13 results on '"Sittichai Netwijitpan"'
Search Results
2. Effects of Low-dose Aspirin on Serum Uric Acid among Asymptomatic Hyperuricemia Patients with Cardiovascular Risk Factors.
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Silisay, Vilay, Chingching Foocharoen, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Sittichai Netwijitpan, and Nanagara, Ratanavadee
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ASYMPTOMATIC patients ,DISEASE risk factors ,CARDIOVASCULAR diseases risk factors ,URIC acid ,ASPIRIN ,CLUSTER headache - Abstract
Objective: Several drugs can cause hyperuricemia including low-dose aspirin (LDA), which is commonly prescribed for primary prevention of cardiovascular disease. The effect of LDA on serum uric acid (SUA) level in asymptomatic hyperuricemia patients needed exploration. The authors' aim was to determine the prevalence of a significant change in the SUA level and onset of any new acute gouty attack in asymptomatic hyperuricemia patients with cardiovascular risk factors as indicated by taking LDA. Materials and Methods: An experimental study was performed in 128 Thai asymptomatic hyperuricemia patients with cardiovascular risks at Srinagarind Hospital, Khon Kaen University, Thailand, between October 2016 and October 2017. Both clinical and laboratory assessments were performed before and after taking LDA for 2 weeks. Results: Data analysis was performed on the 120 patients who completed the present study. Seven patients were excluded because of being lost to follow-up, and another was withdrawn because of having an acute gouty attack. The mean SUA level at baseline was 7.5 mg/dl. After 2 weeks of LDA, 75.8% of the participants had a significantly decreased SUA level. Only 4.2% of participants had an increased SUA level. One of our participants experienced an acute gouty attack at the first metatarsophalangeal joint after LDA initiation. Conclusion: The influence of 2 weeks of LDA on the SUA level was demonstrated in asymptomatic hyperuricemia patients with cardiovascular risks. The SUA level showed an unexpected, significant decrease in two-third of the study population, and less than 1% of the participants experienced an acute gouty attack after 7 days of aspirin initiation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais
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Sittichai Netwijitpan, Ajanee Mahakkanukrauh, Ratanvadee Nanagara, Chingching Foocharoen, Piyakarn Watcharenwong, and Siraphop Suwannaroj
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Thais ,Scleroderma ,Diagnosis, Differential ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Predictive Value of Tests ,Risk Factors ,Scleroderma, Limited ,Internal medicine ,Odds Ratio ,Humans ,Medicine ,Aged ,Autoantibodies ,Retrospective Studies ,030203 arthritis & rheumatology ,Hand deformity ,Chi-Square Distribution ,integumentary system ,biology ,business.industry ,Autoantibody ,Overlap syndrome ,Odds ratio ,Middle Aged ,Prognosis ,Thailand ,medicine.disease ,biology.organism_classification ,Logistic Models ,030104 developmental biology ,DNA Topoisomerases, Type I ,Scleroderma, Diffuse ,biology.protein ,Female ,Antibody ,business ,Centromere Protein B ,Biomarkers ,Centromere Protein A ,Preliminary Data ,Cohort study - Abstract
Objective Autoantibody profiles in systemic sclerosis (SSc) and their relative clinical association vary between studies. The rate for being anti-topoisomerase-I (ATA) positive and the association with diffuse cutaneous the SSc subset (dcSSc) is higher among Thais than among Caucasians. The objective was to evaluate the relevance of clinical presentation, namely being positive for one or more autoantibodies among Thai SSc patients. Method A retrospective, cohort study was performed among SSc patients over 18 years of age at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006 to December 2013. Autoantibodies comprising 13 SSc-specific antigens were evaluated using the EUROIMMUN AG (Lubeck, Germany) in order to define their clinical association(s). Results Two hundred and eighty-five scleroderma patients (200 female; 85 male) were included. The majority (66.7%) were dcSSc subset. ATA was the most common antibody profile in our patients (231 cases; 81.1%), followed by anti-Ro 52 (87 cases; 30.5%). Eleven of our patients (3.9%) were negative for all antibody profiles and 44 cases (15.4%) were negative for ATA and anti-centromere antibody (anti-CENP). Almost 40% (112 cases) were positive for at least two autoantibodies. There was an association between the presence of ATA and hand deformity (odds ratio [OR] 3.94; 95% CI 1.12–13.84), anti-CENP and hand deformity (OR 0.20; 95% CI 0.02–0.90), anti-Ku and scleroderma-polymyositis overlap syndrome (OR 6.58; 95% CI 2.16–19.39) and the absence of both ATA and anti-CENP with female sex (OR 2.90; 95% CI 1.12–7.51), limited cutaneous SSc subset (OR 2.70; 95% CI 1.30–5.55) and scleroderma-polymyositis overlap syndrome (OR 2.53; 95% CI 1.04–6.16). Neither ATA nor anti-CENP were associated with the SSc subset. Conclusions ATA and anti-CENP were not helpful in differentiating the SSc subset in Thai SSc patients, albeit they were good for predicting hand function. Coexisting ATA and anti-CENP negativity were associated with less extensive skin tightness and SSc overlap syndrome.
