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8. Interleukin‐15 and high‐intensity exercise: relationship with inflammation, body composition and fitness in cancer survivors.

Author

Farley, Morgan J., Boytar, Alexander N., Adlard, Kirsten N., Salisbury, Chloe E., Hart, Nicolas H., Schaumberg, Mia A., Jenkins, David G., and Skinner, Tina L.

Subjects
INTERLEUKIN-1, INFLAMMATION, BODY composition, CANCER survivors, CARDIOPULMONARY system
Abstract

Pre‐clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth. These anti‐oncogenic effects of exercise were associated with the exercise‐mediated release of myokines such as interleukin (IL)‐15. However, no study has quantified the acute IL‐15 response in human cancer survivors, and whether physiological adaptations to exercise training (i.e. body composition and cardiorespiratory fitness) influence this response. In the present study breast, prostate and colorectal cancer survivors (n = 14) completed a single bout of high‐intensity interval exercise (HIIE) [4×4 min at 85–95% heart rate (HR) peak, 3 min at 50–70% HR peak] before and after 7 months of three times weekly high‐intensity interval training (HIIT) on a cycle ergometer. At each time point venous blood was sampled before and immediately after HIIE to assess the acute myokine (IL‐15, IL‐6, IL‐10, IL‐1ra) responses. Markers of inflammation, cardiorespiratory fitness and measures of body composition were obtained at baseline and 7 months. An acute bout of HIIE resulted in a significant increase in IL‐15 concentrations (pre‐intervention: 113%; P = 0.013, post‐intervention: 102%; P = 0.005). Post‐exercise IL‐15 concentrations were associated with all other post‐exercise myokine concentrations, lean mass (P = 0.031), visceral adipose tissue (P = 0.039) and absolute V̇O2${{\dot{V}}_{{{{\mathrm{O}}}_{\mathrm{2}}}}}$ peak (P = 0.032). There was no significant effect of 7 months of HIIT on pre‐ or post‐HIIE IL‐15 concentrations (P > 0.05). This study demonstrates HIIE is a sufficient stimulus to increase circulating IL‐15 and other myokines including IL‐6, IL‐10 and IL‐1ra which may be clinically relevant in the anti‐oncogenic effect of exercise and repetitive exposure to these effects may contribute to the positive relationship between exercise and cancer recurrence. Key points: Exercise has been demonstrated to reduce the risk of cancer recurrence.Pre‐clinical murine and in vitro models have demonstrated that exercise suppresses tumour and cancer cell growth, mediated by exercise‐induced myokines (IL‐6 and IL‐15).High‐intensity interval exercise significantly increased myokines associated with the anti‐oncogenic effect of exercise and the magnitude of response was associated with lean mass, but training did not appear to influence this response.Given IL‐15 has been implicated in the anti‐oncogenic effect of exercise and is being explored as an immunotherapy agent, high‐intensity interval exercise may improve outcomes for people living beyond cancer through IL‐15‐mediated pathways.Interventions that increase lean mass may also enhance this response. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Safety, Feasibility, and Acceptability of a Multi-Site Individualized Exercise Intervention for People with Multiple Myeloma

Author

Nicol, Jennifer L., primary, Cunningham, Brent, additional, Woodrow, Carmel, additional, Adlard, Kirsten, additional, Papinczak, Zoe, additional, Spence, Rosalind R., additional, Boytar, Alex N., additional, Mollee, Peter, additional, Weber, Nicholas, additional, Nicol, Andrew J., additional, Hill, Michelle M., additional, and Skinner, Tina L., additional

Published
2023
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14. Cardiopulmonary exercise testing of patients with metastatic castrate-resistant prostate cancer as screening for vigorous exercise medicine prescription.

