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4. Polarization independent lattice-coupled terahertz toroidal excitations

Author

Bhattacharya, Angana, Chouhan, Bhagwat S., Bhowmik, Bhairov K., Singh, Rajan, and Kumar, Gagan

Subjects
Physics - Optics
Abstract

The toroidal dipole excitation is an important field for metamaterial research because of their low-loss attribute. In this study, we demonstrate numerically and experimentally, a unique polarization independent terahertz metamaterial that modulates a broad resonance into a sharp mode by coupling the inherent toroidal dipole excitation to the lattice mode of the metasurface. The advantage of polarization independence in the metasurface enables the excitation of lattice-coupled toroidal mode for both the transverse electric and transverse magnetic modes of the incident terahertz radiation. The interaction of the two dark low-loss modes results in the significant enhancement of the quality factor of the metasurface at the point of resonance matching. Such a polarization independent lattice-matched toroidal excitation-based device has the potential to impact the development of low loss terahertz component for ultrasensitive sensors, low loss equipment, and slow light devices for enhanced light matter interaction., Comment: 6 figures, 4 pages

Published
2023
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5. Observation of tunable discrete time crystalline phases

Author

Sarkar, Arnab, Anurag, Singh, Rajan, Makki, Aamir A., Mondal, Javed A., Rathi, Ateesh K., Nicholl, Ryan J. T., Chakraborty, Sagar, Bolotin, Kirill I., and Ghosh, Saikat

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Discrete time crystals (DTCs) are emergent non-equilibrium phases of periodically driven many-body systems, with potential applications ranging from quantum computing to sensing and metrology. There has been significant recent interest in understanding mechanisms leading to DTC formation and a search for novel DTC phases beyond subharmonic entrainment. Here, we report observation of multiple DTC phases in a nanoelectromechanical system (NEMS) based on coupled graphene and silicon nitride membranes. We confirm the time-crystalline nature of these symmetry broken phases by establishing their many-body characters, long-range time and spatial order, and rigidity against parameter fluctuation or noise. Furthermore, we employ controlled mechanical strain to drive the transitions between phases with different symmetries, thereby mapping the emergent time-crystalline phase diagram. Overall, our work takes a step towards establishing time crystals as a system with complexity rivaling that of solid state crystals., Comment: 8 pages, 4 figures

Published
2023

7. Re-assessment of Existing Offshore Platform for Life Extension

Author

Singh, Shikha, Singh, Rajan, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Nehdi, Moncef, editor, Hung, Mo Kim, editor, Venkataramana, Katta, editor, Antony, Jiji, editor, Kavitha, P. E., editor, and Beena B R, editor

Published
2024
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8. Investigation of Normally-Off β-Ga2O3 Power MOSFET Using Ferroelectric Gate

Author

Singh, Rajan, Purnachandra Rao, G., Lenka, Trupti Ranjan, Prasad, S. V. S., Dasari, Kiran, Singh, Pulkit, Nguyen, Hieu Pham Trung, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Tan, Kay Chen, Series Editor, Lenka, Trupti Ranjan, editor, Saha, Samar K., editor, and Fu, Lan, editor

Published
2024
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15. Designing of Ternary to Binary Half Adder Using CMOS

Author

Singh, Rajan, Kumar, Bittu, Dasari, Kiran, Prasad, S. V. S., Maneela, Kota, Gadi, Bhagavathi, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Nagaria, R. K., editor, Tripathi, V. S., editor, Zamarreno, Carlos Ruiz, editor, and Prajapati, Yogendra Kumar, editor

Published
2023
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16. Optimized RTL Design of a Vending Machine Through FSM Using Verilog HDL

Author

Chidananda Datta, Pulumati, Vinay Kumar, Chappa, Singh, Rajan, Mummaneni, Kavicharan, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Lenka, Trupti Ranjan, editor, Misra, Durgamadhab, editor, and Fu, Lan, editor

Published
2023
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18. Operation Principle of AlGaN/GaN HEMT

Author

Rao, G. Purnachandra, Singh, Rajan, Lenka, Trupti Ranjan, Kaushik, Brajesh Kumar, Series Editor, Kolhe, Mohan Lal, Series Editor, Lenka, Trupti Ranjan, editor, and Nguyen, Hieu Pham Trung, editor

Published
2023
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29. Novel Roles of Follistatin/Myostatin in Transforming Growth Factor-β Signaling and Adipose Browning: Potential for Therapeutic Intervention in Obesity Related Metabolic Disorders