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- 2017
4. Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature
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Sittichai Netwijitpan, Wichien Sirithanaphol, Sakkarn Sangkhamanon, and Chingching Foocharoen
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granulomatous disease ,medicine.medical_specialty ,Urinary bladder ,malakoplakia ,Cyclophosphamide ,medicine.diagnostic_test ,systemic sclerosis ,business.industry ,Genitourinary system ,Urology ,Malakoplakia ,Case Report ,Cystoscopy ,medicine.disease ,Dermatology ,Gross hematuria ,Scleroderma ,hematuria ,medicine.anatomical_structure ,Biopsy ,medicine ,scleroderma ,business ,medicine.drug - Abstract
Malakoplakia, an anecdotal reactive granulomatous lesion, is a rare pathologic entity but relatively more common in genitourinary tracts. Here we report a case of malakoplakia in the urinary bladder in systemic sclerosis. The patient was a 66-year-old female treated with long-term corticosteroid and cyclophosphamide. She presented with gross hematuria, and cystoscopy and biopsy revealed malakoplakia. There was no tumor and the stains for infectious organism were all negative. To the best of our knowledge, this is the first case report of malakoplakia in a systemic sclerosis patient.
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- 2018
5. Clinical characteristics of scleroderma overlap syndromes: comparisons with pure scleroderma
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Siraphop Suwannaroj, Ratanavadee Nanagara, Sittichai Netwijitpan, Ajanee Mahakkanukrauh, and Chingching Foocharoen
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Arthritis ,030204 cardiovascular system & hematology ,Scleroderma ,Serology ,Hospitals, University ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Predictive Value of Tests ,medicine ,Humans ,Serologic Tests ,Age of Onset ,skin and connective tissue diseases ,Aged ,Retrospective Studies ,Aged, 80 and over ,030203 arthritis & rheumatology ,Scleroderma, Systemic ,Lupus erythematosus ,integumentary system ,business.industry ,Retrospective cohort study ,Overlap syndrome ,Syndrome ,Middle Aged ,Thailand ,medicine.disease ,Dermatology ,stomatognathic diseases ,Phenotype ,Treatment Outcome ,DNA Topoisomerases, Type I ,Antibodies, Antinuclear ,Predictive value of tests ,Female ,Steroids ,Age of onset ,business ,Biomarkers ,Immunosuppressive Agents - Abstract
Background Scleroderma with characteristics of other connective tissue diseases is called scleroderma overlap syndrome (SOV); the clinical features of which have yet to be investigated among Thai patients. Objective To determine the clinical differences between pure scleroderma and SOV. Methods A historical cohort study was conducted among patients with pure scleroderma versus those with SOV. Subjects were over 18 years of age and followed up at Srinagarind Hospital, Khon Kaen University, Thailand, between January 2006 and December 2011. Results Four hundred and three medical records were included (276 female vs. 127 male). SOV was found in 68 cases (16.9%): (i) scleroderma–polymyositis overlap (SOV-PM), the most common type of SOV (48 cases; 70.6%); (ii) scleroderma–systemic lupus