Author

Newton, Robert Usher, primary, Hart, Nicolas H., additional, Kenfield, Stacey A., additional, Galvao, Daniel Abido, additional, Courneya, Kerry S., additional, Ryan, Charles M, additional, Chan, June M., additional, Catto, James W.F., additional, Winters-Stone, Kerri M., additional, Van Hemelrijck, Mieke, additional, Wylie, Harriet, additional, Schumann, Moritz, additional, Skinner, Tina, additional, Praet, Stephan, additional, and Saad, Fred, additional

Published
2023
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18. Supplementary Tables 1-4; Supplementary Figures 1-4 from Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk

Author

Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Skinner, Tina L., primary, Lay, Jannelle, primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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19. Data from Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk

Author

Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Skinner, Tina L., primary, Lay, Jannelle, primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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20. Supplementary Figure from Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk

Author

Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Skinner, Tina L., primary, Lay, Jannelle, primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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21. Data from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Chong, Jamie E., primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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22. Supplementary Figure from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Chong, Jamie E., primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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23. Figure S1A from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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24. Table S6B from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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25. Figure 1 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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26. Data from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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27. Table S1 from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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28. Figure S1E from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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29. Table 1 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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30. Table 1 from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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31. Figure 2 from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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32. Figure 1 from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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33. Figure 3 from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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34. Figure 3 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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35. Figure 2 from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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36. Figure 4 from Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., primary, Swain, Christopher T.V., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, van Roekel, Eline H., primary, Skinner, Tina L., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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37. Data from Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., primary, Milne, Roger L., primary, English, Dallas R., primary, Brown, Kristy A., primary, Lou, Makayla W.C., primary, Boing, Leonessa, primary, Bageley, Amy, primary, Skinner, Tina L., primary, van Roekel, Eline H., primary, Moore, Melissa M., primary, Gaunt, Tom R., primary, Martin, Richard M., primary, Lewis, Sarah J., primary, and Lynch, Brigid M., primary

Published
2023
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41. Benefits beyond cardiometabolic health: the potential of frequent high intensity 'exercise snacks' to improve outcomes for those living with and beyond cancer.

Author

Jenkins, David G., Devin, James L., Weston, Kathryn L., Jenkins, Joseph G., and Skinner, Tina L.

Abstract

High intensity interval training (HIIT) has been shown to consistently elicit rapid and significant adaptations in a number of physiological systems, across many different healthy and clinical populations. In addition, there is increasing interest in how some acute, yet transient responses to high intensity exercise potentially reduce the risks of particular diseases. Recent work has shown that discrete, brief bouts of high intensity exercise (termed 'exercise snacks') can improve glucose control and vascular health and thus counter the negative cardiometabolic consequences of prolonged, uninterrupted periods of inactivity. In this brief review, we advance the case, using evidence available from pre‐clinical studies in the exercise oncology literature, that brief, frequently completed bouts of high intensity exercise embedded within an individual's overall daily and weekly physical activity schedule, may transiently impact the tumour microenvironment and improve the health outcomes for those who have been diagnosed and treated for cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation

Author

Swain, Christopher T.V., primary, Drummond, Ann E., additional, Milne, Roger L., additional, English, Dallas R., additional, Brown, Kristy A., additional, Lou, Makayla W.C., additional, Boing, Leonessa, additional, Bageley, Amy, additional, Skinner, Tina L., additional, van Roekel, Eline H., additional, Moore, Melissa M., additional, Gaunt, Tom R., additional, Martin, Richard M., additional, Lewis, Sarah J., additional, and Lynch, Brigid M., additional

Published
2023
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45. Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk

Author

Lou, Makayla W.C., primary, Drummond, Ann E., additional, Swain, Christopher T.V., additional, Milne, Roger L., additional, English, Dallas R., additional, Brown, Kristy A., additional, van Roekel, Eline H., additional, Skinner, Tina L., additional, Moore, Melissa M., additional, Gaunt, Tom R., additional, Martin, Richard M., additional, Lewis, Sarah J., additional, and Lynch, Brigid M., additional

Published
2023
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