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5. Sexual dimorphism in COVID-19: potential clinical and public health implications

Author

Bechmann, Nicole, Barthel, Andreas, Schedl, Andreas, Herzig, Stephan, Varga, Zsuzsanna, Gebhard, Catherine, Mayr, Manuel, Hantel, Constanze, Beuschlein, Felix, Wolfrum, Christian, Perakakis, Nikolaos, Poston, Lucilla, Andoniadou, Cynthia L, Siow, Richard, Gainetdinov, Raul R, Dotan, Arad, Shoenfeld, Yehuda, Mingrone, Geltrude, and Bornstein, Stefan R

Published
2022
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11. Community-based mpox and sexually transmitted disease surveillance using discarded condoms in the global south [Correspondence]

Author

Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Besa, John Jefferson V., Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T., Ounjai, Puey, Werawatte, W.K.C.P., Rad S.M., Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk, Al-Dois, Marily, Bani, Rapong, Thuptiang, Wanwara, Khan, Sifat, Tacharoenmuang, Ratana, Cynthia, Bernadina, Vitharana, S.P.H. Spencer, Ngamwongsatit, Natharin, Ishikawa, Hitoshi, Singer, Andrew C., Ragupathi, Naveen Kumar Devanga, Furukawa, Takashi, Sei, Kazunari, Nanbo, Asuka, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Chatsuwan, Tanittha, Higgins, Paul G., Sano, Daisuke, Kicic, Anthony, Rockstroh, Jürgen Kurt, Siow, Richard, Trowsdale, Sam, Hongsing, Parichart, Khatib, Aisha, Shibuya, Kenji, Abe, Shuichi, Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Besa, John Jefferson V., Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T., Ounjai, Puey, Werawatte, W.K.C.P., Rad S.M., Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk, Al-Dois, Marily, Bani, Rapong, Thuptiang, Wanwara, Khan, Sifat, Tacharoenmuang, Ratana, Cynthia, Bernadina, Vitharana, S.P.H. Spencer, Ngamwongsatit, Natharin, Ishikawa, Hitoshi, Singer, Andrew C., Ragupathi, Naveen Kumar Devanga, Furukawa, Takashi, Sei, Kazunari, Nanbo, Asuka, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Chatsuwan, Tanittha, Higgins, Paul G., Sano, Daisuke, Kicic, Anthony, Rockstroh, Jürgen Kurt, Siow, Richard, Trowsdale, Sam, Hongsing, Parichart, Khatib, Aisha, Shibuya, Kenji, and Abe, Shuichi

Published
2024

12. Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies

Author

Wang, He-Ling, Siow, Richard, Schmauck-Medina, Tomas, Zhang, Jianying, Sandset, Per Morten, Filshie, Clare, Lund, Øystein, Partridge, Linda, Bergersen, Linda Hildegard, Juel Rasmussen, Lene, Palikaras, Konstantinos, Sotiropoulos, Ioannis, Storm-Mathisen, Jon, Rubinsztein, David C, Spillantini, Maria Grazia, De Zeeuw, Chris I, Watne, Leiv Otto, Vyhnalek, Martin, Veverova, Katerina, Liang, Kristina Xiao, Tavernarakis, Nektarios, Bohr, Vilhelm A, Yokote, Koutaro, Saarela, Janna, Nilsen, Hilde, Gonos, Efstathios S, Scheibye-Knudsen, Morten, Chen, Guobing, Kato, Hisaya, Selbæk, Geir, Fladby, Tormod, Nilsson, Per, Simonsen, Anne, Aarsland, Dag, Lautrup, Sofie, Ottersen, Ole Petter, Cox, Lynne S, Fang, Evandro F, Wang, He-Ling, Siow, Richard, Schmauck-Medina, Tomas, Zhang, Jianying, Sandset, Per Morten, Filshie, Clare, Lund, Øystein, Partridge, Linda, Bergersen, Linda Hildegard, Juel Rasmussen, Lene, Palikaras, Konstantinos, Sotiropoulos, Ioannis, Storm-Mathisen, Jon, Rubinsztein, David C, Spillantini, Maria Grazia, De Zeeuw, Chris I, Watne, Leiv Otto, Vyhnalek, Martin, Veverova, Katerina, Liang, Kristina Xiao, Tavernarakis, Nektarios, Bohr, Vilhelm A, Yokote, Koutaro, Saarela, Janna, Nilsen, Hilde, Gonos, Efstathios S, Scheibye-Knudsen, Morten, Chen, Guobing, Kato, Hisaya, Selbæk, Geir, Fladby, Tormod, Nilsson, Per, Simonsen, Anne, Aarsland, Dag, Lautrup, Sofie, Ottersen, Ole Petter, Cox, Lynne S, and Fang, Evandro F

