1. Neural guidance factors as hubs of immunometabolic cross-talk.
- Author
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Nakanishi Y, Kang S, and Kumanogoh A
- Subjects
- Animals, Humans, Signal Transduction immunology, Sirolimus immunology, Sirolimus metabolism, Nerve Tissue Proteins immunology, Nerve Tissue Proteins metabolism, Semaphorins immunology, Semaphorins metabolism
- Abstract
Semaphorins were originally identified as axon-guidance molecules essential for neural development. In addition to their functions in the neural system, members of the semaphorin family have critical functions in many pathophysiological processes, including immune responses, bone homeostasis, cancer and metabolic disorders. In particular, several lines of evidence indicate that mammalian/mechanistic target of rapamycin (mTOR), a central regulator of cell metabolism, regulates the functions of semaphorins in various types of cells, revealing a novel link between semaphorins and cell metabolism. In this review, we discuss recent advances in the immunometabolic functions of semaphorins, with a particular focus on mTOR signaling., (© The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Society for Immunology.)
- Published
- 2021
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