112 results on '"Sinanovic O"'
Search Results
2. Executive Function in Children with Intellectual Disability--The Effects of Sex, Level and Aetiology of Intellectual Disability
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Memisevic, H. and Sinanovic, O.
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Background: Executive function is very important in the children's overall development. The goal of this study was to assess the executive function in children with intellectual disability (ID) through the use of the Behavior Rating Inventory of Executive Function (BRIEF) teacher version. An additional goal was to examine the differences in executive function in relation to child's sex, level and aetiology of ID. Method: The sample consisted of 90 children with ID attending two special education schools in Sarajevo, Bosnia and Herzegovina. There were 42 children with mild ID and 48 children with moderate ID. Of those, 54 were boys and 36 were girls. Children were classified into three etiological categories: 30 children with Down syndrome, 30 children with other genetic cause or organic brain injury and 30 children with unknown aetiology of ID. Special education teachers, who knew the children for at least 6 months filled the BRIEF. Results: Children with ID had a significant deficit in executive function as measured by the BRIEF. There were no statistically significant differences in executive function in relation to the child's sex. Level of ID had a significant effect on executive function. In relation to the aetiology of ID, the only significant difference was on the Shift scale of the BRIEF. Conclusions: Knowing what executive function is most impaired in children with ID will help professionals design better intervention strategies. More attention needs to be given to the assessment of executive function and its subsequent intervention in the school settings.
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- 2014
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3. Hypermethylation of the monoamine oxidase A gene – a new epigenetic marker for posttraumatic stress disorder?
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Ziegler, C., primary, Wolf, C., additional, Schiele, M., additional, Bojic, E. Feric, additional, Kucukalic, S., additional, Dzananovic, E. Sabic, additional, Uka, A. Goci, additional, Hoxha, B., additional, Haxhibeqiri, V., additional, Haxhibeqiri, S., additional, Kravic, N., additional, Umihanic, M. Muminovic, additional, Franc, A. Cima, additional, Jaksic, N., additional, Babic, R., additional, Pavlovic, M., additional, Warrings, B., additional, Mehmedbasic, A. Bravo, additional, Rudan, D., additional, Aukst-Margetic, B., additional, Kucukalic, A., additional, Marjanovic, D., additional, Babic, D., additional, Bozina, N., additional, Jakovljevic, M., additional, Sinanovic, O., additional, Avdibegovic, E., additional, Agani, F., additional, Dzubur-Kulenovic, A., additional, Deckert, J., additional, and Domschke, K., additional
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- 2018
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4. Post-stroke dementia - a comprehensive review
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Mijajlovic, M.D., Pavlovic, A., Brainin, M., Heiss, W.D., Quinn, T.J., Ihle-Hansen, H.B., Hermann, D.M., Assayag, E.B., Richard, E., Thiel, A., Kliper, E., Shin, Y.I., Kim, Y.H., Choi, S., Jung, S., Lee, Y.B., Sinanovic, O., Levine, D.A., Schlesinger, I., Mead, G., Milosevic, V., Leys, D., Hagberg, G., Ursin, M.H., Teuschl, Y., Prokopenko, S., Mozheyko, E., Bezdenezhnykh, A., Matz, K., Aleksic, V., Muresanu, D., Korczyn, A.D., Bornstein, N.M., Mijajlovic, M.D., Pavlovic, A., Brainin, M., Heiss, W.D., Quinn, T.J., Ihle-Hansen, H.B., Hermann, D.M., Assayag, E.B., Richard, E., Thiel, A., Kliper, E., Shin, Y.I., Kim, Y.H., Choi, S., Jung, S., Lee, Y.B., Sinanovic, O., Levine, D.A., Schlesinger, I., Mead, G., Milosevic, V., Leys, D., Hagberg, G., Ursin, M.H., Teuschl, Y., Prokopenko, S., Mozheyko, E., Bezdenezhnykh, A., Matz, K., Aleksic, V., Muresanu, D., Korczyn, A.D., and Bornstein, N.M.
- Abstract
Contains fulltext : 170402.pdf (publisher's version ) (Open Access), Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of assessment, with differing instruments needed for brief screening (e.g., Montreal Cognitive Assessment) or diagnostic formulation (e.g., NINDS VCI battery). A comprehensive evaluation should include assessment of pre-stroke cognition (e.g., using Informant Questionnaire for Cognitive Decline in the Elderly), mood (e.g., using Hospital Anxiety and Depression Scale), and functional consequences of cognitive impairments (e.g., using modified Rankin Scale). A large number of biomarkers for PSD, including indicators for genetic polymorphisms, biomarkers in the cerebrospinal fluid and in the serum, inflammatory mediators, and peripheral microRNA profiles have been proposed. Currently, no specific biomarkers have been proven to robustly discriminate vulnerable patients ('at risk brains') from those with better prognosis or to discriminate Alzheimer's disease dementia from PSD. Further, neuroimaging is an important diagnostic tool in PSD. The role of computerized tomography is limited to demonstrating type and location of the underlying primary lesion and indicating atrophy and severe white matter changes. Magnetic resonance imaging is the key neuroimaging modality and has high sensitivity and specificity for detecting pathological changes, including small vessel disease. Advanced multi-modal imaging includes diffusion tensor imaging for fiber tracking, by which changes in networks can be detected. Quantitative imaging of cerebral blood flow and metabolism by positron emission tomography can differentiate between vascular dementia and degenerative dementia and show the interaction between vascula
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- 2017
5. P.3.013 - Hypermethylation of the monoamine oxidase A gene – a new epigenetic marker for posttraumatic stress disorder?
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Ziegler, C., Wolf, C., Schiele, M., Bojic, E. Feric, Kucukalic, S., Dzananovic, E. Sabic, Uka, A. Goci, Hoxha, B., Haxhibeqiri, V., Haxhibeqiri, S., Kravic, N., Umihanic, M. Muminovic, Franc, A. Cima, Jaksic, N., Babic, R., Pavlovic, M., Warrings, B., Mehmedbasic, A. Bravo, Rudan, D., Aukst-Margetic, B., Kucukalic, A., Marjanovic, D., Babic, D., Bozina, N., Jakovljevic, M., Sinanovic, O., Avdibegovic, E., Agani, F., Dzubur-Kulenovic, A., Deckert, J., and Domschke, K.
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- 2018
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6. Angiotensin-converting enzyme I/D gene polymorphism in multiple sclerosis
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Stanković, Aleksandra, Gasparovic, I., Peterlin, B., Klupka-Saric, I., Živković, Maja, Starčević Čizmarević, Nada, Lovrecic, L., Sinanovic, O., Dinčić, Evica, Perkovic, O., Rudolf, G., Vidovic, M., Stojković, Ljiljana S., Lavtar, P., Sehanovic, A., and Ristic, S.