Abstract

Unhealthy ageing poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the ageing process offers a promising approach to reduce the burden of a number of age-related diseases, such as dementia, promoting healthy longevity in the old population. In response to the challenge of the ageing population and with a view to the future, Norway and the UK are fostering collaborations, supported by a "Money Follows Cooperation agreement" between the two nations. The inaugural Norway-UK joint meeting on ageing and dementia gathered leading experts on ageing and dementia from the two nations to share their latest discoveries in related fields. Since ageing is an international challenge, and to foster collaborations, we also invited leading scholars from 11 additional countries to join this event. This report provides a summary of the conference, highlighting recent progress on molecular ageing mechanisms, genetic risk factors, DNA damage and repair, mitophagy, autophagy, as well as progress on a series of clinical trials (e.g., using NAD+ precursors). The meeting facilitated dialogue among policy makers, administrative leaders, researchers, and clinical experts, aiming to promote international research collaborations and to translate findings into clinical applications and interventions to advance healthy ageing.

Published
2024

13. Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia:Recent Progress on the Mechanisms and Interventional Strategies

Author

Wang, He Ling, Siow, Richard, Schmauck-Medina, Tomas, Zhang, Jianying, Sandset, Per Morten, Filshie, Clare, Lund, Øystein, Partridge, Linda, Bergersen, Linda Hildegard, Juel Rasmussen, Lene, Palikaras, Konstantinos, Sotiropoulos, Ioannis, Storm-Mathisen, Jon, Rubinsztein, David C., Spillantini, Maria Grazia, De Zeeuw, Chris I., Watne, Leiv Otto, Vyhnalek, Martin, Veverova, Katerina, Liang, Kristina Xiao, Tavernarakis, Nektarios, Bohr, Vilhelm A., Yokote, Koutaro, Saarela, Janna, Nilsen, Hilde, Gonos, Efstathios S., Scheibye-Knudsen, Morten, Chen, Guobing, Kato, Hisaya, Selbæk, Geir, Fladby, Tormod, Nilsson, Per, Simonsen, Anne, Aarsland, Dag, Lautrup, Sofie, Ottersen, Ole Petter, Cox, Lynne S., Fang, Evandro F., Wang, He Ling, Siow, Richard, Schmauck-Medina, Tomas, Zhang, Jianying, Sandset, Per Morten, Filshie, Clare, Lund, Øystein, Partridge, Linda, Bergersen, Linda Hildegard, Juel Rasmussen, Lene, Palikaras, Konstantinos, Sotiropoulos, Ioannis, Storm-Mathisen, Jon, Rubinsztein, David C., Spillantini, Maria Grazia, De Zeeuw, Chris I., Watne, Leiv Otto, Vyhnalek, Martin, Veverova, Katerina, Liang, Kristina Xiao, Tavernarakis, Nektarios, Bohr, Vilhelm A., Yokote, Koutaro, Saarela, Janna, Nilsen, Hilde, Gonos, Efstathios S., Scheibye-Knudsen, Morten, Chen, Guobing, Kato, Hisaya, Selbæk, Geir, Fladby, Tormod, Nilsson, Per, Simonsen, Anne, Aarsland, Dag, Lautrup, Sofie, Ottersen, Ole Petter, Cox, Lynne S., and Fang, Evandro F.

