Search

Your search keyword '"Skirtach, Andre"' showing total 730 results
Start Over Author "Skirtach, Andre"
730 results on '"Skirtach, Andre"'

33. Novel Type of Non‐Toxic, Degradable, Luminescent Ratiometric Thermometers Based on Dyes Embedded in Disulfide‐Bridged Periodic Mesoporous Organosilica Particles.

Author

Premcheska, Simona, Lederer, Mirijam, Mohanty, Sonali, Alici, Ayse, Skirtach, Andre G., and Kaczmarek, Anna M.

Subjects
FLUORESCENT dyes, METAL ions, HEAVY metals, HUMAN body, ORGANIC bases, ORGANIC dyes
Abstract

Despite the excellent thermometric performance of many developed luminescent nanomaterials, their use has not gone beyond proof‐of‐concept in vivo experiments to date. An important issue that needs to be resolved before moving toward true biomedical applications of engineered nanothermometers is their potential toxicity and bioaccumulation in the human body considering the ultimate objective of clinical applications. Since most reported nanothermometers currently are not degradable materials and are mainly based on the incorporation of heavy metal ions, these aspects remain of genuine concern in the fields of nanomedicine, nanobiotechnology, nanotoxicology, and nanopharmacology. This work explores the possibility of designing visible, as well as near‐infrared, emitting luminescent ratiometric nanothermometers based on appropriate organic dye mixtures embedded in hollow disulfide‐bridged periodic mesoporous organosilica (PMO) particles. Such hybrid particles show excellent thermometric performance in the physiological temperature range (20–50 °C), favorable degradability in simulated physiological conditions, as well as no toxicity to healthy normal human dermal fibroblast (NHDF) cells in a wide concentration range. Considering the simplicity of the approach from the synthetic point of view, and the large available library of known fluorescent dyes emitting in various regions of the electromagnetic range, this motif renders a very promising approach to designing novel non‐toxic, decomposable, luminescent ratiometric thermometers. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. Enhanced piezoresponse and surface electric potential of hybrid biodegradable polyhydroxybutyrate scaffolds functionalized with reduced graphene oxide for tissue engineering

Author

Chernozem, Roman V., Romanyuk, Konstantin N., Grubova, Irina, Chernozem, Polina V., Surmeneva, Maria A., Mukhortova, Yulia R., Wilhelm, Michael, Ludwig, Tim, Mathur, Sanjay, Kholkin, Andrei L., Neyts, Erik, Parakhonskiy, Bogdan, Skirtach, Andre G., and Surmenev, Roman A.

Published
2021
Full Text
View/download PDF

42. Diverse Applications of Nanomedicine.

Author

Pelaz, Beatriz, Alexiou, Christoph, Alvarez-Puebla, Ramon A, Alves, Frauke, Andrews, Anne M, Ashraf, Sumaira, Balogh, Lajos P, Ballerini, Laura, Bestetti, Alessandra, Brendel, Cornelia, Bosi, Susanna, Carril, Monica, Chan, Warren CW, Chen, Chunying, Chen, Xiaodong, Chen, Xiaoyuan, Cheng, Zhen, Cui, Daxiang, Du, Jianzhong, Dullin, Christian, Escudero, Alberto, Feliu, Neus, Gao, Mingyuan, George, Michael, Gogotsi, Yury, Grünweller, Arnold, Gu, Zhongwei, Halas, Naomi J, Hampp, Norbert, Hartmann, Roland K, Hersam, Mark C, Hunziker, Patrick, Jian, Ji, Jiang, Xingyu, Jungebluth, Philipp, Kadhiresan, Pranav, Kataoka, Kazunori, Khademhosseini, Ali, Kopeček, Jindřich, Kotov, Nicholas A, Krug, Harald F, Lee, Dong Soo, Lehr, Claus-Michael, Leong, Kam W, Liang, Xing-Jie, Ling Lim, Mei, Liz-Marzán, Luis M, Ma, Xiaowei, Macchiarini, Paolo, Meng, Huan, Möhwald, Helmuth, Mulvaney, Paul, Nel, Andre E, Nie, Shuming, Nordlander, Peter, Okano, Teruo, Oliveira, Jose, Park, Tai Hyun, Penner, Reginald M, Prato, Maurizio, Puntes, Victor, Rotello, Vincent M, Samarakoon, Amila, Schaak, Raymond E, Shen, Youqing, Sjöqvist, Sebastian, Skirtach, Andre G, Soliman, Mahmoud G, Stevens, Molly M, Sung, Hsing-Wen, Tang, Ben Zhong, Tietze, Rainer, Udugama, Buddhisha N, VanEpps, J Scott, Weil, Tanja, Weiss, Paul S, Willner, Itamar, Wu, Yuzhou, Yang, Lily, Yue, Zhao, Zhang, Qian, Zhang, Qiang, Zhang, Xian-En, Zhao, Yuliang, Zhou, Xin, and Parak, Wolfgang J

Subjects
Animals, Humans, Neoplasms, Drug Carriers, Drug Delivery Systems, Particle Size, Nanotechnology, Nanomedicine, Nanoparticles, Bioengineering, Prevention, Biotechnology, 5.1 Pharmaceuticals, Generic Health Relevance, Nanoscience & Nanotechnology
Abstract

The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products. Here, we provide an overview of recent developments in nanomedicine and highlight the current challenges and upcoming opportunities for the field and translation to the clinic.