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- 2011
7. Reccurent form of parsonage-turner syndrome: case Report
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Sinanovic, O., primary, Zukic, S., additional, Jusufovic, E., additional, Muminovic Umihanic, M., additional, Barucija, M., additional, and Muftic, M., additional
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- 2015
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8. Operations research to improve financial sustainability in three Bolivian NGOs
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Lee Dj, J Sarmento, E B Rolandsen, Sinanovic O, Quy Ht, A Infuso, Avdibegovic E, Kim Ch, Ait-Belghiti F, Huong Nt, Choi Cm, Gakusi Ae, E Heldal, Arce J, Garenne M, Kim Dh, R M Araujo, Haslegrave M, Falzon D, Worley H, Co Nv, Tung Lb, Kang Ci, Ramirez C, Merida M, Mabala R, Duong Bd, Moscoso D, Riveros P, and Nelson Martins
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Operations research ,Cost estimate ,Cost effectiveness ,business.industry ,Market analysis ,Medicine ,Revenue ,Fixed cost ,Activity-based costing ,business ,Unit cost ,Variable cost - Abstract
Many NGOs providing reproductive health (RH) services are facing reductions in donor funding requiring them to generate more of their own resources. Prosalud CIES and APSAR Bolivian NGOs wanted to build skills in costing and market research to support efforts to improve financial sustainability. Staffs attended a one-week workshop followed by implementation of three operations research (OR) studies designed to reinforce skills and generate information for decision-making. The Prosalud and CIES studies included the calculation of unit cost per service; measurement of client willingness to pay (WTP) higher prices for services and a market segmentation assessment in selected areas where Prosalud clinics are located. The APSAR study focused on cost estimation exclusively. Prosalud had very high levels of cost recovery (83 to 109 percent depending on the service) CIES had lower levels of cost recovery (38-46 percent depending on the service) and APSAR only 10 --25 percent depending on the service. The WTP studies conducted by both Prosalud and CIES found that clients rejected the idea of paying higher prices for clinical services; and the market assessment also suggested that it would be difficult for the organizations to increase prices. Two potential avenues for increasing financial sustainability were identified for Prosalud: (1) investing in new services that can be sold at a profit and will attract new clients and (2) investing in new approaches that will result in selling more revenue generating services to existing clients. Both alternatives will be examined in a second round of OR studies. An experiment to test the cost recovery of a new service package will be tested and a model for estimating costs and revenues of new services under consideration by Prosalud will be developed. CIES had very high costs especially fixed costs and their priority should be costcontrol. APSAR does not recover its variable costs indicating that every additional client served will result in greater financial loss. Unless it is possible to increase prices the organization will be unable to increase its financial sustainability. (excerpt)
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- 2006
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9. Executive function in children with intellectual disability – the effects of sex, level and aetiology of intellectual disability
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Memisevic, H., primary and Sinanovic, O., additional
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- 2013
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10. Frequency of writing and reading disorders in Bosnia and Herzegovina population of acute stroke patients
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Sinanovic, O., primary, Zukić, S., additional, Mrkonjić, Z., additional, and Vidović, M., additional
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- 2013
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11. Superego and the personality characteristics in children of war veterans with posttraumatic stress disorder
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Selimbasic, Z., primary, Kravic, N., additional, Avdibegovic, E., additional, and Sinanovic, O., additional
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- 2012
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12. P-331 - Emotional and behavioral problems in children of war veterans with posttraumatic stress disorder
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Selimbasic, Z., primary, Sinanovic, O., additional, and Avdibegovic, E., additional
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- 2012
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13. P3.186 Depressive symptoms and nucturnal disturbances in Bosnia-Herzegovina patients with Parkinsons's disease
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Sinanovic, O., primary, Hudić, J., additional, Hamidovic, J., additional, Ibrahimagic, O., additional, and Dostovic, Z., additional
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- 2009
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14. FP22-TU-05 Connection of severity and type of postroke aphasic syndrome with quality of life
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Sinanovic, O., primary, Mrkonjic, Z., additional, and Zecic, S., additional
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- 2009
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15. PTSD among adolescents from three different geographical settings in Bosnia-Herzegovina after 1992-95 war
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Hasanovic, M., primary, Sinanovic, O., additional, and Pavlovic, S., additional
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- 2007
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16. Four years of day hospital treatment of psycho-traumatized persons in post-war Bosnia and Herzegovina
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Avdibegovic, E., primary, Hasanovic, M., additional, Selimbasic, Z., additional, Pajevic, I., additional, Sinanovic, O., additional, and Kopric, A., additional
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- 2007
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17. Emotional profile of women victims of domestic violence
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Avdibegovic, E., primary and Sinanovic, O., additional
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- 2007
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18. Forensic-psychiatric war and peacetime comparison of homicide - timing, psychiatric diagnoses and mental accountability
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Sutovic, A., primary, Hodzic, R., additional, and Sinanovic, O., additional
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- 2007
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19. Sucide of people with mental disorders in war and peace circumstances
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Avdibegovic, E., primary, Jarakovic, M., additional, and Sinanovic, O., additional
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- 2007
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20. PTSD, depression, anxiety, and substance misuse among of medical and phylosphy university students in Bosnia-Herzegovina after 1992-95 war
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Sinanovic, O., primary, Hasanovic, M., additional, Babajic, E., additional, Salkic, M., additional, Mujanovic, J., additional, Begic, A., additional, and Music, Z., additional
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- 2007
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21. Posttraumatic stress reactions of children whose parents suffered from posttraumatic stress disorder
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Selimbasic, Z., primary, Avdibegovic, E., additional, and Sinanovic, O., additional
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- 2007
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22. 1.177 Dementia and depression in Parkinson's disease
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Sinanovic, O., primary, Hudic, J., additional, and Ibrahimagic, O., additional
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- 2007
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23. Stressful Life Events and Psoriasis during the War in Bosnia
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Suljagic, E., primary, Sinanovic, O., additional, Tupkovic, E., additional, and Moro, L., additional
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- 2000
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24. 1258 – Quality of life of war veterans with posttraumatic stress disorder in bosnia-herzegovina
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Hasanović, M., Sinanović, O., Izet, P., Esmina, A., and Frančišković, T.
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- 2013
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25. Short-term postnatal quality of life in women with previous Misgav Ladach caesarean section compared to Pfannenstiel-Dorffler caesarean section method.
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Fatusic Z, Hudic I, Sinanovic O, Kapidzic M, Hotic N, and Music A
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- 2011
26. Posters, Tuesday 17 October.
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Titianova, E., Velcheva, I., Nader, J., Smajlovic, D., Tupkovic, E., Kapidzic, A., Sinanovic, O., Sievart, H., Bösenberg, I., Theis, R., Beykirch, K-F., Pfeil, W., Rubel, C., Ensslen, R., Fach, A., Spies, H., Merle, H., and Toncev, S.
