15 results on '"Simeoni, Camila L"'
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2. Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: an immunological study
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Souza, William M, Amorim, Mariene R, Sesti-Costa, Renata, Coimbra, Lais D, Brunetti, Natalia S, Toledo-Teixeira, Daniel A, de Souza, Gabriela F, Muraro, Stefanie P, Parise, Pierina L, Barbosa, Priscilla P, Bispo-dos-Santos, Karina, Mofatto, Luciana S, Simeoni, Camila L, Claro, Ingra M, Duarte, Adriana S S, Coletti, Thais M, Zangirolami, Audrey B, Costa-Lima, Carolina, Gomes, Arilson B S P, Buscaratti, Lucas I, Sales, Flavia C, Costa, Vitor A, Franco, Lucas A M, Candido, Darlan S, Pybus, Oliver G, de Jesus, Jaqueline G, Silva, Camila A M, Ramundo, Mariana S, Ferreira, Giulia M, Pinho, Mariana C, Souza, Leandro M, Rocha, Esmenia C, Andrade, Pamela S, Crispim, Myuki A E, Maktura, Grazielle C, Manuli, Erika R, Santos, Magnun N N, Camilo, Cecilia C, Angerami, Rodrigo N, Moretti, Maria L, Spilki, Fernando R, Arns, Clarice W, Addas-Carvalho, Marcelo, Benites, Bruno D, Vinolo, Marco A R, Mori, Marcelo A S, Gaburo, Nelson, Dye, Christopher, Marques-Souza, Henrique, Marques, Rafael E, Farias, Alessandro S, Diamond, Michael S, Faria, Nuno R, Sabino, Ester C, Granja, Fabiana, and Proença-Módena, Jose Luiz
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- 2021
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3. Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020
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Amorim, Mariene R., Souza, William M., Barros, Antonio C.G., Jr., Toledo-Teixeira, Daniel A., Bispo-dos-Santos, Karina, Simeoni, Camila L., Parise, Pierina L., Vieira, Aline, Forato, Julia, Claro, Ingra M., Mofatto, Luciana S., Barbosa, Priscila P., Brunetti, Natalia S., Franca, Emerson S.S., Pedroso, Gisele A., Carvalho, Barbara F.N., Zaccariotto, Tania R., Krywacz, Kamila C.S., Vieira, Andre S., Mori, Marcelo A., Farias, Alessandro S., Pavan, Maria H.P., Bachur, Luis Felipe, Cardoso, Luis G.O., Spilki, Fernando R., Sabino, Ester C., Faria, Nuno R., Santos, Magnun N.N., Angerami, Rodrigo, Leme, Patricia A.F., Schreiber, Angelica, Moretti, Maria L., Granja, Fabiana, and Proenca-Modena, Jose Luiz
- Subjects
Diagnosis ,Development and progression ,Case studies ,Risk factors ,Health aspects ,Respiratory tract infections -- Diagnosis -- Development and progression ,Recurrence (Disease) -- Risk factors ,Medical personnel -- Case studies -- Health aspects ,COVID-19 -- Diagnosis -- Development and progression ,Diseases -- Relapse - Abstract
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, in late 2019. As of April 8, 2021, COVID-19 has affected >132 [...]
