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Your search keyword '"Sindic, C. J. M."' showing total 130 results
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130 results on '"Sindic, C. J. M."'

17. Treatment of Guillain-Barre syndrome with mycophenolate mofetil: a pilot study (vol 78, pg 1012, 2007)

Author

Garssen, M. P. J., van Koningsveld, R., van Doorn, P. A., Merkies, I. S. J., Scheltens-de Boer, M., van Leusden, J. A., van Schaik, I. N., Linssen, W. H. J. P., Visscher, F., Boon, A. M., Faber, C. G., Meulstee, J., Prick, M. J. J., van den Berg, L. H., Franssen, H., Hiel, J. A. P., van den Bergh, P. Y. K., Sindic, C. J. M., AII - Amsterdam institute for Infection and Immunity, ANS - Amsterdam Neuroscience, and Neurology

Published
2007

21. Paucisymptomatic brainstem lesions revealing CNS schistosomiasis

Author

Rommel, D., Ragé, M., Thierry Duprez, Parent, M., Sindic, C. J. M., UCL - Cliniques universitaires Saint-Luc, UCL - MD/RAIM - Département de radiologie et d'imagerie médicale, UCL - (SLuc) Service de radiologie, UCL - MD/NOPS - Département de neurologie et de psychiatrie, and UCL - (SLuc) Service de neurologie

Subjects
parasitic cerebral disease, cerebral schistosomiasis, Schistosomia mansoni, human activities
Abstract

We describe clinical and magnetic resonance (MR) features in a 69-year-old, Caucasian woman presenting with an unusual meningeal onset of cerebral schistosomiasis. Magnetic resonance work-up demonstrated supra- and infratentorial lesions with prominent brain-stem involvement contrasting with the paucisymptomatic clinical presentation. Because of a recent stay in Uganda, including swimming in Lake Victoria, a diagnosis of neuroschistosomiasis was suggested. Serological tests and rectal biopsy confirmed the putative diagnosis. The patient was successfully treated with praziquantel at a dose of 50 mg/kg/day for 15 days. Brain MRI abnormalities improved dramatically within two months.

Published
2005

24. CSF-Phospho-tau (181P) as a Promising Marker for Discriminating Alzheimer's Disease from Dementia with Lewy Bodies

Author

Vanmechelen, E., primary, Van Kerschaver, E., additional, Blennow, K., additional, De Deyn, P. P., additional, Galasko, D., additional, Parnetti, L., additional, Sindic, C. J. M., additional, Arai, H., additional, Riemenschneider, M., additional, Hampel, H., additional, Pottel, H., additional, Valgaeren, A., additional, Hulstaert, F., additional, and Vanderstichele, H., additional

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25. A double-blind clinical trial of mitoxantrone versus methylprednisolone in relapsing, secondary progressive multiple sclerosis

Author

Wyngaert, F. A., Beguin, C., Marie D'hooghe, Dooms, G., Lissoir, F., Carton, H., Sindic, C. J. M., Clinical sciences, Neuroprotection & Neuromodulation, and Neurology

Subjects
Adult, Male, Methylprednisolone/adverse effects, Patient Dropouts, Alopecia/chemically induced, Immunosuppressive Agents/adverse effects, Phlebitis/chemically induced, Vomiting/chemically induced, contrast media, Methylene Blue/therapeutic use, Severity of Illness Index, Nausea/chemically induced, Pyrrolidines/therapeutic use, Treatment Outcome, Double-Blind Method, Recurrence, Mitoxantrone/adverse effects, Humans, magnetic resonance imaging, Multiple Sclerosis/drug therapy, Female, Lymphocyte Count, Pulmonary Embolism/etiology, gadolinium, Follow-Up Studies
Abstract

A double-blind clinical trial of mitoxantrone versus methylprednisolone was performed in 49 patients with relapsing, secondary multiple sclerosis. Patients were randomized to receive 13 infusions of mitoxantrone 12 mg/m2 (n = 28), or 13 infusions of 1 g of methylprednisolone (n = 21), over 32 months. Twenty-four patients completed the trial. There were no statistical differences between the two groups of patients at study entry. A significant improvement in the Expanded Disability Scale Score (EDSS) was observed in the mitoxantrone group after one year of treatment (p < 0.0022). The total number of relapses, the mean number of relapses/patient/year, and the total number of gadolinium-enhanced lesions on bi-annual MRI scans were significantly decreased in the mitoxantrone group throughout the study period. Nausea, vomiting, and alopecia were more frequent in the mitoxantrone-treated patients. Mitoxantrone has a role in the treatment of MS patients with frequent exacerbations and rapid disease progression.

