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ABSTRACT It is believed that oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system's ability to neutralize the reactive intermediates. Oxidative damage [...]

Abstract Background: Hand dermatitis is a chronic inflammatory skin disorder for which systemic immunosuppressive therapy is often needed. Topical treatments could complement the use of systemic corticosteroids. Objective: To evaluate [...]

Background: Hydrocortisone butyrate (HCB) is currently marketed as a cream, ointment, and solution. A new lotion formulation of hydrocortisone butyrate 0.1% (Locoid[R] lotion) has been developed and evaluated. Objective: The objective of this study was to evaluate the efficacy and safety of HCB 0.1% lotion compared to the vehicle in subjects aged 3 months to less than 18 years with mild to moderate atopic dermatitis (AD). Methods: In this multicenter double-blind study, 284 subjects with mild to moderate AD were randomized 1:1 to receive HCB 0.1% lotion or the vehicle for a duration of 4 weeks. 'Treatment success' was defined as those subjects with a final Physician Global Assessment (PGA) score of 0 or 1 that had at least a 2-point reduction in the PGA score from baseline to day 29. Safety was assessed by monitoring adverse events. Results: Analyses of the final PGA score showed a significant treatment effect (P Limitations: The study did not assess the durability of the treatment effects (ie, safety and efficacy) after completion of the 4-week treatment period nor the potential need for longer term therapy given the chronic nature of AD. Conclusion: Results demonstrate the safety and efficacy of HCB 0.1% lotion in the treatment of mild to moderate AD in children 3 months to 18 years of age., Introduction Topical corticosteroids have become the cornerstone of treatment for a variety of inflammatory dermatoses, including atopic dermatitis (AD), eczema, and psoriasis. A wide selection of topical corticosteroid products is [...]

Abstract Topical anesthetic agents are frequently used by dermatologists to decrease the pain associated with a variety of cutaneous procedures, including laser surgery, soft tissue augmentation, and other cosmetic surgical [...]

Abstract Evidence of the signs associated with skin aging often first appears in the periorbital area and includes wrinkles, eyelid bags, circles around the eye, or a 'tired' look. This [...]

A drug called mepolizumab may benefit patients with a skin disease called eosinophilic dermatitis, according to a study of three patients. This drug is a monoclonal antibody against interleukin-5, which is produced in greater than normal amounts in these patients. The drug may benefit patients who do not respond to other drugs used for this disease.

ABSTRACT Prior to 1962, some of the most versatile drugs in dermatology were approved by the U.S. Food and Drug Administration (FDA) solely on the basis of safety. One of [...]

ABSTRACT Interstitial granulomatous dermatitis is most commonly associated with rheumatoid arthritis (RA) but may be induced by medications as well. Darifenacin is a muscarinic antagonist which was FDA approved for [...]

Byline: Paula. Torres-Camacho, Andres. Tirado-Sanchez, Rosa. Ponce-Olivera Sir, Erythroderma, first described by Hebra in 1868, is an inflammatory disorder characterized by erythema and scaling involving more than 90% of the [...]

Byline: Debasish. Basu, Nitesh. Painuly, Manoj. Sahoo Dermatitis artefacta is a disorder in which the skin is the target of self-inflicted injury. We report a case of dermatitis artefacta, in [...]

Byline: Asok. Gangopadhyay, Jayanta. Das, Sujata. Sengupta Sir, Schamberg's disease (SD), (progressive pigmentary dermatosis), is of uncertain etiology.[sup] [1] Irregular patches of brown pigmentation due to hemosiderin deposits, with characteristic [...]

Byline: Kaushal. Verma, R. Mahesh, Pushplata. Srivastava, M. Ramam, A. Mukhopadhyaya Background: Parthenium hysterophorus is the commonest cause of airborne contact dermatitis in India. Azathioprine has been shown to be [...]

Byline: V. Sehgal, A. Aggarwal, G. Srivastava, A. Sharma Hand dermatitis or eczema poses an extraordinary challenge in diagnosis and treatment and demands expeditious and aggressive attention to prevent disability [...]

Byline: S. Murthy, Karjigi. Siddalingappa, T. Suresh Sir, Nicolau's syndrome (NS) is a rare injection site reaction, following intramuscular administration of drugs, with varying degrees of tissue damage. It is [...]