erythematosus overlap (11 cases; 16.2%); and (iii) scleroderma–rheumatoid arthritis overlap (nine cases; 13.2%). Mean age at onset of non-systemic sclerosis symptoms was 46.9 ± 11.8 years (range, 19.8–74.3). Characteristically, sufferers of SOV as against pure scleroderma were younger, had less frequent anti-topoisomerase I (ATA) and needed moderate- to high-dose steroid and immunosuppressant therapy during follow-up. SOV-PM presented the clinical features of scleroderma at onset and during follow-up looks like pure scleroderma having vasculopathy, severity of skin tightness, and gastrointestinal, cardiopulmonary and renal involvement. Anti-Ro52 was the most common serology among sufferers of SOV (31.6%). ATA was associated with pure scleroderma patients (P = 0.047). Conclusions SOV rather than pure scleroderma presented in younger Thai scleroderma patients and SOV-PM was the most common subtype and its clinical features were similar to those of pure scleroderma. ATA was strongly associated with the latter.
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- 2016
6. Clinical characteristics and mortality rate of Thai elderly-onset systemic sclerosis
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Ruethairat, Apipattarakul, Chingching, Foocharoen, Sittichai, Netwijitpan, Ajanee, Mahakkanukrauh, Siraphop, Suwannaroj, Panita, Limpawattana, and Ratanavadee, Nanagara
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Male ,Scleroderma, Systemic ,Health Status ,Incidence ,Middle Aged ,Prognosis ,Thailand ,Medical Records ,Cost of Illness ,Muscular Diseases ,Risk Factors ,Activities of Daily Living ,Disease Progression ,Humans ,Female ,Age of Onset ,Exercise ,Preliminary Data - Abstract
To identify the clinical differences and mortality rate between adult and elderly onset systemic sclerosis (SSc).We conducted a historical cohort study of SSc patients during January 2007-December 2011. The SSc patients were 60 and over classified as elderly onset SSc. Cox regression analysis was used to estimate the probability of survival and for assessing the factors associated with mortality.The medical records of 350 SSc patients were reviewed; 53 (15.1%) had elderly onset SSc. According to the multivariate analysis, elderly onset SSc has a higher WHO functional class, more frequent weakness, more frequent hyperCKaemia, and less pulmonary fibrosis than adult onset SSc (p=0.004, 0.02, 0.02, 0.02, respectively). The incidence of mortality was 3.8 per 100 person-year with a median survival rate of 15.9 years (95%CI 12.4-17.3). The mortality rate of elderly SSc onset was significantly higher than that of adult SSc onset (HR 5.71; 95%CI 3.54-9.20). The median survival of elderly and adult onset SSc was 4.9 years and 16.1 years, respectively. The Cox regression analysis indicated that presence of digital ulcer and tendon friction rub had a respective HR of 7.39 (95%CI 1.28-42.60) and 37.23 (95%CI 2.10-659.09) for predicting mortality of elderly onset SSc.Myopathy and limitation of physical activity were frequently found among elderly onset SSc over against pulmonary involvement than in adult onset SSc. Mortality of elderly onset SSc was 5.7 times higher, and median survival was 11 years shorter, than adult onset SSc.