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- 2021
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4. Electrochemical Paper-Based Nanobiosensor for Rapid and Sensitive Detection of Monkeypox Virus
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de Lima, Lucas F., primary, Barbosa, Priscilla P., additional, Simeoni, Camila L., additional, de Paula, Rosemeire F. de O., additional, Proenca-Modena, José Luiz, additional, and de Araujo, William R., additional
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- 2023
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5. SARS-CoV-2 uses CD4 to infect T helper lymphocytes
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Brunetti, Natalia S, primary, Davanzo, Gustavo G, primary, de Moraes, Diogo, primary, Ferrari, Allan JR, primary, Souza, Gabriela F, primary, Muraro, Stéfanie Primon, primary, Knittel, Thiago L, primary, Boldrini, Vinicius O, primary, Monteiro, Lauar B, primary, Virgílio-da-Silva, João Victor, primary, Profeta, Gerson S, primary, Wassano, Natália S, primary, Nunes Santos, Luana, primary, Carregari, Victor C, primary, Dias, Artur HS, primary, Veras, Flavio P, additional, Tavares, Lucas A, additional, Forato, Julia, additional, Castro, Icaro MS, additional, Silva-Costa, Lícia C, additional, Palma, André C, additional, Mansour, Eli, additional, Ulaf, Raisa G, additional, Bernardes, Ana F, additional, Nunes, Thyago A, additional, Ribeiro, Luciana C, additional, Agrela, Marcus V, additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I, additional, Crunfli, Fernanda, additional, Ludwig, Raissa G, additional, Gerhardt, Jaqueline A, additional, Munhoz-Alves, Natália, additional, Marques, Ana Maria, additional, Sesti-Costa, Renata, additional, Amorim, Mariene R, additional, Toledo-Teixeira, Daniel A, additional, Parise, Pierina Lorencini, additional, Martini, Matheus Cavalheiro, additional, Bispos-dos-Santos, Karina, additional, Simeoni, Camila L, additional, Granja, Fabiana, additional, Silvestrini, Virgínia C, additional, de Oliveira, Eduardo B, additional, Faca, Vitor M, additional, Carvalho, Murilo, additional, Castelucci, Bianca G, additional, Pereira, Alexandre B, additional, Coimbra, Laís D, additional, Dias, Marieli MG, additional, Rodrigues, Patricia B, additional, Gomes, Arilson Bernardo SP, additional, Pereira, Fabricio B, additional, Santos, Leonilda MB, additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C, additional, Whelan, Sean, additional, Sposito, Andrei C, additional, Carvalho, Robson F, additional, Vieira, André S, additional, Vinolo, Marco AR, additional, Damasio, André, additional, Velloso, Licio, additional, Figueira, Ana Carolina M, additional, da Silva, Luis LP, additional, Cunha, Thiago Mattar, additional, Nakaya, Helder I, additional, Marques-Souza, Henrique, additional, Marques, Rafael E, additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S, additional, Proenca-Modena, Jose Luiz, additional, Moraes-Vieira, Pedro MM, additional, Mori, Marcelo A, additional, and Farias, Alessandro S, additional
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- 2023
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6. Author response: SARS-CoV-2 uses CD4 to infect T helper lymphocytes
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Brunetti, Natalia S, primary, Davanzo, Gustavo G, primary, de Moraes, Diogo, primary, Ferrari, Allan JR, primary, Souza, Gabriela F, primary, Muraro, Stéfanie Primon, primary, Knittel, Thiago L, primary, Boldrini, Vinicius O, primary, Monteiro, Lauar B, primary, Virgílio-da-Silva, João Victor, primary, Profeta, Gerson S, primary, Wassano, Natália S, primary, Nunes Santos, Luana, primary, Carregari, Victor C, primary, Dias, Artur HS, primary, Veras, Flavio P, additional, Tavares, Lucas A, additional, Forato, Julia, additional, Castro, Icaro MS, additional, Silva-Costa, Lícia C, additional, Palma, André C, additional, Mansour, Eli, additional, Ulaf, Raisa G, additional, Bernardes, Ana F, additional, Nunes, Thyago A, additional, Ribeiro, Luciana C, additional, Agrela, Marcus V, additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I, additional, Crunfli, Fernanda, additional, Ludwig, Raissa G, additional, Gerhardt, Jaqueline A, additional, Munhoz-Alves, Natália, additional, Marques, Ana Maria, additional, Sesti-Costa, Renata, additional, Amorim, Mariene R, additional, Toledo-Teixeira, Daniel A, additional, Parise, Pierina Lorencini, additional, Martini, Matheus Cavalheiro, additional, Bispos-dos-Santos, Karina, additional, Simeoni, Camila L, additional, Granja, Fabiana, additional, Silvestrini, Virgínia C, additional, de Oliveira, Eduardo B, additional, Faca, Vitor