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Kmiotek Patrycja, Materniak Andrzej, Skrzydło-Radomańska Barbara. Proton pump inhibitors overuse - consequences among patients. Journal of Education, Health and Sport. 2019;9(8):655-660. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3407285 http://ojs.ukw.edu.pl/index.php/johs/article/view/7243 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.07.2019. Revised: 25.07.2019. Accepted: 12.08.2019. Proton pump inhibitors overuse - consequences among patients Patrycja Kmiotek¹, Andrzej Materniak², Barbara Skrzydło-Radomańska³ 1. Students’ Research Group at the Department of Gastroenterology with Endoscopic Unit, Medical University of Lublin, Poland 2. Department of Pediatric Radiology, Medical University of Lublin, Poland 3. Department of Gastroenterology with Endoscopic Unit, Medical University of Lublin, Poland Corresponding author: p.kmiotek@o2.pl ORCID ID: Patrycja Kmiotek https://orcid.org/0000-0002-0937-8953 Andrzej Materniak https://orcid.org/0000-0001-5063-8844 Barbara Skrzydło-Radomańska https://orcid.org/0000-0002-9047-1046 Abstract Introduction Omeprazole was first proton pump inhibitor (PPI) approved for use by patients. Thirty years have passed since then. Due to their effectiveness, low price and safety proton pump inhibitors have become one of the most frequently prescribed medicines in the world. In recent years, more attention has been paid to the problem of their overuse. Aim of the study The aim of our study was to investigate the scale of proton pump inhibitors overprescription and possible resulting side effects. State of knowledge Analyzed observational studies proves that problem is present both in hospitals and ambulatory clinics. Research shows increasingly frequent use of this medicines in case of non-specific abdominal discomfort or in many cases without any indications. This results in prolonged and unnecessary therapy. The possibility of obtaining medicines over the counter and patients non-compliance, are also a challenge in maintaining high-quality therapy. In many cases patients taking drugs irregularly or do not stop therapy, even being free from symptoms. Conclusions Despite the fact that proton pump inhibitors are considered safe drugs, more attention should be paid to the compatibility of their use with recommendations. There are also evidences about the possibility of side effects associated with long-term proton pump inhibitor therapy, which can be particularly dangerous for older patients with multiple diseases. It is necessary to inform patients about the need of discontinuation therapy in case of recovery, which will reduce the risk of adverse effects. Keywords: Proton Pump Inhibitors; PPI; Proton pump

Kuśmierczuk Kinga, Borowik Joanna, Kozak Katarzyna, Jawoszek Patryk, Brodowski Wojciech, Skrzydło-Radomańska Barbara. Chronic vomiting as a nonspecific symptom of small intestine cancer - case report. Journal of Education, Health and Sport. 2019;9(9):589-598. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3445612 http://ojs.ukw.edu.pl/index.php/johs/article/view/7456 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 10.09.2019. Revised: 19.09.2019. Accepted: 19.09.2019. Chronic vomiting as a nonspecific symptom of small intestine cancer - case report Kuśmierczuk Kinga Justyna, kinga.kusmierczuk@gmail.com, Students’ Research Group at the Department of Gastroenterology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland Borowik Joanna Urszula, joannaa.borowik@gmail.com, Students’ Research Group at the Department of Gastroenterology and Endoscopy, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland Kozak Katarzyna Anna, katarzyna.kozak95@gmail.com, Students’ Research Group at the Department of Gastroenterology and Endoscopy, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland Jawoszek Patryk, patryk.jawoszek@gmail.com, Students’ Research Group at the Department of Gastroenterology and Endoscopy, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland Brodowski Wojciech, brodowski.wojciech@gmail.com, Students’ Research Group at the Department of Gastroenterology and Endoscopy, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland Szydło-Radomańska Barbara, barbara.skrzydlo-radomanska@umlub.pl, Department of Gastroenterology and Endoscopy, Medical University of Lublin, , Jaczewskiego 8, 20-090 Lublin, Poland Abstract Introduction: Small intestine cancer is a rare gastrointestinal cancer (less than 5%) and makes up 0.3% of all malignancies. The most common clinical symptoms include abdominal pain, vomiting and gastrointestinal bleeding. Aim of study: The aim of the study is to draw attention to the rare cases of SBA.The second aim of the study is to review the literature on the diagnosis and therapeutic process of patients suffering from small intestine cancer. Methods:The research method was an individual case study. The research material was the patient's medical record.An unsystematic review of Polish and English-language scientific literature was conducted. Electronic databases: PubMed, SCOPUS and Google Scholar were searched using the following keywords: adenocarcinoma, small intestine, small bowel obstruction, chronic vomiting. Findings:A 39-year-old patient was diagnosed with G2 stage of the SBA with metastases to the nearby lymph nodes. Due to nonspecific symptoms the correct diagnosis was made at an advanced stage of the disease, and thus the implementation of appropriate treatment was delayed. Conclusions: A small number of cases of the disease and non-specific symptoms make the diagnosis of small intestinal cancer extremely difficult. The disease usually develops insidiously and at the time of diagnosis the cancer is already at an advanced stage. A significant weight loss within a short period of time along with persistent vomiting should prompt the doctor for thorough diagnostic procedures. Key words: adenocarcinoma, small intestine, small bowel obstruction, chronic vomiting

Zasady nadzoru kolonoskopowego po polipektomii zawarte w prezentowanym artykule opracowano na podstawie europejskich wytycznych dotyczących zapewnienia jakości w badaniach przesiewowych i diagnostyce raka jelita grubego. Zalecenia oparto na istniejących dowodach naukowych i uzupełniono o opinie ekspertów w sprawach niepopartych dowodami, a całość została zaakceptowana przez Zarząd Główny Polskiego Towarzystwa Gastroenterologii. Stwierdzenia, w których istnieją różnice w porównaniu z wytycznymi europejskimi, oznaczono znakiem „#”. The presented guidelines for colonoscopy surveillance after polypectomy are based on recently published European guidelines for quality assurance in colorectal cancer screening and diagnosis. The guidelines are evidence-based and supplemented with experts’ opinion on topics with little evidence; the entire document has been accepted by the Governing Board of the Polish Society of Gastroenterology. Statements that differ from original statements in European guidelines are marked with “#”.