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Nachdem bereits der Fall „Rechtsreferendar III. Weg“ für Diskussionen um Zugangsvoraussetzungen zum juristischen Vorbereitungsdienst gesorgt hat, tritt mit dem kürzlich ergangenen Beschluss des OVG Berlin-Brandenburg eine weitere gerichtliche Entscheidung mit eigenen Argumentationsansätzen auf den Plan. Das Gericht hatte sich mit der relevanten Frage zu beschäftigen, ob einem Kandidaten die Aufnahme in den juristischen Vorbereitungsdienst verwehrt werden kann, wenn er die Verfassungsordnung aktiv bekämpft, ohne sich dabei strafbar zu machen. Der Beschluss offenbart erneut die unklare und uneinheitliche Rechtsprechungslinie.

Abstract Background Dermatology teaching is fundamental for the promotion of young colleagues in our specialty. However, traditional teaching methods are being scrutinized by students of the ‘Generation Y and Z’, which can pose new challenges for teaching institutions. We therefore aimed to assess the motivational impact and reception of a newly created four-week curriculum containing modernized teaching methods integrated into clinical routine. Methods In this single-center study, 67 medical students completed this curriculum composed of weekly learning objectives including knowledge of morphological terms, 10 common dermatoses, communication and presentation skills. The participants provided information on their level of interest in dermatology each week as well as positive and negative aspects of the curriculum. Results During the curriculum a significant median increase in interest in dermatology was reported with no differences between the genders. Low initial interest could be improved, high initial interest maintained. Participants with an interest in scientific work (20.9%) were more motivated during the curriculum. The variety, quality of teaching and structure were the main aspects rated positively. Suggestions for improvement included the need for more teaching by senior doctors, transfer of responsibility, and a working environment updated to the latest technology standards. Conclusion The presented curriculum was well received by the participants and allowed to better define learning preferences of new generations which can be helpful to modernize traditional teaching methods. Interest in scientific work could be a factor to identify students with a particularly strong interest in dermatology.

(1) Objective: This study aims to lay a foundation for noncontact intensive care monitoring of premature babies. (2) Methods: Arterial oxygen saturation and heart rate were measured using a monochrome camera and time-division multiplex controlled lighting at three different wavelengths (660 nm, 810 nm and 940 nm) on a piglet model. (3) Results: Using this camera system and our newly designed algorithm for further analysis, the detection of a heartbeat and the calculation of oxygen saturation were evaluated. In motionless individuals, heartbeat and respiration were separated clearly during light breathing and with only minor intervention. In this case, the mean difference between noncontact and contact saturation measurements was 0.7% (RMSE = 3.8%, MAE = 2.93%). (4) Conclusions: The new sensor was proven effective under ideal animal experimental conditions. The results allow a systematic improvement for the further development of contactless vital sign monitoring systems. The results presented here are a major step towards the development of an incubator with noncontact sensor systems for use in the neonatal intensive care unit.

We confirm TOI-4201 b as a transiting Jovian-mass planet orbiting an early M dwarf discovered by the Transiting Exoplanet Survey Satellite. Using ground-based photometry and precise radial velocities from NEID and the Planet Finder Spectrograph, we measure a planet mass of ${2.59}_{-0.06}^{+0.07}$ M _J , making this one of the most massive planets transiting an M dwarf. The planet is ∼0.4% of the mass of its 0.63 M _⊙ host and may have a heavy-element mass comparable to the total dust mass contained in a typical class II disk. TOI-4201 b stretches our understanding of core accretion during the protoplanetary phase and the disk mass budget, necessitating giant planet formation to take place either much earlier in the disk lifetime or perhaps through alternative mechanisms like gravitational instability.

Molecular analysis of atmospheric microparticles in West Antarctica reveals chlorine-enriched aerosols are abundant in sea salt generated by photolytic products, while ice core records suggest increasing chlorine depletion since the onset of stratospheric ozone reduction.

