010
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38. Human epidermal growth factor receptor 2 (HER2) in gastric cancer: a new therapeutic target
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De Vita, F., Giuliani, F., Silvestris, N., Catalano, G., Ciardiello, F., and Orditura, M.
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- 2010
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39. New molecular targets in bone metastases
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Santini, D., Galluzzo, S., Zoccoli, A., Pantano, F., Fratto, M.E., Vincenzi, B., Lombardi, L., Gucciardino, C., Silvestris, N., Riva, E., Rizzo, S., Russo, A., Maiello, E., Colucci, G., and Tonini, G.
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- 2010
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- View/download PDF
40. The process of truth disclosure: an assessment of the results of information during the diagnostic phase in patients with cancer
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Numico, G., Anfossi, M., Bertelli, G., Russi, E., Cento, G., Silvestris, N., Granetto, C., Di Costanzo, G., Occelli, M., Fea, E., Garrone, O., Gasco, M., Colantonio, I., and Merlano, M.
- Published
- 2009
- Full Text
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41. Correction to: Angiogenesis Genotyping and Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib: The ALICE‑2 Study (Targeted Oncology, (2020), 15, 1, (115-126), 10.1007/s11523-020-00698-x)
- Author
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Faloppi L., Puzzoni M., Casadei-Gardini A., Silvestris N., Masi G., Marisi G., Vivaldi C., Gadaleta C. D., Ziranu P., Bianconi M., Loretelli C., Demurtas L., Lai E., Giampieri R., Galizia E., Ulivi P., Battelli N., Falcone A., Cascinu S., Scartozzi M., Faloppi, L., Puzzoni, M., Casadei-Gardini, A., Silvestris, N., Masi, G., Marisi, G., Vivaldi, C., Gadaleta, C. D., Ziranu, P., Bianconi, M., Loretelli, C., Demurtas, L., Lai, E., Giampieri, R., Galizia, E., Ulivi, P., Battelli, N., Falcone, A., Cascinu, S., and Scartozzi, M.
- Abstract
The listing of the author names and affiliations, which previously read.
- Published
- 2020
42. Second-line chemotherapy in advanced biliary cancer: the present now will later be past
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Vivaldi, C., Fornaro, L., Cereda, S., Aprile, G., Santini, D., Silvestris, N., Lonardi, S., Leone, F., Milella, M., Brandi, G., and Vasile, E.
- Published
- 2014
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- View/download PDF
43. Oxaliplatin plus fluoropyrimidines as adjuvant therapy for colon cancer in older patients: A subgroup analysis from the TOSCA trial
- Author
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Rosati, Gerardo, primary, Lonardi, Sara, additional, Galli, Fabio, additional, Di Bartolomeo, Maria, additional, Ronzoni, Monica, additional, Zampino, Maria G., additional, Banzi, Maria, additional, Zaniboni, Alberto, additional, Pasini, Felice, additional, Bozzarelli, Silvia, additional, Garattini, Silvio K., additional, Ferrari, Daris, additional, Montesarchio, Vincenzo, additional, Mambrini, Andrea, additional, Ciuffreda, Libero, additional, Galli, Francesca, additional, Pusceddu, Valeria, additional, Carlomagno, Chiara, additional, Bidoli, Paolo, additional, Amoroso, Domenico, additional, Bochicchio, Anna M., additional, Frassineti, Luca, additional, Corsi, Domenico, additional, Bilancia, Domenico, additional, Pastorino, Alessandro, additional, De Stefano, Alfonso, additional, Labianca, Roberto, additional, Bilancia, D., additional, Rosati, G., additional, Montesarchio, V., additional, Iaffaioli, R.V., additional, Nasti, G., additional, Daniele, B., additional, Zagonel, V., additional, Lonardi, S., additional, Pella, N., additional, Aprile, G., additional, Pasini, F., additional, Marchetti, Roma P., additional, Romiti, A., additional, Ciuffreda, L., additional, Ferrari, D., additional, Foa, P., additional, Zaniboni, A., additional, Labianca, R., additional, Mosconi, S., additional, Sobrero, A., additional, Bidoli, P., additional, Cazzaniga, M., additional, Beretta, G.D., additional, Corsi, D.C., additional, Cortesi, E., additional, Barni, S., additional, Petrelli, F., additional, Allione, P., additional, D'Arco, A.M., additional, Valmadre, G., additional, Piazza, E., additional, Veltri, E., additional, Ramus, G. Vietti, additional, Giustini, L., additional, Tumulo, S., additional, Cascinu, S., additional, Granetto, C., additional, Testore, F., additional, Giordano, M., additional, Moroni, M., additional, Di Seri, M., additional, Nuzzo, A., additional, Angelelli, L., additional, Gori, S., additional, Farina, G., additional, Aglietta, M., additional, Franchi, R., additional, Comandé, M., additional, Giordani, P., additional, Tonini, G., additional, Bucci, E., additional, Ballestrero, A., additional, Benasso, M., additional, Graiff, C., additional, Bravi, S., additional, Caffo, O., additional, Silva, R.R., additional, Frontini, L., additional, Rota, S., additional, Cozzi, L., additional, Cantore, M., additional, Maiello, E., additional, Cinieri, S., additional, Silvestris, N., additional, Romito, S., additional, Gebbia, V., additional, Banzi, M., additional, Santoro, A., additional, Artioli, F., additional, Mattioli, R., additional, Contu, A., additional, Di Costanzo, F., additional, Leonardi, F., additional, Cavanna, L., additional, Passalacqua, R., additional, Amoroso, D., additional, Sozzi, P., additional, D'Amico, M., additional, Amadori, D., additional, Frassineti, L., additional, Turci, D., additional, Ravaioli, A., additional, Pasquini, E., additional, Gambi, A., additional, Faedi, M., additional, Cruciani, G., additional, Bajetta, E., additional, Di Bartolomeo, M., additional, Gianni, L., additional, Ronzoni, M., additional, Ionta, M.T., additional, Massidda, B., additional, Scartozzi, M., additional, Zampino, M.G., additional, Bochicchio, A.M., additional, Ciarlo, A., additional, Di Leo, A., additional, Frustaci, S., additional, Rangoni, G., additional, Arizzoia, A., additional, Pavesi, L., additional, Verusio, C., additional, Pinotti, G., additional, Iop, A., additional, De Placido, S., additional, Carlomagno, C., additional, Adamo, V., additional, Ficorella, C., additional, Natale, D., additional, Greco, E., additional, Rulli, E., additional, Galli, F., additional, Poli, D., additional, Porcu, L., additional, and Torri, V., additional
