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278 results on '"Skordalakes, Emmanuel"'

1. A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription

Author

Jiao, Xuanmao, Di Sante, Gabriele, Casimiro, Mathew C., Tantos, Agnes, Ashton, Anthony W., Li, Zhiping, Quach, Yen, Bhargava, Dharmendra, Di Rocco, Agnese, Pupo, Claudia, Crosariol, Marco, Lazar, Tamas, Tompa, Peter, Wang, Chenguang, Yu, Zuoren, Zhang, Zhao, Aldaaysi, Kawthar, Vadlamudi, Ratna, Mann, Monica, Skordalakes, Emmanuel, Kossenkov, Andrew, Du, Yanming, and Pestell, Richard G.

Published
2024
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12. Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

Author

Chen, Ke, primary, Jiao, Xuanmao, additional, Di Rocco, Agnese, additional, Shen, Duanwen, additional, Xu, Shaohua, additional, Ertel, Adam, additional, Yu, Zuoren, additional, Di Sante, Gabriele, additional, Wang, Min, additional, Li, Zhiping, additional, Pestell, Timothy G., additional, Casimiro, Mathew C., additional, Skordalakes, Emmanuel, additional, Achilefu, Samuel, additional, and Pestell, Richard G., additional

Published
2023
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14. Data from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, primary, Kossenkov, Andrew V., primary, Lee, Yu Geon, primary, Tang, Hsin-Yao, primary, Agarwal, Ekta, primary, Gabrilovich, Dmitry I., primary, Languino, Lucia R., primary, Speicher, David W., primary, Shastrula, Prashanth K., primary, Storaci, Alessandra Maria, primary, Ferrero, Stefano, primary, Gaudioso, Gabriella, primary, Caroli, Manuela, primary, Tosi, Davide, primary, Giroda, Massimo, primary, Vaira, Valentina, primary, Rebecca, Vito W., primary, Herlyn, Meenhard, primary, Xiao, Min, primary, Fingerman, Dylan, primary, Martorella, Alessandra, primary, Skordalakes, Emmanuel, primary, and Altieri, Dario C., primary

Published
2023
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15. Supplementary Data from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, primary, Kossenkov, Andrew V., primary, Lee, Yu Geon, primary, Tang, Hsin-Yao, primary, Agarwal, Ekta, primary, Gabrilovich, Dmitry I., primary, Languino, Lucia R., primary, Speicher, David W., primary, Shastrula, Prashanth K., primary, Storaci, Alessandra Maria, primary, Ferrero, Stefano, primary, Gaudioso, Gabriella, primary, Caroli, Manuela, primary, Tosi, Davide, primary, Giroda, Massimo, primary, Vaira, Valentina, primary, Rebecca, Vito W., primary, Herlyn, Meenhard, primary, Xiao, Min, primary, Fingerman, Dylan, primary, Martorella, Alessandra, primary, Skordalakes, Emmanuel, primary, and Altieri, Dario C., primary

Published
2023
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16. Figure S5 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, primary, Kossenkov, Andrew V., primary, Lee, Yu Geon, primary, Tang, Hsin-Yao, primary, Agarwal, Ekta, primary, Gabrilovich, Dmitry I., primary, Languino, Lucia R., primary, Speicher, David W., primary, Shastrula, Prashanth K., primary, Storaci, Alessandra Maria, primary, Ferrero, Stefano, primary, Gaudioso, Gabriella, primary, Caroli, Manuela, primary, Tosi, Davide, primary, Giroda, Massimo, primary, Vaira, Valentina, primary, Rebecca, Vito W., primary, Herlyn, Meenhard, primary, Xiao, Min, primary, Fingerman, Dylan, primary, Martorella, Alessandra, primary, Skordalakes, Emmanuel, primary, and Altieri, Dario C., primary

Published
2023
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17. Supplementary Movie S2 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, primary, Kossenkov, Andrew V., primary, Lee, Yu Geon, primary, Tang, Hsin-Yao, primary, Agarwal, Ekta, primary, Gabrilovich, Dmitry I., primary, Languino, Lucia R., primary, Speicher, David W., primary, Shastrula, Prashanth K., primary, Storaci, Alessandra Maria, primary, Ferrero, Stefano, primary, Gaudioso, Gabriella, primary, Caroli, Manuela, primary, Tosi, Davide, primary, Giroda, Massimo, primary, Vaira, Valentina, primary, Rebecca, Vito W., primary, Herlyn, Meenhard, primary, Xiao, Min, primary, Fingerman, Dylan, primary, Martorella, Alessandra, primary, Skordalakes, Emmanuel, primary, and Altieri, Dario C., primary