Abstract

Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related diseases, such as dementia, and promoting healthy longevity in the old population. In response to the challenge of the aging population and with a view to the future, Norway and the United Kingdom are fostering collaborations, supported by a “Money Follows Cooperation agreement” between the 2 nations. The inaugural Norway–UK joint meeting on aging and dementia gathered leading experts on aging and dementia from the 2 nations to share their latest discoveries in related fields. Since aging is an international challenge, and to foster collaborations, we also invited leading scholars from 11 additional countries to join this event. This report provides a summary of the conference, highlighting recent progress on molecular aging mechanisms, genetic risk factors, DNA damage and repair, mitophagy, autophagy, as well as progress on a series of clinical trials (eg, using NAD+ precursors). The meeting facilitated dialogue among policymakers, administrative leaders, researchers, and clinical experts, aiming to promote international research collaborations and to translate findings into clinical applications and interventions to advance healthy aging., Unhealthy aging poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the aging process offers a promising approach to reduce the burden of a number of age-related diseases, such as dementia, and promoting healthy longevity in the old population. In response to the challenge of the aging population and with a view to the future, Norway and the United Kingdom are fostering collaborations, supported by a "Money Follows Cooperation agreement" between the 2 nations. The inaugural Norway-UK joint meeting on aging and dementia gathered leading experts on aging and dementia from the 2 nations to share their latest discoveries in related fields. Since aging is an international challenge, and to foster collaborations, we also invited leading scholars from 11 additional countries to join this event. This report provides a summary of the conference, highlighting recent progress on molecular aging mechanisms, genetic risk factors, DNA damage and repair, mitophagy, autophagy, as well as progress on a series of clinical trials (eg, using NAD+ precursors). The meeting facilitated dialogue among policymakers, administrative leaders, researchers, and clinical experts, aiming to promote international research collaborations and to translate findings into clinical applications and interventions to advance healthy aging.

Published
2024

14. Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1 [Correspondence]

Author

Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T., Ounjai, Puey, Singer, Andrew C., Ragupathi, Naveen Kumar Devanga, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Chatsuwan, Tanittha, Higgins, Paul G., Nanbo, Asuka, Kicic, Anthony, Siow, Richard, Trowsdale, Sam, Hongsing, Parichart, Khatib, Aisha, Shibuya, Kenji, Abe, Shuichi, Ishikawa, Hitoshi, Thuptiang, Wanwara, Rad S.M., Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk, Tacharoenmuang, Ratana, Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T., Ounjai, Puey, Singer, Andrew C., Ragupathi, Naveen Kumar Devanga, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Chatsuwan, Tanittha, Higgins, Paul G., Nanbo, Asuka, Kicic, Anthony, Siow, Richard, Trowsdale, Sam, Hongsing, Parichart, Khatib, Aisha, Shibuya, Kenji, Abe, Shuichi, Ishikawa, Hitoshi, Thuptiang, Wanwara, Rad S.M., Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk, and Tacharoenmuang, Ratana

Published
2024

15. Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1

Author

Wannigama, Dhammika Leshan, primary, Amarasiri, Mohan, additional, Phattharapornjaroen, Phatthranit, additional, Hurst, Cameron, additional, Modchang, Charin, additional, Chadsuthi, Sudarat, additional, Anupong, Suparinthon, additional, Miyanaga, Kazuhiko, additional, Cui, Longzhu, additional, Fernandez, Stefan, additional, Huang, Angkana T, additional, Ounjai, Puey, additional, Singer, Andrew C, additional, Ragupathi, Naveen Kumar Devanga, additional, Sano, Daisuke, additional, Furukawa, Takashi, additional, Sei, Kazunari, additional, Leelahavanichkul, Asada, additional, Kanjanabuch, Talerngsak, additional, Chatsuwan, Tanittha, additional, Higgins, Paul G, additional, Nanbo, Asuka, additional, Kicic, Anthony, additional, Siow, Richard, additional, Trowsdale, Sam, additional, Hongsing, Parichart, additional, Khatib, Aisha, additional, Shibuya, Kenji, additional, Abe, Shuichi, additional, Ishikawa, Hitoshi, additional, Thuptiang, Wanwara, additional, Rad S.M., Ali Hosseini, additional, Vatanaprasan, Porames, additional, Jay, Dylan John, additional, Saethang, Thammakorn, additional, Luk-in, Sirirat, additional, Storer, Robin James, additional, Kanthawee, Phitsanuruk, additional, and Tacharoenmuang, Ratana, additional