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NEUROLOGY ,CEREBROVASCULAR disease - Abstract
Presents several abstracts on neurology. 'Neuroimaging Testing of the Clinical Classification of Ischemic Stroke'; Carotid Angioplasty and Stent Implantation: Acute and Follow-up Results in 100 Consecutive Lesion'; ultrasonography for Asymptomatic Carotid Stenosis in Patients with Peripheral Vascular Disease.'
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- 2000
27. 3. Electrophysiological characteristics and clinical significance of Martin–Gruber anastomosis
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Sinanović, O.
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- 2011
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28. The influence of religiosity on mental stabylity of war veterans
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Pajević, I., Sinanović, O., and Hasanović, M.
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- 2007
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29. The spiritual approach in the group psychotherapy treatment of psychotraumatized persons in post-war Bosnia and Herzegovina
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Hasanović, M., Pajević, I., and Sinanović, O.
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- 2007
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30. Post-stroke writing and reading disorders
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Sinanović Osman and Mrkonjić Zamir
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alexia ,agraphia ,acalculia ,stroke ,Medicine (General) ,R5-920 - Abstract
The writing and reading disorders in stroke patients (alexias, agraphias and acalculias) are more frequent than verified in routine exam, not only in the less developed but also in large neurological departments. Alexia is an acquired type of sensory aphasia where damage to the brain causes a patient to lose the ability to read. It is also called word blindness, text blindness or visual aphasia. Alexia refers to an acquired inability to read caused by brain damage and must be distinguished from dyslexia, a developmental abnormality in which the individual is unable to learn to read, and from illiteracy, which reflects a poor educational back-ground. Most aphasics are also alexic, but alexia may occur in the absence of aphasia and may occasionally be the sole disability resulting from specific brain lesions. There are different classifications of alexias. Traditionally, the alexias are divided into three categories: pure alexia with agraphia, pure alexia without agraphia, and alexia associated with aphasia ("aphasic alexia"). Agraphia is defined as the disruption of previously intact writing skills by brain damage. Writing involves several elements - language processing, spelling, visual perception, visual-spatial orientation for graphic symbols, motor planning, and motor control of writing. A disturbance of any of these processes can impair writing. Agraphia may occur by itself or as association with aphasias, alexia, agnosia and apraxia. Agraphia can also result from "peripheral" involvement of the motor act of writing. Like alexia, agraphia must be distinguished from illiteracy, where writing skills were never developed. Acalculia is a clinical syndrome of acquired deficits in mathematical calculation, either mentally or with paper and pencil. This language disturbances can be classified differently, but there are three principal types of acalculia: acalculia associated with language disturbances, including number paraphasia, number agraphia, or number alexia; acalculia secondary to visual-spatial dysfunction with malalignment of numbers and columns, and a primary anarithmetria entailing disruption of the computation process.
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- 2013
31. Molecular mechanisms of posttraumatic stress disorder (PTSD) as a basis for individualized and personalized therapy: Rationale, design and methods of the south eastern Europe (SEE)-PTSD study
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Alma Dzubur Kulenovic, Agani, F., Avdibegovic, E., Jakovljevic, M., Babic, D., Kucukalic, A., Kucukalic, S., Dzananovic, E. S., Mehmedbasic, A. B., Uka, A. G., Haxhibeqiri, S., Haxhibeqiri, V., Hoxha, B., Sinanovic, O., Kravic, N., Muminovic, M., Aukst-Margetic, B., Jaksic, N., Franc, A. C., Rudan, D., Pavlovic, M., Babic, R., Bojic, E. F., Marjanovic, D., Bozina, N., Ziegler, C., Wolf, C., Warrings, B., Domschke, K., and Deckert, J.
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Adult ,Bosnia and Herzegovina ,Male ,PTSD ,South Eastern Europe ,genetics ,epigenetics ,molecular mechanisms ,individualized therapy ,personalized therapy ,Warfare ,Croatia ,PTSD, Personalized Therapy, South Eastern Europe ,Kosovo ,education ,Epigenesis, Genetic ,Stress Disorders, Post-Traumatic ,Case-Control Studies ,Germany ,Humans ,Female ,Cooperative Behavior - Abstract
Posttraumatic Stress Disorder (PTSD) is a major health problem in South Eastern Europe (SEE). Available treatment options are not efficient enough and the course is often chronic. Little is known about molecular mediators and moderators of pathogenesis and therapy. Genetic and epigenetic variation may be one central molecular mechanism. We therefore established a consortium combining clinical expertise on PTSD from SEE countries Bosnia-Herzegovina (Sarajevo, Tuzla and Mostar), Kosovo (Prishtina) and Croatia (Zagreb) with genetic and epigenetic competence from Germany (Würzburg) in 2011 within the framework of the DAAD (Deutscher Akademischer Austauschdienst)- funded Stability Pact for South Eastern Europe. After obtaining ethical votes and performing rater trainings as well as training in DNA extraction from EDTA blood between 2011 and 2013, we recruited 747 individuals who had experienced war- related trauma in the SEE conflicts between 1991 and 1999. 236 participants had current PTSD, 161 lifetime PTSD and 350 did not have and never had PTSD. Demographic and clinical data are currently merged together with genetic and epigenetic data in a single database to allow for a comprehensive analysis of the role of genetic and epigenetic variation in the pathogenesis and therapy of PTSD. Analyses will be done to a great degree by PhD students from participating SEE centers who in addition to participation in the project had an opportunity to take part in spring and summer schools of the DFG (Deutsche Forschungsgemeinschaft) funded Research Training Group (RTG) 1253 and thus meet PhD students from Germany and other countries We are confident that our project will not only contribute to a better understanding of genetic and epigenetic mechanisms of PTSD as a basis for future individualized and personalized therapies, but also to the academic development of South Eastern Europe.
32. Familial occurence of myasthenia gravis and polymyositis/dermatomyositis in three cases
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Sinanović, O., Apostolski, S., and Dožić, S.
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- 1991
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33. Prevalence of restless legs syndrome during pregnancy and postpartum period.
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Lepuzanovic M, Sinanovic O, Aziraj-Smajic V, Kapic D, Basagic E, and Muftic M
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- Humans, Female, Pregnancy, Prevalence, Adult, Young Adult, Cross-Sectional Studies, Case-Control Studies, Restless Legs Syndrome epidemiology, Restless Legs Syndrome diagnosis, Pregnancy Complications epidemiology, Postpartum Period
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Objectives: Restless legs syndrome (RLS) is a disease from the spectrum of movement disorders, the prevalence of which increases significantly during pregnancy and is associated with poor sleep, a drop in daytime energy, and the development of psychological disorders during pregnancy and the postpartum period., Methods: The IRLSS scale was used to determine the presence of RLS symptoms. The total test sample that included the tested and control groups was (n=390) subjects. The examined group consisted of pregnant women (n=260), and the control group consisted of female students (n=130). In total, 260 pregnant women were monitored 6 months after pregnancy. Three measurements were performed, first in the third trimester of pregnancy, second two months after delivery, third 6 months after delivery, while one cross-sectional measurement was performed for the control group., Results: The prevalence of RLS in pregnancy is highest in the third trimester and amounts to 26.5 %. In the postpartum period, a significant decrease in the prevalence of RLS was observed, measured two months after delivery (18.1 %). Postpartum, over time, a decrease in the prevalence of RLS was noticed, and six months after delivery it was (7.3 %), when it practically approached the prevalence of the control group (standard population) which was (6.2 %)., Conclusions: The prevalence of RLS is highest during the third trimester of pregnancy and decreases after delivery so that 6 months after delivery it approaches the prevalence of the standard population., (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
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- 2024
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34. The impact of the comorbid seizure/epilepsy on the health related quality of life in people with multiple sclerosis: an international multicentric study.
