106 results on '"Skvarca, P"'
Search Results
2. A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model
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McMillen, Cynthia M., Chapman, Nathaniel S., Hoehl, Ryan M., Skvarca, Lauren B., Schwarz, Madeline M., Handal, Laura S., Crowe, Jr., James E., and Hartman, Amy L.
- Published
- 2023
- Full Text
- View/download PDF
3. Prevalence and correlates of restless legs syndrome in men living with HIV
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Wallace, Douglas M, Alcaide, Maria L, Wohlgemuth, William K, Weiss, Deborah L Jones, Starita, Claudia Uribe, Patel, Sanjay R, Stosor, Valentina, Levine, Andrew, Skvarca, Carling, Long, Dustin M, Rubtsova, Anna, Adimora, Adaora A, Gange, Stephen J, Spence, Amanda B, Anastos, Kathryn, Aouizerat, Bradley E, Anziska, Yaacov, and Punjabi, Naresh M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Sexually Transmitted Infections ,Sleep Research ,Brain Disorders ,Behavioral and Social Science ,HIV/AIDS ,Infectious Diseases ,Neurosciences ,Infection ,Good Health and Well Being ,Aged ,Case-Control Studies ,Cohort Studies ,Comorbidity ,HIV Infections ,Homosexuality ,Male ,Humans ,Male ,Middle Aged ,Prevalence ,Restless Legs Syndrome ,Sexual and Gender Minorities ,Sleep Initiation and Maintenance Disorders ,Surveys and Questionnaires ,General Science & Technology - Abstract
BackgroundData on the prevalence and correlates of restless legs syndrome (RLS) in people with HIV are limited. This study sought to determine the prevalence of RLS, associated clinical correlates, and characterize sleep-related differences in men with and without HIV.MethodsSleep-related data were collected in men who have sex with men participating in the Multicenter AIDS Cohort Study (MACS). Demographic, health behaviors, HIV status, comorbidities, and serological data were obtained from the MACS visit coinciding with sleep assessments. Participants completed questionnaires, home polysomnography, and wrist actigraphy. RLS status was determined with the Cambridge-Hopkins RLS questionnaire. RLS prevalence was compared in men with and without HIV. Multinomial logistic regression was used to examine correlates of RLS among all participants and men with HIV alone. Sleep-related differences were examined in men with and without HIV by RLS status.ResultsThe sample consisted of 942 men (56% HIV+; mean age 57 years; 69% white). The prevalence of definite RLS was comparable in men with and without HIV (9.1% vs 8.7%). In multinomial regression, HIV status was not associated with RLS prevalence. However, white race, anemia, depression, and antidepressant use were each independently associated with RLS. HIV disease duration was also associated with RLS. Men with HIV and RLS reported poorer sleep quality, greater sleepiness, and had worse objective sleep efficiency/fragmentation than men without HIV/RLS.ConclusionsThe prevalence of RLS in men with and without HIV was similar. Screening for RLS may be considered among people with HIV with insomnia and with long-standing disease.
- Published
- 2021
4. Transient ice loss in the Patagonia Icefields during the 2015–2016 El Niño event
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Gómez, Demián D., Bevis, Michael G., Smalley, Jr., Robert, Durand, Michael, Willis, Michael J., Caccamise, II, Dana J., Kendrick, Eric, Skvarca, Pedro, Sobrero, Franco S., Parra, Héctor, and Casassa, Gino
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- 2022
- Full Text
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5. Superior Diagnostic Performance of the GLP-1 Receptor Agonist [Lys40(AhxHYNIC-[99mTc]/EDDA)NH2]-Exendin-4 over Conventional Imaging Modalities for Localization of Insulinoma
- Author
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Senica, Katra, Tomazic, Ales, Skvarca, Ales, Kolenc Peitl, Petra, Mikolajczak, Renata, Hubalewska-Dydejczyk, Alicja, and Lezaic, Luka
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- 2020
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6. The role of macrophages during acute kidney injury: destruction and repair
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Han, Hwa I., Skvarca, Lauren B., Espiritu, Eugenel B., Davidson, Alan J., and Hukriede, Neil A.
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- 2019
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7. Constraining glacier elevation and mass changes in South America
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Braun, Matthias H., Malz, Philipp, Sommer, Christian, Farías-Barahona, David, Sauter, Tobias, Casassa, Gino, Soruco, Alvaro, Skvarca, Pedro, and Seehaus, Thorsten C.
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- 2019
- Full Text
- View/download PDF
8. Recommendations for the collection and synthesis of Antarctic Ice Sheet mass balance data
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Abdalati, W, Allison, I, Carsey, F, Casassa, G, Fily, M, Frezzotti, M, Flicker, HA, Genthon, C, Goodwin, I, Guo, Z, Hamilton, GS, Hindmarsh, RCA, Hulbe, CL, Jacka, TH, Jezek, KC, Kwok, R, Li, J, Nixdorf, U, Paltridge, G, Rignot, E, Ritz, C, Satow, K, Scambos, TA, Shuman, C, Skvarca, P, Takahashi, S, van de Wal, RSW, Vaughan, DG, Wang, WL, Warner, RC, Wingham, DJ, Young, NW, and Zwally, HJ
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Antarctica ,ice sheet ,ice shelf ,ice mass balance ,remote sensing ,Networking & Telecommunications ,Earth Sciences - Abstract
Recent unexpected changes in the Antarctic Ice Sheet, including ice sheet thinning, ice shelf collapse and changes in ice velocities, along with the recent realization that as much as one third of ice shelf mass loss is due to bottom melt, place a new urgency on understanding the processes involved in these changes. Technological advances, including very new or forthcoming satellite-based (e.g. ICESat, CryoSat) remote sensing missions, will improve our ability to make meaningful determinations of changes in Antarctic Ice Sheet mass balance. This paper is the result of a workshop held to develop a strategy for international collaboration aimed at the collection and synthesis of Antarctic Ice Sheet mass balance data, and at understanding the processes involved so that we might predict future change. Nine sets of recommendations are made, concerning the most important and sensitive measurements, temporal ranges and study areas. A final tenth recommendation calls for increased synthesis of ice sheet data and communication between the field measurement, satellite observation and modelling communities. © 2004 Published by Elsevier B.V.
- Published
- 2004
9. A novel technique to estimate intravillous fetal vasculature on routine placenta histologic sections.
- Author
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Kozai, Andrea C., Brilli Skvarca, Lauren, Parks, William Tony, Lane, Abbi, Barone Gibbs, Bethany, and Catov, Janet M.