BackgroundTeledermatology is currently finding its place in modern health care worldwide as a rapidly evolving field. ObjectiveThe aim of this study was to investigate the acceptance of teledermatology compared to in-person consultation from the perspective of patients and professionals. MethodsThis multicenter, cross-sectional pilot study was performed at secondary and tertiary referral centers of dermatology in Switzerland from August 2019 to January 2020. A customized questionnaire addressing demographics and educational data, experience with telemedicine, and presumed willingness to replace in-patient consultations with teledermatology was completed by dermatological patients, dermatologists, and health care workers in dermatology. ResultsAmong a total of 664 participants, the ones with previous telemedicine experience (171/664, 25.8%) indicated a high level of overall experience with it (patients: 73/106, 68.9%, dermatologists: 6/8, 75.0%, and health care workers: 27/34, 79.4%). Patients, dermatologists, and health care workers were most likely willing to replace in-person consultations with teledermatology for minor health issues (353/512, 68.9%; 37/45, 82.2%; and 89/107, 83.2%, respectively). We observed a higher preference for telemedicine among individuals who have already used telemedicine (patients: P

Updated formation and structure models of Jupiter predict a metal-poor envelope. This is at odds with the two to three times solar metallicity measured by the Galileo probe. Additionally, Juno data imply that water and ammonia are enriched. Here, we explore whether Jupiter could have a deep radiative layer separating the atmosphere from the deeper interior. The radiative layer could be caused by a hydrogen-transparency window or depletion of alkali metals. We show that heavy-element accretion during Jupiter’s evolution could lead to the desired atmospheric enrichment and that this configuration would be stable over billions of years. The origin of the heavy elements could be cumulative small impacts or one large impact. The preferred scenario requires a deep radiative zone, due to a local reduction of the opacity at ∼2000 K by ∼90%, which is supported by Juno data, and vertical mixing through the boundary with an efficiency similar to that of molecular diffusion ( D ≲ 10 ^−2 cm ^2 s ^−1 ). Therefore, most of Jupiter’s molecular envelope could have solar composition while its uppermost atmosphere is enriched with heavier elements. The enrichment likely originates from the accretion of solid objects. This possibility resolves the long-standing mismatch between Jupiter’s interior models and atmospheric composition measurements. Furthermore, our results imply that the measured atmospheric composition of exoplanets does not necessarily reflect their bulk compositions. We also investigate whether the enrichment could be due to the erosion of a dilute core and show that this is highly unlikely. The core-erosion scenario is inconsistent with evolution calculations, the deep radiative layer, and published interior models.

Recent discoveries of transiting giant exoplanets around M-dwarf stars (GEMS), aided by the all-sky coverage of TESS, are starting to stretch theories of planet formation through the core-accretion scenario. Recent upper limits on their occurrence suggest that they decrease with lower stellar masses, with fewer GEMS around lower-mass stars compared to solar-type. In this paper, we discuss existing GEMS both through confirmed planets, as well as protoplanetary disk observations, and a combination of tests to reconcile these with theoretical predictions. We then introduce the Searching for GEMS survey, where we utilize multidimensional nonparameteric statistics to simulate hypothetical survey scenarios to predict the required sample size of transiting GEMS with mass measurements to robustly compare their bulk-density with canonical hot Jupiters orbiting FGK stars. Our Monte Carlo simulations predict that a robust comparison requires about 40 transiting GEMS (compared to the existing sample of ∼15) with 5 σ mass measurements. Furthermore, we discuss the limitations of existing occurrence estimates for GEMS and provide a brief description of our planned systematic search to improve the occurrence rate estimates for GEMS.