Published
2017

43. Toward Upconversion (Yb–Er) and near-Infrared (Yb–Ho–Er, Nd–Yb) Thermometry with Sea Urchin Type GdPO4Nanoarchitectures

Author

Mohanty, Sonali, García-Balduz, Jorge, Alıcı, Ayşe, Premcheska, Simona, Lederer, Mirijam, Skirtach, Andre, Van Hecke, Kristof, and Kaczmarek, Anna M.

Abstract

In recent years, optical temperature probes operating in the second near-infrared (BW-II) and third near-infrared (BW-III) biological windows have garnered significant attention in the scientific community. For biological applications these probes offer distinct advantages, including enhanced tissue penetration depth, minimal autofluorescence, and a remarkable improvement in imaging sensitivity and spatial resolution. Moving toward theranostic applications, there is a growing demand for the development of materials that integrate both BW-II and BW-III thermometry systems with drug delivery functionalities. In this study, we concentrate on the development of GdPO4materials, utilizing both hard and sacrificial template routes to synthesize (hollow) GdPO4porous sea urchin-like particles. We first investigated the development of a Boltzmann-type thermometer utilizing an Yb–Er upconversion system, designed to operate within the physiological temperature range. Our exploration extends to the potential of GdPO4particles in near-infrared (NIR) thermometry, spanning the first, second, and third biological windows with systems like Yb–Ho–Er, Nd–Yb, and Ho–Yb, respectively. We further examined the temperature impact of the Yb–Ho–Er system on the NIR emission within a biologically relevant setting, using a phantom that replicates biological tissue. Furthermore, we illustrate the successful loading of these materials with doxorubicin (DOX·HCl), a model anticancer drug, showing these particles exhibit pH-dependent DOX release. This demonstrates the versatility of these materials as upconversion and NIR thermometers while simultaneously serving as an on-demand drug carrier. The investigation involves assessing their cytotoxicity on specific human cells (Normal Human Dermal Fibroblasts (NHDFs)), to determine their viability for potential use in biological applications. The study also investigates how effectively loading the particles with DOX enables targeted delivery to a cellular model of lymphoma (Jurkat E6-1), resulting in cell death. This comprehensive analysis highlights the promising potential of GdPO4particles for medical applications.

Published
2024
Full Text
View/download PDF

46. Exploring the potential of lanthanide-doped oxyfluoride materials for bright green upconversion and their promising applications towards temperature sensing and drug delivery.

Author

Mohanty, Sonali, Lederer, Mirijam, Premcheska, Simona, Rijckaert, Hannes, De Buysser, Klaartje, Bruneel, Els, Skirtach, Andre, Van Hecke, Kristof, and Kaczmarek, Anna M.

Abstract

The most efficient upconversion (UC) materials reported to date are based on fluoride hosts with low phonon energies, which reduce the amount of nonradiative transitions. In particular, NaYF4 doped with Yb3+ and Er3+ at appropriate ratios is known as one of the most efficient UC phosphors. However, its low thermal stability limits its use for certain applications. On the other hand, oxide hosts exhibit better thermal stability, yet they have higher phonon energies and are thus prone to lower UC efficiencies. As a result, developing host nanomaterials that combine the robustness of oxides with the high upconversion efficiencies of fluorides remains an intriguing prospect. Herein, we demonstrate the formation of ytrrium doped oxyfluoride (YOF:Yb3+,Er3+) particles, which are prepared by growing a NaYF4:Yb3+,Er3+ layer around SiO2 spherical particles and consecutively applying a high-temperature annealing step followed by the removal of SiO2 template. Our interest lies in employing these materials as Boltzmann type physiological range luminescence thermometers, but their weak green emission is a drawback. To overcome this issue, and engineer materials suitable for Boltzmann type thermometry, we have studied the effect of introducing different metal ion co-dopants (Gd3+, Li+ or Mn2+) into the YOF:Yb3+,Er3+ particles, focusing on the overall emission intensity, as well as the green to red ratio, upon 975 nm laser excitation. These materials are explored for their use as ratiometric thermometers, and further also as drug carriers, including their simultaneous use for these two applications. The investigation also includes examining their level of toxicity towards specific human cells – normal human dermal fibroblasts (NHDFs) – to evaluate their potential use for biological applications. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results