Published
2001

26. Rate of pregnancy-related relapse in multiple sclerosis

Author

Confavreux C, Hutchinson M, Hours, Mm, Cortinovis Tourniaire, P, Alpérovitch, Moreau T. A., Carton, H., D’Hooghe, M. B., Hommes, O., Biron, A., Grimaud, J., Chauplannaz, G., Latombe, D., Clanet, M., Glau, G. Lau, Rumbach, L., Goas, J. Y., Rouhart, F., Ingue, A. Maz, Roullet, E., Madigand, M., Hautecoeur, P., Brunet, P., Edan, G., Allaire, C., Riffault, G., Leche, J., Benoit, T., Simonin, C., Ziegler, F., Baron, J. C., Rivrain, Y., Dumas, R., Loche, D., Bourrin, J. C., Huttin, B., Delisse, B., Gibert, I., Boulay, C., Verceletto, M., Durand, G., Bonneviot, G., Gil, R., Hedreville, M. A., Cbelair, C. Belair, Poitevin, R. J., Devoize, J. L., Pwyremblewski, P. Wyremblewski, Delestre, F., Setiey, A., Comi, G., Fillippi, M., Ghezzi, A., Martinelli, V., Rossi, P., Zaffaroni, M., Tola, M. R., Amato, M. P., Fioretti, C., Gmeucci, G. Meucci, Inglese, MARIA MATILDE, Mancardi, GIOVANNI LUIGI, Gambi, D., Thomas, A., Cavazzuti, M., Citterio, A., Aheltberg, A. Heltberg, Hansen, H. J., Fernandez, O., Romero, F., Arbizu, T., Hernandez, J. J., Frutos, C. De Andres de, Sclarky, D. Geffner, Benito, Y. Aladro, Yanez, P. Reyes, Aguilar, M., Burguera, J. A., Yaya, R., Dib, W. Bowakim, Sindic, C. J. M., Medaer, R., Roose, H., Geens, K. M. J., Guillaume, D., Zandycke, M. Van, Janssens, J., Cornette, M., Mol, L., Weilbach, F., Flachenecke, P., Hartung, H. P., Haas, J., Tendolkar, I., Sindern, E., Kölmel, H. W., Reichel, D., Rauch, M., Preuss, S., Poser, S., Mauch, E., Strasser Fuchs, S., Kollegger, H., Hawkins, S., Howell, S. J. L., Rees, J. E., Thompson, A., Johnson, M., Boggild, M., Gregory, R. P., Bates, D., Bone, I., Polman, C., Frequin, S., Jongen, P., J. Correia de, Sa, Rio, M. E., Huber, S., Lechner Scott, J., Confavreux, C, Hutchinson, M, Hours, Mm, Cortinovis Tourniaire, P, Moreau, T, the Pregnancy in Multiple Sclerosis, Group, Filippi, Massimo, and Comi, Giancarlo

Subjects
Adult, medicine.medical_specialty, Multiple Sclerosis, Obstetrical, Disease, Relapse rate, Kurtzke Expanded Disability Status Scale, Central nervous system disease, Pregnancy, Recurrence, medicine, Humans, Prospective Studies, Severe disability, Prospective cohort study, Post partum, Analgesia, Epidural, Analgesia, Obstetrical, Breast Feeding, Disease Progression, Female, Postpartum Period, Pregnancy Complications, Medicine (all), business.industry, Obstetrics, Multiple sclerosis, General Medicine, medicine.disease, Surgery, First trimester, Epidural, Gestation, Analgesia, business, Complication, Breast feeding, Postpartum period
Abstract

Background and Methods Multiple sclerosis often occurs in young women, and the effect of pregnancy on the disease is poorly understood. We studied 254 women with multiple sclerosis during 269 pregnancies in 12 European countries. The women were followed during their pregnancies and for up to 12 months after delivery to determine the rate of relapse per trimester and the score on the Kurtzke Expanded Disability Status Scale (range, 0 to 10, with higher scores indicating more severe disability). The relapse rate in each trimester was compared with the rate during the year before the pregnancy. The effects of epidural analgesia and breast-feeding on the frequency of relapse during the first three months post partum and the disability score at 12 months post partum were also determined. Results The mean (±SD) rate of relapse was 0.7±0.9 per woman per year in the year before pregnancy; it was 0.5±1.3 during the first trimester (P=0.03 for the comparison with the rate before pregnancy), 0.6±1.6 during the secon...