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- 2017
7. Clinical differences between Thai systemic sclerosis patients with positive versus negative anti-topoisomerase I
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Ratanavadee Nanagara, Sittichai Netwijitpan, Chingching Foocharoen, Siraphop Suwannaroj, Ajanee Mahakkanukrauh, and Prangsuporn Suwannachat
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Adult ,Male ,0301 basic medicine ,Adolescent ,Pulmonary Fibrosis ,Scleroderma ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Predictive Value of Tests ,Risk Factors ,Scleroderma, Limited ,Hand Deformities, Acquired ,mental disorders ,Odds Ratio ,Prevalence ,Humans ,Medicine ,Serologic Tests ,Anti-Topoisomerase I ,Aged ,Autoantibodies ,Retrospective Studies ,030203 arthritis & rheumatology ,Autoimmune disease ,Chi-Square Distribution ,business.industry ,Raynaud Disease ,Middle Aged ,Thailand ,medicine.disease ,Logistic Models ,030104 developmental biology ,Increased risk ,DNA Topoisomerases, Type I ,Multivariate Analysis ,Scleroderma, Diffuse ,Immunology ,I antibody ,Organ involvement ,Female ,business ,Biomarkers - Abstract
Anti-topoisomerase I antibody (ATA) carries an increased risk of systemic sclerosis (SSc) internal organ involvement. There have been no published comparisons of the clinical characteristics of patients positive and negative for ATA in Thailand, where the positive rate for ATA is higher than among Caucasians.To define the clinical differences between SSc, positive versus negative, for ATA.A retrospective cohort study was performed among SSc patients over 18 at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006-December 2013. SSc-overlap syndrome was excluded.Two hundred and ninety-four SSc patients were included (female : male 2.5 : 1). The majority (68.6%) were the diffuse cutaneous SSc subset (dcSSc). ATA was positive in 252 patients (85.7%), among whom 71.7% had dcSSc and 28.2% limited cutaneous SSc (lcSSc). Using a multivariate analysis, hand deformity had a significantly positive association with ATA (odds ratio [OR] 7.01; 95% CI 1.02-48.69), whereas being anti-centromere (ACA) positive had a negative association (OR 0.17; 95% CI 0.03-0.92). After doing a subgroup analysis of the SSc subset, the median duration of disease at time of pulmonary fibrosis detection among ATA positive dcSSc was significantly shorter than the ATA negative group (1.05 vs. 6.77 years, P = 0.01). Raynaud's phenomenon (RP) at onset was significantly more frequent in lcSSc sufferers who were ATA negative than those who were ATA positive (90.5% vs. 56.9%, P = 0.005).A high prevalence of ATA positivity was found among Thai SSc patients and this was associated with a high frequency of hand deformity, ACA negativity, a short duration of pulmonary fibrosis in dcSSc and a lower frequency of RP in lcSSc.
- Published
- 2014
8. Incidence of Pulmonary Hypertension in Patients With Systemic Sclerosis and No Pulmonary Symptoms
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Burabha Pussadhamma, Sittichai Netwijitpan, Ajanee Mahakkanukrauh, Chingching Foocharoen, Siraphop Suwannaroj, and Ratanavadee Nanagara
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Adult ,Male ,medicine.medical_specialty ,Hypertension, Pulmonary ,Comorbidity ,Unnecessary Procedures ,Doppler echocardiography ,Severity of Illness Index ,Asymptomatic ,Cohort Studies ,Rheumatology ,Risk Factors ,Internal medicine ,Severity of illness ,Confidence Intervals ,medicine ,Humans ,Mass Screening ,Mass screening ,Retrospective Studies ,Scleroderma, Systemic ,medicine.diagnostic_test ,business.industry ,Incidence ,Incidence (epidemiology) ,Retrospective cohort study ,Middle Aged ,Thailand ,medicine.disease ,Pulmonary hypertension ,Echocardiography, Doppler ,Heart catheterization ,Cardiology ,Female ,medicine.symptom ,business - Abstract
Background Annual echocardiographic screening has been recommended for early detection of pulmonary hypertension (PHT) in systemic sclerosis (SSc) patient; however, the cost benefit for cases with no pulmonary symptoms is not well established. Objectives The objective of this study was to determine the incidence and clinical predictors of echocardiographic diagnosis of PHT in "asymptomatic" SSc patients. Methods A historical cohort of adult SSc patients who underwent echocardiographic screening for PHT at least twice in Khon Kaen University, Thailand, during January 1, 2005, to December 31, 2011, was included. Pulmonary hypertension was defined by an estimate of right ventricular systolic pressure of greater than 40 mm Hg. Results A total of 143 medical records were reviewed (female-to-male ratio = 1.7:1). The majority had the diffuse subset (94 cases; 69.6%). Seventy-five (52.4%) were without pulmonary symptoms throughout the follow-up period. Of the 403.1 person-years under observation in the asymptomatic group, only 1 had pulmonary arterial hypertension confirmed by right-sided heart catheterization. The incidence of PHT among such SSc patients was 0.2 per 100 person-years (95% confidence interval [CI], 0.006-0.01 per 100 person-years). The disease duration at the time of PHT detection by echocardiography was 5.1 years. The declining functional class (FC) led to the higher incidence of PHT, with incidence of PHT in those who had declining FC I to FC II and FC I to FC III of 2.1 (95% CI, 0.4-6.0) and 4.2 (95% CI, 0.1-23.3), respectively. Conclusions The incidence of echocardiography-diagnosed PHT among Thai with SSc, and no pulmonary symptoms was low. Annual echocardiography is less beneficial among such patients; repeated echocardiography should instead be performed on those with a declining FC.