Published
2024
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17. Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies

Author

Wang, He-Ling, primary, Siow, Richard, additional, Schmauck-Medina, Tomas, additional, Zhang, Jianying, additional, Sandset, Per Morten, additional, Filshie, Clare, additional, Lund, Øystein, additional, Partridge, Linda, additional, Bergersen, Linda Hildegard, additional, Juel Rasmussen, Lene, additional, Palikaras, Konstantinos, additional, Sotiropoulos, Ioannis, additional, Storm-Mathisen, Jon, additional, Rubinsztein, David C, additional, Spillantini, Maria Grazia, additional, De Zeeuw, Chris I, additional, Watne, Leiv Otto, additional, Vyhnalek, Martin, additional, Veverova, Katerina, additional, Liang, Kristina Xiao, additional, Tavernarakis, Nektarios, additional, Bohr, Vilhelm A, additional, Yokote, Koutaro, additional, Saarela, Janna, additional, Nilsen, Hilde, additional, Gonos, Efstathios S, additional, Scheibye-Knudsen, Morten, additional, Chen, Guobing, additional, Kato, Hisaya, additional, Selbæk, Geir, additional, Fladby, Tormod, additional, Nilsson, Per, additional, Simonsen, Anne, additional, Aarsland, Dag, additional, Lautrup, Sofie, additional, Ottersen, Ole Petter, additional, Cox, Lynne S, additional, and Fang, Evandro F, additional

Published
2024
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18. Quantum healthy longevity from cells to cities.

Author

Woods, Tina, Palmarini, Nic, Corner, Lynne, and Siow, Richard

Subjects
HEALTH care reform, ATTITUDES toward aging, PSYCHOLOGICAL resilience, ECOLOGY, HEALTH expectancy, SOCIOECONOMIC factors, HEALTH equity, LONGEVITY, ACTIVE aging, BIOMARKERS, COGNITIVE aging
Published
2024
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19. A Randomised, Double-Blind, Placebo-Controlled, Cross-Over Clinical Trial to Evaluate the Biological Effects and Safety of a Polyphenol Supplement on Healthy Ageing.

Author

Chong, Joyce Ruifen, de Lucia, Chiara, Tovar-Rios, Diego Alejandro, Castellanos-Perilla, Nicolas, Collins, Christopher, Kvernberg, Silje Meihack, Ballard, Clive, Siow, Richard C., and Aarsland, Dag

Subjects
CROSSOVER trials, MEDITERRANEAN diet, BODY mass index, DNA methylation, OXIDATIVE stress
Abstract

DailyColors™ is a supplement made up of several phytonutrients that aims to replicate elements from the Mediterranean diet. These include fruit, berry and vegetable extracts that are rich in key phytochemicals such as Quercetin, Catechins, Phloretin, Ellagic Acid, and Anthocyanins. Here, we determined the effects of DailyColors™ on the blood biomarkers associated with the diverse mechanisms implicated in ageing and age-related diseases, including mitochondrial function, inflammation, and oxidative stress, as well as on saliva's DNA methylation pattern. Thirty adult participants (mean (SD) age = 67.0 (7.5) years) with a body mass index over 25 were recruited into this randomised, double-blind, placebo-controlled, cross-over trial (two one-week treatment periods, separated by a one-week washout period). During the placebo period, we observed a significant increase in blood CD38 concentrations from the baseline to 24 h (p-value = 0.019). This was not observed in the active period. Increased CD38 is reportedly associated with subsequent mitochondrial dysfunction and inflammation. Next, there was a decreasing trend of plasma 4-HNE levels, an oxidative stress biomarker, after a one-week intake of DailyColors™. Furthermore, following a one-month open-label follow-up in 26 participants, we observed hypermethylation of the candidate CpG site cg13108341 (q-value = 0.021), which was against the observed trend for this site during ageing. Taken together, while minimal effects were observed in this study, DailyColors™ supplementation may be beneficial by altering and alleviating age-related changes. Longer and larger scale trials of DailyColors™ supplementation are warranted. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The Longevity Med Summit: insights on healthspan from cell to society.