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Drulovic J, Pekmezovic T, Tamas O, Adamec I, Aleksic D, Andabaka M, Basic Kes V, Butkovic Soldo S, Cukic M, Despinic L, Dincic E, Djelilovic Vranic J, Grgic S, Habek M, Hristova SI, Ivanovic J, Jovanovic A, Jovicevic V, Krbot Skoric M, Kuzmanovski I, Maric G, Mesaros S, Milanov IG, Miletic Drakulic S, Sinanovic O, Skarpa Prpic I, Sremec J, Tadic D, Toncev G, and Sokic D
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- Humans, Quality of Life, Cross-Sectional Studies, Comorbidity, Seizures epidemiology, Multiple Sclerosis epidemiology, Multiple Sclerosis psychology, Epilepsy epidemiology
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Introduction: The health-related quality of life (HRQoL) of people with (Pw) multiple sclerosis (MS) is usually deteriorated. It has been recently suggested that comorbidities may have the negative influence on the quality of life of the PwMS, but according to the best of our knowledge, only one study investigated, although in a very small cohort, the impact of individual comorbidity on the quality of life of PwMS. The aim of our investigation was to assess, in an international, multicentric study, the impact of comorbid seizure/epilepsy on the HRQoL in PwMS., Methods: We conducted cross-sectional study at numerous neurological centers in Serbia, Croatia, Bulgaria, Montenegro, Northern Macedonia, and Bosnia and Herzegovina (Federation of Bosnia and Herzegovina and Republic of Srpska). For each patient, demographic and clinical data were collected, including Expanded disability status scale (EDSS) score. Beck Depression Inventory (BDI) and the 36-Item Short Form Health Survey (SF-36) questionnaires were administered to all patients., Results: The study comprised 326 PwMS in total, 127 PwMS with seizure/epilepsy and 209 PwMS without. Both mean Physical health composite (PHC) and mental health composite (MHC) scores, were statistically significantly higher in PwMS without seizure/epilepsy, implicating worse quality of life in PwMS with comorbid seizure/epilepsy. Presence of seizure/epilepsy in pwMS was statistically significant independent predictor of both PHC and MHC, in multivariate linear regression model after adjustment for potential confounding variables. The hierarchical multivariate regression analysis was performed in order to establish the most important predictors of the PHC and MHC of the SF-36, in PwMS with seizure/epilepsy; older age, higher level of disability, as measured by EDSS, higher depression score, drug-resistant epilepsy and shorter time since last seizure were found to significantly predict worse MHC score in PwMS with seizure/epilepsy., Discussion: Our results point to the possible role of theinterventions related to the adequate control of epilepsy along with improvement of the mental health status to be important in order to reduce MS burden in the PwMS with comorbid seizure/epilepsy., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Drulovic, Pekmezovic, Tamas, Adamec, Aleksic, Andabaka, Basic Kes, Butkovic Soldo, Cukic, Despinic, Dincic, Djelilovic Vranic, Grgic, Habek, Hristova, Ivanovic, Jovanovic, Jovicevic, Krbot Skoric, Kuzmanovski, Maric, Mesaros, Milanov, Miletic Drakulic, Sinanovic, Skarpa Prpic, Sremec, Tadic, Toncev and Sokic.)
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- 2023
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35. Communication of the Elderly During the COVID-19 Pandemic.
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Banovic S, Sinanovic O, Jankovic S, Patkovic N, and Smajlovic S
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Background: Restrictive measures implemented by governments around the world to control the coronavirus have an impact on communication, especially the communication of the elderly., Objective: The aim for the article is to determine the attitudes of the elderly towards the ways of communication during the COVID 19 pandemic, and to present the challenges faced by the elderly when using digital ways of communication. The goal is also to point out the importance of providing adequate social support to the elderly., Methods: The sample consisted of 71 respondents from Bosnia and Herzegovina, aged over 60 years, divided into two groups. The questionnaire was used to gather information from respondents on their demographic characteristics as well as to examine participants' attitudes and confidence regarding the manner and risk of communication associated with COVID-19., Results and Discussion: The results of this research showed that the elderly are actively using digital technologies, but that they are largely dissatisfied with their skills in using digital technologies. Most of the information during the COVID 19 pandemic is given to elderly people via television and telephone (video) conversations with family members and friends. 57.7% of the elderly stated that they greatly lacked direct communication, and it turned out that people living in elderly homes were in a slightly more favorable position. As many as 4/5 of the respondents reported feelings of anxiety, fear, loneliness, and depression., Conclusion: The older part of the population (those over 60 years old), especially in developing countries, including Bosnia and Herzegovina, is facing the challenge of "digitization of communication". In the context of the COVID-19 pandemic, the elderly are "calling" for special support and the provision of training and access to technological resources in order to reduce negative psychological consequences and go one step further in creating an "elder-friendly" society., Competing Interests: There are no conflicts of interest., (© 2022 Silva Banovic, Osman Sinanovic, Slavica Jankovic, Nedim Patkovic, Samir Smajlovic.)
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- 2022
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36. Association of polygenic risk scores, traumatic life events and coping strategies with war-related PTSD diagnosis and symptom severity in the South Eastern Europe (SEE)-PTSD cohort.
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Weber H, Maihofer AX, Jaksic N, Bojic EF, Kucukalic S, Dzananovic ES, Uka AG, Hoxha B, Haxhibeqiri V, Haxhibeqiri S, Kravic N, Umihanic MM, Franc AC, Babic R, Pavlovic M, Mehmedbasic AB, Aukst-Margetic B, Kucukalic A, Marjanovic D, Babic D, Bozina N, Jakovljevic M, Sinanovic O, Avdibegović E, Agani F, Warrings B, Domschke K, Nievergelt CM, Deckert J, Dzubur-Kulenovic A, and Erhardt A
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- Adaptation, Psychological, Emotions, Europe, Eastern, Humans, Risk Factors, Stress Disorders, Post-Traumatic diagnosis, Stress Disorders, Post-Traumatic genetics, Stress Disorders, Post-Traumatic psychology
- Abstract
Objectives: Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables., Methods: Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables., Results: The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD., Conclusions: The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk., (© 2021. The Author(s).)