Published
1998

30. Quality Assurance for Cerebrospinal Fluid Protein Analysis: International Consensus by an Internet-Based Group Discussion

Author

Reiber, H., primary, Thompson, E. J., additional, Grimsley, G., additional, Bernardi, G., additional, Adam, P., additional, Almeida, S. Monteiro de, additional, Fredman, P., additional, Keir, G., additional, Lammers, M., additional, Liblau, R., additional, Menna-Barreto, M., additional, Sá, M. J., additional, Seres, E., additional, Sindic, C. J. M., additional, Teelken, A., additional, Trendelenburg, C., additional, Trojano, M., additional, Antwerpen, M. van, additional, and Verbeek, M. M., additional

Published
2003
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32. CSF-Phospho-tau (181P) as a Promising Marker for Discriminating Alzheimer's Disease from Dementia with Lewy Bodies.

Author

Vanmechelen, E., Van Kerschaver, E., Blennow, K., De Deyn, P. P., Galasko, D., Parnetti, L., Sindic, C. J. M., Arai, H., Riemenschneider, M., Hampel, H., Pottel, H., Valgaeren, A., Hulstaert, F., and Vanderstichele, H.

Subjects
DEMENTIA, NEUROBEHAVIORAL disorders, LEWY body dementia, ALZHEIMER'S disease, BIOMARKERS, CEREBROSPINAL fluid
Abstract

Increased levels of the microtuble-associated protein tau in cerebrospinal fluid is a consistent finding in more than 80% of patients with Alzheimer's disease. As tau protein accumulates in the Alzheimer's disease brain in a hyperphosphorylated form, the determination of phosphorylated tau in cerebrospinal fluid as opposed to total tau might increase the assay specificity. Several recent studies suggest, but do not yet clearly demonstrate, that assays based on phospho-tau are more specific for Alzheimer's disease than those based on total tau. For this reason, the phospho-tau (181P-specific assay) was evaluated in Alzheimer's disease and closely related dementia. Since the relative absence of phosphorylated tau biochemically distinguishes senile dementia with Lewy bodies from Alzheimer's disease, our primary aim was to determine whether there is a significant difference in phospho-tau levels between these two forms of dementia. [ABSTRACT FROM PUBLISHER]

Published
2001

37. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report.

Author

Andersson, M., primary, Alvarez-Cermeno, J., additional, Bernardi, G., additional, Cogato, I., additional, Fredman, P., additional, Frederiksen, J., additional, Fredrikson, S., additional, Gallo, P., additional, Grimaldi, L. M., additional, Gronning, M., additional, Keir, G., additional, Lamers, K., additional, Link, H., additional, Magalhaes, A., additional, Massaro, A. R., additional, Ohman, S., additional, Reiber, H., additional, Ronnback, L., additional, Schluep, M., additional, Schuller, E., additional, Sindic, C. J. M., additional, Thompson, E. J., additional, Trojano, M., additional, and Wurster, U., additional

Published
1994
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38. Anti-α-glucose--based glycan IgM antibodies predict relapse activity in multiple sclerosis after the first neurological event.

Author

Freedman, M. S., Laks, J., Dotan, N., Altstock, R. T., Dukler, A., and Sindic, C. J. M.

Subjects
MULTIPLE sclerosis research, IMMUNOFLUORESCENCE, PROGNOSIS, DISEASE relapse, IMMUNOGLOBULINS
Abstract

Background There is no specific serum-based biomarker for the diagnosis or prognosis of relapsing-remitting multiple sclerosis (RRMS). Objective We investigated whether levels of IgM antibodies to Glc(a1,4)Glc(a) (GAGA4) or to a panel of four glucose-based glycans could differentiate MS from other neurological diseases (OND) or predict risk of early relapse following first presentation (FP) of RRMS. Methods Retrospective analysis of 440 sera samples of three cohorts: A) FP-RRMS (n = 44), OND (n = 44); B) FP-RRMS (n = 167), OND (n = 85); and C) FP (n = 100). Anti-GAGA4 IgM levels were measured by enzyme immunoassay in cohort-A and cohort-B. Cohort-C IgM antibodies to glucose-based glycan panel were measured by immunofluorescence. Results FP-RRMS had higher levels of anti-GAGA4 IgM than OND patients (cohort-A, P = 0.01; cohort-B, P = 0.0001). Sensitivity and specificity were 27% and 97% for cohort-A; and 26% and 90% for cohort-B, respectively. In cohort-C, 58 patients experienced early relapse (<24 months), 31 had late relapse (≥24 months), and 11 did not experience second attack during follow-up. Kaplan-Meier curves demonstrated decrease in time to next relapse for patients positive for the antibody panel (P = 0.02, log rank). Conclusions Serum anti-GAGA4 IgM discerns FP-RRMS patients from OND patients. Higher levels of serum anti-α-glucose IgM in FP patients predict imminent early relapse. [ABSTRACT FROM AUTHOR]

Published
2009
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39. Paraneoplastic Rhombencephalitis and Brachial Plexopathy in Two Cases of Amphiphysin Auto-Immunity.

