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14 results on '"Simonds, Naoko I."'

3. Leveraging Epidemiology and Clinical Studies of Cancer Outcomes: Recommendations and Opportunities for Translational Research

Author

Elena, Joanne W., Travis, Lois B., Simonds, Naoko I., Ambrosone, Christine B., Ballard-Barbash, Rachel, Bhatia, Smita, Cerhan, James R., Hartge, Patricia, Heist, Rebecca S., Kushi, Lawrence H., Lash, Timothy L., Morton, Lindsay M., Onel, Kenan, Pierce, John P., Robison, Leslie L., Rowland, Julia H., Schrag, Deborah, Sellers, Thomas A., Seminara, Daniela, Shu, Xiao Ou, Thomas, Nancy E., Ulrich, Cornelia M., and Freedman, Andrew N.

Published
2013
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7. Use of Next-Generation Sequencing Tests to Guide Cancer Treatment: Results From a Nationally Representative Survey of Oncologists in the United States

Author

Freedman, Andrew N., primary, Klabunde, Carrie N., additional, Wiant, Kristine, additional, Enewold, Lindsey, additional, Gray, Stacy W., additional, Filipski, Kelly K., additional, Keating, Nancy L., additional, Leonard, Debra G.B., additional, Lively, Tracy, additional, McNeel, Timothy S., additional, Minasian, Lori, additional, Potosky, Arnold L., additional, Rivera, Donna R., additional, Schilsky, Richard L., additional, Schrag, Deborah, additional, Simonds, Naoko I., additional, Sineshaw, Helmneh M., additional, Struewing, Jeffery P., additional, Willis, Gordon, additional, and de Moor, Janet S., additional

Published
2018
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12. Leveraging Epidemiology and Clinical Studies of Cancer Outcomes: Recommendations and Opportunities for Translational Research

Author

Elena, Joanne W., primary, Travis, Lois B., additional, Simonds, Naoko I., additional, Ambrosone, Christine B., additional, Ballard-Barbash, Rachel, additional, Bhatia, Smita, additional, Cerhan, James R., additional, Hartge, Patricia, additional, Heist, Rebecca S., additional, Kushi, Lawrence H., additional, Lash, Timothy L., additional, Morton, Lindsay M., additional, Onel, Kenan, additional, Pierce, John P., additional, Robison, Leslie L., additional, Rowland, Julia H., additional, Schrag, Deborah, additional, Sellers, Thomas A., additional, Seminara, Daniela, additional, Shu, Xiao Ou, additional, Thomas, Nancy E., additional, Ulrich, Cornelia M., additional, and Freedman, Andrew N., additional

Published
2012
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14. The Effect of Cancer Treatments on Telomere Length: A Systematic Review of the Literature.

Author

Gallicchio L, Gadalla SM, Murphy JD, and Simonds NI

Subjects
Animals, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols adverse effects, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Humans, Neoplasms drug therapy, Treatment Outcome, Neoplasms epidemiology, Neoplasms genetics, Telomere Homeostasis drug effects, Telomere Homeostasis genetics
Abstract

Background: It has been hypothesized that cancer treatments cause accelerated aging through a mechanism involving the shortening of telomeres. However, the effect of cancer treatments on telomere length is unclear., Methods: We systematically reviewed the epidemiological evidence evaluating the associations between cancer treatment and changes in telomere length. Searches were performed in PubMed for the period of January 1966 through November 2016 using the following search strategy: telomere AND (cancer OR tumor OR carcinoma OR neoplasm) AND (survivor OR patient). Data were extracted and the quality of studies was assessed., Results: A total of 25 studies were included in this review. Ten were solid cancer studies, 11 were hematological malignancy studies, and 4 included a mixed sample of both solid and hematological cancers. Three of the 10 solid tumor studies reported a statistically significant association between cancer treatment and telomere length shortening, and one reported longer telomere length after treatment. Among the hematological cancer studies, three showed statistically significant decreases in telomere length with treatment, and two showed elongation. When these studies were rated using quality criteria, most of the studies were judged to be of moderate quality., Conclusions: The findings from this review indicate that the effect of cancer treatment on telomere length may differ by cancer type and treatment as well as other factors. Definitive conclusions cannot be made based on the published literature, because sample sizes tended to be small; treatments, cancer types, and biospecimens were heterogenous; and the length of follow-up times differed greatly.

Published
2018
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