- Abstract
Placental histopathologic lesions are dichotomized into "present" or "absent" and have limited inter-rater reliability. Continuous metrics are needed to characterize placental health and function. Tissue sections (N = 64) of human placenta were stained with CD34 antibody and hematoxylin. Proportion of the villous space occupied by fetal vascular endothelium (%FVE; pixels positive for CD34/total pixels) was evaluated for effect sizes associated with pregnancy outcomes, smoking status, and subtypes of lesions (n = 30). Time to fixation>60 min significantly increased the quantification. Large effect sizes were found between %FVE and both preterm birth and intrauterine growth restriction. These results demonstrate proof-of-concept for this vascular estimation. • Novel quantification of fetal vascular development may relate to pregnancy outcomes. • Lower vascularization may be present in cases of adverse fetal outcomes. • Quantification complements traditional histopathology. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Little Ice Age fluctuations of small glaciers in the Monte Fitz Roy and Lago del Desierto areas, south Patagonian Andes, Argentina
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Masiokas, M.H., Luckman, B.H., Villalba, R., Delgado, S., Skvarca, P., and Ripalta, A.
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- 2009
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11. Assessment of placental morphology in Uganda and the US using PlacentaVision computer vision segmentation models.
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Walker, Rachel E., Pan, Yimu, Mehta, Manas, Gallagher, Kelly, Bebell, Lisa M., Ngonzi, Joseph, Roberts, Drucilla J., Catov, Janet M., Sadovsky, Yoel, Skvarca, Lauren B., Goldstein, Jeffrey A., Wang, James Z., and Gernand, Alison D.
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- 2024
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12. Glacier Acceleration and Thinning after Ice Shelf Collapse in the Larsen B Embayment, Antarctica
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Scambos, T. A, Bohlander, J. A, Shuman, C. A, and Skvarca, P
- Subjects
Geophysics - Abstract
Ice velocities derived from five Landsat 7 images acquired between January 2000 and February 2003 show a two- to six-fold increase in centerline speed of four glaciers flowing into the now-collapsed section of the Larsen B Ice Shelf. Satellite laser altimetry from ICEsat indicates the surface of Hektoria Glacier lowered by up to 38 +/- 6 m a six-month period beginning one year after the break-up in March 2002. Smaller elevation losses are observed for Crane and Jorum glaciers over a later 5-month period. Two glaciers south of the collapse area, Flask and Leppard, show little change in speed or elevation. Seasonal variations in speed preceding the large post-collapse velocity increases suggest that both summer melt percolation and changes in the stress field due to shelf removal play a major role in glacier dynamics.
- Published
- 2004
13. Breakup and conditions for stability of the northern Larsen Ice Shelf, Antarctica
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Doake, C. S. M., Corr, H. F. J., Rott, H., Skvarca, P., and Young, N. W.
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- 1998
14. Regional climate of the Larsen B embayment 1980-2014
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Leeson, Amber, Van Wessem, J. M., Ligtenberg, S. R.M., Shepherd, A., Van Den Broeke, M. R., Killick, R., Skvarca, P., Marinsek, S., Colwell, S., Sub Dynamics Meteorology, and Marine and Atmospheric Research
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climate change ,ice-shelf break-up ,melt - surface ,ice shelves ,Earth-Surface Processes - Abstract
Understanding the climate response of the Antarctic Peninsula ice sheet is vital for accurate predictions of sea-level rise. However, since climate models are typically too coarse to capture spatial variability in local scale meteorological processes, our ability to study specific sectors has been limited by the local fidelity of such models and the (often sparse) availability of observations. We show that a high-resolution (5.5 km × 5.5 km) version of a regional climate model (RACMO2.3) can reproduce observed interannual variability in the Larsen B embayment sufficiently to enable its use in investigating long-term changes in this sector. Using the model, together with automatic weather station data, we confirm previous findings that the year of the Larsen B ice shelf collapse (2001/02) was a strong melt year, but discover that total annual melt production was in fact ~30% lower than 2 years prior. While the year before collapse exhibited the lowest melting and highest snowfall during 1980-2014, the ice shelf was likely pre-conditioned for collapse by a series of strong melt years in the 1990s. Melt energy has since returned to pre-1990s levels, which likely explains the lack of further significant collapse in the region (e.g. of SCAR Inlet).
- Published
- 2017
15. Dynamic Response of Sjögren Inlet Glaciers, Antarctic Peninsula, to Ice Shelf Breakup Derived from Multi-Mission Remote Sensing Time Series
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Seehaus, T.C., Marinsek, S., Skvarca, P., van Wessem, J.M., Reijmer, C.H., Seco, J.L., Braun, M., Sub Dynamics Meteorology, and Marine and Atmospheric Research
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Glacier ice accumulation ,010504 meteorology & atmospheric sciences ,Ice stream ,Antarctic sea ice ,010502 geochemistry & geophysics ,01 natural sciences ,Ice shelf ,Prince Gustav Channel ,remote sensing ,Antarctic Peninsula ,sensitivity analysis ,glacier change ,Sea ice ,Cryosphere ,Earth Science ,glacier mass balance ,Geomorphology ,0105 earth and related environmental sciences ,Remote sensing ,geography ,geography.geographical_feature_category ,Naturwissenschaftliche Fakultät ,Glacier morphology ,contribution to sea level rise ,General Earth and Planetary Sciences ,ddc:500 ,Ice sheet ,Geology - Abstract
The substantial retreat or disintegration of numerous ice shelves has been observed on the Antarctic Peninsula. The ice shelf in the Prince Gustav Channel has retreated gradually since the late 1980s and broke up in 1995. Tributary glaciers reacted with speed-up, surface lowering and increased ice discharge, consequently contributing to sea level rise. We present a detailed long-term study (1993–2014) of the dynamic response of Sjögren Inlet glaciers to the disintegration of the Prince Gustav Ice Shelf. We analyzed various remote sensing datasets to identify the reactions of the glaciers to the loss of the buttressing ice shelf. A strong increase in ice surface velocities was observed, with maximum flow speeds reaching 2.82 ± 0.48 m d−1 in 2007 and 1.50 ± 0.32 m d−1 in 2004 at Sjögren and Boydell glaciers respectively. Subsequently, the flow velocities decelerated, however in late 2014, we still measured approximately twice the values of our first observations in 1996. The Sjögren Inlet glaciers retreated 61.7 ± 3.1 km2 behind the former grounding line in 1996. For the glacier area below 1000 m a.s.l. and above the 2014 grounding (399 km2), a mean surface lowering of −68 ± 10 m (−3.1 m a−1) was observed in the period 1993–2014. The lowering rate decreased to −2.2 m a−1 in the period 2012–2014. Based on the surface lowering rates, geodetic mass balances of the glaciers were derived for different time periods. A strongly negative mass change rate of −1.16 ± 0.38 Gt a−1 was found for the area of all Sjögren Inlet glaciers (including the area above 1000 m a.s.l.) above the 2014 grounding line (559 km2) for the earliest period (1993–2001). Due to the dynamic adjustments of the glaciers to the new boundary conditions the rate changed to −0.54 ± 0.13 Gt a−1 in the period 2012–2014, resulting in an average mass change rate of −0.84 ± 0.18 Gt a−1 (1993–2014) for the same domain. Including the retreat of the ice front and grounding line, a total mass change of −37.5 ± 8.2 Gt (−1.79 ± 0.39 Gt a−1) and a contribution to sea level rise of 20.9 ± 5.2 Gt (−0.99 ± 0.25 Gt a−1) were computed for the period 1993–2014. Analysis of the ice flux revealed that available bedrock elevation estimates at Sjögren Inlet are too shallow and are the major uncertainty in ice flux computations. This temporally dense time series analysis of Sjögren Inlet glaciers shows that the adjustments of tributary glaciers to ice shelf disintegration are still ongoing and provides detailed information of the changes in glacier dynamics.