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- 2014
9. Inter- and Intra-Observer Reliability of Modified Rodnan Skin Score Assessment in Thai Systemic Sclerosis Patients: A Validation for Multicenter Scleroderma Cohort Study
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Chingching, Foocharoen, Bandit, Thinkhamrop, Ajanee, Mahakkanukrauh, Siraphop, Suwannaroj, Sittichai, Netwijitpan, Kwanleutai, Sripavatakul, Wiriya, Chuealee, Bodin, Boottam, Patapong, Towiwat, Patcharawan, Seubmee, Kittikorn, Daungkum, Darunee, Kongpan, Jintara, Mangkala, and Ratanavadee, Nanagara
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Adult ,Cohort Studies ,Male ,Observer Variation ,Scleroderma, Systemic ,Surveys and Questionnaires ,Humans ,Reproducibility of Results ,Female ,Middle Aged ,Thailand ,Physical Examination ,Skin - Abstract
Assessment of the severity of skin tightness by the modified Rodnan skin score (mRSS) for systemic sclerosis (SSc) has been found feasible, valid, and reliable. Despite being a major clinical outcome, it has not yet been validated by Scleroderma Research Group.To (a) determine the inter-observer variability vis-à-vis mRSS assessment by members ofthe Scleroderma Research Group before and after mRSS-assessment training by an experienced rheumatologist and (b) determine intra-observer variability.Between June and August 2013, we conducted a descriptive study of Thai adult SSc patients and all rheumatologists in the Scleroderma Research Group at Srinagarind Hospital, Khon Kaen University, Northeast Thailand. Eleven rheumatologists assessed the mRSS of 22 SSc patients three times (i.e., before and after training, and eight weeks after training). The intra-class correlation coefficient (ICC) and its 95% CI were estimated at week 8 after training.The mean and standard deviation (SD) of mRSS for inter-observer variability analysis was slightly decreased from before training, after training (by an experienced rheumatologist), and at week 8 after training (17.3 ± 11.9, 16.5 ± 11.1, and 16.2 ± 10.3, respectively). Intra-observer variability had moderate agreement before training (ICC 0.59; 95% CI 0.38-0.78), which increased to good agreement after training and at week 8 after training (ICC 0.60; 95% CI 0.42-0.76 vs. 0.68; 95% CI 0.53-0.82, respectively).Inter-observer variability for mRSS assessment decreased after training and the reduction persisted for eight weeks after training. The ICC rose from moderate agreement at baseline to good agreement at the end of the study. The mRSS assessment by members of the Scleroderma Research Group was reliable.
