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459 results on '"Singh, Dharam"'

5. Speech-to-Speech Translation Using Transformer Neural Network

Author

Kashyap, Suryakant, Singh, Shailendra, Singh, Dharam Vir, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Pant, Millie, editor, Deep, Kusum, editor, and Nagar, Atulya, editor

Published
2024
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35. Lysine and citric acid based pegylated polymeric dendritic nano drug delivery carrier and their bioactivity evaluation.

Author

Chand, Avtar, Kumar, Subhash, Kapoor, Smita, Singh, Dharam, and Gaur, Bharti

Subjects
ESCHERICHIA coli, ERYTHROCYTES, SURFACE topography, GRAM-positive bacteria, GRAM-negative bacteria, CITRIC acid
Abstract

The main objective of this work is to synthesize multifunctional nanodendritic structural molecules that can effectively encapsulate hydrophilic as well as hydrophobic therapeutic agents. Four different types of fourth-generation lysine-citric acid based dendrimer have been synthesized in this work: PE-MC-Lys-CA-PEG, TMP-MC-Lys-CA-PEG, PE-MS-Lys-CA-PEG, and TMP-MS-Lys-CA-PEG. The antibacterial drug cefotaxime (CFTX) was further conjugated to these dendrimers. The dendrimer and drug-dendrimer conjugate structures were characterized with the help of FTIR,1H-NMR, and 13C-NMR spectroscopy. Zeta sizer, AFM, and HR-TEM techniques were used to investigate the particle size, surface topography, and structural characteristics of drug-dendrimer conjugates. In vitro drug release was then investigated using dialysis method. Various kinetic drug release models were examined to evaluate the type of kinetic drug release mechanism of the formulations. Cytotoxicity study revealed that the dendrimers encapsulated with CFTX exhibited 2-3% toxicity against healthy epithelial cells, indicating their safe use. Plain dendrimers show 10-15% hemolytic toxicity against red blood cells (RBC), and the toxicity was reduced to 2-3% when CFTX was conjugated to the same dendrimers. The 3rd and 4th generation synthesized drug-dendrimer conjugates exhibit a significantly effective zone of inhibition (ZOI) against both Gram-positive and Gram-negative bacteria. For Gram-positive bacteria, the lower concentration of 0.1 mg/mL showed more than 98% inhibition of drug-dendrimer conjugate samples against B. subtilis and more than 50% inhibition against S. aureus using 0.2 mg/mL, respectively. Moreover, samples with concentrations of 0.5 and 1.0 mg/mL exhibited more than 50% inhibition against S. typhimurium and E. coli, respectively. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Thermohydraulic performance parameter based experimental investigation of frustum shaped roughened solar air heater.

Author

Singh, Dharam and Kumar, Vikash

Subjects
SOLAR air heaters, NUSSELT number, REYNOLDS number, THERMAL hydraulics
Abstract

An outdoor experimental investigation was conducted to explore the thermohydraulic characteristic (Nusselt no. and friction factor) of artificial roughened solar air heater (ARSAH) having frustrum shaped roughened element on absorber plate. Data were recorded and further processed to generate Nusselt number and friction factor correlation to predict the effect of flow and roughness parameter on performance of ARSAH. The investigation was conducted by varying Reynolds number in range of 2500–12,500. Dimensionless parameter for Frustrum shaped roughness was relative frustum height (e/Dh) from 0.013 to 0.054, relative frustum pitch (p/e) from 8 to 14, Relative frustum height to base diameter (e/d1) from 0.37 to 0.75, relative frustum diametral ratio (d1/d2) from 1 to 3. Maximum performance for ARSAH was obtained corresponding to the optimum value of flow and geometric parameter. The geometric orientation of the proposed roughness geometry produced tremendous rise in Nu with an acceptable rise in friction (f). Maximum enhancement in Nu for varying p/e, e/Dh, e/d1, and d1/d2 was, 4.58, 5.21, 6.62 and 6.09 times and that of friction was 5.59, 4.69, 4.92 and 4.66 times respectively over conventional SAH. Maximum Thermohydraulic performance was 3.7, 3.6, 3.9 and 3.8 at p/e = 12, e/Dh = 0.054, e/d1 = 0.75 and d1/d2 = 3. [ABSTRACT FROM AUTHOR]

Published
2024
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