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- 2016
- Full Text
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16. Decidual Vasculopathy Identification in Whole Slide Images Using Multiresolution Hierarchical Convolutional Neural Networks
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Clymer, Daniel, Kostadinov, Stefan, Catov, Janet, Skvarca, Lauren, Pantanowitz, Liron, Cagan, Jonathan, and LeDuc, Philip
- Abstract
After a child is born, the examination of the placenta by a pathologist for abnormalities, such as infection or maternal vascular malperfusion, can provide important information about the immediate and long-term health of the infant. Detection of the pathologic placental blood vessel lesion decidual vasculopathy (DV) has been shown to predict adverse pregnancy outcomes, such as preeclampsia, which can lead to mother and neonatal morbidity in subsequent pregnancies. However, because of the high volume of deliveries at large hospitals and limited resources, currently a large proportion of delivered placentas are discarded without inspection. Furthermore, the correct diagnosis of DV often requires the expertise of an experienced perinatal pathologist. We introduce a hierarchical machine learning approach for the automated detection and classification of DV lesions in digitized placenta slides, along with a method of coupling learned image features with patient metadata to predict the presence of DV. Ultimately, the approach will allow many more placentas to be screened in a more standardized manner, providing feedback about which cases would benefit most from more in-depth pathologic inspection. Such computer-assisted examination of human placentas will enable real-time adjustment to infant and maternal care and possible chemoprevention (eg, aspirin therapy) to prevent preeclampsia, a disease that affects 2% to 8% of pregnancies worldwide, in women identified to be at risk with future pregnancies.
- Published
- 2020
- Full Text
- View/download PDF
17. Regional climate of the Larsen B embayment 1980-2014
- Author
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Sub Dynamics Meteorology, Marine and Atmospheric Research, Leeson, Amber, Van Wessem, J. M., Ligtenberg, S. R.M., Shepherd, A., Van Den Broeke, M. R., Killick, R., Skvarca, P., Marinsek, S., Colwell, S., Sub Dynamics Meteorology, Marine and Atmospheric Research, Leeson, Amber, Van Wessem, J. M., Ligtenberg, S. R.M., Shepherd, A., Van Den Broeke, M. R., Killick, R., Skvarca, P., Marinsek, S., and Colwell, S.
- Published
- 2017
18. Regional climate of the Larsen B embayment 1980–2014
- Author
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Leeson, A.A., Van Wessem, J.M., Ligtenberg, S.R.M., Shepherd, A., Van Den Broeke, M.R., Killick, R., Skvarca, P., Marinsek, S., Colwell, S., Leeson, A.A., Van Wessem, J.M., Ligtenberg, S.R.M., Shepherd, A., Van Den Broeke, M.R., Killick, R., Skvarca, P., Marinsek, S., and Colwell, S.
- Abstract
Understanding the climate response of the Antarctic Peninsula ice sheet is vital for accurate predictions of sea-level rise. However, since climate models are typically too coarse to capture spatial variability in local scale meteorological processes, our ability to study specific sectors has been limited by the local fidelity of such models and the (often sparse) availability of observations. We show that a high-resolution (5.5 km × 5.5 km) version of a regional climate model (RACMO2.3) can reproduce observed interannual variability in the Larsen B embayment sufficiently to enable its use in investigating long-term changes in this sector. Using the model, together with automatic weather station data, we confirm previous findings that the year of the Larsen B ice shelf collapse (2001/02) was a strong melt year, but discover that total annual melt production was in fact ~30% lower than 2 years prior. While the year before collapse exhibited the lowest melting and highest snowfall during 1980–2014, the ice shelf was likely pre-conditioned for collapse by a series of strong melt years in the 1990s. Melt energy has since returned to pre-1990s levels, which likely explains the lack of further significant collapse in the region (e.g. of SCAR Inlet).
- Published
- 2017
19. Detection of decidual vasculopathy using multiresolution hierarchical neural network
- Author
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Sahai, Mangalam, Skvarca, Lauren, Yousif, Mustafa, Pantanowitz, Liron, Cagan, Jonathan, and LeDuc, Philip R.
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- 2024
- Full Text
- View/download PDF
20. Glacier Acceleration and Thinning after Ice Shelf Collapse in the Larsen B Embayment, Antarctica
- Author
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Scambos, T. A., Bohlander, J. A., Shuman, Christopher, and Skvarca, P.
- Abstract
Ice velocities derived from five Landsat 7 images acquired between January 2000 and February 2003 show a two- to six-fold increase in centerline speed of four glaciers flowing into the now-collapsed section of the Larsen B Ice Shelf. Satellite laser altimetry from ICESat indicates the surface of Hektoria Glacier lowered by up to 38 �� 6 m in a six-month period beginning one year after the break-up in March 2002. Smaller elevation losses are observed for Crane and Jorum glaciers over a later 5-month period. Two glaciers south of the collapse area, Flask and Leppard, show little change in speed or elevation. Seasonal variations in speed preceding the large post-collapse velocity increases suggest that both summer melt percolation and changes in the stress field due to shelf removal play a major role in glacier dynamics.
- Published
- 2014
- Full Text
- View/download PDF
21. Dynamic response of Sjögren Inlet glaciers, Antarctic Peninsula, to ice shelf breakup derived from multi-mission remote sensing time series.
- Author
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Sub Dynamics Meteorology, Marine and Atmospheric Research, Seehaus, T.C., Marinsek, S., Skvarca, P., van Wessem, J.M., Reijmer, C.H., Seco, J.L., Braun, M., Sub Dynamics Meteorology, Marine and Atmospheric Research, Seehaus, T.C., Marinsek, S., Skvarca, P., van Wessem, J.M., Reijmer, C.H., Seco, J.L., and Braun, M.
- Published
- 2016
22. Observation of Changes in Ice Dynamics at the northern Antarctic Peninsula
- Author
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Seehaus, Thorsten, Marinsek, Sebastián, Helm, Veit, Steinhage, Daniel, Skvarca, P., Seco, J., Braun, M., Seehaus, Thorsten, Marinsek, Sebastián, Helm, Veit, Steinhage, Daniel, Skvarca, P., Seco, J., and Braun, M.