M, additional, Carvalho, Murilo, additional, Castelucci, Bianca G, additional, Pereira, Alexandre B, additional, Coimbra, Laís D, additional, Dias, Marieli MG, additional, Rodrigues, Patricia B, additional, Gomes, Arilson Bernardo SP, additional, Pereira, Fabricio B, additional, Santos, Leonilda MB, additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C, additional, Whelan, Sean, additional, Sposito, Andrei C, additional, Carvalho, Robson F, additional, Vieira, André S, additional, Vinolo, Marco AR, additional, Damasio, André, additional, Velloso, Licio, additional, Figueira, Ana Carolina M, additional, da Silva, Luis LP, additional, Cunha, Thiago Mattar, additional, Nakaya, Helder I, additional, Marques-Souza, Henrique, additional, Marques, Rafael E, additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S, additional, Proenca-Modena, Jose Luiz, additional, Moraes-Vieira, Pedro MM, additional, Mori, Marcelo A, additional, and Farias, Alessandro S, additional
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- 2023
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7. SARS-CoV-2 uses CD4 to infect T helper lymphocytes
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Brunetti, Natalia S, Davanzo, Gustavo G, de Moraes, Diogo, Ferrari, Allan JR, Souza, Gabriela F, Muraro, Stéfanie Primon, Knittel, Thiago L, Boldrini, Vinicius O, Monteiro, Lauar B, Virgílio-da-Silva, João Victor, Profeta, Gerson S, Wassano, Natália S, Nunes Santos, Luana, Carregari, Victor C, Dias, Artur HS, Veras, Flavio P, Tavares, Lucas A, Forato, Julia, Castro, Icaro MS, Silva-Costa, Lícia C, Palma, André C, Mansour, Eli, Ulaf, Raisa G, Bernardes, Ana F, Nunes, Thyago A, Ribeiro, Luciana C, Agrela, Marcus V, Moretti, Maria Luiza, Buscaratti, Lucas I, Crunfli, Fernanda, Ludwig, Raissa G, Gerhardt, Jaqueline A, Munhoz-Alves, Natália, Marques, Ana Maria, Sesti-Costa, Renata, Amorim, Mariene R, Toledo-Teixeira, Daniel A, Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Bispos-dos-Santos, Karina, Simeoni, Camila L, Granja, Fabiana, Silvestrini, Virgínia C, de Oliveira, Eduardo B, Faca, Vitor M, Carvalho, Murilo, Castelucci, Bianca G, Pereira, Alexandre B, Coimbra, Laís D, Dias, Marieli MG, Rodrigues, Patricia B, Gomes, Arilson Bernardo SP, Pereira, Fabricio B, Santos, Leonilda MB, Bloyet, Louis-Marie, Stumpf, Spencer, Pontelli, Marjorie C, Whelan, Sean, Sposito, Andrei C, Carvalho, Robson F, Vieira, André S, Vinolo, Marco AR, Damasio, André, Velloso, Licio, Figueira, Ana Carolina M, da Silva, Luis LP, Cunha, Thiago Mattar, Nakaya, Helder I, Marques-Souza, Henrique, Marques, Rafael E, Martins-de-Souza, Daniel, Skaf, Munir S, Proenca-Modena, Jose Luiz, Moraes-Vieira, Pedro MM, Mori, Marcelo A, Farias, Alessandro S, Brunetti, Natalia S, Davanzo, Gustavo G, de Moraes, Diogo, Ferrari, Allan JR, Souza, Gabriela F, Muraro, Stéfanie Primon, Knittel, Thiago L, Boldrini, Vinicius O, Monteiro, Lauar B, Virgílio-da-Silva, João Victor, Profeta, Gerson S, Wassano, Natália S, Nunes Santos, Luana, Carregari, Victor C, Dias, Artur HS, Veras, Flavio P, Tavares, Lucas A, Forato, Julia, Castro, Icaro MS, Silva-Costa, Lícia C, Palma, André C, Mansour, Eli, Ulaf, Raisa G, Bernardes, Ana F, Nunes, Thyago A, Ribeiro, Luciana C, Agrela, Marcus V, Moretti, Maria Luiza, Buscaratti, Lucas I, Crunfli, Fernanda, Ludwig, Raissa G, Gerhardt, Jaqueline A, Munhoz-Alves, Natália, Marques, Ana Maria, Sesti-Costa, Renata, Amorim, Mariene R, Toledo-Teixeira, Daniel A, Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Bispos-dos-Santos, Karina, Simeoni, Camila L, Granja, Fabiana, Silvestrini, Virgínia C, de Oliveira, Eduardo B, Faca, Vitor M, Carvalho, Murilo, Castelucci, Bianca G, Pereira, Alexandre B, Coimbra, Laís D, Dias, Marieli MG, Rodrigues, Patricia B, Gomes, Arilson Bernardo SP, Pereira, Fabricio B, Santos, Leonilda MB, Bloyet, Louis-Marie, Stumpf, Spencer, Pontelli, Marjorie C, Whelan, Sean, Sposito, Andrei C, Carvalho, Robson F, Vieira, André S, Vinolo, Marco AR, Damasio, André, Velloso, Licio, Figueira, Ana Carolina M, da Silva, Luis LP, Cunha, Thiago Mattar, Nakaya, Helder I, Marques-Souza, Henrique, Marques, Rafael E, Martins-de-Souza, Daniel, Skaf, Munir S, Proenca-Modena, Jose Luiz, Moraes-Vieira, Pedro MM, Mori, Marcelo A, and Farias, Alessandro S
- Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4+ T helper cells, but not CD8+ T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS-CoV-2 in T helper cells. This leads to impaired CD4 T cell function and may cause cell death. SARS-CoV-2-infected T helper cells express higher levels of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may contribute to a poor immune response in COVID-19 patients.