The increased relevance of large-volume metrology (LVM) in industrial applications entails certain challenges: measurements must be cost-efficient and the technologies must be easy to use while ensuring accuracy and reliability. Portable photogrammetry shows great potential to overcome such challenges, but industrial users do not yet rely on its accuracy for large scenarios (3 to 64 m), especially when mass-market cameras are not conceived of as industrial metrology instruments. Furthermore, the measurement results might also depend on the operator’s skills and knowledge of the key process variables. In this work, a methodology was designed so that the measurement uncertainty of portable photogrammetry can be evaluated under controlled conditions for LVM. To do so, PTB’s reference wall, which was designed to assess laser-based methods applied to large volumes, was used as a reference artefact to study the measurement performance under different conditions, enabling an analysis of the relative influence of two process variables: the spatial arrangement of the optical instruments on the scene, and the relative camera poses for an accurate triangulation. According to these variables, different measuring conditions were designed (Monte Carlo analysis), and experimentally evaluated and reported (LME, length measuring errors), analysing the performance figures expected from both unskilled and expert users.

The characterisation of giant exoplanets is crucial to constrain giant planet formation and evolution theory and for putting the solar-system’s giant planets in perspective. Typically, mass-radius (M-R) measurements of moderately irradiated warm Jupiters are used to estimate the planetary bulk composition, which is an essential quantity for constraining giant planet formation, evolution and structure models. The successful launch of the James Webb Space Telescope (JWST) and the upcoming ARIEL mission open a new era in giant exoplanet characterisation as atmospheric measurements provide key information on the composition and internal structure of giant exoplanets. In this review, we discuss how giant planet evolution models are used to infer the planetary bulk composition, and the connection between the compositions of the interior and atmosphere. We identify the important theoretical uncertainties in evolution models including the equations of state, atmospheric models, chemical composition, interior structure and main energy transport processes. Nevertheless, we show that atmospheric measurements by JWST and ARIEL and the accurate determination of stellar ages by PLATO can significantly reduce the degeneracy in the inferred bulk composition. Furthermore, we discuss the importance of evolution models for the characterisation of direct-imaged planets. We conclude that giant planet theory has a critical role in the interpretation of observation and emphasise the importance of advancing giant planet theory.

RNA binding protein HDLBP (or Vigilin) localizes in the endoplasmic reticulum (ER) membrane. Here the authors show that HDLBP contributes to translation of ER-targeted mRNAs.

Abstract We aimed to analyze the number and type of contacts involving the risk of respiratory disease transmission during football match play. We analysed 50 matches from different playing levels. Two reviewers evaluated the contacts of all players in each match. We focused on between-player contacts, crowding, actions with potentially increased aerosol and droplet production and within-player hand-to-head contacts. We categorized the duels with direct contact into frontal and other ones and measured contact duration. The number of between-player contacts were similar between playing levels (median 28.3 [IQR 22.6, 33] contacts per player-hour). Frontal contacts summed up to 8% of all contacts. Contacts involving the head occurred less than once per player and match with none lasting longer than 3 s. Crowding included between two and six players and the duration was mostly less than 10 s. Aerosol and droplet producing activities were three to four times more frequent in adult compared to youth players. Our results suggest that the risk of respiratory pathogen transmission is low during football matches. This conclusion is based on the finding that most close contact situations are of short duration and on the fact that it is an outdoor sport.

Accurate 3D representations of lithium-ion battery electrodes can help in understanding and ultimately improving battery performance. Here, the authors report a methodology for using deep-learning tools to reliably distinguish the different electrode material phases where standard approaches fail.

Antihydrogen atoms are a unique type of antimatter that can be used to probe small violations of fundamental laws of physics. The authors present experimental results obtained with the AEgIS project at CERN for the production of antihydrogen atoms (Hbar) via charge exchange with laser excited positronium that allow for precise timing of Hbar production.