- Abstract
The physical conditions along the Antarctic Peninsula have undergone considerable changes during the last 50 years. A period of pronounced air temperature raise, increasing ocean temperatures as well as changes in the precipitation pattern have been reported by various authors. Consequently, the glacial systems showed changes including widespread retreat, surface lowering as well as increased flow speeds. During the last decades numerous ice shelves along the Antarctic Peninsula retreated, started to break-up or disintegrated completely. The loss of the buttressing effect caused tributary glaciers to accelerate with increasing ice discharge along the Antarctic Peninsula. Quantification of the mass changes is still subject to considerable errors although numbers derived from the different methods are converging. We analysed time series of various SAR satellite sensors (ERS-1/2 SAR, ENVISAT ASAR, RADARSAT-1, ALOS PALSAR, TerraSAR-X/TanDEM-X, Sentinel-1) to detect changes in ice flow speed and surface elevation. The aim is to study the reaction of glaciers to the changing climatic conditions, especially the readjustments of tributary glaciers to ice shelf disintegration, as well as to better quantify the ice mass loss and its temporal changes. We applyed intensity feature tracking techniques on time series from different SAR satellites over the last 20 years to infer changes in glacier surface velocities. Variations in ice front position are mapped in conjunction with the velocity data sets. High resolution bi-static TanDEM-X satellite data was used to derive digital elevation models by differential SAR interferometry. In combination with ASTER and SPOT stereo images, changes in surface elevations were determined. Altimeter data from ICESat, CryoSat-2 and NASA operation IceBridge ATM were used for vertical referencing and quality assessment of the digital elevation models. Airborne laser scanning, ground penetrating radar (AWI Polar-5/6, NASA operation ice-bridge) and
- Published
- 2016
23. Protocol for development of software to rapidly assess placenta images at birth.
- Author
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Gernand, Alison D., Goldstein, Jeffery A., Gallagher, Kelly, Walker, Rachel E., Pan, Yimu, Mehta, Manas, Davaasuren, Dolzodmaa, Wu, Chenyan, Catov, Janet M., Sadovsky, Yoel, Skvarca, Lauren B., Ngonzi, Joseph, Bebell, Lisa M., Roberts, Drucilla J., and Wang, James Z.
- Published
- 2023
- Full Text
- View/download PDF
24. Impact of Ki-67 Labeling Index on Prognostic Significance of the Chemotherapy Response Score in Women With Tubo-ovarian Cancer Treated With Neoadjuvant Chemotherapy
- Author
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Heayn, Michelle, Skvarca, Lauren B., Zhu, Li, Edwards, Robert P., Olawaiye, Alexander B., Modugno, Francesmary, Elishaev, Esther, and Bhargava, Rohit
- Abstract
The chemotherapy response score (CRS) proposed by Bohm and colleagues in 2015 has been validated as a reproducible method for determining histopathologic response of tubo-ovarian carcinoma to neoadjuvant chemotherapy and stratifies tumor response into 3 groups: CRS1 is defined as minimal/no response, CRS2 as moderate response, and CRS3 as marked response. Although described as a 3-tiered system, it essentially works as a 2-tiered system (CRS1/CRS2 vs. CRS3) for assessing prognosis. Here, we analyzed the prognostic value of CRS in a large cohort of tubo-ovarian carcinomas at a tertiary care center and evaluated the potential for Ki-67 labeling index on post-neoadjuvant chemotherapy samples to provide additional prognostic information. We included 170 patients with tubo-ovarian carcinoma treated with neoadjuvant chemotherapy followed by interval debulking surgery. We determined CRS for each case by reviewing slides from the interval debulking surgery resection specimen and calculated progression-free survival and overall survival. For each case with residual disease (CRS1 and CRS2, n=123, 72%), we also performed Ki-67 antibody staining and determined both average and highest Ki-67 labeling index. Consistent with prior studies, patients in our cohort with CRS1 and CRS2 showed significantly shorter progression-free survival and overall survival compared with CRS3. Further, in the subset of cases with CRS1 and CRS2, Ki-67 labeling index was predictive of OS at multiple cutoff points. An average Ki-67 labeling index of 20% (log rank test P-value: 0.0004) or a highest Ki-67 labeling index of 50% (log rank test P-value: 0.0002) could provide a practically useful cutoff. Multivariable cox proportional hazard model showed worse overall survival with both, average Ki-67 >20% (hazard ratios: 2.02, P-value: 0.00422, confidence interval: 1.25–3.28) and highest Ki-67 >50% (hazard ratios: 1.88, P-value: 0.0205, confidence interval: 1.1–3.2). We propose adding Ki-67 labeling index to CRS to provide additional prognostic separation between patients with CRS1 and CRS2.
- Published
- 2024
- Full Text
- View/download PDF
25. Inventory and recent changes of small glaciers on the northeast margin of the Southern Patagonia Icefield, Argentina
- Author
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Masiokas, M.H., primary, Delgado, S., additional, Pitte, P., additional, Berthier, E., additional, Villalba, R., additional, Skvarca, P., additional, Ruiz, L., additional, Ukita, J., additional, Yamanokuchi, T., additional, Tadono, T., additional, Marinsek, S., additional, Couvreux, F., additional, and Zalazar, L., additional
- Published
- 2015
- Full Text
- View/download PDF
26. Monitoring glacier changes on the Antarctic Peninsula
- Author
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Kargel, J.S., Leonard, G.J., Bishop, M.P., Kääb, Andreas, Raup, B.H., Arigony-Neto, J, Skvarca, P., Marinsek, S., Braun, Matthias, Humbert, Angelika, Wilson Mendes, C. Junior, Jaña, R, Kargel, J.S., Leonard, G.J., Bishop, M.P., Kääb, Andreas, Raup, B.H., Arigony-Neto, J, Skvarca, P., Marinsek, S., Braun, Matthias, Humbert, Angelika, Wilson Mendes, C. Junior, and Jaña, R
- Abstract
The Antarctic Peninsula has exhibited some of the most spectacular changes observed in glacial systems in recent decades. The events include disintegration of ice shelves, acceleration and thinning of glaciers, variations in the limits between glacier facies, and retreat of glacier fronts. However, due to the lack of both consistent systematic observations of the glacial systems and information on their boundary conditions, it is difficult to accurately predict the contribution of Antarctic Peninsula glaciers to sea level rise and further responses of these ice masses to climatic and oceanographic changes. In this context, the activities of the GLIMS Regional Center for the Antarctic Peninsula and its network of international collaborators are based on the use of various types of Earth observation imagery, mainly optical and radar data. Although a complete glacier inventory is still lacking, we present the results of changes in glacier frontal positions and boundaries of glacier facies as well as links to dynamical adjustments for various locations in the Antarctic Peninsula’s ice masses. Evaluation of Advanced Spaceborne Thermal Emission and reflection Radiometer (ASTER) digital elevation models generated for the Antarctic Peninsula is also discussed.