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- 2021
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44. Laparoscopic vs. open mesorectal excision for rectal cancer: Are these approaches still comparable? A systematic review and meta-analysis: Are these approaches still comparable? A systematic review and meta-analysis
- Author
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Conticchio, M. (Maria), Papagni, V. (Vincenzo), Notarnicola, M. (Margherita), Delvecchio, A. (Antonella), Riccelli, U. (Umberto), Ammendola, M. (Michele), Currò, G. (Giuseppe), Pessaux, P. (Patrick), Silvestris, N. (Nicola), and Memeo, R. (Riccardo)
- Subjects
Aucun ,Sciences du Vivant [q-bio]/Médecine humaine et pathologie - Abstract
BACKGROUND: To analyze pathologic and perioperative outcomes of laparoscopic vs. open resections for rectal cancer performed over the last 10 years. METHODS: A systematic literature search of the following databases was conducted: Cochrane Central Register of Controlled Trials, MEDLINE (through PubMed), EMBASE, and Scopus. Only articles published in English from January 1, 2008 to December 31, 2018 (i.e. the last 10 years), which met inclusion criteria were considered. The review only included articles which compared Laparoscopic rectal resection (LRR) and Open Rectal Resection (ORR) for rectal cancer and reported at least one of the outcomes of interest. The analyses followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement checklist. Only prospective randomized studies were considered. The body of evidence emerging from this study was evaluated using the Grading of Recommendations Assessment Development and Evaluation (GRADE) system. Outcome measures (mean and median values, standard deviations, and interquartile ranges) were extracted for each surgical treatment. Pooled estimates of the mean differences were calculated using random effects models to consider potential inter-study heterogeneity and to adopt a more conservative approach. The pooled effect was considered significant if p
- Published
- 2020
45. A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave?
- Author
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Silvestris, N., Apolone, G., Botti, G., Ciliberto, G., Costantini, M., De Paoli, P., Franceschi, S., Opocher, G., Paradiso, A., Pronzato, P., Sgambato, A., and De Maria, R.
- Subjects
0301 basic medicine ,Cancer Research ,Pneumonia, Viral ,Medical Oncology ,lcsh:RC254-282 ,Alliance against Cancer ,Scientific evidence ,Betacoronavirus ,03 medical and health sciences ,Globalization ,Government Agencies ,0302 clinical medicine ,Settore MED/04 - PATOLOGIA GENERALE ,Neoplasms ,Political science ,Pandemic ,medicine ,Humans ,Viral ,Pandemics ,Cancer ,Government ,SARS-CoV-2 ,business.industry ,Social distance ,Research ,Alliance against Cancer, Cancer, COVID-19, Research, Therapy, Betacoronavirus, Coronavirus Infections, Government Agencies, Humans, Italy, Medical Oncology, Neoplasms, Pneumonia, Viral, Pandemics ,COVID-19 ,Pneumonia ,Public relations ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,030104 developmental biology ,Alliance ,Italy ,Oncology ,Multinational corporation ,030220 oncology & carcinogenesis ,Commentary ,Therapy ,Coronavirus Infections ,business - Abstract
If we focus our attention on seven main features of COVID-19 infection (heterogeneity, fragility, lack of effective treatments and vaccines, “miraculous cures”, psychological suffering, deprivation, and globalization), we may establish parallelism with the challenges faced in the steep road to the understanding and treatment of neoplastic diseases. How the similarities between these two conditions can help us cope with the emergency effort represented by the management of cancer patients in the COVID-19 era, today and in the future? In a manner similar to the Cancer Moonshot initiative in the United States, we can hypothesize a multinational moonshot project towards the management of cancer patients during COVID-19 pandemic. In particular, we believe that the main road to elaborate meaningful scientific evidence is represented by the collection of all the data on COVID-19 and cancer comorbidity that are and will become available in cancer centers, coupled with the design of large clinical studies. To address this goal, it is essential to identify the entity that can produce this scientific evidences and the potentially most successful research strategy to undertake. The largest Italian organization for cancer research, Alliance Against Cancer (Alleanza Contro il Cancro, ACC), is called to play a scientific leadership in addressing these challenges, which requires the coordination of oncology teams at regional, national, and international levels. To fulfill this commitment, ACC will create a liaison with health government agencies in order to develop “dynamic” indications able to fight such an unpredictable pandemic.