Author

Pervin, Shehla, Reddy, Srinivasa T, and Singh, Rajan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition, Diabetes, Obesity, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Cardiovascular, Cancer, Metabolic and endocrine, Stroke, Adipose Tissue, Beige, Adipose Tissue, Brown, Animals, Energy Metabolism, Fibronectins, Follistatin, Follistatin-Related Proteins, Humans, Ligands, Metabolic Diseases, Mice, Myostatin, Signal Transduction, Thermogenesis, Transforming Growth Factor beta1, Uncoupling Protein 1, follistatin, myostatin, obesity, transforming growth Factor &#946, UCP1, adipose tissue, transforming growth Factor β, Nutrition and Dietetics, Clinical sciences
Abstract

Obesity is a global health problem and a major risk factor for several metabolic conditions including dyslipidemia, diabetes, insulin resistance and cardiovascular diseases. Obesity develops from chronic imbalance between energy intake and energy expenditure. Stimulation of cellular energy burning process has the potential to dissipate excess calories in the form of heat via the activation of uncoupling protein-1 (UCP1) in white and brown adipose tissues. Recent studies have shown that activation of transforming growth factor-β (TGF-β) signaling pathway significantly contributes to the development of obesity, and blockade or inhibition is reported to protect from obesity by promoting white adipose browning and increasing mitochondrial biogenesis. Identification of novel compounds that activate beige/brown adipose characteristics to burn surplus calories and reduce excess storage of fat are actively sought in the fight against obesity. In this review, we present recent developments in our understanding of key modulators of TGF-β signaling pathways including follistatin (FST) and myostatin (MST) in regulating adipose browning and brown adipose mass and activity. While MST is a key ligand for TGF-β family, FST can bind and regulate biological activity of several TGF-β superfamily members including activins, bone morphogenic proteins (BMP) and inhibins. Here, we review the literature supporting the critical roles for FST, MST and other proteins in modulating TGF-β signaling to influence beige and brown adipose characteristics. We further review the potential therapeutic utility of FST for the treatment of obesity and related metabolic disorders.

Published
2021

30. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth

Author

Jimenez, Thalia, Friedman, Theodore, Vadgama, Jaydutt, Singh, Vineeta, Tucker, Alexandria, Collazo, Javier, Sinha, Satyesh, Hikim, Amiya Sinha, Singh, Rajan, and Pervin, Shehla

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Breast Cancer, Obesity, Nutrition, Prevention, Women's Health, Tobacco Smoke and Health, Tobacco, 2.1 Biological and endogenous factors, Aetiology, Animal Feed, Animals, Anti-Inflammatory Agents, Breast Neoplasms, Cell Line, Tumor, Cell Proliferation, Diet, High-Fat, Female, Humans, Imidazoles, Inflammasomes, Inflammation, Mammary Neoplasms, Animal, Mecamylamine, Mice, Neoplasm Transplantation, Neoplastic Stem Cells, Nicotine, Oxidative Stress, Pyridines, Up-Regulation, p38 Mitogen-Activated Protein Kinases
Abstract

Breast cancer results from a complex interplay of genetics and environment that alters immune and inflammatory systems to promote tumorigenesis. Obesity and cigarette smoking are well-known risk factors associated breast cancer development. Nicotine known to decrease inflammatory signals also modulates immune responses that favor breast cancer development. However, the mechanisms by which nicotine and obesity contribute to breast cancer remain poorly understood. In this study, we examined potential mechanisms by which nicotine (NIC) and high-fat diet (HFD) promote growth of HCC70 and HCC1806 xenografts from African American (AA) triple negative (TN) breast cancer cells. Immunodeficient mice fed on HFD and treated with NIC generated larger HCC70 and HCC1806 tumors when compared to NIC or HFD alone. Increased xenograft growth in the presence of NIC and HFD was accompanied by higher levels of tissue-resident macrophage markers and anti-inflammatory cytokines including IL4, IL13, and IL10. We further validated the involvement of these players by in vitro and ex vivo experiments. We found a proinflammatory milieu with increased expression of IL6 and IL12 in xenografts with HFD. In addition, nicotine or nicotine plus HFD increased a subset of mammary cancer stem cells (MCSCs) and key adipose browning markers CD137 and TMEM26. Interestingly, there was upregulation of stress-induced pp38 MAPK and pERK1/2 in xenografts exposed to HFD alone or nicotine plus HFD. Scratch-wound assay showed marked reduction in proliferation/migration of nicotine and palmitate-treated breast cancer cells with mecamylamine (MEC), a nicotine acetylcholine receptor (nAchR) antagonist. Furthermore, xenograft development in immune-deficient mice, fed HFD plus nicotine, was reduced upon cotreatment with MEC and SB 203580, a pp38MAPK inhibitor. Our study demonstrates the presence of nicotine and HFD in facilitating an anti-inflammatory tumor microenvironment that influences breast tumor growth. This study also shows potential efficacy of combination therapy in obese breast cancer patients who smoke.