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- 2016
10. CPAP Therapy Improves Intractable Hemifacial Spasm
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Verajit Chotmongkol, Sittichai Netwijitpan, Somsak Tiamkao, Kittisak Sawanyawisuth, Narongrit Kasemsap, Kannikar Kongbunkiat, Noppadol Aekphachaisawat, and Panita Limpawattana
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business.industry ,medicine.medical_treatment ,Case Report ,medicine.disease ,lcsh:RC346-429 ,nervous system diseases ,respiratory tract diseases ,Obstructive sleep apnea ,body regions ,stomatognathic diseases ,Cpap therapy ,Anesthesia ,medicine ,otorhinolaryngologic diseases ,Continuous positive airway pressure ,General Agricultural and Biological Sciences ,business ,lcsh:Neurology. Diseases of the nervous system ,Hemifacial spasm - Abstract
The correlation between obstructive sleep apnea (OSA) and hemifacial spasm has never been reported in the literature. Here, we report a case of OSA-induced hypertension with intractable hemifacial spasm in which both conditions improved after continuous positive airway pressure treatment.
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- 2015
11. Causes and prevalence of inadequate pulmonary function testing among patients with systemic sclerosis
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Pichaporn Sumphao-Ngern, Chingching Foocharoen, Watchara Boonsawat, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Uraiwan Sae-Oue, Sittichai Netwijitpan, Ratanavadee Nanagara, and Scleroderma Research Group
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Spirometry ,Vital capacity ,Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,systemic sclerosis ,General Medicine ,Disease ,medicine.disease ,Scleroderma ,Pulmonary function testing ,pulmonary function test ,Lung disease ,Clinical Research ,forced vital capacity ,Internal medicine ,Expiration Time ,Medicine ,Restrictive lung disease ,scleroderma ,business - Abstract
Introduction Spirometry is a screening tool for evaluating the degree of restrictive lung disease in systemic sclerosis (SSc). Observations indicated that some patients could not complete the test. The aim of the study was to identify the prevalence, causes and clinical predictors of an inadequate pulmonary function test (PFT) in SSc. Material and methods A cross-sectional study was performed among SSc patients over 18 years old followed up at Srinagarind Hospital, Khon Kaen, Thailand, during January 2006–December 2012. The adequacy of the PFT was based on the acceptable blow criteria as set out by the American Thoracic Society and the European Respiratory Society 2005 Standardizations of Spirometry. Results Two hundred and forty-nine patients were included (female to male ratio was 2 : 1). The mean age at performing PFT was 51.4 ±11.1 years (range: 19.6–79.5). Median duration of disease at performing PFT was 2 years (IQR: 0.6–4.4). Inadequate PFT occurred in 73 cases (prevalence 29.3%: 95% CI: 23.6–35.0); the majority (60 cases; 82.2%) had an expiration time < 6 s and the others were due to plateau < 1 s (11 cases; 15%), air leak around mouth piece (1 case; 1.4%) and hesitation (1 case; 1.4%). Thirteen of 73 (17.8%) had an unusable graph with the overall prevalence of 5.2% (95% CI: 2.4–8.0). The factor associated with inadequate PFT was docy mass index (BMI) < 18.5 kg/m2 (OR = 2.17: 95% CI: 1.49–3.17); the same factor was associated with an unusable graph, which was confirmed by the multivariate analysis (OR = 5.21; 95% CI: 1.60–16.95). Conclusions One-third of Thai SSc patients had an inadequate pulmonary function test – the majority because of inadequate time for expiring. Low BMI influenced the effectiveness of the test, leading to an incomplete graph for evaluating lung disease in SSc.