Author

Falshaw, Natalie, Sagner, Michael, and Siow, Richard C.

Subjects
DISEASE risk factors, CLINICAL medicine, PREVENTIVE medicine, RESEARCH personnel, ECONOMIC impact
Abstract

In recent years, there has been a paradigm shift with regards to ageing, challenging its traditional perception as an inevitable and natural process. Researchers have collectively identified hallmarks of ageing, nine of which were initially proposed in 2013 and expanded in 2023 to include disabled macroautophagy, chronic inflammation, and dysbiosis, enhancing our understanding of the ageing process at microscopic, cellular, and systemwide levels. Strategies to manipulate these hallmarks present opportunities for slowing, preventing, or reversing age-related diseases, thereby promoting longevity. The interdependence of these hallmarks underscores the necessity of a comprehensive, systems-based approach to address the complex processes contributing to ageing. As a primary risk factor for various diseases, ageing diminishes healthspan, leading to extended periods of compromised health and multiple age-related conditions towards the end of life. The significant gap between healthspan and lifespan holds substantial economic and societal implications. The inaugural Longevity Med Summit (4-5 May 2023, Cascais, Portugal) provided an international forum to discuss the academic and industry landscape of healthy longevity research, preventive medicine and clinical practice to enhance healthspan. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Community-based mpox and sexually transmitted disease surveillance using discarded condoms in the global south

Author

Werawatte, W.K.C.P., Rad S.M., Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk, Al-Dois, Marily, Bani, Rapong, Thuptiang, Wanwara, Khan, Sifat, Tacharoenmuang, Ratana, Cynthia, Bernadina, Vitharana, S.P.H Spencer, Ngamwongsatit, Natharin, Ishikawa, Hitoshi, Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Besa, John Jefferson V, Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T, Ounjai, Puey, Singer, Andrew C, Ragupathi, Naveen Kumar Devanga, Furukawa, Takashi, Sei, Kazunari, Nanbo, Asuka, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Chatsuwan, Tanittha, Higgins, Paul G, Sano, Daisuke, Kicic, Anthony, Rockstroh, Jürgen Kurt, Siow, Richard, Trowsdale, Sam, Hongsing, Parichart, Khatib, Aisha, Shibuya, Kenji, and Abe, Shuichi

Published
2024
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23. Increased faecal shedding in SARS-CoV-2 variants BA.2.86 and JN.1

Author

Thuptiang, Wanwara, Rad S.M., Ali Hosseini, Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Kanthawee, Phitsanuruk, Tacharoenmuang, Ratana, Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Fernandez, Stefan, Huang, Angkana T, Ounjai, Puey, Singer, Andrew C, Ragupathi, Naveen Kumar Devanga, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Chatsuwan, Tanittha, Higgins, Paul G, Nanbo, Asuka, Kicic, Anthony, Siow, Richard, Trowsdale, Sam, Hongsing, Parichart, Khatib, Aisha, Shibuya, Kenji, Abe, Shuichi, and Ishikawa, Hitoshi

Published
2024
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25. Tracing the transmission of Mpox through wastewater surveillance in Southeast Asia

