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10. Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

Author

Torta, Federico, Hoffmann, Nils, Burla, Bo, Alecu, Irina, Arita, Makoto, Bamba, Takeshi, Bennett, Steffany A. L., Bertrand-Michel, Justine, Brügger, Britta, Cala, Mónica P., Camacho-Muñoz, Dolores, Checa, Antonio, Chen, Michael, Chocholoušková, Michaela, Cinel, Michelle, Chu-Van, Emeline, Colsch, Benoit, Coman, Cristina, Connell, Lisa, Sousa, Bebiana C., Dickens, Alex M., Fedorova, Maria, Eiríksson, Finnur Freyr, Gallart-Ayala, Hector, Ghorasaini, Mohan, Giera, Martin, Guan, Xue Li, Haid, Mark, Hankemeier, Thomas, Harms, Amy, Höring, Marcus, Holčapek, Michal, Hornemann, Thorsten, Hu, Chunxiu, Hülsmeier, Andreas J., Huynh, Kevin, Jones, Christina M., Ivanisevic, Julijana, Izumi, Yoshihiro, Köfeler, Harald C., Lam, Sin Man, Lange, Mike, Lee, Jong Cheol, Liebisch, Gerhard, Lippa, Katrice, Lopez-Clavijo, Andrea F., Manzi, Malena, Martinefski, Manuela R., Math, Raviswamy G. H., Mayor, Satyajit, Meikle, Peter J., Monge, María Eugenia, Moon, Myeong Hee, Muralidharan, Sneha, Nicolaou, Anna, Nguyen-Tran, Thao, O’Donnell, Valerie B., Orešič, Matej, Ramanathan, Arvind, Riols, Fabien, Saigusa, Daisuke, Schock, Tracey B., Schwartz-Zimmermann, Heidi, Shui, Guanghou, Singh, Madhulika, Takahashi, Masatomo, Thorsteinsdóttir, Margrét, Tomiyasu, Noriyuki, Tournadre, Anthony, Tsugawa, Hiroshi, Tyrrell, Victoria J., van der Gugten, Grace, Wakelam, Michael O., Wheelock, Craig E., Wolrab, Denise, Xu, Guowang, Xu, Tianrun, Bowden, John A., Ekroos, Kim, Ahrends, Robert, and Wenk, Markus R.

Published
2024
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33. Recent trends in irrigation in endodontics.

Author

Singh, Madhulika, Sawhny, Asheesh, Kushwaha, Annu, Singh, Prateek, and Singh, Richa

Subjects
*ROOT canal treatment, *IRRIGATION (Medicine), *DENTAL pulp cavities, *SODIUM hypochlorite, *IRRIGATION
Abstract

Local wound debridement within the diseased pulp space is a crucial step in root canal treatment to prevent the tooth from becoming a source of infection. The success of root canal therapy relies on a combination of proper instrumentation, irrigation, and obturation of the root canal. Among these essential steps, irrigation plays the most significant role in promoting the healing of periapical tissues. During the procedure, the root canal is shaped under continuous irrigation to remove inflamed and necrotic tissues, microbes, biofilms, and other debris. However, no single irrigating solution can fulfill all the required functions. Optimal irrigation is achieved through the combined use of two or more solutions in a specific sequence to ensure safe and effective results. This article explores various irrigants, their ideal properties, and the latest advancements in irrigation solutions. [ABSTRACT FROM AUTHOR]

Published
2025

34. Sterilization in Endodontics : A newer concept.

Author

Singh, Madhulika, Sawhny, Asheesh, Kushwaha, Annu, Singh, Prateek, and Singh, Richa

Subjects
*STERILIZATION (Disinfection), *BLOODBORNE infections, *HEPATITIS B, *INFECTION control, *ENDODONTICS
Abstract

The endodontic procedure involves several steps, including isolating the tooth using a rubber dam, creating an access cavity with burs, cleaning and shaping the canal, and compactly obturating the canal. Throughout each phase, sterilization of instruments is essential to prevent blood-borne diseases such as HIV, Hepatitis B, and other infections. Proper understanding and adherence to sterilization protocols at every stage are crucial for effective infection control. Sterilization involves the complete removal of microorganisms and spores from treated surfaces, with autoclave-based heat sterilization being the most commonly used method. Before the invention of the autoclave, the dry heat method was widely employed in dentistry. This review highlights the various sterilization methods used in endodontics. [ABSTRACT FROM AUTHOR]

Published
2025

45. Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Author

Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J, Ermens, Anton A M, Harms, Amy C, Portengen, Lutzen, Vermeulen, Roel C H, Dik, Willem A, Langerak, Anton W, van der Velden, Vincent H J, Hankemeier, Thomas, Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J, Ermens, Anton A M, Harms, Amy C, Portengen, Lutzen, Vermeulen, Roel C H, Dik, Willem A, Langerak, Anton W, van der Velden, Vincent H J, and Hankemeier, Thomas

Abstract

The severity of COVID-19 is linked to an imbalanced immune response. The dysregulated metabolism of small molecules and bioactive lipids has also been associated with disease severity. To promote understanding of the disease biochemistry and provide targets for intervention, we applied a range of LC-MS platforms to analyze over 100 plasma samples from patients with varying COVID-19 severity and with detailed clinical information on inflammatory responses (>30 immune markers). This is the third publication in a series, and it reports the results of comprehensive lipidome profiling using targeted LC-MS/MS. We identified 1076 lipid features across 25 subclasses, including glycerophospholipids, sterols, glycerolipids, and sphingolipids, among which 531 lipid features were dramatically changed in the plasma of intensive care unit (ICU) patients compared to patients in the ward. Patients in the ICU showed 1.3-57-fold increases in ceramides, (lyso-)glycerophospholipids, diglycerides, triglycerides, and plasmagen phosphoethanolamines, and 1.3-2-fold lower levels of a cyclic lysophosphatidic acid, sphingosine-1-phosphates, sphingomyelins, arachidonic acid-containing phospholipids, lactosylceramide, and cholesterol esters compared to patients in the ward. Specifically, phosphatidylinositols (PIs) showed strong fatty acid saturation-dependent behavior, with saturated fatty acid (SFA)- and monosaturated fatty acid (MUFA)-derived PI decreasing and polystaturated (PUFA)-derived PI increasing. We also found ~4000 significant Spearman correlations between lipids and multiple clinical markers of immune response with |R| ≥ 0.35 and FDR corrected Q < 0.05. Except for lysophosphatidic acid, lysophospholipids were positively associated with the CD4 fraction of T cells, and the cytokines IL-8 and IL-18. In contrast, sphingosine-1-phosphates were negatively correlated with innate immune markers such as CRP and IL-6. Further indications of metabolic changes in moderate COVID-19 di

Published
2024

46. Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients

Author

IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J, Ermens, Anton A M, Harms, Amy C, Portengen, Lutzen, Vermeulen, Roel C H, Dik, Willem A, Langerak, Anton W, van der Velden, Vincent H J, Hankemeier, Thomas, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Zhang, Zhengzheng, Karu, Naama, Kindt, Alida, Singh, Madhulika, Lamont, Lieke, van Gammeren, Adriaan J, Ermens, Anton A M, Harms, Amy C, Portengen, Lutzen, Vermeulen, Roel C H, Dik, Willem A, Langerak, Anton W, van der Velden, Vincent H J, and Hankemeier, Thomas

Published
2024

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