- Published
- 2014
27. Recommendations for the collection and synthesis of Antarctic Ice Sheet mass balance data
- Author
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Abdalati, W., Allison, I., Carsey, F., Casassa, G., Fily, M., Frezzotti, M., Fricker, H.A., Genthon, C., Goodwin, I., Guo, Z., Hamilton, G.S., Hindmarsh, R.C.A., Hulbe, C.L., Jacka, T.H., Jezek, K.C., Kwok, R., Li, J., Nixdorf, U., Paltridge, G., Rignot, E., Ritz, C., Satow, K., Scambos, T.A., Shuman, C., Skvarca, P., Takahashi, S., van de Wal, R.S.W., Vaughan, D.G., Wang, W.L., Warner, R.C., Wingham, D.J., Young, N.W., Zwally, H.J., Abdalati, W., Allison, I., Carsey, F., Casassa, G., Fily, M., Frezzotti, M., Fricker, H.A., Genthon, C., Goodwin, I., Guo, Z., Hamilton, G.S., Hindmarsh, R.C.A., Hulbe, C.L., Jacka, T.H., Jezek, K.C., Kwok, R., Li, J., Nixdorf, U., Paltridge, G., Rignot, E., Ritz, C., Satow, K., Scambos, T.A., Shuman, C., Skvarca, P., Takahashi, S., van de Wal, R.S.W., Vaughan, D.G., Wang, W.L., Warner, R.C., Wingham, D.J., Young, N.W., and Zwally, H.J.
- Abstract
Recent unexpected changes in the Antarctic Ice Sheet, including ice sheet thinning, ice shelf collapse and changes in ice velocities, along with the recent realization that as much as one third of ice shelf mass loss is due to bottom melt, place a new urgency on understanding the processes involved in these changes. Technological advances, including very new or forthcoming satellite-based (e.g. ICESat, CryoSat) remote sensing missions, will improve our ability to make meaningful determinations of changes in Antarctic Ice Sheet mass balance. This paper is the result of a workshop held to develop a strategy for international collaboration aimed at the collection and synthesis of Antarctic Ice Sheet mass balance data, and at understanding the processes involved so that we might predict future change. Nine sets of recommendations are made, concerning the most important and sensitive measurements, temporal ranges and study areas. A final tenth recommendation calls for increased synthesis of ice sheet data and communication between the field measurement, satellite observation and modelling communities.
- Published
- 2004
28. Monitoring ice shelf velocities from repeat MODIS and Landsat data – a method study on the Larsen C ice shelf, Antarctic Peninsula, and 10 other ice shelves around Antarctica
- Author
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Haug, T., primary, Kääb, A., additional, and Skvarca, P., additional
- Published
- 2010
- Full Text
- View/download PDF
29. Northern Larsen Ice Shelf, Antarctica: further retreat after collapse
- Author
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Rott, H., Rack, Wolfgang, Skvarca, P., Angelis, H. de, Rott, H., Rack, Wolfgang, Skvarca, P., and Angelis, H. de
- Abstract
Changes of Larsen Ice Shelf, Antarctica, and the surrounding glaciers after its collapse in 1995 were investigated using satellite radar imagery, with emphasis onchanges in the glaciers which previously nourished the ice shelf north of Seal Nunataks. The large glaciers retreated several kilometres inland of the previousgrounding line. The velocity field of Drygalski Glacier, the largest glacier in this area, was mapped by means of interferograms derived from pairs of ERS syntheticaperture radar images from 1995 and 1999. The main part of the glacier showed significant acceleration of flow over these 4 years, with an increase of veocity upto three-fold at the terminus. Similar accelerations were observed by means of interferometry on several other grounded glaciers, suggesting that the removal ofice shelves could lead to an effect on eustatic sea level. For Larsen B, the northernmost surviving part of Larsen Ice Shelf, the retreat of the ice front to October2000 is documented.
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- 2002
30. Glacier Acceleration and Thinning after Ice Shelf Collapse in the Larsen B Embayment, Antarctica
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Scambos, T. A., primary, Bohlander, J. A., additional, Shuman, C. A., additional, and Skvarca, P., additional
- Published
- 2009
- Full Text
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31. BEDMAP: A new ice thickness and subglacial topographic model of Antarctica
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Lythe, Matthew, Vaughan, David G., Lambrecht, A., Miller, H., Nixdorf, U., Oerter, H., Steinhage, D., Allison, I.F., Craven, M., Goodwin, I.D., Jacka, J., Morgan, V., Ruddell, A., Young, N., Wellman, P., Cooper, A.P.R., Corr, H.F.J., Doake, C.S.M., Hindmarsh, R.C.A., Jenkins, A., Johnson, M.R., Jones, P., King, E.C., Smith, A.M., Thomson, J.W., Thorley, M.R., Jezek, K., Li, B., Liu, H., Damm, V., Nishio, F., Fujita, S., Skvarca, P., Remy, F., Testut, L., Sievers, J., Kapitsa, A., Macheret, Y., Scambos, T., Filina, I., Masolov, V., Popov, S., Johnstone, G., Jacobel, B., Holmlund, P., Naslund, J., Anandakrishnan, S., Bamber, J.L., Bassford, R., Decleir, H., Huybrechts, P., Rivera, A., Grace, N., Casassa, G., Tabacco, I., Blankenship, D., Morse, D., Gades, T., Nereson, N., Bentley, C.R., Lord, N., Lange, M., Sandhäger, H., Lythe, Matthew, Vaughan, David G., Lambrecht, A., Miller, H., Nixdorf, U., Oerter, H., Steinhage, D., Allison, I.F., Craven, M., Goodwin, I.D., Jacka, J., Morgan, V., Ruddell, A., Young, N., Wellman, P., Cooper, A.P.R., Corr, H.F.J., Doake, C.S.M., Hindmarsh, R.C.A., Jenkins, A., Johnson, M.R., Jones, P., King, E.C., Smith, A.M., Thomson, J.W., Thorley, M.R., Jezek, K., Li, B., Liu, H., Damm, V., Nishio, F., Fujita, S., Skvarca, P., Remy, F., Testut, L., Sievers, J., Kapitsa, A., Macheret, Y., Scambos, T., Filina, I., Masolov, V., Popov, S., Johnstone, G., Jacobel, B., Holmlund, P., Naslund, J., Anandakrishnan, S., Bamber, J.L., Bassford, R., Decleir, H., Huybrechts, P., Rivera, A., Grace, N., Casassa, G., Tabacco, I., Blankenship, D., Morse, D., Gades, T., Nereson, N., Bentley, C.R., Lord, N., Lange, M., and Sandhäger, H.
- Abstract
Measurements of ice thickness on the Antarctic ice sheet collected during surveys undertaken over the past 50 years have been brought together into a single database. From these data, a seamless suite of digital topographic models have been compiled for Antarctica and its surrounding ocean. This includes grids of ice sheet thickness over the grounded ice sheet and ice shelves, water column thickness beneath the floating ice shelves, bed elevation beneath the grounded ice sheet, and bathymetry to 60°S, including the sub-ice-shelf cavities. These grids are consistent with a recent high-resolution surface elevation model of Antarctica. While the digital models have a nominal spatial resolution of 5 km, such high resolution is justified by the original data density only over a few parts of the ice sheet. The suite does, however, provide an unparalleled vision of the geosphere beneath the ice sheet and a more reliable basis for ice sheet modeling than earlier maps. The total volume of the Antarctic ice sheet calculated from the BEDMAP grid is 25.4 million km3, and the total sea level equivalent, derived from the amount of ice contained within the grounded ice sheet, is 57 m, comprising 52 m from the East Antarctic ice sheet and 5 m from the West Antarctic ice sheet, slightly less than earlier estimates. The gridded data sets can be obtained from the authors.