Published
2020

32. List of contributors

Author

Andrés, Juan, primary, Arjona, Noé, additional, Asokan, K., additional, Ayoub, Irfan, additional, Bera, Susanta, additional, Chattopadhyay, S., additional, Chaurasiya, Rajneesh, additional, Chen, Fan, additional, Ciola Amoresi, Rafael Aparecido, additional, Coleto Junior, Ubirajara, additional, Dalpian, Gustavo Martini, additional, Das, P.K., additional, Du, Wenjing, additional, Dutta, Somrita, additional, El Filali, Brahim, additional, Esposito, Vincenzo, additional, Frechero, M.A., additional, Gadani, Keval, additional, Gnanamani, Muthu Kumaran, additional, Guerra-Balcázar, Minerva, additional, Hamed Mashhadzadeh, Amin, additional, Jana, D., additional, Jiang, Yanyan, additional, Joseph, D. Paul, additional, Joshi, A.D., additional, Kabir, Ahsanul, additional, Kamble, Vinayak, additional, Khan, Hasmat, additional, Kolkovsky, Vladimir, additional, Kovendhan, M., additional, Kumar, Vijay, additional, Kumar Singh, Rajan, additional, Lal Meena, Mohan, additional, Li, Hui, additional, Lim, Way Foong, additional, Lin, Shawn D., additional, Liu, Wei, additional, Liu, Jiurong, additional, Longo, Elson, additional, Lu, Chung-Hsin, additional, Ma, Yingjie, additional, Mallick, P., additional, Michejevs Padilha, Antonio Claudio, additional, Molina, M.C., additional, Mondal, A., additional, Naskar, Atanu, additional, Pal, S., additional, Perazolli, Leinig Antonio, additional, Polupan, Georgiy, additional, Rajabathar, Jothi Ramalingam, additional, Ramarajan, R., additional, Rocha, Alexandre Reily, additional, Saeb, Mohammad Reza, additional, Salmankhani, Azam, additional, Sarkar, A., additional, Sehgal, Rishabh, additional, Sehgal, Rakesh, additional, Shah, N.A., additional, Sharma, Vishal, additional, Shrimali, V.G., additional, Simões, Alexandre Zirpoli, additional, Solanki, P.S., additional, Som, Sudipta, additional, Spitas, Christos, additional, Stübner, Ronald, additional, Swaminathan, Jayashree, additional, Swart, Hendrik C., additional, Terny, S., additional, Thangaraju, K., additional, Tinti, Victor Buratto, additional, Álvarez-Contreras, Lorena, additional, Torchynska, Tetyana V., additional, Velázquez-Hernández, Isaac, additional, Wang, Zhou, additional, Wang, Fenglong, additional, Wu, Lili, additional, Zanetti de Florio, Daniel, additional, Zarghami Dehghani, Maryam, additional, Zhang, Xingfan, additional, Zhang, Xue, additional, and Zheng, Peiru, additional

Published
2023
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34. Metal oxides based materials for display devices

Author

Meena, Mohan Lal, primary, Som, Sudipta, additional, Lu, Chung-Hsin, additional, Badgoti, Ranveer Singh, additional, Dutta, Somrita, additional, Singh, Rajan Kumar, additional, Lin, Shawn D., additional, and Swart, Hendrik C., additional

Published
2023
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35. Contributors