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- 2023
8. Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds
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Borin, Alexandre, primary, Coimbra, Laís D., additional, Bispo-dos-Santos, Karina, additional, Naciuk, Fabrício F., additional, Fontoura, Marina, additional, Simeoni, Camila L., additional, Gomes, Giovanni F., additional, Amorim, Mariene R., additional, Gravina, Humberto D., additional, Shimizu, Jacqueline Farinha, additional, Passos, Amanda S. C., additional, de Oliveira, Isadora M., additional, de Carvalho, Ana Carolina, additional, Cardoso, Alisson Campos, additional, Parise, Pierina L., additional, Toledo-Teixeira, Daniel A., additional, Sotorilli, Giuliana E., additional, Persinoti, Gabriela F., additional, Claro, Ingra Morales, additional, Sabino, Ester C., additional, Alborghetti, Marcos R., additional, Rocco, Silvana A., additional, Franchini, Kleber G., additional, de Souza, William M., additional, Oliveira, Paulo S. L., additional, Cunha, Thiago M., additional, Granja, Fabiana, additional, Proença-Módena, José Luiz, additional, Trivella, Daniela B.B., additional, Bruder, Marjorie, additional, Cordeiro, Artur T., additional, and Marques, Rafael Elias, additional
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- 2022
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9. Identification of SARS-CoV-2 on the ocular surface in a cohort of COVID-19 patients from Brazil
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Gasparini, Matheus S, primary, dos Santos, Leandro M, additional, Hamade, Ahmad MA, additional, Gross, Luísa G, additional, Favarato, Arthur P, additional, de Vasconcellos, José PC, additional, de Melo, Mônica B, additional, Parise, Pierina L, additional, Simeoni, Camila L, additional, Silva, Natália B, additional, da Silva Mori, Marcelo A, additional, Vieira, André S, additional, dos Santos Farias, Alessandro, additional, Granja, Fabiana, additional, Schreiber, Angelica Z, additional, Moretti, Maria L, additional, Proença-Modena, José L, additional, and Alves, Mônica, additional
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- 2021
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10. Evolution and epidemic spread of SARS-CoV-2 in Brazil
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Candido, Darlan S, Claro, Ingra M, de Jesus, Jaqueline G, Souza, William M, Moreira, Filipe RR, Dellicour, Simon, Mellan, Thomas A, du Plessis, Louis, Pereira, Rafael HM, Sales, Flavia CS, Manuli, Erika R, Thézé, Julien, Almeida, Luiz, Menezes, Mariane T, Voloch, Carolina M, Fumagalli, Marcilio J, Coletti, Thaís M, da Silva, Camila AM, Ramundo, Mariana S, Amorim, Mariene R, Hoeltgebaum, Henrique H, Mishra, Swapnil, Gill, Mandev S, Carvalho, Luiz M, Buss, Lewis F, Prete, Carlos A, Ashworth, Jordan, Nakaya, Helder I, Peixoto, Pedro S, Brady, Oliver J, Nicholls, Samuel M, Tanuri, Amilcar, Rossi, Átila D, Braga, Carlos KV, Gerber, Alexandra L, de C Guimarães, Ana Paula, Gaburo, Nelson, Alencar, Cecila Salete, Ferreira, Alessandro CS, Lima, Cristiano X, Levi, José Eduardo, Granato, Celso, Ferreira, Giulia M, Francisco, Ronaldo S, Granja, Fabiana, Garcia, Marcia T, Moretti, Maria Luiza, Perroud, Mauricio W, Castiñeiras, Terezinha MPP, Lazari, Carolina S, Hill, Sarah C, de Souza Santos, Andreza Aruska, Simeoni, Camila L, Forato, Julia, Sposito, Andrei C, Schreiber, Angelica Z, Santos, Magnun NN, de Sá, Camila Zolini, Souza, Renan P, Resende-Moreira, Luciana C, Teixeira, Mauro M, Hubner, Josy, Leme, Patricia AF, Moreira, Rennan G, Nogueira, Maurício L, Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics an, Ferguson, Neil M, Costa, Silvia F, Proenca-Modena, José Luiz, Vasconcelos, Ana Tereza R, Bhatt, Samir, Lemey, Philippe, Wu, Chieh-Hsi, Rambaut, Andrew, Loman, Nick J, Aguiar, Renato S, Pybus, Oliver G, Sabino, Ester C, and Faria, Nuno Rodrigues