- Published
- 2001
32. Calving and ice-shelf break-up processes investigated by proxy: Antarctic tabular iceberg evolution during northward drift
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Scambos, T., primary, Ross, R., additional, Bauer, R., additional, Yermolin, Y., additional, Skvarca, P., additional, Long, D., additional, Bohlander, J., additional, and Haran, T., additional
- Published
- 2008
- Full Text
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33. Interferometric analysis of the deformation pattern of the northern Larsen Ice Shelf, Antarctic Peninsula, compared to field measurements and numerical modeling
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Rack, Wolfgang, Doake, C. S. M., Rott, H., Siegel, A., Skvarca, P., Rack, Wolfgang, Doake, C. S. M., Rott, H., Siegel, A., and Skvarca, P.
- Abstract
The motion field of the northern Larsen Ice Shelf, Antarctic Peninsula, was analyzed using radar interferometry in combination with field measurements and finite element model calculations. The ice shelf between Jason Peninsula and Seal Nunataks is in steady retreat since January 1995. Model calculations suggest that the ice shelf is in a stage of irreversible retreat since the last calving events in summer 1998/1999. The interferometric analysis is based on SAR data of the Tandem mission of ERS-1 and ERS-2 in austral spring 1995. The phase contributions due to tidal motion were estimated from the vertical displacement at those parts of the grounding zone where the horizontal motion is close to zero in order to separate the vertical and horizontal motion components over the ice shelf. Satellite derived velocities compare well with the long-term field measurements along a transverse and a longitudinal profile. The real interferograms and synthetic interferograms, calculated from model velocities, show reasonable agreement over the main parts of the ice shelf, but differ in the boundary zones where the details are not resolved by the model.
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- 2000
34. The Motion Field of Northern Larsen Ice Shelf Derived from Satellite Imagery
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Rack, Wolfgang, Rott, H., Siegel, A., Skvarca, P., Rack, Wolfgang, Rott, H., Siegel, A., and Skvarca, P.
- Abstract
The motion field of the northern Larsen Ice Shelf, Antarctic Peninsula, was analyzed, based on Landsat data from 1986 to 1989, ERS-SAR data from1992 to 1997, and comparative field measurements along three transects. During this period the northern sections of the ice shelf showed steadyretreat, which culminated in the disintegration of the two ice shelf sections north of the Seal Nunataks in January 1995. Velocities of these two sectionswere derived by cross-correlation, using SAR images of one-year time intervals and Landsat images of one- to three-year intervals. A slight increaseof velocity was observed, as crevasses and rifts opened before the final disintegration. In addition, an interferometric motion analysis was carried outfor the ice shelf around and south of Seal Nunataks based on an image pair from the ERS-1/ERS-2 Tandem Mission in 1995. This analysis reveals acomplex pattern of tidal flexure in the grounding zones, as well as rifting and shear zones on the ice shelf. In addition, the motion of the main inputglaciers was derived.
- Published
- 1999
35. 34 year satellite time series to monitor characteristics, extent and dynamics of Larsen B, Antarctic Peninsula
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Skvarca, P., Rack, W., Rott, H., Skvarca, P., Rack, W., and Rott, H.
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A variety of data are used to investigate Larsen B, which is at present the northernmost section of the Larsen Ice Shelf. Recently declassified USArgon satellite photographs of 1963, Kosmos photographs of 1975, Landsat images of 1986, 1988 and 1990, ERS-1/2 SAR images from 1992 to1997, Radarsat of 1998 and field surveys are used to analyze the areal extent, surface characteristics and dynamic behaviour of this ice shelf sectionover more than three decades. Visible and radar imagery together with field observations are used synergistically to describe the ice shelf morphology,including meltwater features and rifts. In contrast to the retreat of the ice shelf sections in the north, Larsen B advanced steadily from 1963 to early1995 when the area decreased significantly due to a major calving event. Analysis of different satellite images indicates that melting is proceedingfurther south in coincidence with the regional warming trend. In addition, fracturing processes and rapid development of new rifts are observed,associated with recent acceleration of ice motion close to the front. All observations indicate that major calving events should be expected for this iceshelf section in the near future.
- Published
- 1999
36. Climatic trend, retreat and disintegration of ice shelves on the Antarctic Peninsula: an overview
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Skvarca, P., Rack, Wolfgang, Rott, H., Ibarzábal y Donángelo, T., Skvarca, P., Rack, Wolfgang, Rott, H., and Ibarzábal y Donángelo, T.
- Abstract
Observations of the retreat and disintegration of ice shelves around the Antarctic Peninsula during the last three decades and associated changes in airtemperature, measured at various meteorological stations on the Antarctic Peninsula, are reviewed. The climatically induced retreat of the northernLarsen Ice Shelf on the east coast and of the Wordie, George VI, and Wilkins ice shelves on the west coast amounted to about 10 000 km2 since themid 1960s. A summary is presented on the recession history of the Larsen Ice Shelf and on the collapse of that sections north of Robertson Island inearly 1995. The area changes were derived from images of various satellites, dating back to late 1963 due to an image from the recently declassifiedUS Argon space missions. This photograph reveals a previously unknown, minor advance of the northern Larsen Ice Shelf before 1975. During theperiod of retreat a consistent and pronounced warming trend was observed at the stations on both east and west coast of the Antarctic Peninsula but amajor cause of the fast retreat and final collapse of the northernmost sections of the Larsen Ice Shelf were several unusually warm summers. Atemperature record from the nearby station Marambio shows that a positive mean summer temperature was reached for the first time in 1992-93.Recent observations indicate that the process of ice shelf disintegration is proceeding further south on both sides of the Antarctic Peninsula.
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- 1999
37. Climatically induced retreat and collapse of Northern Larsen Ice Shelf, Antarctic Peninsula
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Rott, H., Rack, Wolfgang, Nagler, T., Skvarca, P., Rott, H., Rack, Wolfgang, Nagler, T., and Skvarca, P.
- Published
- 1998
38. Climatically Induced Retreat and Collapse of Northern Larsen Ice Shelf
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Rott, H., Rack, Wolfgang, Nagler, T., Skvarca, P., Rott, H., Rack, Wolfgang, Nagler, T., and Skvarca, P.
- Published
- 1998
39. Evidence of recent climatic warming on the eastern Antarctic Peninsula
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Skvarca, P., Rack, Wolfgang, Rott, H., Ibarzábal y Donángelo, T., Skvarca, P., Rack, Wolfgang, Rott, H., and Ibarzábal y Donángelo, T.