- Published
- 2020
46. 1664P Italian Association for Medical Oncology (AIOM) guideline application in real-world: Multi-institutional based survey of adjuvant and first-line pancreatic ductal adenocarcinoma treatment in Italy (GARIBALDI) - survival analyses in the metastatic cohort
- Author
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Reni, M., Giommoni, E., Bergamo, F., Cavanna, L., Latiano, T.P., Spada, M., Bernardini, I., Cordio, S.S., Simionato, F., Spallanzani, A., Di Marco, M.C., Silvestris, N., Macchini, M., Orsi, G., Modesti, M., Procaccio, L., Santoni, A., Caldirola, L., Galli, F., and Pinto, C.
- Published
- 2023
- Full Text
- View/download PDF
47. COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial
- Author
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Agrati, C., Di Cosimo, S., Fenoglio, D., Apolone, G., Ciceri, F., Ciliberto, G., Baldanti, F., Costantini, M., Giannarelli, D., Ippolito, G., Locatelli, Franco, Mantovani, A., Morrone, A., Tagliavini, F., Uccelli, A., Zinzani, P. L., Silvestris, N., Rescigno, M., Locatelli F. (ORCID:0000-0002-7976-3654), Agrati, C., Di Cosimo, S., Fenoglio, D., Apolone, G., Ciceri, F., Ciliberto, G., Baldanti, F., Costantini, M., Giannarelli, D., Ippolito, G., Locatelli, Franco, Mantovani, A., Morrone, A., Tagliavini, F., Uccelli, A., Zinzani, P. L., Silvestris, N., Rescigno, M., and Locatelli F. (ORCID:0000-0002-7976-3654)
- Abstract
Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.
- Published
- 2021
48. Immune checkpoint inhibitors in colorectal cancer: Challenges and future prospects
- Author
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Makaremi, S., Asadzadeh, Z., Hemmat, N., Baghbanzadeh, A., Sgambato, Alessandro, Ghorbaninezhad, F., Safarpour, H., Argentiero, A., Brunetti, O., Bernardini, R., Silvestris, N., Baradaran, B., Sgambato A. (ORCID:0000-0002-9487-4563), Makaremi, S., Asadzadeh, Z., Hemmat, N., Baghbanzadeh, A., Sgambato, Alessandro, Ghorbaninezhad, F., Safarpour, H., Argentiero, A., Brunetti, O., Bernardini, R., Silvestris, N., Baradaran, B., and Sgambato A. (ORCID:0000-0002-9487-4563)
- Abstract
Immunotherapy is a new pillar of cancer therapy that provides novel opportunities to treat solid tumors. In this context, the development of new drugs targeting immune checkpoints is considered a promising approach in colorectal cancer (CRC) treatment because it can be induce specific and durable anti-cancer effects. Despite many advances in the immunotherapy of CRC, there are still limitations and obstacles to successful treatment. The immunosuppressive function of the tumor microenvironment (TME) is one of the causes of poor response to treatment in CRC patients. For this reason, checkpoint-blocking antibodies have shown promising outcomes in CRC patients by blocking inhibitory immune checkpoints and enhancing immune responses against tumors. This review summarizes recent advances in immune checkpoint inhibitors (ICIs), such as CTLA-4, PD-1, PD-L1, LAG-3, and TIM-3 in CRC, and it discusses various therapeutic strategies with ICIs, including the double blockade of ICIs, combination therapy of ICIs with other immunotherapies, and conventional treatments. This review also delineates a new hopeful path in the combination of anti-PD-1/anti-PD-L1 with other ICIs such as anti-CTLA-4, anti-LAG-3, and anti-TIM-3 for CRC treatment.
- Published
- 2021
49. Role of liposomal anthracyclines in breast cancer
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Lorusso, V., Manzione, L., and Silvestris, N.
- Published
- 2007
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50. Failure of primary breast cancer neoangiogenesis to predict pattern of distant metastasis
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Paradiso, A., Ranieri, G., Silvestris, N., Naccarato, G., Bevilacqua, G., Mangia, A., Leone, B., Vallejo, C., Simone, G., Schittulli, F., and De Lena, M.
- Published
- 2001
- Full Text
- View/download PDF
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