Published
2023
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18. Table S2 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, primary, Kossenkov, Andrew V., primary, Lee, Yu Geon, primary, Tang, Hsin-Yao, primary, Agarwal, Ekta, primary, Gabrilovich, Dmitry I., primary, Languino, Lucia R., primary, Speicher, David W., primary, Shastrula, Prashanth K., primary, Storaci, Alessandra Maria, primary, Ferrero, Stefano, primary, Gaudioso, Gabriella, primary, Caroli, Manuela, primary, Tosi, Davide, primary, Giroda, Massimo, primary, Vaira, Valentina, primary, Rebecca, Vito W., primary, Herlyn, Meenhard, primary, Xiao, Min, primary, Fingerman, Dylan, primary, Martorella, Alessandra, primary, Skordalakes, Emmanuel, primary, and Altieri, Dario C., primary

Published
2023
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19. Supplementary Figure S1 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, primary, Kossenkov, Andrew V., primary, Lee, Yu Geon, primary, Tang, Hsin-Yao, primary, Agarwal, Ekta, primary, Gabrilovich, Dmitry I., primary, Languino, Lucia R., primary, Speicher, David W., primary, Shastrula, Prashanth K., primary, Storaci, Alessandra Maria, primary, Ferrero, Stefano, primary, Gaudioso, Gabriella, primary, Caroli, Manuela, primary, Tosi, Davide, primary, Giroda, Massimo, primary, Vaira, Valentina, primary, Rebecca, Vito W., primary, Herlyn, Meenhard, primary, Xiao, Min, primary, Fingerman, Dylan, primary, Martorella, Alessandra, primary, Skordalakes, Emmanuel, primary, and Altieri, Dario C., primary

Published
2023
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20. Supplementary Data S1-S7 and Table S1 from Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Author

Miller, Katelyn D., primary, Pniewski, Katherine, primary, Perry, Caroline E., primary, Papp, Sara B., primary, Shaffer, Joshua D., primary, Velasco-Silva, Jesse N., primary, Casciano, Jessica C., primary, Aramburu, Tomas M., primary, Srikanth, Yellamelli V.V., primary, Cassel, Joel, primary, Skordalakes, Emmanuel, primary, Kossenkov, Andrew V., primary, Salvino, Joseph M., primary, and Schug, Zachary T., primary

Published
2023
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21. Data from Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Author

Miller, Katelyn D., primary, Pniewski, Katherine, primary, Perry, Caroline E., primary, Papp, Sara B., primary, Shaffer, Joshua D., primary, Velasco-Silva, Jesse N., primary, Casciano, Jessica C., primary, Aramburu, Tomas M., primary, Srikanth, Yellamelli V.V., primary, Cassel, Joel, primary, Skordalakes, Emmanuel, primary, Kossenkov, Andrew V., primary, Salvino, Joseph M., primary, and Schug, Zachary T., primary

Published
2023
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22. Supplementary Figure S2 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Author

Peng, Hongzhuang, primary, Talebzadeh-Farrooji, Mehdi, primary, Osborne, Michael J., primary, Prokop, Jeremy W., primary, McDonald, Paul C., primary, Karar, Jayashree, primary, Hou, Zhaoyuan, primary, He, Mei, primary, Kebebew, Electron, primary, Orntoft, Torben, primary, Herlyn, Meenhard, primary, Caton, Andrew J., primary, Fredericks, William, primary, Malkowicz, Bruce, primary, Paterno, Christopher S., primary, Carolin, Alexandra S., primary, Speicher, David W., primary, Skordalakes, Emmanuel, primary, Huang, Qihong, primary, Dedhar, Shoukat, primary, Borden, Katherine L.B., primary, and Rauscher, Frank J., primary

Published
2023
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23. Supplementary Figure Legends and References from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Author