Author

Wannigama, Dhammika Leshan, primary, Amarasiri, Mohan, additional, Phattharapornjaroen, Phatthranit, additional, Hurst, Cameron, additional, Modchang, Charin, additional, Chadsuthi, Sudarat, additional, Anupong, Suparinthon, additional, Miyanaga, Kazuhiko, additional, Cui, Longzhu, additional, Thuptimdang, Wanwara, additional, Ali Hosseini Rad, S M, additional, Fernandez, Stefan, additional, Huang, Angkana T, additional, Vatanaprasan, Porames, additional, Jay, Dylan John, additional, Saethang, Thammakorn, additional, Luk-in, Sirirat, additional, Storer, Robin James, additional, Ounjai, Puey, additional, Ragupathi, Naveen Kumar Devanga, additional, Kanthawee, Phitsanuruk, additional, Sano, Daisuke, additional, Furukawa, Takashi, additional, Sei, Kazunari, additional, Leelahavanichkul, Asada, additional, Kanjanabuch, Talerngsak, additional, Higgins, Paul G, additional, Nanbo, Asuka, additional, Kicic, Anthony, additional, Singer, Andrew C, additional, Chatsuwan, Tanittha, additional, Trowsdale, Sam, additional, Siow, Richard, additional, Shibuya, Kenji, additional, Abe, Shuichi, additional, Ishikawa, Hitoshi, additional, and Hongsing, Parichart, additional

Published
2023
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28. Tracing the transmission of mpox through wastewater surveillance in Southeast Asia

Author

Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Thuptimdang, Wanwara, Ali Hosseini Rad, S.M., Fernandez, Stefan, Huang, Angkana T., Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Ounjai, Puey, Ragupathi, Naveen Kumar Devanga, Kanthawee, Phitsanuruk, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Higgins, Paul G., Nanbo, Asuka, Kicic, Anthony, Singer, Andrew C., Chatsuwan, Tanittha, Trowsdale, Sam, Siow, Richard, Shibuya, Kenji, Abe, Shuichi, Ishikawa, Hitoshi, Hongsing, Parichart, Wannigama, Dhammika Leshan, Amarasiri, Mohan, Phattharapornjaroen, Phatthranit, Hurst, Cameron, Modchang, Charin, Chadsuthi, Sudarat, Anupong, Suparinthon, Miyanaga, Kazuhiko, Cui, Longzhu, Thuptimdang, Wanwara, Ali Hosseini Rad, S.M., Fernandez, Stefan, Huang, Angkana T., Vatanaprasan, Porames, Jay, Dylan John, Saethang, Thammakorn, Luk-in, Sirirat, Storer, Robin James, Ounjai, Puey, Ragupathi, Naveen Kumar Devanga, Kanthawee, Phitsanuruk, Sano, Daisuke, Furukawa, Takashi, Sei, Kazunari, Leelahavanichkul, Asada, Kanjanabuch, Talerngsak, Higgins, Paul G., Nanbo, Asuka, Kicic, Anthony, Singer, Andrew C., Chatsuwan, Tanittha, Trowsdale, Sam, Siow, Richard, Shibuya, Kenji, Abe, Shuichi, Ishikawa, Hitoshi, and Hongsing, Parichart

Abstract

High population density and tourism in Southeast Asia increase the risk of mpox due to frequent interpersonal contacts. Our wastewater surveillance in six Southeast Asian countries revealed positive signals for Monkeypox virus (MPXV) DNA, indicating local transmission. This alerts clinicians and helps allocate resources like testing, vaccines and therapeutics in resource-limited countries.

Published
2023

29. Interactions between zinc and NRF2 in vascular redox signalling.

Author

Fan Yang, Smith, Matthew J., Siow, Richard C. M., Aarsland, Dag, Maret, Wolfgang, and Mann, Giovanni E.

