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13 results on '"Skau, Colleen T."'

9. Retraction Notice to: FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis

Author

Skau, Colleen T., primary, Fischer, Robert S., additional, Gurel, Pinar, additional, Thiam, Hawa Racine, additional, Tubbs, Anthony, additional, Baird, Michelle A., additional, Davidson, Michael W., additional, Piel, Matthieu, additional, Alushin, Gregory M., additional, Nussenzweig, Andre, additional, Steeg, Patricia S., additional, and Waterman, Clare M., additional

Published
2018
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10. FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis

Author

Skau, Colleen T., Fischer, Robert S., Gurel, Pinar, Racine-Thiam, Hawa, Tubbs, Anthony, Baird, Michelle A., Davidson, Michael W., Piel, Matthieu, Alushin, Gregory M., Nussenzweig, Andre, Steeg, Patricia S., and Waterman, Clare M.

Subjects
Cell Nucleus, Focal Adhesions, Lung Neoplasms, Microfilament Proteins, Formins, Nuclear Proteins, Nerve Tissue Proteins, Embryo, Mammalian, Actins, Article, Extracellular Matrix, Mice, Inbred C57BL, Mice, Animals, Humans, DNA Breaks, Double-Stranded, Female, Neoplasm Metastasis, Melanoma
Abstract

Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nucleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previously characterized actin/FA structures. This system controls nuclear shape and positioning in cells migrating on 2D surfaces. In confined 3D microenvironments, FMN2 promotes cell survival by limiting nuclear envelope damage and DNA double-strand breaks. We found that FMN2 is upregulated in human melanomas, and show that disruption of FMN2 in mouse melanoma cells inhibits their extravasation and metastasis to the lung. Our results indicate a critical role for FMN2 in generating a perinuclear actin/FA system that protects the nucleus and DNA from damage to promote cell survival during confined migration, and thus promote cancer metastasis.

Published
2015

13. FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Author

Skau, Colleen T., Fischer, Robert S., Gurel, Pinar, Thiam, Hawa Racine, Tubbs, Anthony, Baird, Michelle A., Davidson, Michael W., Piel, Matthieu, Alushin, Gregory M., Nussenzweig, Andre, Steeg, Patricia S., and Waterman, Clare M.

Subjects
*CYTOSKELETAL proteins, *DNA damage, *CELL migration, *CYTOLOGY periodicals, *METASTASIS
Abstract

Summary Cell migration in confined 3D tissue microenvironments is critical for both normal physiological functions and dissemination of tumor cells. We discovered a cytoskeletal structure that prevents damage to the nucleus during migration in confined microenvironments. The formin-family actin filament nucleator FMN2 associates with and generates a perinuclear actin/focal adhesion (FA) system that is distinct from previously characterized actin/FA structures. This system controls nuclear shape and positioning in cells migrating on 2D surfaces. In confined 3D microenvironments, FMN2 promotes cell survival by limiting nuclear envelope damage and DNA double-strand breaks. We found that FMN2 is upregulated in human melanomas and showed that disruption of FMN2 in mouse melanoma cells inhibits their extravasation and metastasis to the lung. Our results indicate a critical role for FMN2 in generating a perinuclear actin/FA system that protects the nucleus and DNA from damage to promote cell survival during confined migration and thus promote cancer metastasis. [ABSTRACT FROM AUTHOR]

Published
2016
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