Author

Coppens, T., Van den Bergh, P., Duprez, T. J., Jeanjean, A., De Ridder, F., and Sindic, C. J. M.

Subjects
PARANEOPLASTIC syndromes, ENCEPHALITIS, AUTOIMMUNITY, CRANIAL nerves, BREAST cancer, NEUROPATHY
Abstract

Amphiphysin, a synaptic vesicle protein, is an auto-immune target in rare cases of paraneoplastic neurological disorders. We report two additional cases with distinct neurological syndromes and paraneoplastic anti-amphiphysin antibodies. The first patient, a 59-year-old man, presented with cerebellar and cranial nerve dysfunction and small cell lung carcinoma. The second, a 77-year- old woman, presented with left brachial plexopathy followed by sensorimotor neuropathy and breast carcinoma. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2006
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40. The elution of IgG from subacute sclerosing panencephalitis and multiple sclerosis brains.

Author

Sindic, C. J. M., Cambiaso, C. L., Masson, P. L., and Laterre, E. C.

Subjects
*IMMUNOGLOBULIN G, *MULTIPLE sclerosis, *VIRUS diseases, *SUBACUTE sclerosing panencephalitis, *ENCEPHALITIS, *MEASLES complications
Abstract

IgG was extracted from sections of a multiple sclerosis brain by repeated washing with phosphate-buffered saline. After this extraction, no IgG was recovered by further washing at pH 2.2. This indicates that the IgG of the plaques has no strong affinity for insoluble constituents of the brain. Sections of a subacute sclerosing panencephalitis brain were used as positive controls: after repeated extraction with phosphate-buffered saline, IgG with anti-measles antibody activity was eluted at acid pH. [ABSTRACT FROM AUTHOR]

Published
1980

41. The binding of myelin basic protein to the Fc region of aggregated IgG and to immune complexes.

Author

Sindic, C. J. M., Cambiaso, C. L., Masson, P. L., and Laterre, E. C.

Subjects
*MYELIN proteins, *IMMUNOGLOBULINS, *NERVE tissue proteins, *AGGLUTINATION, *ANTIGEN-antibody reactions, *ALKYLATION
Abstract

Bovine myelin basic protein was found to agglutinate polystyrene particles coated with human polyclonal IgG, monoclonal IgG1, or IgG Fc fragments, but not those coated with IgG F(ab′)2 fragments, IgA, or IgM. The agglutination of Fc-coated particles was inhibited by heat-aggregated polyclonal IgG or monoclonal IgG2, IgG3 and IgG4, but not by native IgG. Reduction and alkylation of aggregated IgG did not affect their inhibitory activities. Soluble immune complexes displayed the highest inhibitory activity at a two-fold antigen excess. The interaction between myelin basic protein and aggregated IgG was confirmed by gel exclusion experiments on Sephadex G-200, The possible consequence of these findings could be significant in the interpretation of IgG deposits in brain plaques of multiple sclerosis patients and of the results of immunohistochemical studies, titration of anti-myelin basic protein antibodies and immunoassay of myelin basic protein. [ABSTRACT FROM AUTHOR]

Published
1980

42. Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.

Author

Houssiau, F. A., Bukasa, K., Sindic, C. J. M., Van Damme, J., and Van Snick, J.