PURPOSE: As recommended by the WHO and many national healthcare authorities, health care institutions of most industrialised countries have employed a critical incident reporting system (CIRS). However, little is known about differences in critical incidents across clinical specialties, the use of CIRSs amongst different professional groups, the types, severity and risk of reoccurrence of critical incidents, their contributing factors and the preventive actions taken in response. METHODS: In this retrospective, descriptive study we critically reviewed all reports filed in the CIRS of our institution between 2013 and 2019 and analysed characteristics over time. RESULTS: Of the 5493 analysed incidents, the main types were related to medications (32.8%), clinical procedures (32.6%) or behaviour of employees (23.3%). Only 21.6% of reports were made by physicians, 51.3% were rated at least “high risk”. Major contributing factors were personal factors (44.0%), lack of training and knowledge (43.7%) and communication errors (36.1%). Most actions taken to prevent similar events aimed at improving communications (23.6%); in 46.3% no actions whatsoever were taken. Longitudinal analysis revealed that reporting increased in internal medicine and obstetrics but collapsed in laboratory medicine / microbiology. Steady increases in medication-type incidents as well as lack of training and knowledge as contributing factors were observed. CONCLUSION: This study revealed that the efferent loop (feedback, preventive actions taken) was the weakest part of the CIRS in our institution, indicating that no learning may have resulted from a large number of reports. In particular, the actions taken appeared to not adequately address the major contributing factors. This highlights that special attention must be paid to the efferent loop of a CIRS to fulfil the purpose of such a reporting system and ultimately to improve patient safety.

Abstract A priori calculation of thermophysical properties and predictive thermodynamic models can be very helpful for developing new industrial processes. Group contribution methods link the target property to contributions based on chemical groups or other molecular subunits of a given molecule. However, the fragmentation of the molecule into its subunits is usually done manually impeding the fast testing and development of new group contribution methods based on large databases of molecules. The aim of this work is to develop strategies to overcome the challenges that arise when attempting to fragment molecules automatically while keeping the definition of the groups as simple as possible. Furthermore, these strategies are implemented in two fragmentation algorithms. The first algorithm finds only one solution while the second algorithm finds all possible fragmentations. Both algorithms are tested to fragment a database of 20,000+ molecules for use with the group contribution model Universal Quasichemical Functional Group Activity Coefficients (UNIFAC). Comparison of the results with a reference database shows that both algorithms are capable of successfully fragmenting all the molecules automatically. Furthermore, when applying them on a larger database it is shown, that the newly developed algorithms are capable of fragmenting structures previously thought not possible to fragment.

Multidomain RNA-binding proteins recognize specific target sequences through mechanisms that are not well understood. Here the authors present an integrated approach to define the RNA-binding specificity and RNP topology and apply it to the analysis of the prototypical multidomain RNA-binding protein IMP3.

This study focuses on seafloor methane seep sites and their distribution in the northwestern part of the German North Sea. Methane seepage is a common phenomenon along marine shelves and known to occur in the North Sea, but proof of their existence was lacking in the study area. Using a ship-based multibeam echosounder we detected a minimum of 166 flares that are indicative for free gas releases from the seafloor in the German “Entenschnabel” area, which are not related to morphologic expressions at the seafloor. However, a group of small depressions was detected lacking water column anomalies but with indications of dissolved fluid release. Spatial analysis revealed that flares were not randomly distributed but show a relation to locations of subsurface salt diapirs. More than 60% of all flares were found in the vicinity of the salt diapir “Berta”. Dissolved methane concentrations of ∼100 nM in bottom waters were ten times the background value in the “Entenschnabel” area (CH4 < 10 nM), supporting the finding of enhanced seepage activity in this part of our study area. Furthermore, locations of flares were often related to acoustic blanking and high amplitude reflections in sediment profiler echograms, most prominently observed at location Berta. These hydroacoustic signatures are interpreted to result from increased free gas concentrations in the sediments. Electromagnetic seabed mapping depicts local sediment conductivity anomalies below a flare cluster at Berta, which can be explained by small amounts of free gas in the sediment. In our area of interest, ten abandoned well sites were included in our mapping campaign, but flare observations were spatially not related to these wells. Naturally seeping methane is presumably transported to the seafloor along sub-vertical faults, which have formed concurrently to the updoming salt. Due to the shallow water depths of 30 to 50 m in the study area, flares were observed to reach close to the sea surface and a slight oversaturation of surface waters with methane in the flare-rich northeastern part of the working area indicates that part of the released methane through seepage may contribute to the atmospheric inventory.