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- 2022
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37. Spastic Paraparesis After SARS-CoV-2 Infection Without Radiological Changes.
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Zukic S, Topcic E, Hodzic R, Sinanovic O, and Vidovic M
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Coronavirus disease 2019 (COVID-19) is primarily a disease of the respiratory system but severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause several immune-related complications including different neurological disorders, such as myelopathy with paraparesis.In this atypical case a female patient with progressive spastic paraparesis after COVID-19 infection, brisk reflexes and positive Babinski sign, reduced vibratory sensation to the thoracic level, elevated immunoglobulin levels (IgG) in cerebrospinal fluid, but negative magnetic resonance imaging (MRI) of the brain and spine, is presented. A 57-year-old woman with spastic paraparesis and inability to walk was admitted to our neurological department. About four months before hospitalization, she started feeling numbness and tingling in the feet and lumbar spine area. Gradually, numbness and tingling ascended to the thoracic spine level Th7/8, and she developed weakness mostly in her legs. In the neurological exam she had spastic paraparesis. MRI of the brain, cervical and thoracic spine did not reveal any signal abnormality. Serological testing for SARS-CoV-2 was performed and results were highly positive IgG and IgM+IgA levels. The lumbar puncture finding confirmed the suspicion of immune-related complications after SARS-CoV-2 infection (intrathecal IgG synthesis). This case draws attention to spastic paraparesis or progressive MRI-negative myelitis after SARS-CoV-2 infection, which obviously has immune-mediated pathogenesis that happen in response to the virus or its antibodies. Similarities in spastic paraparesis after human T-lymphotropic virus (HTLV-1) or human immunodeficiency virus (HIV-1) and SARS-CoV-2 infections were observed. The patient had a good response to corticosteroid therapy and had good recovery., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Zukic et al.)
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- 2022
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38. Neurogenic Stuttering: Etiology, Symptomatology, and Treatment.
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Junuzovic-Zunic L, Sinanovic O, and Majic B
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- Diagnosis, Differential, Humans, Brain Injuries, Nervous System Diseases, Stuttering diagnosis, Stuttering etiology, Stuttering therapy
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Background: Neurogenic stuttering is a subtype of acquired stuttering, and it is characterized by disfluencies associated with acquired brain damage., Objective: To provide an insight into pathophysiology, symptomatology, differential diagnosis, assessment, and treatment of neurogenic stuttering through a critical review of the literature., Methods: Studies published during the past and recent years were searched and analyzed on neurogenic stuttering., Results: Neurogenic stuttering is a complex disorder. The pathophysiological mechanism of neurogenic stuttering is not yet fully understood. It appears with several neurological diseases and conditions, and the use of some drugs. Differential diagnosis of neurogenic and psychogenic stuttering is a challenge for clinicians. Treatment usually requires a joint effort from speech therapists and doctors, most often neurologists., Conclusion: Although research on neurogenic stuttering can be found in the literature, the complexity of this disorder still requires detailed monitoring and studying to provide the best treatment for patients., Competing Interests: There are no conflicts of interest., (© 2021 Lejla Junuzovic-Zunic, Osman Sinanovic, Blazenka Majic.)
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- 2021
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39. Prevalence of Accessory Deep Peroneal Nerve in Sample of Bosnia and Herzegovina Subjects: an Electrophysiological Study.
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Sinanovic O, Zukic S, Muftic M, and Tinjic N
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Background: The accessory deep peroneal nerve (ADPN) is as an anomalous nerve derived from the superficial peroneal nerve or its branch and supplies motor innervations for extensor digitorum brevis (EDB) and sensory innervations for the lateral part of the ankle and foot regions. It is the most common anomalous innervation present in the lower limb., Objective: The aim of this study was to determine the prevalence of ADPN electrophysiologically in a sample of Bosnia and Herzegovina subjects who referred to an electromyography lab., Methods: This cross-sectional descriptive study included 316 lower limbs from 171 subjects referred for electrodiagnostic studies to Electromyography Lab, Department of Neurology, University Clinical Center Tuzla (Bosnia and Herzegovina) (102 females/60% and 69/40%) males). Motor nerve conduction studies for the peroneal nerve and ADPN were done. Compound muscle action potential (CMAP) and nerve conduction velocity (NCV) of deep peroneal nerve (DPN) were measured by using EMG machine by stimulating DPN at knee, ankle and lateral malleolus areas accordingly, with recording from extensor digitorum brevis (EDB) muscle., Results: ADPN was found in 46 (14.5%) of 316 legs. ADPN was found in 18 (39.1%) right lower limbs and 28 (60.9%) left lower limbs. Ten subjects (5.8%) had bilateral ADPN. There was no statistically significant difference between the occurrence of ADPN in women versus men (p=0.757), as well as in right versus left legs (p=0.237)., Conclusion: This study demonstrated that ADPN prevalence, in a sample of Bosnia and Herzegovina subjects who referred to an electromyography lab is 14.5%. Recognition of ADPN is very important for proper interpretation of lower limbs electrophysiological data., Competing Interests: There are no conflicts of interest., (© 2021 Osman Sinanovic, Sanela Zukic, Mirsad Muftic, Nihad Tinjic.)
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- 2021
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40. Balkan Clinical Research Registry: Established by Academy of Medical Sciences of Bosnia and Herzegovina.
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Masic I, Jankovic SM, Kurjak A, Donev DM, Zildzic M, Sinanovic O, Hozo I, Milicevic S, Hasukic S, Mujanovic E, Arnautovic K, Trnacevic S, Mesic E, Biscevic M, Sefic M, Gerc V, Kucukalic A, Hrgovic Z, Bergsland J, and Grujic M
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- Bosnia and Herzegovina, Humans, Biomedical Research standards, Biomedical Research statistics & numerical data, Clinical Studies as Topic standards, Clinical Studies as Topic statistics & numerical data, Guidelines as Topic, Registries standards, Registries statistics & numerical data
- Abstract
Background: From 2013 the World Medical Association's Declaration of Helsinki explicitly requires pre-registration of a study involving human subjects. The registration gives a chance for improvement of design and avoidance of bias., Objective: The aim of this article was to describe process of bearing decision to create regional registry of clinical studies for Balkan countries., Methods: After finding relevant studies about research registries and designing the concept and structure of future regional registry an article was published in IJBH journal. The article was than used as basis for discussion at 2020 meeting of Academy of Medical Sciences of Bosnia and Herzegovina (AMSBH), and final decision was made by the Academy to create the research registry., Results: Regional registry of clinical studies will be under the auspices of AMSBH and web-based, with the option of online registration of new studies. The data required to be entered in the moment of registration relate to key elements of research plan: topic, variables, sample, type of the study and the study population. After applying for registration of a clinical study, the authors will soon receive the review made by the AMSBH expert committee. The application could be accepted, rejected or returned for major or minor revision. After an application is accepted, it will be deposited in the searchable database and given the registration number., Conclusion: The AMSBH's decision to create the regional registry of clinical studies will satisfy needs of researchers from Balkan countries in the first place, who share cultural and lingual similarities. It will also help with increasing standards of clinical research in the region., Competing Interests: None declared, (© 2020 Izet Masic, Slobodan M. Jankovic, Asim Kurjak, Doncho M. Donev, Muharem Zildzic, Osman Sinanovic, Izet Hozo, Snjezana Milicevic, Sefik Hasukic, Emir Mujanovic, Kenan Arnautovic, Senaid Trnacevic, Enisa Mesic, Mirza Biscevic, Mustafa Sefic, Vjekoslav Gerc, Abdulah Kucukalic, Zlatko Hrgovic, Jacob Bergsland, Mirko Grujic.)