- Abstract
Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February and 11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average traveled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil and provides evidence that current interventions remain insufficient to keep virus transmission under control in this country.
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- 2020
11. Levels of SARS-CoV-2 Lineage P.1 Neutralization by Antibodies Elicited after Natural Infection and Vaccination
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de Souza, William M., primary, Amorim, Mariene R., additional, Sesti-Costa, Renata, additional, Coimbra, Lais D., additional, Toledo-Teixeira, Daniel Augusto de, additional, Parise, Pierina L., additional, Barbosa, Priscilla P., additional, Bispo-dos-Santos, Karina, additional, Mofatto, Luciana S., additional, Simeoni, Camila L., additional, Brunetti, Natalia S., additional, Claro, Ingra M., additional, Duarte, Adriana S. S., additional, Coletti, Thais M., additional, Zangirolami, Audrey B., additional, Costa-Lima, Carolina, additional, Gomes, Arilson Bernardo S. P., additional, Buscaratti, Lucas I., additional, Sales, Flavia C., additional, Costa, Vitor A., additional, Franco, Lucas A.M., additional, Candido, Darlan S., additional, Pybus, Oliver G., additional, de Jesus, Jaqueline G., additional, Silva, Camila A. M., additional, Ramundo, Mariana S., additional, Ferreira, Giulia M., additional, Pinho, Mariana C., additional, Souza, Leandro M., additional, Rocha, Esmenia C., additional, Andrade, Pamela S., additional, Crispim, Myuki A.E., additional, Maktura, Grazielle C., additional, Manuli, Erika R., additional, Santos, Magnun N.N., additional, Camilo, Cecilia C., additional, Angerami, Rodrigo N., additional, Moretti, Maria L., additional, Spilki, Fernando R., additional, Arns, Clarice W., additional, Addas-Carvalho, Marcelo, additional, Benites, Bruno D., additional, Mori, Marcelo A., additional, Gaburo, Nelson, additional, Dye, Christopher, additional, Wu, Chieh-Hsi, additional, Marques-Souza, Henrique, additional, Marques, Rafael E., additional, Farias, Alessandro, additional, Diamond, Michael S., additional, Faria, Nuno R., additional, Sabino, Ester C., additional, Granja, Fabiana, additional, and Proenca-Modena, Jose Luiz, additional
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- 2021
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12. SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes
