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Your search keyword '"Skirtach, A. G."' showing total 569 results
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569 results on '"Skirtach, A. G."'

29. Novel Type of Non‐Toxic, Degradable, Luminescent Ratiometric Thermometers Based on Dyes Embedded in Disulfide‐Bridged Periodic Mesoporous Organosilica Particles.

Author

Premcheska, Simona, Lederer, Mirijam, Mohanty, Sonali, Alici, Ayse, Skirtach, Andre G., and Kaczmarek, Anna M.

Subjects
FLUORESCENT dyes, METAL ions, HEAVY metals, HUMAN body, ORGANIC bases, ORGANIC dyes
Abstract

Despite the excellent thermometric performance of many developed luminescent nanomaterials, their use has not gone beyond proof‐of‐concept in vivo experiments to date. An important issue that needs to be resolved before moving toward true biomedical applications of engineered nanothermometers is their potential toxicity and bioaccumulation in the human body considering the ultimate objective of clinical applications. Since most reported nanothermometers currently are not degradable materials and are mainly based on the incorporation of heavy metal ions, these aspects remain of genuine concern in the fields of nanomedicine, nanobiotechnology, nanotoxicology, and nanopharmacology. This work explores the possibility of designing visible, as well as near‐infrared, emitting luminescent ratiometric nanothermometers based on appropriate organic dye mixtures embedded in hollow disulfide‐bridged periodic mesoporous organosilica (PMO) particles. Such hybrid particles show excellent thermometric performance in the physiological temperature range (20–50 °C), favorable degradability in simulated physiological conditions, as well as no toxicity to healthy normal human dermal fibroblast (NHDF) cells in a wide concentration range. Considering the simplicity of the approach from the synthetic point of view, and the large available library of known fluorescent dyes emitting in various regions of the electromagnetic range, this motif renders a very promising approach to designing novel non‐toxic, decomposable, luminescent ratiometric thermometers. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Enhanced piezoresponse and surface electric potential of hybrid biodegradable polyhydroxybutyrate scaffolds functionalized with reduced graphene oxide for tissue engineering

Author

Chernozem, Roman V., Romanyuk, Konstantin N., Grubova, Irina, Chernozem, Polina V., Surmeneva, Maria A., Mukhortova, Yulia R., Wilhelm, Michael, Ludwig, Tim, Mathur, Sanjay, Kholkin, Andrei L., Neyts, Erik, Parakhonskiy, Bogdan, Skirtach, Andre G., and Surmenev, Roman A.

Published
2021
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36. Diverse Applications of Nanomedicine.

Author

Pelaz, Beatriz, Alexiou, Christoph, Alvarez-Puebla, Ramon A, Alves, Frauke, Andrews, Anne M, Ashraf, Sumaira, Balogh, Lajos P, Ballerini, Laura, Bestetti, Alessandra, Brendel, Cornelia, Bosi, Susanna, Carril, Monica, Chan, Warren CW, Chen, Chunying, Chen, Xiaodong, Chen, Xiaoyuan, Cheng, Zhen, Cui, Daxiang, Du, Jianzhong, Dullin, Christian, Escudero, Alberto, Feliu, Neus, Gao, Mingyuan, George, Michael, Gogotsi, Yury, Grünweller, Arnold, Gu, Zhongwei, Halas, Naomi J, Hampp, Norbert, Hartmann, Roland K, Hersam, Mark C, Hunziker, Patrick, Jian, Ji, Jiang, Xingyu, Jungebluth, Philipp, Kadhiresan, Pranav, Kataoka, Kazunori, Khademhosseini, Ali, Kopeček, Jindřich, Kotov, Nicholas A, Krug, Harald F, Lee, Dong Soo, Lehr, Claus-Michael, Leong, Kam W, Liang, Xing-Jie, Ling Lim, Mei, Liz-Marzán, Luis M, Ma, Xiaowei, Macchiarini, Paolo, Meng, Huan, Möhwald, Helmuth, Mulvaney, Paul, Nel, Andre E, Nie, Shuming, Nordlander, Peter, Okano, Teruo, Oliveira, Jose, Park, Tai Hyun, Penner, Reginald M, Prato, Maurizio, Puntes, Victor, Rotello, Vincent M, Samarakoon, Amila, Schaak, Raymond E, Shen, Youqing, Sjöqvist, Sebastian, Skirtach, Andre G, Soliman, Mahmoud G, Stevens, Molly M, Sung, Hsing-Wen, Tang, Ben Zhong, Tietze, Rainer, Udugama, Buddhisha N, VanEpps, J Scott, Weil, Tanja, Weiss, Paul S, Willner, Itamar, Wu, Yuzhou, Yang, Lily, Yue, Zhao, Zhang, Qian, Zhang, Qiang, Zhang, Xian-En, Zhao, Yuliang, Zhou, Xin, and Parak, Wolfgang J

Subjects
Animals, Humans, Neoplasms, Drug Carriers, Drug Delivery Systems, Particle Size, Nanotechnology, Nanomedicine, Nanoparticles, Bioengineering, Prevention, Biotechnology, 5.1 Pharmaceuticals, Generic Health Relevance, Nanoscience & Nanotechnology
Abstract