- Abstract
Air temperatures at the stations Marambio, Esperanza and Matienzo have been analysed to investigate recent climate change on the eastern part of the Antarctic Peninsula. The data are compared with the station Orcadas on the South Orkney Islands, the longest record available in Antarctica, and with Faraday on the western coast of the Peninsula. Though the interannual variability is comparatively high and the stations are located in different climatic regimes, a pronounced warming trend shows-up in all records. At Marambio a temperature increase of 1.5°C has been observed since the beginning of the record in 1971. This is of similar magnitude as the increase at the station Faraday on the west coast with 2.5°C for the longer period since 1945. The steady retreat and collapse of the northern Larsen Ice Shelf coincided with this warming trend. Of particular importance for the ice shelf mass balance in this region are the summer temperatures which show a statistically significant warming trend at the stations Marambio and Esperanza. The representativity of the summer temperatures of Marambio for northern Larsen Ice Shelf is confirmed by intercomparison with the parallel measurements at Matienzo which is located on the ice shelf.
- Published
- 1998
40. Significant Ice Retreat in the Region Patagonia - Antarctic Peninsula Oberved by ERS SAR
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Rott, H., Skvarca, P., Rack, Wolfgang, Stuefer, M., Rott, H., Skvarca, P., Rack, Wolfgang, and Stuefer, M.
- Abstract
Areal changes and flow dynamics of glaciers of the Southern Patagonian Icefield (SPI) and of northern Larsen Ice Shelf (LIS) on the Antarctic Peninsula have been investigated based on ERS-1 and ERS-2 SAR data and on field work. After a period of steady retreat, coinciding with regional atmospheric warming during the last five decades, the two northernmost sections of the LIS (north of 65°S) disintegrated within a few days in early 1995. At the same time a large calving event occurred also in the section of the LIS south of 65°S. Recent observations of the ice front and of rifting zones indicate that the retreat of this section might accelerate in the near future. Studies of major outlet glaciers on the east side of the SPI, which extends from 48.3°S to 51.5°S, revealed significant retreat for the majority of glaciers. As an example, areal changes of Upsala Glacier, calving into Lago Argentino, are shown. The retreat accelerated considerably after 1993 resulting in unusually large calving events. The region Patagonia - Antarctic Peninsula, located in the west wind zone, reveals steep climatic gradients and therefore is particularly sensitive to climate change as indicated by the retreat of glaciers and ice shelves.
- Published
- 1997
41. Abstract P246: Association Between Life’s Essential 8 Cardiovascular Health Scores During Pregnancy and Vascular Integrity in the Placenta
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Kozai, Andrea, Parks, W. Tony, Catov, Janet M, Lane, Abbi D, Skvarca, Lauren B, Jones, Melissa, Whitaker, Kara M, and Barone Gibbs, Bethany
- Abstract
Background:Adverse pregnancy outcomes (APOs) identify pregnant people at increased risk of later cardiovascular disease. Poor antenatal cardiovascular health (CVH) quantified using components of the Life’s Simple 7 ideal CVH framework has been associated with higher APO incidence, indicating modifiable aspects of CVH during pregnancy may be related to pregnancy health. Placental pathology is also common in APOs, but it is unclear if antenatal CVH is directly related to placental health. Further, clinically-used dichotomous measures of placental pathology limit investigation of associations. Thus, the aim of this study was to examine the relationship between antenatal CVH and a novel, continuous marker of placental vascularization.Hypothesis:We hypothesized higher (healthier) antenatal CVH scores would be associated with higher (healthier) vascularization in the placenta.Methods:Participants enrolled in the Magee Obstetric Maternal & Infant Biobank and one of two prospective observational cohort studies examining activity patterns in pregnancy (MoM Health or Pregnancy 24/7). Antenatal CVH was quantified with a pregnancy-adapted Life’s Essential 8 framework assessed during each trimester and averaged across gestation. Components included sleep, diet, smoking, objective physical activity, pre-pregnancy BMI, blood pressure, 50g glucose challenge test results, and gestational weight gain. Component scores were averaged for a composite score (possible range, 0-100; higher indicated better CVH). Immunohistochemistry of placenta tissue was performed. Sections were stained with CD34 antibody to highlight vascular endothelial cells and counterstained with hematoxylin. Whole-slide images were digitized. Software computed the number of pixels positive for CD34 (numerator) and the total pixels (denominator); the ratio was the outcome of fetal vascular percentage (FV%), or the proportion of villous tissue occupied by fetal vessels. Linear regression associated CVH scores with FV%.Results:Placenta tissue was obtained from 64 participants (mean±SD age = 32±4.9 years). CVH score averaged across gestation was 72.6±10.7 points and decreased significantly from the first to third trimester (72.8±12.7 vs. 65.1±11.9, p<0.01). FV% was 26.3±5.13 percentage points. Associations between CVH scores and FV% approached but did not reach significance (p<0.2) in each trimester and across gestation. A 10-point increase in CVH averaged across gestation was non-significantly associated with a 0.82 percentage point increase in FV% (p=0.18). Post-hoc power analysis of this novel metric identified sufficient power to detect a 1.5 percentage point change in FV% per 10-point change in CVH score.Conclusion:Antenatal CVH was not significantly associated with placental vasculature, though a small sample size limits conclusions. Replication in a fully-powered sample is warranted.
- Published
- 2023
- Full Text
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42. Calving rates in fresh water: new data from southern Patagonia
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Skvarca, P., primary, Angelis, H. De, additional, Naruse, R., additional, Warren, C.R., additional, and Aniya, M., additional
- Published
- 2002
- Full Text
- View/download PDF
43. Thermal structure of proglacial lakes in Patagonia
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Sugiyama, Shin, Minowa, Masahiro, Sakakibara, Daiki, Skvarca, Pedro, Sawagaki, Takanobu, Ohashi, Yoshihiko, Naito, Nozomu, and Chikita, Kazuhisa
- Abstract
Calving glaciers are rapidly retreating in many regions under the influence of ice‐water interactions at the glacier front. In contrast to the numerous researches conducted on fjords in front of tidewater glaciers, very few studies have been reported on lakes in which freshwater calving glaciers terminate. To better understand ice‐water interactions at the front of freshwater calving glaciers, we measured lakewater temperature, turbidity, and bathymetry near Glaciar Perito Moreno, Upsala, and Viedma, large calving glaciers of the Southern Patagonia Icefield. The thermal structures of these lakes were significantly different from those reported in glacial fjords. There was no indication of upwelling subglacial meltwater; instead, turbid and cold glacial water discharge filled the region near the lake bottom. This was because water density was controlled by suspended sediment concentrations rather than by water temperature. Near‐surface wind‐driven circulation reaches a depth of ~180 m, forming a relatively warm isothermal layer (mean temperature of ~5–6°C at Perito Moreno, ~3–4°C at Upsala, and ~6–7°C at Viedma), which should convey heat energy to the ice‐water interface. However, the deeper part of the glacier front is in contact with stratified cold water, implying a limited amount of melting there. In the lake in front of Glaciar Viedma, the region deeper than 120 m was filled entirely with turbid and very cold water at pressure melting temperature. Our results revealed a previously unexplored thermal structure of proglacial lakes in Patagonia, suggesting its importance in the subaqueous melting of freshwater calving glaciers. Lakewater temperature, turbidity, and bathymetry measured near large calving glaciers of the Southern Patagonia IcefieldThermal structure of the lakes characterized by wind‐mixed warm water near the surface and cold/turbid glacial discharge near the bottomCold water at pressure melting point fills lower half of the lake of Glaciar Viedma, affecting subaqueous melting of the ice front
- Published
- 2016
- Full Text
- View/download PDF
44. Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury
- Author
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Skrypnyk, Nataliya I., Sanker, Subramaniam, Skvarca, Lauren Brilli, Novitskaya, Tatiana, Woods, Clara, Chiba, Takuto, Patel, Kevin, Goldberg, Natasha D., McDermott, Lee, Vinson, Paige N., Calcutt, M. Wade, Huryn, Donna M., Vernetti, Lawrence A., Vogt, Andreas, Hukriede, Neil A., and de Caestecker, Mark P.