The German Baltic Sea coastline is characterized by sea-land transitions zones, specifically coastal peatlands. Such transition zones exhibit highly fluctuating environmental parameters and dynamic gradients that affect physiological processes of inhabiting organisms such as microphytobenthic communities. In the present study four representative and abundant benthic diatom strains [Melosira nummuloides, Nitzschia filiformis, Planothidium sp. (st. 1) and Planothidium sp. (st.2)] were isolated from a Baltic Sea beach and three peatlands that are irregularly affected by Baltic Sea water intrusion. Ecophysiological and cell biological traits of the strains were investigated for the first time as function of light, temperature and salinity. The four strains exhibited euryhaline growth over a range of 1–39 SA, surpassing in situ salinity of the respective brackish habitats. Furthermore, they showed eurythermal growth over a temperature range from 5 to 30°C with an optimum temperature between 15 and 20°C. Growth rates did not exhibit any differences between the peatland and Baltic Sea strains. The photosynthetic temperature optimum of the peatland diatom isolates, however, was much higher (20–35°C) compared to the Baltic Sea one (10°C). All strains exhibited light saturation points ranging between 29.8 and 72.6 μmol photons m–2 s–1. The lipid content did not change in response to the tested abiotic factors. All data point to wide physiological tolerances in these benthic diatoms along the respective sea-land transitions zones. This study could serve as a baseline for future studies on microphytobenthic communities and their key functions, like primary production, under fluctuating environmental stressors along terrestrial-marine gradients.

The oncofetal IGF2 mRNA-binding protein 1 (IGF2BP1) promotes tumor progression in a variety of solid tumors and its expression is associated with adverse prognosis. The main role proposed for IGF2BP1 in cancer cells is the stabilization of mRNAs encoding pro-oncogenic factors. Several IGF2BP1-RNA association studies, however, revealed a plethora of putative IGF2BP1-RNA targets. Thus, at present the main conserved target RNAs and pathways controlled by IGF2BP1 in cancer remain elusive. In this study, we present a set of genes and cancer hallmark pathways showing a conserved pattern of deregulation in dependence of IGF2BP1 expression in cancer cell lines. By the integrative analysis of these findings with publicly available cancer transcriptome and IGF2BP1-RNA association data, we compiled a set of prime candidate target mRNAs. These analyses confirm a pivotal role of IGF2BP1 in controlling cancer cell cycle progression and reveal novel cancer hallmark pathways influenced by IGF2BP1. For three novel target mRNAs identified by these studies, namely AURKA, HDLBP and YWHAZ, we confirm IGF2BP1 mRNA stabilization. In sum our findings confirm and expand previous findings on the pivotal role of IGF2BP1 in promoting oncogenic gene expression by stabilizing target mRNAs in a mainly 3’UTR, m6A-, miRNA-, and potentially AU-rich element dependent manner.

Silicon is a promising electrode material for lithium-ion batteries; however, morphological changes shorten battery lifetimes. Here the authors use imaging techniques based on electrons and X-rays to quantify such processes at micro- and nanoscales and suggest routes to mitigate battery degradation.

The RNA–binding protein Musashi–1 (MSI1) promotes stemness during development and cancer. By controlling target mRNA turnover and translation, MSI1 is implicated in the regulation of cancer hallmarks such as cell cycle or Notch signaling. Thereby, the protein enhanced cancer growth and therapy resistance to standard regimes. Due to its specific expression pattern and diverse functions, MSI1 represents an interesting target for cancer therapy in the future. In this review we summarize previous findings on MSI1′s implications in developmental processes of other organisms. We revisit MSI1′s expression in a set of solid cancers, describe mechanistic details and implications in MSI1 associated cancer hallmark pathways and highlight current research in drug development identifying the first MSI1–directed inhibitors with anti–tumor activity.