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Brunetti, Natália S., primary, Davanzo, Gustavo G., additional, de Moraes, Diogo, additional, Ferrari, Allan J. R., additional, de Souza, Gabriela F., additional, Muraro, Stefanie P., additional, Knittel, Thiago L., additional, Boldrini, Vinícius O., additional, Monteiro, Lauar B., additional, Virgilio-da-Silva, João Victor, additional, Profeta, Gerson S., additional, Wassano, Natália S., additional, Santos, Luana N., additional, Carregari, Victor C., additional, Dias, Artur H. S., additional, Veras, Flavio P., additional, Tavares, Lucas A., additional, Forato, Julia, additional, Castro, Ícaro, additional, Silva-Costa, Lícia C., additional, Palma, Andre, additional, Mansour, Eli, additional, Ulaf, Raisa G., additional, Bernardes, Ana F., additional, Nunes, Thyago A., additional, Ribeiro, Luciana C., additional, Agrela, Marcus V., additional, Moretti, Maria Luiza, additional, Buscaratti, Lucas I., additional, Crunfli, Fernanda, additional, Ludwig, Raissa G., additional, Gerhardt, Jaqueline A., additional, Munhoz-Alves, Natália, additional, Marques, Ana M., additional, Sesti-Costa, Renata, additional, Amorim, Mariene R., additional, Texeira, Daniel A. T., additional, Parise, Pierina L., additional, Martini, Matheus C., additional, Bispo-dos-Santos, Karina, additional, Simeoni, Camila L., additional, Granja, Fabiana, additional, Silvestrini, Virginia C., additional, de Oliveira, Eduardo B., additional, Faça, Vitor M., additional, Carvalho, Murilo, additional, Castelucci, Bianca G., additional, Pereira, Alexandre B., additional, Coimbra, Laís D., additional, Dias, Marieli M. G., additional, Rodrigues, Patricia B., additional, S. P. Gomes, Arilson Bernardo, additional, Pereira, Fabricio B., additional, Santos, Leonilda M. B., additional, Bloyet, Louis-Marie, additional, Stumpf, Spencer, additional, Pontelli, Marjorie C., additional, Whelan, Sean P. J., additional, Sposito, Andrei C., additional, Carvalho, Robson F., additional, Vieira, Andre S., additional, Vinolo, Marco A. R., additional, Damasio, André, additional, Velloso, Licio A., additional, M. Figueira, Ana Carolina, additional, da Silva, Luis L. P., additional, Cunha, Thiago M., additional, Nakaya, Helder I., additional, Marques-Souza, Henrique, additional, Marques, Rafael E., additional, Martins-de-Souza, Daniel, additional, Skaf, Munir S., additional, Proença-Modena, José Luiz, additional, Moraes-Vieira, Pedro M., additional, Mori, Marcelo A., additional, and Farias, Alessandro S., additional
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- 2020
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13. Epidemiology of capybara-associated Brazilian spotted fever
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Luz, Hermes R., primary, Costa, Francisco B., additional, Benatti, Hector R., additional, Ramos, Vanessa N., additional, de A. Serpa, Maria Carolina, additional, Martins, Thiago F., additional, Acosta, Igor C. L., additional, Ramirez, Diego G., additional, Muñoz-Leal, Sebastián, additional, Ramirez-Hernandez, Alejandro, additional, Binder, Lina C., additional, Carvalho, Marcio Port, additional, Rocha, Vlamir, additional, Dias, Thiago C., additional, Simeoni, Camila L., additional, Brites-Neto, José, additional, Brasil, Jardel, additional, Nievas, Ana Maria, additional, Monticelli, Patricia Ferreira, additional, Moro, Maria Estela G., additional, Lopes, Beatriz, additional, Aguiar, Daniel M., additional, Pacheco, Richard C., additional, Souza, Celso Eduardo, additional, Piovezan, Ubiratan, additional, Juliano, Raquel, additional, Ferraz, Katia Maria P. M. B., additional, Szabó, Matias P. J., additional, and Labruna, Marcelo B., additional
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- 2019
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14. Reemergence of Oropouche virus between 2023 and 2024 in Brazil.