Peng, Hongzhuang, primary, Talebzadeh-Farrooji, Mehdi, primary, Osborne, Michael J., primary, Prokop, Jeremy W., primary, McDonald, Paul C., primary, Karar, Jayashree, primary, Hou, Zhaoyuan, primary, He, Mei, primary, Kebebew, Electron, primary, Orntoft, Torben, primary, Herlyn, Meenhard, primary, Caton, Andrew J., primary, Fredericks, William, primary, Malkowicz, Bruce, primary, Paterno, Christopher S., primary, Carolin, Alexandra S., primary, Speicher, David W., primary, Skordalakes, Emmanuel, primary, Huang, Qihong, primary, Dedhar, Shoukat, primary, Borden, Katherine L.B., primary, and Rauscher, Frank J., primary

Published
2023
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24. Supplementary Table S1 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Author

Peng, Hongzhuang, primary, Talebzadeh-Farrooji, Mehdi, primary, Osborne, Michael J., primary, Prokop, Jeremy W., primary, McDonald, Paul C., primary, Karar, Jayashree, primary, Hou, Zhaoyuan, primary, He, Mei, primary, Kebebew, Electron, primary, Orntoft, Torben, primary, Herlyn, Meenhard, primary, Caton, Andrew J., primary, Fredericks, William, primary, Malkowicz, Bruce, primary, Paterno, Christopher S., primary, Carolin, Alexandra S., primary, Speicher, David W., primary, Skordalakes, Emmanuel, primary, Huang, Qihong, primary, Dedhar, Shoukat, primary, Borden, Katherine L.B., primary, and Rauscher, Frank J., primary

Published
2023
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25. Data from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase

Author

Peng, Hongzhuang, primary, Talebzadeh-Farrooji, Mehdi, primary, Osborne, Michael J., primary, Prokop, Jeremy W., primary, McDonald, Paul C., primary, Karar, Jayashree, primary, Hou, Zhaoyuan, primary, He, Mei, primary, Kebebew, Electron, primary, Orntoft, Torben, primary, Herlyn, Meenhard, primary, Caton, Andrew J., primary, Fredericks, William, primary, Malkowicz, Bruce, primary, Paterno, Christopher S., primary, Carolin, Alexandra S., primary, Speicher, David W., primary, Skordalakes, Emmanuel, primary, Huang, Qihong, primary, Dedhar, Shoukat, primary, Borden, Katherine L.B., primary, and Rauscher, Frank J., primary

Published
2023
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29. Functional Interactions of Kluyveromyces lactis Telomerase Reverse Transcriptase with the Three-Way Junction and the Template Domains of Telomerase RNA

Author

Al-Shareef, Wasif, primary, Brown, Yogev, additional, Bryan, Christopher, additional, Shuvaeva, Elena, additional, Bsoul, Shhadeh, additional, Greenman, Raanan, additional, Kabaha, Majdi M., additional, Ulyanov, Nikolai B., additional, Skordalakes, Emmanuel, additional, and Tzfati, Yehuda, additional

Published
2022
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35. Telomere dysfunction implicates POT1 in patients with idiopathic pulmonary fibrosis

Author

Kelich, Joseph, primary, Aramburu, Tomas, additional, van der Vis, Joanne J., additional, Showe, Louise, additional, Kossenkov, Andrew, additional, van der Smagt, Jasper, additional, Massink, Maarten, additional, Schoemaker, Angela, additional, Hennekam, Eric, additional, Veltkamp, Marcel, additional, van Moorsel, Coline H.M., additional, and Skordalakes, Emmanuel, additional

Published
2022
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38. Telomouse – a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Author

Smoom, Riham, primary, May, Catherine Lee, additional, Ortiz, Vivian, additional, Tigue, Mark, additional, Kolev, Hannah M., additional, Rowe, Melissa, additional, Reizel, Yitzhak, additional, Morgan, Ashleigh, additional, Egyes, Nachshon, additional, Lichtental, Dan, additional, Skordalakes, Emmanuel, additional, Kaestner, Klaus H., additional, and Tzfati, Yehuda, additional

Published
2021
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39. Structure of the Tribolium castaneum telomerase catalytic subunit TERT

Author

Gillis, Andrew J., Schuller, Anthony P., and Skordalakes, Emmanuel

Subjects
Structure, Genetic aspects, Properties, Cancer cells -- Structure -- Genetic aspects, Telomerase -- Properties -- Genetic aspects
Abstract

A common hallmark of human cancers is the overexpression of telomerase, a ribonucleoprotein complex that is responsible for maintaining the length and integrity of chromosome ends. Telomere length deregulation and [...]