Subjects
PROTEINS, INTERLEUKIN-6, INTERFERONS, CENTRAL nervous system, B cells, HYBRIDOMAS, LYMPHOKINES
Abstract

We reported recently that a human protein, previously described as IL- I inducible 26K factor (26K) or interferon-β2, was a potent growth factor for B cell hybridomas in vitro, Subsequently, it appeared that this protein was also identical with the lymphokine B cell stimulatory factor 2. Here we report that the levels of 26K are considerably increased during the early stages of acute infections of the central nervous system. This elevation in 26K titres was not observed in either chronic infections or in non-infectious diseases. [ABSTRACT FROM AUTHOR]

Published
1988

48. Short-term brain volume change in relapsing-remitting multiple sclerosis: Effect of glatiramer acetate and implications

Author

Rovaris, M., Comi, G., Rocca, M. A., Wolinsky, J. S., Filippi, M., Guillaume, D., D Harcour, J. B., Sindic, C. J. M., Thierry Duprez, Truyen, L., Nagels, G., Parizel, P. M., Sanders, E. A. C. M., Versteylen, R. J., Rice, G., Kennedy, K., Metz, L., Patry, D., Yeung, M., Davis, A., Curtis, S., Francis, G., Arnold, D. L., Leroux, G., Lyon-Caen, O., Tourbah, A., Bataillard, M., Kraehenbuhl, I. R., Cabanis, E. A., Bracard, S., Debouverie, M., Anxionnat, R., Storch-Hagenlocher, B., Sartor, K., Gehlen, W., Schmidt, A., Weiller, C., Behrendt, W., Zaffaroni, M., Fieschi, C., Bastianello, S., Capra, R., Gasparotti, R., Mancardi, G. L., Inglese, M., Sardanelli, F., Cosi, V., Uggetti, C., Zappoli, F., Hawkins, C. P., Haq, N., Barnes, D., Clifton, A., Bates, D., Coulthard, A., Perkin, G., Colquhoun, I., Young, C. A., Nixon, T., Francis, D., Yates, D., Neary, D., Jackson, A., Blumhardt, L. D., Jaspan, T., Brenner, R., Valentine, A., Pye, I., and Cherryman, G.

49. Diagnostic and therapeutic pitfalls in neurosarcoïdosis

Author

Visée, H., Thierry Duprez, Godfraind, C., Sindic, C. J. M., UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de neurologie, and UCL - MD/RAIM - Département de radiologie et d'imagerie médicale

Subjects
Male, Adult, Young Adult, Spinal Cord, Sarcoidosis, Humans, Brain, Nervous System Diseases, Magnetic Resonance Imaging
Abstract

Neurosarcoidosis is a diagnostic challenge, especially in the absence of systemic involvement, even when cerebral biopsies show noncaseating granulomas. We report a patient with a pineal germinoma associated with a extensive peri- and intra- tumoural granulomatous reaction, who was first diagnosed as possible neurosarcoïdosis. A second patient was initially considered as suffering from Multiple Sclerosis. Brain biopsy showed typical granulomas and gallium scintigraphy revealed other locations of the disease. Unfortunately, he developed a severe, steroid-induced, epidural lipomatosis at the Th3-Th8 levels and died unexpectedly after surgical decompression. Granulomatous inflammation in a tissue obtained by biopsy from a midline lesion should be always considered for the differential diagnosis of germinoma. Corticosteroid-sparing immunosuppressant drugs should be used early in neurosarcoïdosis.

50. Short-term correlations between clinical and MR imaging findings in relapsing-remitting multiple sclerosis

Author

Rovaris, M., Comi, G., Ladkani, D., Wolinsky, J. S., Filippi, M., Guillaume, D., D Harcour, J. B., Sindic, C. J. M., Duprez, T. P. J., Truyen, L., Nagels, G., Parizel, P. M., Sanders, E. A. C. M., Versteylen, R. J., Rice, G., Kennedy, K., Metz, L., Patry, D., Yeung, M., Davis, A., Curtis, S., Francis, G., Arnold, D. L., Leroux, G., Lyon-Caen, O., Tourbah, A., Bataillard, M., Kraehenbuhl, I. R., Cabanis, E. A., Bracard, S., Debouverie, M., Anxionnat, R., Storch-Hagenlocher, B., Sartor, K., Gehlen, W., Schmidt, A., Weiller, C., Behrendt, W., Ghezzi, A., Fieschi, C., Bastianello, S., Capra, R., Gasparotti, R., Mancardi, G. L., Inglese, M., Sardanelli, F., Cosi, V., Uggetti, C., Zappoli, F., Hawkins, C. P., Haq, N., Barnes, D., Clifton, A., Bates, D., Coulthard, A., Perkin, G., Colquhoun, I., Young, C. A., Nixon, T., Francis, D., Yates, D., Neary, D., Jackson, A., Blumhardt, L. D., Jaspan, T., Brenner, R., Valentine, A., Pye, I., Cherryman, G., Barkhof, F., Horsfield, M. A., Johnson, K. P., Hommes, O., Feigin, P., Stark, Y., Michael Gurevich, Kadosh, S., Zak, B., and Pinchassi, I.

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