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Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas, with 50% of cases associated with type 1 neurofibromatosis (NF-1). A 27-year-old male patient was referred to our department with an extended right nasal cavity MPNST. The lesion extended to the skull base, intracranial, parapharyngeal space, and infratemporal fossa. NF-1 was also confirmed by a neurologist. The patient was negative for distant metastases. Due to the tumor's proximity to vital structures, it was decided to treat it with chemotherapy and radiotherapy. Nasal cavity MPNSTs are particularly uncommon, with few reported cases. They should be included in the differential diagnosis of nasal masses or recurrent nosebleeds, particularly in patients with NF-1. Careful follow-up is essential to detect early recurrence, which contributes to a better prognosis., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Marini et al.)

Paragangliomas are mostly benign, slow-growing, hypervascular tumors originating from neural crest derivatives. Head and neck (H&N) paragangliomas represent <1% of all H&N tumors and <5% are malignant. They are mostly non-secreting tumors that originate from autonomous parasympathetic paraganglia. We present a case of right middle ear jugulotympanic paraganglioma, a subtype of H&N paragangliomas, which had been misdiagnosed as otosclerosis for about 10 years. The patient was suffering from worsening tinnitus along with hearing impairment. High clinical suspicion of jugular paraganglioma prevented us from taking a biopsy. Complete surgical excision after preoperative embolization was decided. Embolization resulted in facial nerve paralysis, however, facial nerve rerouting was performed during the complete surgical excision of the tumor. The patient remains disease-free three years postoperatively, with House-Brackmann III facial nerve paralysis., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Marini et al.)

Hepatocellular carcinoma (HCC) is the most dominant malignant neoplasm of the liver and constitutes the majority of all primary malignancies. Most reported cases of HCC occur in the developing world and are mainly associated with chronic hepatitis B and C viruses. Both hematogenous and lymphatic spreading is common in HCC. Patients with HCC might manifest extra-hepatic metastases and the lungs are the most common potential site of metastatic deposits. Rare sites of metastatic disease have also been described. Oropharyngeal metastases of HCC are rare and there are few reports available in the literature. We report a rare case of extra-hepatic metastasis of HCC to the right tonsil in an 84-year-old patient. The clinical appearance of metastatic oral lesions could be easily underestimated, and diagnosis of the primary tumor might delay. A biopsy of the oral lesion is important for an accurate diagnosis. Metastasis in the oral cavity and oropharynx of an HCC is usually evidence of widespread disease and predisposes to an ominous prognosis., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Karamitsou et al.)

Mucoepidermoid carcinoma is a common malignant neoplasm of the salivary glands. While quite common in the oral cavity, it is rare in the larynx. A middle-aged male patient presented to the otolaryngology clinic of our institution with the chief complaint of hoarseness. A supraglottic subepithelial mass was detected on the left laryngeal ventricle after a comprehensive clinical examination. Eventually, the diagnosis was established with a biopsy after a direct laryngoscopy. The multidisciplinary team of our institution suggested total laryngectomy without adjuvant modalities. An uneventful procedure followed and the patient remains free of disease and up to date. Mucoepidermoid tumors of the larynx are rare and surgical treatment is strongly indicated as the treatment of choice., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Skliris et al.)

Skin restoration after tumor excision, trauma, or burns may be achieved with full or split-thickness skin grafts or local flaps. The success rate of a skin graft depends on several independent factors. The supraclavicular region is considered a reliable donor site for head and neck skin defects because of its easy access. We present a case of a supraclavicular skin graft harvested to cover a skin deficit after the excision of a squamous cell carcinoma of the scalp. The postoperative course was uneventful regarding graft survival, the healing procedure, and the cosmetic outcome., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Vardaxi et al.)

A neurofibroma is a benign peripheral nerve sheath tumor. Its appearance in the nose and paranasal sinuses is extremely rare. We present the case of a 61-year-old female with a large sinonasal neurofibroma. The patient was referred to our department due to the findings of a large invasive lesion originating from the left sinus with extension to the adjacent structures on computed tomography. A thorough examination revealed a mass within the left nasal cavity and exophthalmos. The initial symptoms of the disease probably appeared three years ago when she reported that she developed facial swelling following dental work. In the following period and due to reported blurred vision, she consulted with several medical specialists without receiving a diagnosis, while later she visited an otorhinolaryngologist, complaining of ear fullness, and local treatment was prescribed. Due to persistent symptoms, the patient was finally referred for computed tomography. Upon arrival at our department, she underwent a biopsy, which revealed the existence of a neurofibroma. The patient underwent endoscopic resection of the tumor and remains under close follow-up with no signs of recurrence. Sinonasal neurofibroma is a rare condition that presents with non-specific symptoms and may take years to reach a diagnosis. Open or endoscopic surgical resection seems to offer satisfactory results; however, similar cases reported in the literature are scarce., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Skalias et al.)

Nasopharyngeal papillary adenocarcinoma (NPAC) is an extremely rare primary malignant tumor. There is only a limited number of cases of NPACs reported in the literature. The neoplasm presents as an exophytic mass with a papillary or polypoid appearance derived from the nasopharyngeal surface epithelium. It can potentially involve any part of the nasopharynx, but it most commonly involves the roof, the lateral, and the posterior wall. The prognosis is very good and no recurrences or metastases have been reported. Nasal obstruction is the most common manifestation. Surgical excision is considered the most appropriate treatment method. There are also reports of patients undergoing radiation therapy. However, its role in the treatment has not been clarified. The presence of this tumor in the nasal cavity could be easily underestimated, because of its appearance. As a result, an index of suspicion is necessary for a timely diagnostic and therapeutic intervention. We present a case of NPAC in a 26-year-old female treated in our hospital., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Karamitsou et al.)

Liposarcomas are rare mesenchymal tissue tumors and are divided into subtypes based on their histopathological characteristics. They are mostly well-differentiated neoplasms with the tendency to recur locally. Lymph node involvement or distant metastases have been reported as extremely rare. Common manifestations are progressive dyspnea, dysphagia, choking, and stridor. Surgical excision of laryngeal liposarcomas is considered the gold standard treatment modality for disease eradication. In persistent or recurrent cases, a total laryngectomy should be performed. There is much controversy regarding the role of radiotherapy which is mostly used as adjuvant treatment in specific cases. We present a case of dedifferentiated laryngeal liposarcoma with multiple recurrences and metachronous transformation to a neoplasm with myxofibrosarcomatous elements., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2022, Karamitsou et al.)

Fibroepithelial polyps represent a frequent cutaneous lesion of mesodermal origin, with a prevalence of 1.2% and are rarely located at palatine tonsils. We present a rare clinical report of a 70-year-old female patient with fibroepithelial polyp of palatine tonsil. This entity represents the eighth case of palatine tonsil fibroepithelial polyp in the English literature. She presented with a polypoid mass at the right tonsil and unspecified throat symptoms. Physicians should pay attention to such lesions because of the residual risk of malignant transformation, along with non-specific symptoms. Differential diagnosis was among neurofibroma, lipoma, squamous papilloma and fibroepithelial polyp. Histopathological examination following tonsillectomy showed a structure rich in vesicles inside lamina propria and surrounding inflammation, establishing the diagnosis of a fibroepithelial polyp. It requires vigilance during complete clinical examination, in order to detect masses at patients with throat symptoms that could have remained undiagnosed until they become even life threatening., Competing Interests: The authors declare no competing interests., (Copyright: Katerina Marini et al.)