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Scachetti GC, Forato J, Claro IM, Hua X, Salgado BB, Vieira A, Simeoni CL, Barbosa ARC, Rosa IL, de Souza GF, Fernandes LCN, de Sena ACH, Oliveira SC, Singh CML, de Lima ST, de Jesus R, Costa MA, Kato RB, Rocha JF, Santos LC, Rodrigues JT, Cunha MP, Sabino EC, Faria NR, Weaver SC, Romano CM, Lalwani P, Proença-Módena JL, and de Souza WM
- Abstract
Background: Oropouche virus (OROV; species Orthobunyavirus oropoucheense ) is an arthropod-borne virus that has caused outbreaks of Oropouche fever in Central and South America since the 1950s. This study investigates virological factors contributing to the reemergence of Oropouche fever in Brazil between 2023 and 2024., Methods: In this study, we combined OROV genomic, molecular, and serological data from Brazil from 1 January 2015 to 29 June 2024, along with in vitro and in vivo characterization. Molecular screening data included 93 patients with febrile illness between January 2023 and February 2024 from the Amazonas State. Genomic data comprised two genomic OROV sequences from patients. Serological data were obtained from neutralizing antibody tests comparing the prototype OROV strain BeAn 19991 and the 2024 epidemic strain. Epidemiological data included aggregated cases reported to the Brazilian Ministry of Health from 1 January 2014 to 29 June 2024., Findings: In 2024, autochthonous OROV infections were detected in previously non-endemic areas across all five Brazilian regions. Cases were reported in 19 of 27 federal units, with 83.2% (6,895 of 8,284) of infections in Northern Brazil and a nearly 200-fold increase in incidence compared to reported cases over the last decade. We detected OROV RNA in 10.8% (10 of 93) of patients with febrile illness between December 2023 and May 2024 in Amazonas. We demonstrate that the 2023-2024 epidemic was caused by a novel OROV reassortant that replicated approximately 100-fold higher titers in mammalian cells compared to the prototype strain. The 2023-2024 OROV reassortant displayed plaques earlier than the prototype, produced 1.7 times more plaques, and plaque sizes were 2.5 larger compared to the prototype. Furthermore, serum collected in 2016 from previously OROV-infected individuals showed at least a 32-fold reduction in neutralizing capacity against the reassortment strain compared to the prototype., Interpretation: These findings provide a comprehensive assessment of Oropouche fever in Brazil and contribute to a better understanding of the 2023-2024 OROV reemergence. The recent increased incidence may be related to a higher replication efficiency of a new reassortant virus that also evades previous immunity., Competing Interests: Declaration of interests The authors declare no competing interests.
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- 2024
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15. Evolution and epidemic spread of SARS-CoV-2 in Brazil.
- Author
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Candido DS, Claro IM, de Jesus JG, Souza WM, Moreira FRR, Dellicour S, Mellan TA, du Plessis L, Pereira RHM, Sales FCS, Manuli ER, Thézé J, Almeida L, Menezes MT, Voloch CM, Fumagalli MJ, Coletti TM, da Silva CAM, Ramundo MS, Amorim MR, Hoeltgebaum HH, Mishra S, Gill MS, Carvalho LM, Buss LF, Prete CA Jr, Ashworth J, Nakaya HI, Peixoto PS, Brady OJ, Nicholls SM, Tanuri A, Rossi ÁD, Braga CKV, Gerber AL, de C Guimarães AP, Gaburo N Jr, Alencar CS, Ferreira ACS, Lima CX, Levi JE, Granato C, Ferreira GM, Francisco RS Jr, Granja F, Garcia MT, Moretti ML, Perroud MW Jr, Castiñeiras TMPP, Lazari CS, Hill SC, de Souza Santos AA, Simeoni CL, Forato J, Sposito AC, Schreiber AZ, Santos MNN, de Sá CZ, Souza RP, Resende-Moreira LC, Teixeira MM, Hubner J, Leme PAF, Moreira RG, Nogueira ML, Ferguson NM, Costa SF, Proenca-Modena JL, Vasconcelos ATR, Bhatt S, Lemey P, Wu CH, Rambaut A, Loman NJ, Aguiar RS, Pybus OG, Sabino EC, and Faria NR
- Subjects
- Basic Reproduction Number, Bayes Theorem, Betacoronavirus classification, Brazil epidemiology, COVID-19, COVID-19 Testing, Cities epidemiology, Clinical Laboratory Techniques, Coronavirus Infections diagnosis, Coronavirus Infections prevention & control, Coronavirus Infections virology, Europe, Evolution, Molecular, Genome, Viral, Humans, Models, Genetic, Models, Statistical, Pandemics prevention & control, Phylogeny, Phylogeography, Pneumonia, Viral prevention & control, Pneumonia, Viral virology, SARS-CoV-2, Spatio-Temporal Analysis, Travel, Urban Population, Betacoronavirus genetics, Coronavirus Infections epidemiology, Coronavirus Infections transmission, Pneumonia, Viral epidemiology, Pneumonia, Viral transmission
- Abstract
Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February and 11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average traveled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil and provides evidence that current interventions remain insufficient to keep virus transmission under control in this country., (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Published
- 2020
- Full Text
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