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- 2020
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41. Guidelines for Editing Biomedical Journals: Recommended by Academy of Medical Sciences of Bosnia and Herzegovina.
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Masic I, Jankovic SM, Kurjak A, Donev DM, Zildzic M, Sinanovic O, Hozo I, Milicevic S, Hasukic S, Mujanovic E, Arnautovic K, Trnacevic S, Mesic E, Biscevic M, Sefic M, Gerc V, Kucukalic A, Hrgovic Z, Bergsland J, and Grujic M
- Abstract
Background: Enormous number of medical journals published around the globe requires standardization of editing practice., Objective: The aim of this article was to enlist main principles of editing biomedical scientific journals adopted at annual meeting of Academy of Medical Sciences of Bosnia & Herzegovina (AMSB&H)., Methods: The evidence for writing this Guideline was systematically searched for during September 2020 in the PUBMED and GOOGLE SCHOLAR databases. The inclusion criteria were: original studies, systematic reviews, invited expert opinions, guidelines and editorials. The exclusion criteria were narrative reviews and uninvited opinion articles. The retrieved evidence was analyzed by members of the AMSB&H, then discussed at 2020 annual meeting of the AMSB&H and adopted by nominal group technique., Results: In total 14 recommendations were made, based on A to C class of evidence. The editors should educate potential authors and instruct them how to structure their manuscript, how to write every segment of the manuscript, and take care about correct use of statistical tests. Plagiarism detection softwares should be used regularly, and statistical and technical editing should be rigorous and thorough. International standards of reporting specific types of studies should be followed, and principles of ethical and responsible behavior of editors, reviewers and authors should be published on the journal's web site. The editors should insist on registration of clinical studies before submission, and check whether non-essential personal information is removed from the articles; when essential personal information has to be included, an article should not be published without signed informed consent by the patient to whom these information relate., Conclusions: Principles of editing biomedical scientific journals recommended in this guideline should serve as one of the means of improving medical journals' quality., Competing Interests: None declared., (© 2020 Izet Masic, Slobodan M. Jankovic, Asim Kurjak, Doncho M. Donev, Muharem Zildzic, Osman Sinanovic, Izet Hozo, Snjezana Milicevic, Sefik Hasukic, Emir Mujanovic, Kenan Arnautovic, Senaid Trnacevic, Enisa Mesic, Mirza Biscevic, Mustafa Sefic, Vjekoslav Gerc, Abdulah Kucukalic, Zlatko Hrgovic, Jacob Bergsland, Mirko Grujic.)
- Published
- 2020
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42. Associations between Polymorphisms in the Solute Carrier Family 6 Member 3 and the Myelin Basic Protein Gene and Posttraumatic Stress Disorder.
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Muminovic Umihanic M, Babic R, Kravic N, Avdibegovic E, Dzubur Kulenovic A, Agani F, Jakovljevic M, Babic D, Kucukalic A, Kucukalic S, Sabic Dzananovic E, Bravo Mehmedbasic A, Goci Uka A, Haxhibeqiri S, Hoxha B, Haxhibeqiri V, Aukst Margetic B, Jaksic N, Cima Franc A, Rudan D, Pavlović M, Feric Bojic E, Marjanovic D, Bozina N, Ziegler C, Wolf C, Warrings B, Domschke K, Deckert J, and Sinanovic O
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- Alleles, Female, Genotype, Humans, Male, Middle Aged, Dopamine Plasma Membrane Transport Proteins genetics, Myelin Basic Protein genetics, Polymorphism, Single Nucleotide, Stress Disorders, Post-Traumatic genetics
- Abstract
Background: Previous research showed inconsistent results concerning a possible association between solute carrier family 6 member 3 (SLC6A3) gene polymorphisms and dopamine symptoms of posttraumatic stress disorder (PTSD). Several studies also indicate that the myelin basic protein (MBP) gene is of importance in the etiology of several psychiatric disorders. The aim of this study was to investigate the relation of distinct SLC6A3 and MBP gene polymorphisms with PTSD and whether SLC6A3 and MBP genotypes contribute to PTSD symptom severity., Subjects and Methods: The study included 719 individuals who had experienced war trauma in the South Eastern Europe (SEE). Genotypes of variable number tandem repeat (VNTR) polymorphism within the SLC6A3 gene were assessed in 696 participants, and the single nucleotide polymorphism (SNP) rs12458282 located within the MBP gene region was genotyped in a total of 703 subjects. The Mini International Neuropsychiatric Interview, the Clinical Administrated PTSD Scale (CAPS) and Brief Symptom Inventory (BSI), were used for data collection., Results: No significant differences concerning the investigated SLC6A3 and MBP polymorphisms was identifiable between PTSD and non PTSD participants. Also we could not detect significant influence of these distinct SLC6A3 and MBP alleles on the severity of PTSD symptoms (CAPS) or BSI scores. However, the results of MBP rs12458282 within the patients with lifetime PTSD may point to a possible correlation of the major allele (T) with elevated CAPS scores., Conclusions: Our results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals. We found that there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power.
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- 2019
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43. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD.