Published
2008

42. Structural Insights into RNA-Dependent Ring Closure and ATPase Activation by the Rho Termination Factor

Author

Skordalakes, Emmanuel and Berger, James M.

Subjects
Adenosine triphosphatase, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2006.08.051 Byline: Emmanuel Skordalakes (1), James M. Berger (1) Abstract: Hexameric helicases and translocases are required for numerous essential nucleic-acid transactions. To better understand the mechanisms by which these enzymes recognize target substrates and use nucleotide hydrolysis to power molecular movement, we have determined the structure of the Rho transcription termination factor, a hexameric RNA/DNA helicase, with single-stranded RNA bound to the motor domains of the protein. The structure reveals a closed-ring 'trimer of dimers' conformation for the hexamer that contains an unanticipated arrangement of conserved loops required for nucleic-acid translocation. RNA extends across a shallow intersubunit channel formed by conserved amino acids required for RNA-stimulated ATP hydrolysis and translocation and directly contacts a conserved lysine, just upstream of the catalytic GKT triad, in the phosphate-binding (P loop) motif of the ATP-binding pocket. The structure explains the molecular effects of numerous mutations and provides new insights into the links between substrate recognition, ATP turnover, and coordinated strand movement. Author Affiliation: (1) Department of Molecular and Cell Biology, University of California, Berkeley, 327B Hildebrand Hall #3206, Berkeley, CA 94720, USA Article History: Received 5 June 2006; Revised 25 July 2006; Accepted 25 August 2006 Article Note: (miscellaneous) Published: November 2, 2006

Published
2006

43. Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth

Author

Miller, Katelyn D., primary, Pniewski, Katherine, additional, Perry, Caroline E., additional, Papp, Sara B., additional, Shaffer, Joshua D., additional, Velasco-Silva, Jesse N., additional, Casciano, Jessica C., additional, Aramburu, Tomas M., additional, Srikanth, Yellamelli V.V., additional, Cassel, Joel, additional, Skordalakes, Emmanuel, additional, Kossenkov, Andrew V., additional, Salvino, Joseph M., additional, and Schug, Zachary T., additional

Published
2021
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46. Bifunctional peptide boronate inhibitors of thrombi: Crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide

Author

Skordalakes, Emmanuel, Engendy, Said, Goodwin, Christopher A., Green, Donovan, Scully, Michael F., Kakkar, Vijay V., Freyssinet, Jean-Marie, Dodson, Guy, and Deadman, John J>

Subjects
Peptides -- Research, Thrombin -- Observations, Biochemistry -- Research, Biological sciences, Chemistry
Abstract

The serine protease thrombin is important in blood coagulation cleaving firbrinogen. A common feature of low molelcular weight thrombin inhibitors is the positive charge at P(sub1). Direct linkage of Hir(super49-69) is not compatible with some active site directed thrombin inhibitors, due to reduced acylating ability. This can be overcome with the introduction of Hir(super47-64) to the P(sub3) N-terminus of two tirpeptide boronate inhibitors of thrombin, Z-D-Phe-Pro-boroIrg and Z-D-Phe-Pro-boroBpg. Increased potency for both compounds is demonstrated.

Published
1998

49. MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Author

Seo, Jae Ho, primary, Chae, Young Chan, additional, Kossenkov, Andrew V., additional, Lee, Yu Geon, additional, Tang, Hsin-Yao, additional, Agarwal, Ekta, additional, Gabrilovich, Dmitry I., additional, Languino, Lucia R., additional, Speicher, David W., additional, Shastrula, Prashanth K., additional, Storaci, Alessandra Maria, additional, Ferrero, Stefano, additional, Gaudioso, Gabriella, additional, Caroli, Manuela, additional, Tosi, Davide, additional, Giroda, Massimo, additional, Vaira, Valentina, additional, Rebecca, Vito W., additional, Herlyn, Meenhard, additional, Xiao, Min, additional, Fingerman, Dylan, additional, Martorella, Alessandra, additional, Skordalakes, Emmanuel, additional, and Altieri, Dario C., additional

Published
2019
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