Subjects
GLYCOGEN synthase kinase, NUCLEAR factor E2 related factor, MITOGEN-activated protein kinases, PROTEIN kinase C, GLUTATHIONE, NITRIC-oxide synthases
Abstract

Recent evidence highlights the importance of trace metal micronutrients such as zinc (Zn) in coronary and vascular diseases. Zn2+ plays a signalling role in modulating endothelial nitric oxide synthase and protects the endothelium against oxidative stress by upregulation of glutathione synthesis. Excessive accumulation of Zn2+ in endothelial cells leads to apoptotic cell death resulting from dysregulation of glutathione and mitochondrial ATP synthesis, whereas zinc deficiency induces an inflammatory phenotype, associated with increased monocyte adhesion. Nuclear factor-E2-related factor 2 (NRF2) is a transcription factor known to target hundreds of different genes. Activation of NRF2 affects redox metabolism, autophagy, cell proliferation, remodelling of the extracellular matrix and wound healing. As a redox-inert metal ion, Zn has emerged as a biomarker in diagnosis and as a therapeutic approach for oxidative-related diseases due to its close link to NRF2 signalling. In non-vascular cell types, Zn has been shown to modify conformations of the NRF2 negative regulators Kelch-like ECH-associated Protein 1 (KEAP1) and glycogen synthase kinase 3β (GSK3β) and to promote degradation of BACH1, a transcriptional suppressor of select NRF2 genes. Zn can affect phosphorylation signalling, including mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinases and protein kinase C, which facilitate NRF2 phosphorylation and nuclear translocation. Notably, several NRF2-targeted proteins have been suggested to modify cellular Zn concentration via Zn exporters (ZnTs) and importers (ZIPs) and the Zn buffering protein metallothionein. This review summarises the cross-talk between reactive oxygen species, Zn and NRF2 in antioxidant responses of vascular cells against oxidative stress and hypoxia/reoxygenation. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Quantum Healthy Longevity for healthy people, planet, and growth

Author

Woods, Tina, primary, Palmarini, Nic, additional, Corner, Lynne, additional, Barzilai, Nir, additional, Bethell, Lord James, additional, Cox, Lynne S, additional, Eyre, Harris, additional, Ferrucci, Luigi, additional, Fried, Linda, additional, Furman, David, additional, Kennedy, Brian, additional, Roddam, Andrew, additional, Scott, Andrew, additional, and Siow, Richard C, additional

Published
2022
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48. Advances in microfluidic in vitro systems for neurological disease modeling

Author

Holloway, Paul M., Willaime‐Morawek, Sandrine, Siow, Richard, Barber, Melissa, Owens, Róisín M., Sharma, Anup D., Rowan, Wendy, Hill, Eric, Zagnoni, Michele, Holloway, Paul M., Willaime‐Morawek, Sandrine, Siow, Richard, Barber, Melissa, Owens, Róisín M., Sharma, Anup D., Rowan, Wendy, Hill, Eric, and Zagnoni, Michele

Abstract

Neurological disorders are the leading cause of disability and the second largest cause of death worldwide. Despite significant research efforts, neurology remains one of the most failure‐prone areas of drug development. The complexity of the human brain, boundaries to examining the brain directly in vivo, and the significant evolutionary gap between animal models and humans, all serve to hamper translational success. Recent advances in microfluidic in vitro models have provided new opportunities to study human cells with enhanced physiological relevance. The ability to precisely micro‐engineer cell‐scale architecture, tailoring form and function, has allowed for detailed dissection of cell biology using microphysiological systems (MPS) of varying complexities from single cell systems to “Organ‐on‐chip” models. Simplified neuronal networks have allowed for unique insights into neuronal transport and neurogenesis, while more complex 3D heterotypic cellular models such as neurovascular unit mimetics and “Organ‐on‐chip” systems have enabled new understanding of metabolic coupling and blood–brain barrier transport. These systems are now being developed beyond MPS toward disease specific micro‐pathophysiological systems, moving from “Organ‐on‐chip” to “Disease‐on‐chip.” This review gives an outline of current state of the art in microfluidic technologies for neurological disease research, discussing the challenges and limitations while highlighting the benefits and potential of integrating technologies. We provide examples of where such toolsets have enabled novel insights and how these technologies may empower future investigation into neurological diseases.

Published
2021

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