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Goçi Uka A, Agani F, Blyta A, Hoxha B, Haxhibeqiri S, Haxhibeqiri V, Sabic Dzananovic E, Kucukalic S, Bravo Mehmedbasic A, Kucukalic A, Dzubur-Kulenovic A, Feric Bojic E, Marjanovic D, Kravic N, Avdibegovic E, Muminovic Umihanic M, Jaksic N, Cima Franc A, Rudan D, Jakovljevic M, Babic R, Pavlovic M, Babic D, Aukst Margetic B, Bozina N, Sinanovic O, Ziegler C, Warrings B, Domschke K, Deckert J, and Wolf C
- Subjects
- Armed Conflicts psychology, Bosnia and Herzegovina, Croatia, Female, Humans, Kosovo, Male, Middle Aged, Alleles, Receptor, Serotonin, 5-HT1A genetics, Stress Disorders, Post-Traumatic genetics, Tryptophan Hydroxylase genetics
- Abstract
Background: Post-traumatic stress disorder (PTSD) is a stress related disorder which can occur in an individual after exposure to a traumatic event. It most commonly co-occurs with depression. The two disorders share not only overlapping symptoms, but also genetic diathesis. The aim of this study was to investigate the potential role of single nucleotide polymorphisms (SNPs) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1A (HTR1A) and tryptophan hydroxylase 2 (TPH2) in the pathogenesis of PTSD and comorbid psychopathology., Subjects and Methods: 719 (487 males, 232 females) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Herzegovina, Kosovo and Croatia were included in the study. The Sociodemographic questionnaire, Mini International Neuropsychiatric Interview (M.I.N.I.), Clinician Administered PTSD Scale (CAPS) and Brief Symptom Inventory (BSI) were used to collect clinical data. The SNPs rs6295 (HTR1A), rs11178997 and rs1386494 (TPH2) were investigated for their association with PTSD and comorbid psychopathology., Results: A nominal significant association was found between the BSI total score in Lifetime PTSD with the SNP rs6295 of the HTR1A gene. The best result was seen in the dominant model (P=0.018), with the minor allele (C) being the risk allele. Several BSI subscores were also associated with the minor (C) allele in Lifetime PTSD. No association was found for the TPH2 SNPs rs11178997 and rs1386494 in relation to PTSD or comorbid psychopathology., Conclusions: Our findings suggest that rs6295 in the HTR1A gene may contribute to the psychopathology of PTSD.
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- 2019
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44. The Role of TaqI DRD2 (rs1800497) and DRD4 VNTR Polymorphisms in Posttraumatic Stress Disorder (PTSD).
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Hoxha B, Goçi Uka A, Agani F, Haxhibeqiri S, Haxhibeqiri V, Sabic Dzananovic E, Kucukalic S, Bravo Mehmedbasic A, Kucukalic A, Dzubur Kulenovic A, Feric Bojic E, Marjanovic D, Kravic N, Avdibegovic E, Muminovic Umihanić M, Jaksic N, Cima Franc A, Rudan D, Jakovljevic M, Babic R, Pavlovic M, Babic D, Aukst Margetic B, Bozina N, Sinanovic O, Ziegler C, Warrings B, Domschke K, Deckert J, Wolf C, and Vyshka G
- Subjects
- Armed Conflicts psychology, Bosnia and Herzegovina, Croatia, Exons genetics, Female, Humans, Kosovo, Male, Middle Aged, Minisatellite Repeats, Polymorphism, Genetic, Receptors, Dopamine D2 genetics, Receptors, Dopamine D4 genetics, Stress Disorders, Post-Traumatic genetics
- Abstract
Background: Posttraumatic stress disorder (PTSD) is a complex stress related disorder, that follows a severe traumatic experience, characterized with an intense sense of terror, fear, and helplessness. The aim of this study is to identify associations of genetic variations within candidate genes DRD2 and DRD4 with various PTSD related phenotypes. PTSD lifetime and PTSD current subjects were analyzed separately, each of them were analyzed in a Case/Control design, as well as regarding BSI and CAPS within cases only., Subjects and Methods: 719 (487 male, 232 female) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Hercegovina, Kosovo and Croatia were included in the study. Sociodemographic questionnaire, Clinician Administered PTSD Scale (CAPS) and the Brief Symptom Inventory (BSI) were used to collect clinical data., Results: The DRD2 rs1800497 variant and a variable number tandem repeat (VNTR) located in exon three of DRD4 were investigated for association with PTSD. In case control analyses we did not identify any significant associations. Within the PTSD current patients, we identified an association of DRD2 rs1800497 with BSI in the genotypic and the recessive model with the T allele as the risk allele., Conclusion: Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.
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- 2019
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45. The Second Mediterranean Seminar on Science Writing, Editing and Publishing (SWEP - 2018), Sarajevo, December 8th, 2018.
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Masic I, Jakovljevic M, Sinanovic O, Gajovic S, Spiroski M, Jusufovic R, Sokolovic S, Prnjavorac B, Zerem E, Djulbegovic B, Porovic S, Jankovic S, Hadzikadic M, Zunic L, Begic E, Nislic E, Begic N, Becirovic E, Cerovac A, Skrijelj V, and Nuhanovic J
- Published
- 2018
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46. Communication Difficulties as a Result of Dementia.
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Banovic S, Zunic LJ, and Sinanovic O
- Abstract
Introduction: Population aging increases the number of people with dementia. Dementia is a set of symptoms that include memory difficulties, learning difficulties, speech and language difficulties, disorientation in time and space, difficulties in understanding and behavioral changes. Dementia is not part of natural aging and needs to be understood as such and have to be recognized at time to provide adequate support for people with dementia., Aim: To present the importance of communication: To present communication difficulties which are the result of dementia; To present adaptations in the way of communicating with people with dementia., Material and Methods: The article has a descriptive character, and represents a review of the literature dealing with this topic., Results: Difficulties in area of language are a common symptom in people with dementia. Those communication difficulties are a consequence of nerve cell failure, and person with dementia should not be blamed of the symptoms that arise. People with dementia show lower results in the area of understanding and verbal expression, repetition, reading and writing. Syntax and phonology remain relatively intact in early stages, but semantic abilities are impaired., Conclusion: Communication for people with dementia and with people with dementia for all persons involved in care (including family members, medical staff and therapists, and members of the community) can be very challenging. It is often necessary to adapt the way of communication to avoid stress and negative feelings in a person with dementia. As the disease causing dementia progresses, communication problems are increasing as well. Many times caregivers and therapists are in situations where their communicative behavior (verbal, but also nonverbal) needs to show support, compassion, care, and desire to help.
- Published
- 2018
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47. Two year outcomes of poststroke writing and reading disorders.
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Zukic S, Sinanovic O, and Zonic L
- Subjects
- Adult, Aged, Dyslexia diagnosis, Female, Humans, Language Disorders classification, Language Disorders diagnosis, Logistic Models, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Vision Disorders etiology, Dyslexia etiology, Language Disorders etiology, Stroke complications, Writing
- Abstract
Poststroke language disorders are frequent and include aphasia, alexia, agraphia, and acalculia. These disorders refer to an acquired inability to read, write and calculate. In this study, we evaluated the two year outcomes of writing and reading disorders in poststroke patients, the natural course, recovery and mortality. We evaluated all the patients with stroke who were admitted to the Department of Neurology, University Clinical Centre Tuzla in period of six months, who developed poststroke alexia, agraphia, acalculia, or different combinations of these language disorders. Outcome of these patients was evaluated again after 24 months. For clinical assessment of alexia, agraphia, and acalculia we used Minnesota Test for Differential Diagnosis of Aphasia. We investigated 59 (30.5%) of 193 stroke patients with alexia, agraphia, acalculia, and combinations. Outcome of these patients after 24 months was: 37 (62.7%) died, 13 (22%) fully recovered, and 9 (15.3%) of them retained the same disorder or developed dementia or blindness. Binary logistic regression analysis showed that patients with combined language disorders had significantly higher mortality. The main factors influencing language disorders recovery in this study are initial severity of reading, writing and calculation impairment, age, neglect, and level of education.