- Abstract
No therapies have been shown to accelerate recovery or prevent fibrosis after acute kidney injury (AKI). In part, this is because most therapeutic candidates have to be given at the time of injury and the diagnosis of AKI is usually made too late for drugs to be efficacious. Strategies to enhance post-AKI repair represent an attractive approach to address this. Using a phenotypic screen in zebrafish, we identified 4-(phenylthio)butanoic acid (PTBA), which promotes proliferation of embryonic kidney progenitor cells (EKPCs), and the PTBA methyl ester UPHD25, which also increases postinjury repair in ischemia-reperfusion and aristolochic acid-induced AKI in mice. In these studies, a new panel of PTBA analogs was evaluated. Initial screening was performed in zebrafish EKPC assays followed by survival assays in a gentamicin-induced AKI larvae zebrafish model. Using this approach, we identified UPHD186, which in contrast to UPHD25, accelerates recovery and reduces fibrosis when administered several days after ischemia-reperfusion AKI and reduces fibrosis after unilateral ureteric obstruction in mice. UPHD25 and 186 are efficiently metabolized to the active analog PTBA in liver and kidney microsome assays, indicating both compounds may act as PTBA prodrugs in vivo. UPHD186 persists longer in the circulation than UPHD25, suggesting that sustained levels of UPHD186 may increase efficacy by acting as a reservoir for renal metabolism to PTBA. These findings validate use of zebrafish EKPC and AKI assays as a drug discovery strategy for molecules that reduce fibrosis in multiple AKI models and can be administered days after initiation of injury.
- Published
- 2016
- Full Text
- View/download PDF
45. Areal changes and motion of northern Larsen Ice Shelf, Antarctic Peninsula
- Author
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Rack, W., primary, Rott, H., additional, Nagler, T., additional, and Skvarca, P., additional
- Published
- 1998
- Full Text
- View/download PDF
46. Surface-velocity field of the northern Larsen Ice Shelf, Antarctica
- Author
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Bindschadler, R. A., primary, Fahnestock, M. A., additional, Skvarca, P., additional, and Scambos, T. A., additional
- Published
- 1994
- Full Text
- View/download PDF
47. Glacier acceleration and thinning after ice shelf collapse in the Larsen B embayment, Antarctica.
- Author
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Scambos, T. A., Bohlander, J. A., Shuman, C. A., and Skvarca, P.
- Published
- 2004
- Full Text
- View/download PDF
48. Adiponectin/leptin ratio and insulin resistance in pregnancy
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Skvarca, A, Tomazic, M, Blagus, R, Krhin, B, and Janez, A
- Abstract
Objective Pregnancy is characterized by progressive insulin resistance. The present study evaluated whether the adiponectin/leptin ratio is associated with insulin resistance in pregnancy, since this ratio has been shown to be associated with insulin resistance in obesity, type 2 diabetes mellitus, metabolic syndrome and polycystic ovary syndrome.Methods In this cross-sectional study, adiponectin and leptin concentrations were measured in pregnant women using enzyme-linked immunosorbent assays. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA–IR).Results Mean ± SD age of the participants (n= 74) was 30.76 ± 4.27 years, mean ± SD gestational age was 26.81 ± 3.52 weeks and median body mass index (BMI) before pregnancy was 22.68 kg/m2(interquartile range 20.75–26.79 kg/m2). There was a significant correlation between the HOMA–IR and leptin concentration, but not between the HOMA–IR and adiponectin concentration. There was a significant inverse correlation between the HOMA–IR and adiponectin/leptin ratio. The adiponectin/leptin ratio was inversely correlated with BMI before pregnancy.Conclusion The adiponection/leptin ratio inversely correlates with HOMA–IR in pregnancy.
- Published
- 2013
- Full Text
- View/download PDF
49. Adipocytokines and Insulin Resistance across Various Degrees of Glucose Tolerance in Pregnancy
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Skvarca, A, Tomazic, M, Krhin, B, Blagus, R, and Janez, A
- Abstract
OBJECTIVE: Gestational diabetes mellitus is characterized by progressive insulin resistance. Adipocytokines are thought to be associated with insulin resistance. This cross-sectional study evaluated the associations between serum concentrations of several adipocytokines and insulin resistance at different stages of glucose tolerance in pregnancy, using the homeostasis model assessment of insulin resistance (HOMA-IR) as a reference. METHODS: According to oral glucose tolerance test results, 74 pregnant women were divided into three groups: normal glucose tolerance (n= 25); intermediate glucose tolerance (n= 19); gestational diabetes mellitus (n= 30). Adiponectin, leptin, resistin, visfatin and retinol-binding protein 4 (RBP4) concentrations were measured using enzyme-linked immunosorbent assays. RESULTS: Groups were comparable regarding age, week of gestation and body mass index before gestation. There were statistically significant between-group differences in HOMA-IR, but no significant differences regarding serum adipocytokine concentrations. CONCLUSIONS: Adiponectin, leptin, resistin, visfatin and RBP4 were not associated with the degree of glucose tolerance in pregnancy. Concentrations of these adipocytokines are not sufficiently sensitive to replace HOMA-IR in pregnancy.
- Published
- 2012
- Full Text
- View/download PDF
50. Applications of High-Precise Three-Dimensional Measurement System
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Hashimoto, Takeshi, Kaneko, Mitsuo, Rövid, András, Ohta, Hiroaki, Fukuda, Akira, Aniya, Masamu, Naito, Nozomu, Enomoto, Hiroyuki, and Skvarca, Pedro
- Abstract
To reveal the influence of global warming on glaciers, highly accurate observations of glacier movement must continue every year. It is thought that there is a close relationship between glacier moving speed and global warming. Thus, there have been precise, detailed observations of the movement of the Perito Moreno glacier in Patagonia of the Argentine Republic over the past five years. The measurement method of using GPS and an optical measuring instrument is generally used to monitor glacier movement, but the measurement accuracy attained is not optimal because of the huge size of the glacier. The measurement system used for the Perito Moreno observations, however, could realize high accuracy measurement over long distance. The measurement system is based on the principle of stereo measurement using cameras. This paper describes the results of the Perito Moreno glacier observations of this year and considers the effectiveness of glacier observation using cameras.
- Published
- 2011
- Full Text
- View/download PDF
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