152 results on '"Silvian, Laura"'
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2. Mechanism of Ubiquitin Ligase Activation of Parkin by a Small Molecule Molecular Glue
3. Insights into Editing from an Ile-tRNA Synthetase Structure with tRNAIle and Mupirocin
4. The Special Sauce—Tom Steitz in the Mid-1990s
5. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model
6. Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure
7. Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
8. Inhibitors of protein–protein interactions: New methodologies to tackle this challenge
9. PINK1/Parkin Pathway Activation for Mitochondrial Quality Control – Which Is the Best Molecular Target for Therapy?
10. Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism
11. Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension
12. Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
13. Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors
14. Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor)
15. Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of nogo-66 receptor
16. Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering
17. Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis
18. Agonist-Induced Transitions of the Acetylcholine Receptor
19. Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity
20. Insights into Editing from an Ile-tRNA Synthetase Structure with tRNAIle and Mupirocin
21. Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens
22. Distance between α-Cys 192 of the Acetylcholine Receptor and Rhodamine-labeled α-Bungarotoxin Complexed to the Receptor
23. Discovery of biaryls as RORγ inverse agonists by using structure-based design
24. Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension
25. Additional file 2: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
26. Additional file 7: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
27. Additional file 1: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
28. Additional file 3: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
29. Additional file 5: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
30. Additional file 6: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
31. Additional file 8: of Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
32. Discovery of biaryl carboxylamides as potent RORγ inverse agonists
33. Structure-based design of low-nanomolar PIM kinase inhibitors
34. Artemin crystal structure reveals insights into heparan sulfate binding
35. How can the structure of germinal-center kinase-like kinase help us in drug discovery?
36. ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis
37. Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension
38. Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
39. Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors
40. Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1
41. Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I)
42. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
43. Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors
44. Structure–activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors
45. Correction to Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism
46. Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism
47. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases
48. Structure of a NEMO/IKK-Associating Domain Reveals Architecture of the Interaction Site
49. Disulfide Structure of the Leucine-Rich Repeat C-Terminal Cap and C-Terminal Stalk Region of Nogo-66 Receptor
50. A Neutralizing Anti-Nogo66 Receptor Monoclonal Antibody Reverses Inhibition of Neurite Outgrowth by Central Nervous System Myelin
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