Author

Abdi, Yaser, primary, Ahmed, Irfan, additional, Ansari, Jamilur R., additional, Arulraj, A., additional, Behrouznejad, Fatemeh, additional, Besleaga, Cristina, additional, Brophy, Rachel Elizabeth, additional, Carmona-Monroy, Paulina, additional, Chandra, Amreesh, additional, Chen, Yonghua, additional, Chowdhury, Faisal Islam, additional, Chowdhury, Towhid H., additional, Cortés-Villena, Alejandro, additional, Cuzminschi, Marina, additional, Derbali, Sarah, additional, Filipoiu, Nicolae, additional, Florea, Mihaela, additional, Galian, Raquel E., additional, Gholipour, Somayeh, additional, Ghosh, Subrata, additional, Grandhi, G. Krishnamurthy, additional, Gussain, Meenakshi, additional, Hadadian, Mahboubeh, additional, Haider, Waseem, additional, Hatamvand, Mohammad, additional, Huang, Wei, additional, Jain, Neha, additional, Kansal, Sakshi, additional, Kateb, Movaffaq, additional, Khalid, Mohammad, additional, Kumar, Dinesh, additional, Liu, Maning, additional, Lu, Chung-Hsin, additional, Mangalaraja, R.V., additional, Manolescu, Andrei, additional, Mariyappan, Pandiyarajan, additional, Meena, Mohan Lal, additional, Mitran, Tudor Luca, additional, Naseh, Md. Farhan, additional, Nemnes, George Alexandru, additional, Pérez-Prieto, Julia, additional, Pintilie, Ioana, additional, Porwal, Shivam, additional, Priya, Surbhi, additional, Rahman, M. Atikur, additional, Rajkumar, C., additional, Roose, Bart, additional, Rosa-Pardo, Ignacio, additional, Sajedi Alvar, Mohammad, additional, Shyju, T.S., additional, Singh, Anupriya, additional, Singh, Rajan Kumar, additional, Singh, Trilok, additional, Solis-Ibarra, Diego, additional, Som, Sudipta, additional, Stancu, Viorica, additional, Sunilbhai, Choudhary Arjun, additional, Tamrakar, Radha, additional, Tomulescu, Andrei G., additional, Vargas, Brenda, additional, Vengatesh, P., additional, Vivo, Paola, additional, Yavari, Mozhgan, additional, and Zhan, Yiqiang, additional

Published
2023
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36. List of contributors

Author

Badgoti, Ranveer Singh, primary, Barsan, Nicolae, additional, Bouhjar, Feriel, additional, Chauhan, Nar Singh, additional, Chinnamuthu, P., additional, Damasceno, Barbara Souza, additional, da Silva Sobrinho, Argemiro Soares, additional, Derbali, Lotfi, additional, Dutta, Somrita, additional, Gangwar, Jitendra, additional, Godoy, Armstrong, additional, Guaita, Julia Marí, additional, Gulati, Kapil, additional, Hlekelele, Lerato, additional, Horta, Isabela Machado, additional, Kumar, Naveen, additional, Kumar, Suresh, additional, Kumar, Gourav, additional, Kumar, Rajesh, additional, Kumari, Vijaya, additional, Kumari, Kavitha, additional, Leite, Douglas Marcel Gonçalves, additional, Lin, Shawn D., additional, Lu, Chung-Hsin, additional, Makgwane, Peter R., additional, Mavuso, Mlungisi A., additional, Meena, Mohan Lal, additional, Mhlongo, M.R., additional, Mittal, Anuj, additional, Mofokeng, S.J., additional, Mofokeng, Sefako, additional, Mokoena, Teboho P., additional, Motaung, David E., additional, Mphahlele-Makgwane, Mabel M., additional, Oosthuizen, Dina N., additional, Pereira, André Luis de Jesus, additional, Pooja, Pheiroijam, additional, Rana, Ravi, additional, Russ, Tamara, additional, Saroha, Bhavna, additional, Sharma, Yashpal, additional, Sharma, Ashok K., additional, Sharma, Pinki, additional, Sharma, Anuradha, additional, Singh, Rajan Kumar, additional, Siroha, Piyush, additional, Som, Sudipta, additional, Swart, Hendrik C., additional, Weimar, Udo, additional, Yadav, Monika, additional, Zhang, Ming, additional, Zhang, Tong, additional, and Zhou, Tingting, additional

Published
2023
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38. Giant Tunable Mechanical Nonlinearity in Graphene-Silicon Nitride Hybrid Resonator

Author

Singh, Rajan, Sarkar, Arnab, Guria, Chitres, Nicholl, Ryan J. T., Chakraborty, Sagar, Bolotin, Kirill I., and Ghosh, Saikat

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

High quality factor mechanical resonators have shown great promise in developing classical or quantum technologies. Simultaneously, progress has been made in developing controlled mechanical nonlinearity. Here we combine these two directions of progress in a single platform consisting of coupled Silicon Nitride (SiNx) and graphene mechanical resonators. We show that nonlinear response can be induced on a large area SiNx resonator mode and can be efficiently controlled by coupling it to a gate-tunable, freely suspended graphene mode. The induced nonlinear response of the hybrid modes, as measured on the SiNx resonator surface is giant, with one of the highest measured Duffing constants. We observe a novel phononic frequency comb which we use as an alternate validation of the measured values, along with numerical simulations which are in overall agreement with measurements.

Published
2019
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42. Exploring Biomarker Identification and Mortality Prediction of COVID-19 Patients Using ML Algorithms

Author

Singh, Rajan, Srivastava, Prashant K., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Mathew, Jimson, editor, Santhosh Kumar, G., editor, P., Deepak, editor, and Jose, Joemon M., editor

Published
2022
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