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9 results on '"Simsek, Ceren"'

5. At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic Transmissions

Author

Simsek, Ceren, primary, Corman, Victor Max, additional, Everling, Hermann Ulrich, additional, Lukashev, Alexander N., additional, Rasche, Andrea, additional, Maganga, Gael Darren, additional, Binger, Tabea, additional, Jansen, Daan, additional, Beller, Leen, additional, Deboutte, Ward, additional, Gloza-Rausch, Florian, additional, Seebens-Hoyer, Antje, additional, Yordanov, Stoian, additional, Sylverken, Augustina, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Vallo, Peter, additional, Leroy, Eric M., additional, Bourgarel, Mathieu, additional, Yinda, Kwe Claude, additional, Van Ranst, Marc, additional, Drosten, Christian, additional, Drexler, Jan Felix, additional, and Matthijnssens, Jelle, additional

Published
2021
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6. At least seven distinct rotavirus genotype constellations in bats with evidence of reassortment and zoonotic transmissions

Author

Simsek, Ceren, primary, Corman, Victor Max, additional, Everling, Hermann Ulrich, additional, Lukashev, Alexander N., additional, Rasche, Andrea, additional, Maganga, Gael Darren, additional, Binger, Tabea, additional, Jansen, Daan, additional, Beller, Leen, additional, Deboutte, Ward, additional, Gloza-Rausch, Florian, additional, Seebens-Hoyer, Antje, additional, Yordanov, Stoian, additional, Sylverken, Augustina, additional, Oppong, Samuel, additional, Sarkodie, Yaw Adu, additional, Vallo, Peter, additional, Leroy, Eric M., additional, Bourgarel, Mathieu, additional, Yinda, Kwe Claude, additional, Van Ranst, Marc, additional, Drosten, Christian, additional, Drexler, Jan Felix, additional, and Matthijnssens, Jelle, additional

Published
2020
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7. Identification of genomic regions associated with caecal microbiota composition in a broiler line

Author

Calenge, Fanny, Estelle, Jordi, Bed'Hom, Bertrand, SIMSEK, Ceren, Hennequet-Antier, Christelle, Gabriel, Irène, Grasteau, Sandrine, Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Recherches Avicoles (SRA), Institut National de la Recherche Agronomique (INRA), GISA GALMIDE, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, and Unité de Recherches Avicoles (URA)

Subjects
Animal biology, Reproductive Biology, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], animal diseases, chicken, [SDV.BA]Life Sciences [q-bio]/Animal biology, digestive, oral, and skin physiology, poulet, food and beverages, microbiote digestif, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, digestive system, digestive efficiency, humanities, caecum, caeca, Biologie animale, Biologie de la reproduction, microbiota, gut, efficacité digestive, Autre (Sciences du Vivant)
Abstract

Identification of genomic regions associated with caecal microbiota composition in a broiler line . 10th European Symposium on Poultry Genetics

Published
2017

8. The Shigella type III effector IpgD recodes Ca 2+ signals during invasion of epithelial cells

Author

Sun, Chun Hui, primary, Wacquier, Benjamin, additional, Aguilar, Daniel I, additional, Carayol, Nathalie, additional, Denis, Kevin, additional, Boucherie, Sylviane, additional, Valencia‐Gallardo, Cesar, additional, Simsek, Ceren, additional, Erneux, Christophe, additional, Lehman, Alexandre, additional, Enninga, Jost, additional, Arbibe, Laurence, additional, Sansonetti, Philippe, additional, Dupont, Geneviève, additional, Combettes, Laurent, additional, and Tran Van Nhieu, Guy, additional

Published
2017
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9. The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells.

Author

Sun, Chun Hui, Wacquier, Benjamin, Aguilar, Daniel I, Carayol, Nathalie, Denis, Kevin, Boucherie, Sylviane, Valencia‐Gallardo, Cesar, Simsek, Ceren, Erneux, Christophe, Lehman, Alexandre, Enninga, Jost, Arbibe, Laurence, Sansonetti, Philippe, Dupont, Geneviève, Combettes, Laurent, and Tran Van Nhieu, Guy

Subjects
SHIGELLA, EPITHELIAL cells, CALPAIN genetics, PROTEINASE genetics, PATHOGENIC microorganisms
Abstract

The role of second messengers in the diversion of cellular processes by pathogens remains poorly studied despite their importance. Among these, Ca2+ virtually regulates all known cell processes, including cytoskeletal reorganization, inflammation, or cell death pathways. Under physiological conditions, cytosolic Ca2+ increases are transient and oscillatory, defining the so-called Ca2+ code that links cell responses to specific Ca2+ oscillatory patterns. During cell invasion, Shigella induces atypical local and global Ca2+ signals. Here, we show that by hydrolyzing phosphatidylinositol-(4,5)bisphosphate, the Shigella type III effector IpgD dampens inositol-(1,4,5)trisphosphate (InsP3) levels. By modifying InsP3 dynamics and diffusion, IpgD favors the elicitation of long-lasting local Ca2+ signals at Shigella invasion sites and converts Shigella-induced global oscillatory responses into erratic responses with atypical dynamics and amplitude. Furthermore, IpgD eventually inhibits InsP3-dependent responses during prolonged infection kinetics. IpgD thus acts as a pathogen regulator of the Ca2+ code implicated in a versatility of cell functions. Consistent with this function, IpgD prevents the Ca2+-dependent activation of calpain, thereby preserving the integrity of cell adhesion structures during the early stages of infection. [ABSTRACT FROM AUTHOR]

Published
2017
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