Search

Your search keyword '"Slattery, J."' showing total 933 results
Start Over Author "Slattery, J."
933 results on '"Slattery, J."'

5. The use of the paramedian forehead flap alone or in combination with other techniques in the reconstruction of periocular defects and orbital exenterations

Author

Ang, TW, Juniat, V, O'Rourke, M, Slattery, J, O'Donnell, B, McNab, AA, Hardy, TG, Caplash, Y, Selva, D, Ang, TW, Juniat, V, O'Rourke, M, Slattery, J, O'Donnell, B, McNab, AA, Hardy, TG, Caplash, Y, and Selva, D

Abstract

PURPOSE: The paramedian forehead flap (PMFF) is a reconstructive option for large eyelid defects and orbital exenterations. We report a series of cases where PMFF reconstruction was carried out at various institutions in Australia. METHODS: This study was a multi-centre, retrospective, non-comparative case series investigating the clinical outcomes of the PMFF for reconstructing periocular defects and orbital exenterations. RESULTS: This case series describes twenty-seven patients (Female = 15, Male = 12), operated between 1991 to 2019, with a median age of 81 years (range: 45-93 years). Defect locations involved combinations of the medial canthus (16/27, 59.3%), upper eyelids (7/27, 25.9%), lower eyelid (4/27, 14.8%), both upper and lower eyelids (5/27, 18.5%), and orbital (7/27, 25.9%). There were no cases of flap necrosis. Minor post-operative complications were observed in ten patients with the most common being lagophthalmos. Median duration of follow-up was 17months (Range: 2months- 23years). CONCLUSIONS: The PMFF is a versatile reconstructive tool for a range of periocular defects and orbital exenterations with minor post-operative complications.

Published
2023

10. Eosinophilic Vasculitis and Arteritic Anterior Ischemic Optic Neuropathy Associated With Anti-PD-L1 Therapy

Author

Berry, EC, Mullany, S, Quinlivan, A, Craig, A, New-Tolley, J, Slattery, J, Sukumaran, S, Klebe, S, Craig, JE, Siggs, OM, Wechalekar, MD, Berry, EC, Mullany, S, Quinlivan, A, Craig, A, New-Tolley, J, Slattery, J, Sukumaran, S, Klebe, S, Craig, JE, Siggs, OM, and Wechalekar, MD

Abstract

Immune checkpoint inhibitor therapy is frequently associated with immune-related adverse events, which occasionally manifest with visual symptoms. Here, we describe a case of unilateral and sudden-onset painless vision loss in an 82-year-old man with metastatic non-small cell lung cancer receiving immunotherapy with the anti-programmed death-ligand 1 agent atezolizumab. Examination demonstrated a right-sided relative afferent pupillary defect, diffusely swollen optic disc, and delayed choroidal and retinal arterial filling on fundus fluorescein angiography, consistent with an arteritic anterior ischemic optic neuropathy. Histology of an ipsilateral temporal artery biopsy revealed a transmural eosinophilic infiltrate without granulomas, while serology revealed the presence of antineutrophil cytoplasmic antibodies. Peripheral eosinophilia was also noted, which preceded treatment by several months. This report highlights the importance of clinician awareness of immune checkpoint inhibitors and their systemic and ophthalmic complications, which rarely appear to extend to eosinophilic temporal arteritis.

Published
2022

12. Antidepressant prescribing in five European countries: application of common definitions to assess the prevalence, clinical observations, and methodological implications

Author

Abbing-Karahagopian, V., Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G. M., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R. G., de Groot, M. C. H., Klungel, O. H., van Staa, T. P., van Dijk, L., Egberts, A. C. G., Gardarsdottir, H., and De Bruin, M. L.

Published
2014
Full Text
View/download PDF

13. Incidence Rates and Trends of Hip/Femur Fractures in Five European Countries: Comparison Using E-Healthcare Records Databases

Author

Requena, G., Abbing-Karahagopian, V., Huerta, C., De Bruin, M. L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P. C., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., De Groot, M. C. H., Bate, A., Ruigómez, A., García Rodríguez, L. A., Johansson, S., de Vries, F., Montero, D., Schlienger, R., Reynolds, R., Klungel, O. H., and de Abajo, F. J.

Published
2014
Full Text
View/download PDF

20. Discussion

Author

King, Campbell, Burtt, Wilson B., Heintzelman, Stuart, Erickson, Hj., Barden, Wm. J., Pillsbury, George B., Slattery, J. R., Mitchell, W. A., Ralston, Robert R., Fiske, Harold C., Bain, Jarvis J., Callan, L. H., and Cassidy, J. Edward

Published
1920

26. Evolution of the male-determining gene SRY within the cat family Felidae

Author

King, V., Goodfellow, P.N., Wilkerson, A.J. Pearks, Johnson, W.E., O'Brien, S.J., and Pecon-Slattery, J.

Subjects
Felidae -- Research, Felidae -- Genetic aspects, Y chromosome -- Research, Biological sciences
Abstract

In most placental mammals, SRY is a single-copy gene located on the Y chromosome and is the trigger for male sex determination during embryonic development. Here, we present comparative genomic analyses of SRY (705 bp) along with the adjacent noncoding 5' flank (997 bp) and 3' flank (948 bp) in 36 species of the cat family Felidae. Phylogenetic analyses indicate that the noncoding genomic flanks and SRY closely track species divergence. However, several inconsistencies are observed in SRY. Overall, the gene exhibits purifying selection to maintain traction ([omega] = 0.815) yet SRY is under positive selection in two of the eight felid lineages. SRY has low numbers of nucleotide substitutions, yet most encode amino acid changes between species, and four different species have significantly altered SRY due to insertion/deletions. Moreover, fixation of nonsynonymous substitutions between sister taxa is not consistent and may occur rapidly, as in the case of domestic cat, or not at all over long periods of time, as observed within the Panthera lineage. The former resembles positive selection during speciation, and the latter purifying selection to maintain function. Thus, SRY evolution in cats likely reflects the different phylogeographic histories, selection pressures, and patterns of speciation in modern felids.

Published
2007

40. Molecular phylogeny of the red panda (Ailurus fulgens)

Author

Slattery, J. Pecon and O'Brien, S.J.

Subjects
Red panda -- Genetic aspects, Phylogeny -- Research, Biological sciences
Abstract

The red panda (Ailurus fulgens) is within the Procyonidae radiation, although with an ancient phylogenetic divergence. This was revealed by a study of the red panda phylogeny using two slowly evolving genetic markers, mitochondrial 12S rRNA sequence and 592 fibroblast proteins resolved by two dimensional gel electrophoresis. Phylogeny was reconstructed using distance-based methods, maximum parsimony and maximum likelihood, which suggest a distinct bifurcation forming the Ursidae and the Procyonidae. The inclusion of the giant panda in the ursid (bear) lineage was also affirmed.

Published
1995

49. Clinical and angiographic predictors of stroke and death from carotid endarterectomy: systematic review

Author

Rothwell, P.M., Slattery, J., and Warlow, C.P.

Subjects
Complications and side effects, Risk factors, Surgery, Endarterectomy, Postoperative complications -- Complications and side effects -- Risk factors, Carotid arteries, Stroke -- Risk factors -- Complications and side effects, Carotid artery, Stroke (Disease) -- Risk factors -- Complications and side effects, Surgery -- Complications
Abstract

Introduction The absolute benefit derived from carotid endarterectomy is limited by the morbidity and mortality caused by the operation itself. The balance of risk and benefit is particularly fine in [...]

Published
1997

Catalog

Books, media, physical & digital resources
See catalog results