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

Published
2017

37. Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture

Author

Internal Medicine of Companion Animals, Interne geneeskunde GD, CS_STEAM, STEAM, Research Department VM - Clinical Sciences, Carpentier, Nathan, Ye, Shicheng, Delemarre, Maarten D, Van der Meeren, Louis, Skirtach, André G, van der Laan, Luc J W, Schneeberger, Kerstin, Spee, Bart, Dubruel, Peter, Van Vlierberghe, Sandra, Internal Medicine of Companion Animals, Interne geneeskunde GD, CS_STEAM, STEAM, Research Department VM - Clinical Sciences, Carpentier, Nathan, Ye, Shicheng, Delemarre, Maarten D, Van der Meeren, Louis, Skirtach, André G, van der Laan, Luc J W, Schneeberger, Kerstin, Spee, Bart, Dubruel, Peter, and Van Vlierberghe, Sandra

Published
2024

43. Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture

Author

Carpentier, Nathan, primary, Ye, Shicheng, additional, Delemarre, Maarten D., additional, Van der Meeren, Louis, additional, Skirtach, André G., additional, van der Laan, Luc J. W., additional, Schneeberger, Kerstin, additional, Spee, Bart, additional, Dubruel, Peter, additional, and Van Vlierberghe, Sandra, additional

Published
2024
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45. Efficient long-range conduction in cable bacteria through nickel protein wires

Author

Boschker, Henricus T. S., Cook, Perran L. M., Polerecky, Lubos, Eachambadi, Raghavendran Thiruvallur, Lozano, Helena, Hidalgo-Martinez, Silvia, Khalenkow, Dmitry, Spampinato, Valentina, Claes, Nathalie, Kundu, Paromita, Wang, Da, Bals, Sara, Sand, Karina K., Cavezza, Francesca, Hauffman, Tom, Bjerg, Jesper Tataru, Skirtach, Andre G., Kochan, Kamila, McKee, Merrilyn, Wood, Bayden, Bedolla, Diana, Gianoncelli, Alessandra, Geerlings, Nicole M. J., Van Gerven, Nani, Remaut, Han, Geelhoed, Jeanine S., Millan-Solsona, Ruben, Fumagalli, Laura, Nielsen, Lars Peter, Franquet, Alexis, Manca, Jean V., Gomila, Gabriel, and Meysman, Filip J. R.

Published
2021
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48. Chlamydia psittaciinfected cell studies by 4Pi Raman and atomic force microscopy

Author

Khalenkow, Dmitry, Tormo, Alejandro Diaz, De Meyst, Anne, Van Der Meeren, Louis, Verduijn, Joost, Rybarczyk, Joanna, Vanrompay, Daisy, Le Thomas, Nicolas, and Skirtach, Andre G

Abstract

Chlamydia psittaciis an avian bacterial pathogen that can cause atypical pneumonia in humans via zoonotic transmission. It is a Gram-negative intracellular bacterium that proliferates inside membrane bound inclusions in the cytoplasm of living eukaryotic cells. The study of such cells with C. psittaciinside without destroying them poses a significant challenge. We demonstrated in this work the utility of a combined multitool approach to analyze such complex samples. Atomic force microscopy was applied to obtain high-resolution images of the surface of infected cells upon entrance of bacteria. Atomic force microscopy scans revealed the morphological changes of the cell membrane of Chlamydiainfected cells such as changes in roughness of cell membrane and the presence of micro vesicles. 4Pi Raman microscopy was used to image and probe the molecular composition of intracellular bacteria inside intact cells. Information about the structure of the inclusion produced by C. psittaciwas obtained and it was found to have a similar molecular fingerprint as that of an intracellular lipid droplet but with less proteins and unsaturated lipids. The presented approach demonstrates complementarity of various microscopy-based approaches and might be useful for characterization of intracellular bacteria.

Published
2024
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49. Advances in Nanoarchitectonics: A Review of "Static" and "Dynamic" Particle Assembly Methods.

Author

Eftekhari, Karaneh, Parakhonskiy, Bogdan V., Grigoriev, Dmitry, and Skirtach, Andre G.

Subjects
ARTIFICIAL organs, TISSUE engineering, BIOMATERIALS, DRUG delivery systems, TISSUE scaffolds, NANOELECTROMECHANICAL systems, THERAPEUTICS, MAGNETIC fields
Abstract

Particle assembly is a promising technique to create functional materials and devices from nanoscale building blocks. However, the control of particle arrangement and orientation is challenging and requires careful design of the assembly methods and conditions. In this study, the static and dynamic methods of particle assembly are reviewed, focusing on their applications in biomaterial sciences. Static methods rely on the equilibrium interactions between particles and substrates, such as electrostatic, magnetic, or capillary forces. Dynamic methods can be associated with the application of external stimuli, such as electric fields, magnetic fields, light, or sound, to manipulate the particles in a non-equilibrium state. This study discusses the advantages and limitations of such methods as well as nanoarchitectonic principles that guide the formation of desired structures and functions. It also highlights some examples of biomaterials and devices that have been fabricated by particle assembly, such as biosensors, drug delivery systems, tissue engineering scaffolds, and artificial organs. It concludes by outlining the future challenges and opportunities of particle assembly for biomaterial sciences. This review stands as a crucial guide for scholars and professionals in the field, fostering further investigation and innovation. It also highlights the necessity for continuous research to refine these methodologies and devise more efficient techniques for nanomaterial synthesis. The potential ramifications on healthcare and technology are substantial, with implications for drug delivery systems, diagnostic tools, disease treatments, energy storage, environmental science, and electronics. [ABSTRACT FROM AUTHOR]

Published
2024
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