MEX3A belongs to the MEX3 (Muscle EXcess) protein family consisting of four members (MEX3A-D) in humans. Characteristic for MEX3 proteins is their domain structure with 2 HNRNPK homology (KH) domains mediating RNA binding and a C-terminal really interesting new gene (RING) domain that harbors E3 ligase function. In agreement with their domain composition, MEX3 proteins were reported to modulate both RNA fate and protein ubiquitination. MEX3 paralogs exhibit an oncofetal expression pattern, they are severely downregulated postnatally, and re-expression is observed in various malignancies. Enforced expression of MEX3 proteins in various cancers correlates with poor prognosis, emphasizing their oncogenic potential. The latter is supported by MEX3A’s impact on proliferation, self-renewal as well as migration of tumor cells in vitro and tumor growth in xenograft studies.

The characterization of terpene-based eutectic solvent systems is performed to describe their solid–liquid phase transitions. Physical properties are measured experimentally and compared to computed correlations for deep eutectic solvents (DES) and the percentage relative error er for the density, surface tension, and refractive index is obtained. The thermodynamic parameters, including the degradation, glass transition and crystallization temperatures, are measured using DSC and TGA. Based on these data, the solid–liquid equilibrium phase diagrams are calculated for the ideal case and predictions are made using the semi-predictive UNIFAC and the predictive COSMO RS models, the latter with two different parametrization levels. For each system, the ideal, experimental, and predicted eutectic points are obtained. The deviation from ideality is observed experimentally and using the thermodynamic models for Thymol:Borneol and Thymol:Camphor. In contrast, a negative deviation is observed only experimentally for Menthol:Borneol and Menthol:Camphor. Moreover, the chemical interactions are analyzed using FTIR and 1H-NMR to study the intermolecular hydrogen bonding in the systems.

Human infection with Puumala virus (PUUV), the most common hantavirus in Central Europe, causes nephropathia epidemica (NE), a disease characterized by acute kidney injury and thrombocytopenia. To determine the clinical phenotype of hantavirus-infected patients and their long-term outcome and humoral immunity to PUUV, we conducted a cross-sectional prospective survey of 456 patients in Germany with clinically and serologically confirmed hantavirus-associated NE during 2001–2012. Prominent clinical findings during acute NE were fever and back/limb pain, and 88% of the patients had acute kidney injury. At follow-up (7–35 mo), all patients had detectable hantavirus-specific IgG; 8.5% had persistent IgM; 25% had hematuria; 23% had hypertension (new diagnosis for 67%); and 7% had proteinuria. NE-associated hypertension and proteinuria do not appear to have long-term consequences, but NE-associated hematuria may. All patients in this study had hantavirus-specific IgG up to years after the infection.

Green nail syndrome (GNS) caused by Pseudomonas aeruginosa is the most common bacterial nail infection. The treatment of GNS is challenging in many cases and recommendations based on clinical trials are lacking. We report two cases with GNS successfully treated with off-label use of topical nadifloxacin, a fluoroquinolone approved for acne and bacterial skin infections in some countries.

A concept that allows the cognitive automation of robotic assembly processes is introduced. An assembly cell comprised of two robots was designed to verify the concept. For the purpose of validation a customer-defined part group consisting of Hubelino bricks is assembled. One of the key aspects for this process is the verification of the assembly group. Hence a software component was designed that utilizes the Microsoft Kinect to perceive both depth and color data in the assembly area. This information is used to determine the current state of the assembly group and is compared to a CAD model for validation purposes. In order to efficiently resolve erroneous situations, the results are interactively accessible to a human expert. The implications for an industrial application are demonstrated by transferring the developed concepts to an assembly scenario for switch-cabinet systems.