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1. Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats

Author

Siti Zawanah Halim, Zainul Amiruddin Zakaria, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Ikarastika Rahayu Abdul Wahab, and Muhammad Nazrul Hakim Abdullah

Subjects
Melastoma malabathricum, Muntingia calabura, Synergistic effect, Gastric ulcer, Antisecretory, Antioxidant, Other systems of medicine, RZ201-999
Abstract

Abstract Background Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective activity of methanolic extract of a mixture of MM and MC (MMMC) at various ratios was evaluated in rat models. Methods Rats were pre-treated orally with 2% Tween 80 (vehicle), 100 mg/kg ranitidine (reference drug) or MMMC (ratios of 1:1, 1:3 and 3:1 (v/v); doses of 15, 150 or 300 mg/kg) and then subjected to the ethanol-induced gastric ulcer or pyloric ligation assays. Stomach of rats from the former assay was collected and subjected to the macroscopic and microscopic observations, and enzymatic and non-enzymatic antioxidant studies while the gastric juice content and tissue from the latter assay were subjected to the antisecretory activity study. The UHPLC analysis of MMMC was also performed. Result MMMC, in the ratio 1:1, demonstrated the most effective (P

Published
2017
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2. Synergistic gastroprotective activity of methanolic extract of a mixture of Melastoma malabathricum and Muntingia calabura leaves in rats

Author

Ikarastika Rahayu Abdul Wahab, Muhammad Nazrul Hakim Abdullah, Norhafizah Mohtarrudin, Siti Zawanah Halim, Maizatul Hasyima Omar, and Zainul Amiruddin Zakaria

Subjects
0301 basic medicine, Male, Antioxidant, Oxygen radical absorbance capacity, DPPH, medicine.medical_treatment, Elaeocarpaceae, Flavonoid, Pharmacology, Antioxidants, Gastric Content, Superoxide dismutase, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Stomach Ulcer, Antisecretory, chemistry.chemical_classification, Melastoma malabathricum, Gastric Juice, biology, Traditional medicine, Plant Extracts, Gastric ulcer, Stomach, General Medicine, lcsh:Other systems of medicine, biology.organism_classification, Malondialdehyde, lcsh:RZ201-999, Anti-Ulcer Agents, Rats, Plant Leaves, 030104 developmental biology, Complementary and alternative medicine, chemistry, Muntingia calabura, 030220 oncology & carcinogenesis, Melastomataceae, biology.protein, Synergistic effect, Research Article
Abstract

Background Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective activity of methanolic extract of a mixture of MM and MC (MMMC) at various ratios was evaluated in rat models. Methods Rats were pre-treated orally with 2% Tween 80 (vehicle), 100 mg/kg ranitidine (reference drug) or MMMC (ratios of 1:1, 1:3 and 3:1 (v/v); doses of 15, 150 or 300 mg/kg) and then subjected to the ethanol-induced gastric ulcer or pyloric ligation assays. Stomach of rats from the former assay was collected and subjected to the macroscopic and microscopic observations, and enzymatic and non-enzymatic antioxidant studies while the gastric juice content and tissue from the latter assay were subjected to the antisecretory activity study. The UHPLC analysis of MMMC was also performed. Result MMMC, in the ratio 1:1, demonstrated the most effective (P

Published
2016

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