- Published
- 2018
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48. Monoamine Oxidase A Gene Methylation and Its Role in Posttraumatic Stress Disorder: First Evidence from the South Eastern Europe (SEE)-PTSD Study.
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Ziegler C, Wolf C, Schiele MA, Feric Bojic E, Kucukalic S, Sabic Dzananovic E, Goci Uka A, Hoxha B, Haxhibeqiri V, Haxhibeqiri S, Kravic N, Muminovic Umihanic M, Cima Franc A, Jaksic N, Babic R, Pavlovic M, Warrings B, Bravo Mehmedbasic A, Rudan D, Aukst-Margetic B, Kucukalic A, Marjanovic D, Babic D, Bozina N, Jakovljevic M, Sinanovic O, Avdibegovic E, Agani F, Dzubur-Kulenovic A, Deckert J, and Domschke K
- Subjects
- Adult, Bosnia and Herzegovina, Croatia, Female, Humans, Kosovo, Male, Middle Aged, Severity of Illness Index, Sex Factors, DNA Methylation genetics, Epigenesis, Genetic genetics, Monoamine Oxidase genetics, Stress Disorders, Post-Traumatic genetics, Stress Disorders, Post-Traumatic physiopathology
- Abstract
Background: Posttraumatic stress disorder is characterized by an overactive noradrenergic system conferring core posttraumatic stress disorder symptoms such as hyperarousal and reexperiencing. Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the monoamine oxidase A gene exonI/intronI region was investigated for the first time regarding its role in posttraumatic stress disorder risk and severity., Methods: Monoamine oxidase A methylation was analyzed via direct sequencing of sodium bisulfite-treated DNA extracted from blood cells in a total sample of N=652 (441 male) patients with current posttraumatic stress disorder, patients with remitted posttraumatic stress disorder, and healthy probands (comparison group) recruited at 5 centers in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo. Posttraumatic stress disorder severity was measured by means of the Clinician-Administered Posttraumatic Stress Disorder Scale and its respective subscores representing distinct symptom clusters., Results: In the male, but not the female sample, patients with current posttraumatic stress disorder displayed hypermethylation of 3 CpGs (CpG3=43656362; CpG12=43656514; CpG13=43656553, GRCh38.p2 Assembly) as compared with remitted Posttraumatic Stress Disorder patients and healthy probands. Symptom severity (Clinician-Administered Posttraumatic Stress Disorder Scale scores) in male patients with current posttraumatic stress disorder significantly correlated with monoamine oxidase A methylation. This applied particularly to symptom clusters related to reexperiencing of trauma (cluster B) and hyperarousal (cluster D)., Conclusions: The present findings suggest monoamine oxidase A gene hypermethylation, potentially resulting in enhanced noradrenergic signalling, as a disease status and severity marker of current posttraumatic stress disorder in males. If replicated, monoamine oxidase A hypermethylation might serve as a surrogate marker of a hyperadrenergic subtype of posttraumatic stress disorder guiding personalized treatment decisions on the use of antiadrenergic agents.
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- 2018
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49. High Burden of Stroke Risk Factors in Developing Country: the Case Study of Bosnia-Herzegovina.
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Bender M, Jusufovic E, Railic V, Kelava S, Tinjak S, Dzevdetbegovic D, Mot D, Tresnjo M, Lakicevic S, Pejanovic-Skobic N, and Sinanovic O
- Abstract
Introduction: The burden of stroke has been increasing worldwide, especially in developing countries. Very few data regarding epidemiology of stroke are available in Bosnia and Herzegovina (BH)., Patients and Methods: We undertook a retrospective hospital-based study in all hospitals existing in five cantons and one district of BH. The patients were recruited between January 1
st , 2014, and December 31st , 2014, and only first-ever-in-lifetime strokes (FES) were included for evaluation., Results: A FES was diagnosed in 1479 patients (age 71.83 ± 11.703 years) during the study period. FES occurred in 709 men (47.9%; age 69.64 ±12.002 years) and 770 women (52.1%; age 73.85± 11.051 years). Stroke was categorized into ischemic stroke (IS), primary intracerebral hemorrhage (PICH), subarachnoid hemorrhage (SAH) and cerebral venous thrombosis (CVT), which was diagnosed in 84%, 12,2%, 3,4% and 0,4% cases respectively. Early 28-day case-fatality was 18.5 % for all patients and both sexes combined. Short-term case-fatality was significantly greater in women (P=0.007). Among all patients with FES, 87% had hypertension, 35% diabetes mellitus, 39% hypercholesterolemia and almost 25 % atrial fibrillation., Discussion: This is the first study that provides us with information on epidemiology of stroke in BH. More than 90% of patients had one or more modifiable risk factors and the number would be even higher if we included smoking. The early stroke case-fatality was lower than that observed in other low- to middle-income countries., Conclusion: All modifiable stroke risk factors, especially high blood pressure, should be understood as a major public health problem in BH and efforts should be focused on the primary prevention of stroke. Our emphasis is on the designing of a stroke register in BH for a better health planning., Competing Interests: • Conflict of interests: the authors declare no conflict of interest in this study.- Published
- 2017
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50. Emotional Profile of Women Victims of Domestic Violence.
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Avdibegovic E, Brkic M, and Sinanovic O
- Abstract
Introduction: Research indicates that women victims of domestic violence show significant cognitive changes, emotional numbing, and avoidance of interpersonal relationships., Aim: The aim of this research was to analyze emotional profile of women victims of domestic violence, and to determine the relationship between dimensions of emotions and frequency of women exposure to domestic violence., Methods: The research was conducted on the sample of 169 women, 111 were victims of domestic violence and 58 were women who did not experience domestic violence. Plutchik's Emotions Profile Index (EPI) was used for measuring of the emotion profile, and the Modified Inventory of Domestic Violence for measuring experiences of different types of violence. Basic socio-demographic data were also collected., Results: Significant differences between women victims of domestic violence and women who did not experience domestic violence were found in a few dimensions of emotional profile. Women victims of domestic violence had higher results in the dimensions of deprivation/depression and aggression/destruction, while women who did not experience domestic violence had higher results in dimensions of reproduction and incorporation. Aggression was in significant negative correlation with reproduction, incorporation and self protection, whereas it was significant positive correlation with deprivation and opposition. There were significant and positive correlation between the dimensions of aggression and deprivation and frequency of all three forms of domestic violence and age of women., Conclusion: According to results obtained in this research, it can be concluded that women victims of domestic violence have significantly more intensive negative emotional dimensions in comparison to women who were not abused. Women victims of domestic violence with higher frequency of abuse describe themselves as more sad, apathetic, lonely, angry, quarrelsome and less sociable. Prominence of negative emotions, deprivation and aggression, can be factor of risk for mental health disorders and for re-victimisation of women victims of domestic violence.
- Published
- 2017
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