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- 2014
12. Indications for hospitalization and in-hospital mortality in Thai systemic sclerosis
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Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Ratanavadee Nanagara, Sittichai Netwijitpan, and Chingching Foocharoen
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Male ,medicine.medical_specialty ,Cross-sectional study ,Anemia ,Rheumatology ,Interquartile range ,Risk Factors ,Internal medicine ,Medicine ,Humans ,Hospital Mortality ,Cause of death ,Proportional Hazards Models ,Retrospective Studies ,Scleroderma, Systemic ,business.industry ,Proportional hazards model ,Hazard ratio ,Bacterial pneumonia ,Retrospective cohort study ,General Medicine ,Length of Stay ,Middle Aged ,medicine.disease ,Thailand ,Surgery ,Hospitalization ,Cross-Sectional Studies ,Female ,business - Abstract
This study aimed to identify the indications for hospitalization, hospital mortality rate, predictors of hospital mortality, and clinical parameters affecting length of stay (LOS) among Thai systemic sclerosis (SSc). A retrospective study was performed in SSc patients admitted in Khon Kaen University, Thailand, between January 2008 and December 2010. The respective clinical factors affecting LOS and predictors of mortality were analyzed using the Spearman's rank correlation and the Cox regression model. There were 202 hospital admissions among 131 SSc patients. The female-to-male ratio was 1.6:1. The median age at admission was 54.7 years (interquartile range (IQR) 49.2–62.9), the duration of disease at admission was 2.9 years (IQR 1.1–7.8), and the LOS was 5 days (IQR 2–10). The indications for hospitalization were divided equally between SSc-related and non-SSc-related events (53.5 vs. 46.5 %, respectively). The most common indication for hospitalization was infection (23.3 %) and pneumonia is the most common cause of infection (58.0 %). Prolonged LOS was related to fatigability status (p
- Published
- 2012
13. Causes and prevalence of inadequate pulmonary function testing among patients with systemic sclerosis.
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Pichaporn Sumphao-Ngern, Chingching Foocharoen, Watchara Boonsawat, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Uraiwan Sae-Oue, Sittichai Netwijitpan, Ratanavadee Nanagara, Sumphao-Ngern, Pichaporn, Foocharoen, Chingching, Boonsawat, Watchara, Mahakkanukrauh, Ajanee, Suwannaroj, Siraphop, Sae-Oue, Uraiwan, Netwijitpan, Sittichai, Nanagara, Ratanavadee, and Scleroderma Research Group
- Subjects
SYSTEMIC scleroderma ,PULMONARY function tests ,BODY mass index ,MULTIVARIATE analysis ,GRAPH theory ,PATIENTS - Abstract
Introduction: Spirometry is a screening tool for evaluating the degree of restrictive lung disease in systemic sclerosis (SSc). Observations indicated that some patients could not complete the test. The aim of the study was to identify the prevalence, causes and clinical predictors of an inadequate pulmonary function test (PFT) in SSc.Material and Methods: A cross-sectional study was performed among SSc patients over 18 years old followed up at Srinagarind Hospital, Khon Kaen, Thailand, during January 2006-December 2012. The adequacy of the PFT was based on the acceptable blow criteria as set out by the American Thoracic Society and the European Respiratory Society 2005 Standardizations of Spirometry.Results: Two hundred and forty-nine patients were included (female to male ratio was 2 : 1). The mean age at performing PFT was 51.4 ±11.1 years (range: 19.6-79.5). Median duration of disease at performing PFT was 2 years (IQR: 0.6-4.4). Inadequate PFT occurred in 73 cases (prevalence 29.3%: 95% CI: 23.6-35.0); the majority (60 cases; 82.2%) had an expiration time < 6 s and the others were due to plateau < 1 s (11 cases; 15%), air leak around mouth piece (1 case; 1.4%) and hesitation (1 case; 1.4%). Thirteen of 73 (17.8%) had an unusable graph with the overall prevalence of 5.2% (95% CI: 2.4-8.0). The factor associated with inadequate PFT was docy mass index (BMI) < 18.5 kg/m(2) (OR = 2.17: 95% CI: 1.49-3.17); the same factor was associated with an unusable graph, which was confirmed by the multivariate analysis (OR = 5.21; 95% CI: 1.60-16.95).Conclusions: One-third of Thai SSc patients had an inadequate pulmonary function test - the majority because of inadequate time for expiring. Low BMI influenced the effectiveness of the test, leading to an incomplete graph for evaluating lung disease in SSc. [ABSTRACT FROM AUTHOR]- Published
- 2015
- Full Text
- View/download PDF
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