Byline: P. Mercy, A. Ghorpade, M. Das, A. Soud, S. Puttoo, D. Sharma, A. Jain Acquired Blaschkoid dermatitis characterised by unilateral relapsing inflammatory disease along the lines of Blaschko. A [...]

Byline: M. Ramam, Trilokraj. Tejasvi, Yashpal. Manchanda, Sandeep. Sharma, Rashmi. Mittal Background: Laboratory tests for the diagnosis of cutaneous tuberculosis lack adequate sensitivity and specificity and a trial of therapy [...]

Byline: Shapour. Omidvari, Hojjatollah. Saboori, Mohammad. Mohammadianpanah, Ahmad. Mosalaei, Niloofar. Ahmadloo, Mohammad. Mosleh-Shirazi, Farideh. Jowkar, Soha. Namaz Background: Although acute radiation dermatitis (ARD) is a common side-effect of radiotherapy (RT), [...]

Byline: C. Srinivas Sir, We first reported the effectiveness of Azathioprine in the management of chronic actinic dermatitis induced by parthenium[1] and hence found the article titled parthenium dermatitis treated [...]

Byline: Kaushal. Verma, Arika. Bansal, G. Sethuraman Background: Parthenium dermatitis is a serious problem in India. Corticosteroids are the mainstay of treatment but the prolonged use of corticosteroids can cause [...]

Sponsored by Merz Pharmaceuticals, LLC. This is a study to assess how safe and effective an investigational product, Belotero[R] is in people with darker skin types with facial wrinkles, such [...]

To the Editor: Bedbugs (Cimex lectularius) are hematophagous insects. Adults are 4-6 mm long, flattened, oval and wingless, and brown to brownish-red (Figure, panel A) (1). They may feed in [...]

Coria Laboratories Ltd recently announced the introduction of Tetrix[TM] cream for treatment of hand eczema and hand dermatitis. This product combines dimethicone and cyclomethicone, with aluminum-magnesium hydroxide stearate, in a [...]

INTRODUCTION The recent controversy of botulinum toxin and potential neurotoxicity to the brain has spurred on a tremendous amount of concern on the part of patients seeking this treatment for [...]

BioForm Medical, Inc recently announced that the FDA approved Radiesse[R] for the long-lasting correction of moderate to severe facial wrinkles and folds, as well as for the long-lasting correction of [...]

Study of Restylane and Perlane in the correction of peri-oral wrinkles.Sponsored by Medicis Global Services Corporation. This is an open-label study of Restylane and Perlane in the correction of peri-oral [...]

Investigators have concluded that pimecrolimus application does not translate into clinically meaningful benefit for patients with cetuximab-related facial dermatitis. A recently published study enrolled 24 patients with metastatic colorectal cancer [...]

Sponsored by Merz Pharmaceuticals, LLC. The purpose of this study is to assess how safe and effective an investigational product, Belotero[R] is in people with darker skin types with facial [...]

Sponsored by DeNova Research; Johnson & Johnson. This study will include dark-skinned, ethnic individuals who have clinical evidence of moderate-to-deep laugh lines to enroll in a clinical trial using EVOLENCE[R] [...]

Sponsors and collaborators: Biomedical Development Corporation and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The purpose of this randomized, double blind, efficacy study is to evaluate the [...]

Sponsored by Merz Pharmaceuticals GmbH. NT 201 is a botulinum toxin type A preparation free of complexing proteins. Injected into the muscle, NT 201 causes a reversible local relaxation of [...]

Sponsored by: University of Miami. The purpose of this study is to determine if taking a dose of the study medication, Polypodium leucotomos (PL), prevents some of the changes in [...]

Sponsored by Northwestern University. The purpose of this study is to determine whether an injectable filler into wrinkles can result in safe, aesthetically-pleasing, and long-lasting correction. Condition Intervention Phase Wrinkles [...]

Sponsored by the University of Miami. The purpose of this study is to determine if taking a dose of the study medication, called Polypodium leucotomos (PL), prevents some of the [...]

Sponsored by Galderma. The purpose of this study is to assess whether Metvix[R] PDT will be effective in correcting the effects related to photodamage and whether it will be well-tolerated. [...]